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Formulation and Evaluation of Yemeni Potash Alum as Hydrophilic Topical Preparations against Candidiasis and Aspergillosis

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Clinical Complementary Medicine and Pharmacology 2022年第4期2卷 26-38页

作者： Moath Refat Anes A.M.Thabit Abdul-Rahman Maqboli hesham siddick Rafaʼa MAl-Ghozee Abdul-baqi A.Thabet Manar Refat Aiman Saleh A.Mohammed Ahmed Al-Sabati Wu Xin’an College of Pharmaceutical Science Lanzhou UniversityLanzhou 730000GansuChina Department of Pharmacy The First Hospital of Lanzhou UniversityLanzhou 730000GansuChina College of Pharmacy University of Science and TechnologyAl-Hodeidah15201Yemen College of Medical Sciences University of Science and TechnologyAl-Hodeidah15201Yemen College of Pharmacy Sana’a UniversitySana’a1247Yemen Pharmacy department Al-Razi UniversitySana’aYemen Department of Pharmacology Faculty of PharmacyUniversity of AdenAden6312Yemen

Background:Skin and soft tissue infections are *** and Aspergillosis are the most common cutaneous fungal *** alum(Aluminium Potassium Sulphate)is a natural mineral with antifungal and antibacterial ***:This study aimed to confirm Yemeni alum’s antifungal effectiveness against selected fungal strains and develop useful topical ***:Using different alum concentrations,we prepared twenty-three formulations,including four non-adjusted aqueous solutions,eight adjusted pH aqueous solutions,eight glycerite solutions,and three Oil/Water cream ***,we examined the antifungal activity against the suggested *** animal skin irritation test evaluated the local skin sensitivity reactions that might happen upon using the formulations we pre-pared on the intact animal’s ***,this study also included six weeks of stability testing to estimate the expected shelf life(t90)of the selected ***:Alum exerted antifungal effect against Candida albicans,Aspergillus niger,and Aspergillus *** animal’s skin was not irritated by any of the formulations *** 5%alum aqueous solution and the 10%alum Oil/Water cream exhibited promising results among all tested *** approximate formulation’s shelf-lives(t90)were 2 and 1.52 years with alum content(%)ranging between 105.75%to 106.02%,***:Based on the results we found,10%alum Oil/Water cream is a promising formulation for large-scale manufacture.

关键词： Potassium alum Yemeni alum Antifungal Topical preparations Skin soft tissue infections Candidiasis Aspergillosis

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