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Patterns and Changes in the Treatment of Patients with Type II Diabetes Mellitus in Egypt: The DISCOVER Program

International Journal of Clinical Medicine 2020年第12期11卷 731-742页

作者： Salah Shelbaya Mohamed Khattab Khalifa Abdallah Yehia Ghanem hesham el hefnawy Enas Shaltout Eman Roshdy Emad R. Issak Endocrinology Department Ain Shams University Cairo Egypt Internal Medicine Department Cairo University Giza Egypt Internal Medicine Department Alexandria University Alexandria Egypt Endocrinology Department National Institute of Diabetes & Endocrinology Cairo Egypt Internal Medicine Department Diabetes Unit Cairo University Giza Egypt Internal Medicine Department Ain Shams University Cairo Egypt

The DISCOVER study is a three-year, non-interventional prospective study conducted in 37 countries, including Egypt, to assess the treatment patterns and outcomes in patients with type 2 diabetes mellitus initiating a second-line antidiabetic therapy (add-on or switch). In this report of the Egyptian cohort of DISCOVER, baseline data were collected according to routine clinical practice at 38 study sites, using a standardized electronic case report form, in the period from December-2014 to November-2019. We enrolled 583 patients (mean age: 52.9 ± 9.8 years and median duration since diagnosis: median 36.5, IQR 18.1, 70.4 months). The mean HbA1c value at baseline was 8.6 ± 1.4%, indicating poor glycemic control. The most commonly prescribed first-line medications were metformin or sulfonylurea monotherapy. For second line-therapy, the majority of patients switched to dual therapy with metformin plus sulfonylureas or DPP-4 inhibitors. Fewer patients switched to triple therapy, treatment by four or more medications, or insulin treatment (15, 12, and 35 patients, respectively). The most commonly cited reasons for switching to second-line therapy were lack of efficacy, weight gain, hypoglycemic events, and side effects (549, 54, 25, and 21 patients, respectively). The set treatment target of enrolled patients at the initiation of second-line therapy was an HbA1c level of 6.9%. Follow-up data will assess the outcomes of such changes in the Egyptian population.

关键词： Diabetes Mellitus Glucose Control Metformin Patient-Reported Outcomes Egypt HbA1c Medication

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Intravesical instillation of platelet-rich plasma for treatment of interstitial cystitis/bladder pain syndrome:A pilot study

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Current Urology 2024年第1期18卷 49-54页

作者： Ahmed S.el hefnawy Mohamed Attya Ahmed Hasan Esam el Sawy Mohamed Abdel-Razik Nasr el-Tabey Mansoura Urology and Nephrology Center Faculty of MedicineMansoura UniversityMansouraEgypt

Objective:The aim of this study was to evaluate the feasibility of intravesical instillation of platelet-rich plasma(PRP)to treat interstitial cystitis/bladder pain syndrome(IC/BPS).Materials and methods:Twenty PRP samples were tested in vitro for stability after exposure to urine samples with different pH.A pilot study involving 21 female patients with IC/BPS was conducted,and 6 weekly doses of autologous PRP(50 mL)were *** were followed up at the 2nd,4th,8th,and 12th weeks after terminating *** primary endpoint was the visual analog scale(VAS)for pain,and the secondary endpoints included the IC symptom index,IC problem index of the O'Leary-Sant questionnaire and global response assessment,urine culture,and *** was defined as a reduction in VAS by 30%or more compared with basal level,and adverse events were ***:The mean±SD of VAS was significantly reduced compared with basal level(4.4±2.6 vs.8.8±1.1,respectively,p=0.001).Meanwhile,80%of cases were considered successful,with a 50.1%reduction in the mean score compared with the basal *** mean±SD of IC symptom index and IC problem index significantly improved compared with the basal *** response assessment was markedly,moderately,and slightly improved in 2(10%),10(50%),and 5(25%)patients,respectively,and showed no change in 3(15%).Three patients had positive urine cultures at follow-up,but 1 withdrew after 2 sessions because of a lack of ***:Repeated intravesical instillation of PRP could be considered an effective and safe approach for treating IC/BPS.

关键词： Bladder pain syndrome Interstitial cystitis Platelet-rich plasma

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3D finite element analysis of composite noise barrier con- structed of polyurethane products

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Frontiers of Structural and Civil Engineering 2017年第1期11卷 100-110页

作者： Ben DAEE hesham el NAGGAR Department of Civil and Environmental Engineering the University of Western Ontario London ON N6A 5B9 Canada

This paper presents a numerical investigation on the structural performance of an innovative noise barrier consisting of poly-block, rigid polyurethane foam （RPF） and polyurea. The mechanical characteristics of RPF as well as the flexural resistance of the proposed wall system （poly-wall） were established and presented in another study. The experimental results are used in the current study to develop, calibrate and verify 3D finite element （FE） models of the wall system. The components of the poly-wall including steel rebars, poly-blocks and RPF cores were simulated and then verified using the results of experiments conducted on the wall components. The results of numerical analysis exhibited a satisfactory agreement with the experimental outcomes for the entire wall system. The verified numerical models were then used to conduct a parametric study on the performance of poly-wall models under uniform wind load and gravity load. The findings of the current study confirmed that the structural performance of poly-wall is satisfactory for noise barrier application. Simulation techniques for improvement of the numerical analysis of multi-martial 3D FE models were discussed.

关键词： 3D finite element sound wall rigid polyurethane foam poly-wall numerical model calibration

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Dynamic Routing Optimization Algorithm for Software Defined Networking

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Computers, Materials & Continua 2022年第1期70卷 1349-1362页

作者： Nancy Abbas el-hefnawy Osama Abdel Raouf Heba Askr Department of Information Systems Tanta UniversityTanta31511Egypt Department of Operations Research and Decision Support Menoufia UniversityShepen AlkomEgypt Department of Information Systems University of Sadat CityAlSadat City048Egypt

Time and space complexity is themost critical problemof the current routing optimization algorithms for Software Defined Networking(SDN).To overcome this complexity,researchers use meta-heuristic techniques inside the routing optimization algorithms in the OpenFlow(OF)based large scale *** paper proposes a hybrid meta-heuristic algorithm to optimize the dynamic routing problem for the large scale *** to the dynamic nature of SDNs,the proposed algorithm uses amutation operator to overcome the memory-based problem of the ant colony ***,it uses the box-covering method and the k-means clustering method to divide the SDN network to overcome the problemof time and space *** results of the proposed algorithm compared with the results of other similar algorithms and it shows that the proposed algorithm can handle the dynamic network changing,reduce the network congestion,the delay and running times and the packet loss rates.

关键词： Dynamic routing optimization Openflow software defined networking

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Comparison of bacterial community structures in two systems of a sewage treatment plant using PCR-DGGE analysis

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Journal of Environmental Sciences 2011年第12期23卷 2049-2054页

作者： Abd el-Latif hesham Rong Qi Min Yang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Genetics Department Faculty of Agriculture Assiut University Assiut Egypt

The combination of PCR amplification of 16S rRNA genes with denaturing gradient gel electrophoresis （DGGE） analysis was used to reveal the compositions and dynamics of bacterial communities in a sewage treatment plant with two systems, i.e., an anoxic- anaerobic-aerobic system （inverted A2O） and an anaerobic-anoxic-aerobic one （conventional A2O） over a period from February to July 2009, during which both systems experienced serious sludge bulking problems. The DGGE patterns showed that there were many common bands in both systems, suggesting the high similarity of bacterial communities of the two systems. Meanwhile, the moving window correlation analysis showed that the two systems experienced different microbial community structure changes during the period, which might be related with the different situations of the occurrence and disappearance of sludge bulking, as being reflected by sludge volume index （SVI） values. Major bands of DGGE patterns of sludge samples were further sequenced. Phylogenetic affiliation indicated that the majority of the sequences obtained were affiliated with Actinobacteria, Firmicutes, Bacteroidetes/Chlorobi group and α- and β-Proteobacteria. Two sequences showed high similarities to typical filamentous bacteria Microthrix parvicella and Nostocoida limicola I, indicating that these bacterial species have been involved in the sludge bulking problems.

关键词： PCR-DGGE bacterial community activated sludge sludge bulking sewage treatment plant

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Hydraulic head difference at two sides of suspended waterproof curtain during multi-grade dewatering of excavation

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Underground Space 2023年第3期10卷 137-149页

作者： Tao Yang Li-yuan Tong M.hesham el Naggar Xin Yan School of Transportation Southeast UniversityNanjing 21000China Department of Civil and Environmental Engineering Western UniversityLondon N6A 5B9Canada

This paper proposes an approach to calculate the head difference at two sides of suspended waterproof curtains during multi-grade *** seepage during the dewatering process can be subdivided into three regions:(i)seepage in pit,(ii)seepage between cur-tains,and(iii)seepage outside the *** flow rate of the first region is equal to the pumping rate,and the flow rate of the second and third regions can be obtained by numerical analysis.A numerical model is established to simulate the seepage in the second and third regions and its performance is validated by using the measured data of a series of field *** flow rate of each region is then used to derive formulae for the head difference in conventional dewatering,which can be used to determine the head difference at two sides of each waterproof curtain during multi-grade *** proposed formula expresses the head difference as a function of the relative depth of the curtain inserted into the confined aquifer,the thickness of the aquifer,the distance between two curtains,and the anisotropy of the hydraulic conductivity of the *** proposed numerical approach is further validated by using data derived from numerical *** validation results demonstrated that the predictions of the proposed approach are acceptable and convenient.

关键词： Head difference Multi-grade dewatering Suspended waterproof curtain Confined aquifer

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electrodeposited Ni and Ni-Co alloys using cysteine and conventional ultrasound waves

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Science China Chemistry 2013年第10期56卷 1446-1454页

作者： el-FEKY hesham NEGEM Mosaad ROY Sudipta HelAL Nadia BARAKA A. Chemistry Department Faculty of Science Fayoum UniversityFayoum 63514 Egypt School of Chemical Engineering and Advanced Materials Newcastle University Newcastle upon TyneNE1 7RU United Kingdom Chemistry Department Faculty of Science Cairo UniversityGiza 12613 Egypt

Ni-Co alloys were electroplated from sulphate electrolyte using addition agents including sodium gluconate, boric acid and eysteine on copper foil by the galvanostatic technique and ultrasound waves. The chemical composition, surface morphologies, crystalline structure and hardness of the Ni-Co alloys were studied using energy dispersive spectroscopy, scanning electron microscope, X-ray diffraction and Vickers testing method, respectively. The effect of current density and addition agents on the microstructure and morphology of Ni-Co alloys were examined. The appropriate concentration of additives and ultrasound waves were found to produce fine and smooth crystals leading to higher hardness of Ni-Co alloys. The microhardness of the Ni-Co alloys was varied between 4860-7530 HV. The surface morphology of coatings was changed from granular to fine due to using of gluconate, boric acid, cysteine and ultrasound waves. The mechanical properties of nanocrystalline Ni-Co alloys showed an increase of the hardness with the growing of Ni content in the alloy. The X-ray diffraction studies indicated that nanocrystalline structure was face-centred cubic for pure Ni and Ni-Co alloys with Co content in the range of 1-75 wt.%. A hexagonal closed-package structure was obtained for pure Co and Ni-Co alloys with the cobalt content with range of 75-99 wt.%.

关键词： electrodeposition nanocrystalline Ni alloys ultrasound microhardness

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Soil enzymatic activities and microbial community structure with different application rates of Cd and Pb

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Journal of Environmental Sciences 2007年第7期19卷 834-840页

作者： KHAN Sardar CAO Qing hesham Abd el-Latif XIA Yue HE Ji-zheng Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Belting 100085 China. Department of Environmental Sciences University of Peshawar 25120 Peshawar Pakistan

This study focused on the changes of soil microbial diversity and potential inhibitory effects of heavy metals on soil enzymatic activities at different application rates of Cd and/or Pb. The soil used for experiments was collected from Beijing and classified as endoaquepts. Pots containing 500 g of the soil with different Cd and/or Pb application rates were incubated for a period of 0, 2, 9, 12 weeks in a glasshouse and the soil samples were analyzed for individual enzymes, including catalase, alkaline phosphatase and dehydrogenase, and the changes of microbial community structure. Results showed that heavy metals slightly inhibited the enzymatic activities in all the samples spiked with heavy metals. The extent of inhibition increased significantly with increasing level of heavy metals, and varied with the incubation periods. The soil bacterial community structure, as determined by polymerase chain reaction- denaturing gradient gel electrophoresis techniques, was different in the contaminated samples as compared to the control. The highest community change was observed in the samples amended with high level of Cd. Positive correlations were observed among the three enzymatic activities, but negative correlations were found between the amounts of the heavy metals and the enzymatic activities.

关键词： soil contamination heavy metals application rate enzymatic activity microbial community

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Numerical modeling of time-dependent deformation and induced stresses in concrete pipes constructed in Queenston shale using micro-tunneling technique

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第2期10卷 290-309页

作者： Hayder Mohammed Salim Al-Maamori M.hesham el Naggar Silvana Micic Department of Civil and Environmental Engineering Western University Geotechnical Research Center Western University

Effects of time-dependent deformation（TDD） on a tunnel constructed using the micro-tunneling technique in Queenston shale（QS） are investigated employing the finite element method. The TDD and strength parameters of the QS were measured from tests conducted on QS specimens soaked in water and lubricant fluids（LFs） used in micro-tunneling such as bentonite and polymer solutions. The numerical model was verified using the results of TDD tests performed on QS samples, field measurements of some documented projects, and the closed-form solutions to circular tunnels in swelling rock. The verified model was then employed to conduct a parametric study considering important micro-tunneling design parameters, such as depth and diameter of the tunnel, in situ stress ratio（K;）, and the time lapse prior to replacing LFs with permanent cement grout around the tunnel. It was revealed that the time lapse plays a vital role in controlling deformations and associated stresses developed in the tunnel *** critical case of a pipe or tunnel in which the maximum tensile stress develops at its springline occurs when it is constructed at shallow depths in the QS layer. The results of the parametric study were used to suggest recommendations for the construction of tunnels in QS employing micro-tunneling.

关键词： Numerical model Micro-tunneling Queenston shale(QS) Lubricant fluids(LFs)

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Impacts of produced water origin on bacterial community structures of activated sludge

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Journal of Environmental Sciences 2015年第11期27卷 192-199页

作者： Zhenyu Wang Feng Pan Abd el-Latif hesham Yingxin Gao Yu Zhang Min Yang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Key Laboratory for Microorganisms and Functional Molecules College of Life Science Henan Normal University Genetics Department Faculty of Agriculture Assiut University

The purpose of this study was to reveal how activated sludge communities respond to influent quality and indigenous communities by treating two produced waters from different origins in a batch reactor in succession. The community shift and compositions were investigated using Polymerase Chain Reaction–denaturing gradient gel electrophoresis（PCR–DGGE） and further16 S ribosomal DNA（r DNA） clone library analysis. The abundance of targeted genes for polycyclic aromatic hydrocarbon（PAH） degradation, nah Ac/phn Ac and C12O/C23 O, was tracked to define the metabolic ability of the in situ microbial community by Most Probable Number（MPN） PCR. The biosystem performed almost the same for treatment of both produced waters in terms of removals of chemical oxygen demand（COD） and PAHs. Sludge communities were closely associated with the respective influent bacterial communities（similarity 〉 60%）, while one sludge clone library was dominated by the Betaproteobacteria（38%） and Bacteriodetes（30%）and the other was dominated by Gammaproteobacteria（52%）. This suggested that different influent and water quality have an effect on sludge community compositions. In addition, the existence of catabolic genes in sludge was consistent with the potential for degradation of PAHs in the treatment of both produced waters.

关键词： Polycyclic aromatic hydrocarbons Indigenous community Wastewater treatment Functional gene

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