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alvimopan对接受简单腹式全子宫切除术患者安全性的一项双盲、随机、安慰剂对照Ⅲ期临床研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 7-7页

作者： herzog t.j. Coleman R.L. Guerrieri jr. j.P. 翁梨驹 Columbia University New YorkNYUnited States Dr.

Objective:the purpose of this study was to investigate the safety and efficacy of alvimopan,a novel peripherally acting mu-opioid receptor antagonist,in patients who undergo simple total abdominal hysterectomy. Study design:Women (n = 519)-were randomized (4:1) to receive alvimopan 12 mg (n = 413) or placebo (n = 106)≥2 hours before the operation then twice daily for 7 days (hospital and home). Adverse events were monitored up to 30 days after the last dose of study drug was administered. Efficacy was assessed for 7 postoperative days. Results:Overall,the most common adverse events were nausea,vomiting,and constipation; tients discontinued use because of adverse events. Alvimopan significantly accelerated the time to first bowel movement (hazard ratio,2.33; P time to first bowel movement was reduced by 22 hours,with more frequent bowel movement and better bowel movement quality found in the treatment cohort. Conclusion:Alvimopan has a safety profile that is similar to that of placebo and provides significantly improved lower gastrointestinal recovery in women who undergo simple total abdominal hysterectomy.

关键词： alvimopan 安慰剂对照阿片受体拮抗剂排粪于术不良反应消化道功能研究设计随机分配

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妊娠期复发性外阴癌

世界核心医学期刊文摘（妇产科学分册） 2005年第3期1卷 51-51页

作者： Ogunleye D. Lewin S.N. Huettner P. herzog t.j. 郭慧方

Vulvar carcinoma is rare in the premenopausal age group. the incidence during pregnancy is even more uncommon. to date, no cases of recurrent vulvar carcinoma in pregnancy have been reported. We describe the first case of recurrent vulvar carcinoma during the same pregnancy. A 36- year- old G5P4004 presented with vulvar pain at 18 weeks of pregnancy. She had a 2.2- cm tender mass anterior to the left labium majus, of which a biopsy revealed invasive squamous cell carcinoma. At 23 weeks gestation, she underwent a modified radical vulvectomy and bilateral inguinofemoral lymph node dissection. Eleven weeks later, she complained of a newly tender area to the right of the clitoris. A biopsy at that time demonstrated predominantly severe vulvar intraepithelial neoplasia (VIN III) with a small focus of invasive squamous cell carcinoma. A radical local excision was performed at 9 weeks postpartum. Careful surveillance is warranted as squamous cell carcinoma recurrence can occur quickly in the setting of pregnancy.

关键词：大阴唇瘤样病变组织活检淋巴结切除术双侧腹股沟病灶切除术鳞癌年龄组

A comparison of lower limb stiffness and mechanical muscle function in ACL-reconstructed,elite,and adolescent alpine ski racers/ski cross athletes

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journal of Sport and Health Science 2018年第4期7卷 416-424页

作者： Matthew j.jordan Per Aagaard Walter herzog Canadian Sport Institute Calgary Calgary AB T2N IN4Canada Department of Sports Science and Clinical Biomechanics SDU Muscle Research ClusterUniversity of Southern DenmarkOdense DK-5230Denmark Human Performance Laboratory University of CalgaryCalgaryAB T2N IN4Canada Corresponding author.E-mail address： mjordan@ucalgary.ca

Purpose： the aim of this study was to compare mechanical muscle function in the eccentric/concentric phases of vertical bilateral jumping in anterior cruciate ligament-reconstructed （ACLR）, elite （ELItE）, and adolescent （ADOL） alpine ski racers and ski cross athletes. Methods： Alpine ski racers/ski crossers （ACLR： n = 12, age = 26.7 ± 3.8 years; ELItE： n = 12, age = 23.9 ± 3.0 years; ADOL： n = 12, age = 17.8 ± 0.7 years; females： n = 6 per group, males： n = 6 per group） performed 5 maximal countermovement.j.mps （CMjs） and 5 squat.j.mps. the ground reaction forces for each limb were analyzed using dual force plate recording to obtain body center of mass （BCM） velocity, displacement, and power. the eccentric deceleration （ECC） and concentric phases were determined from BCM velocity. CMj net concentric and ECC impulses were calculated （body mass normalized） along with the peak and mean BCM power and maximal vertical jump height. CMj lower limb stiffness （LLS） was determined by the slope of the ground reaction forces vs. the BCM displacement curve over the ECC phase. Concentric and ECC asymmetry indices were calculated for each leg, and the left vs. right LLS was compared. Outcome measures （reported as mean ± SD） calculated as a 5-jump mean were normalized to body mass and compared using an analysis of variance. Results： No between-group differences were found for peak and mean power or jump heights. there were no group differences for LLS or net concentric phase impulse, but the net ECC impulse was lower in the ADOL group compared with ELItE skiers （ADOL： 1.33 ± 0.32 Ns/kg; ELItE： 1.59 ± 0.16 Ns/kg; p 〈 0.05）. Although no group differences were found for ECC asymmetry indices, a group × limb interaction was found for LLS （p 〈 0.01）, which was systematically higher in the right vs. the left limb of ADOL skiers （right： 54.1 ± 17.9 N/m/kg; left： 48.7 ± 15.7 N/m/kg;p 〈 0.01）. Conclusion： ADOL skiers demonstrated decreased ECC impulse and systematic right limb dominance in

关键词： Between-limb asymmetry Injury prevention Knee injuries Muscle power Vertical jump

Why are muscles strong, and why do they require little energy in eccentric action?

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journal of Sport and Health Science 2018年第3期7卷 255-264页

作者： Walter herzog Human Performance Laboratory Faculty of Kinesiology University of Calgary

It is well acknowledged that muscles that are elongated while activated(i.e.,eccentric muscle action)are stronger and require less energy(per unit of force)than muscles that are shortening(i.e.,concentric contraction)or that remain at a constant length(i.e.,isometric contraction).Although the cross-bridge theory of muscle contraction provides a good explanation for the increase in force in active muscle lengthening,it does not explain the residual increase in force following active lengthening(residual force enhancement),or except with additional assumptions,the reduced metabolic requirement of muscle during and following active *** from the cross-bridge theory,2 other primary explanations for the mechanical properties of actively stretched muscles have emerged:(1)the so-called sarcomere length nonuniformity theory and(2)the engagement of a passive structural element *** this article,these theories are discussed,and it is shown that the last of these—the engagement of a passive structural element in eccentric muscle action—offers a simple and complete explanation for many hitherto unexplained observations in actively lengthening *** by no means fully proven,the theory has great appeal for its simplicity and beauty,and even if over time it is shown to be wrong,it nevertheless forms a useful framework for direct hypothesis testing.

关键词： Cross-bridge theory Eccentric Force-length relationship Residual force enhancement titin

Improved optical enhancement using double-width plasmonic gratings with nanogaps

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Photonics Research 2016年第5期4卷 173-180页

作者： Ahmad A.Darweesh Stephen j.Bauman joseph B.herzog Microelectronics-Photonics Graduate Program University of Arkansas Department of Physics University of Arkansas

Plasmonic grating structures have been shown effective at increasing near-field optical enhancement. A doublewidth plasmonic grating design is introduced, where each period has two alternating metal widths separated by a nanogap. With this new design, analysis has shown that plasmonic resonances couple between each metal section,resulting in even greater optical enhancement compared with single-width gratings. the geometry that gives the greatest optical enhancement has been determined with a computational model. this work demonstrates that the increased enhancement is due to hybridized modes that couple between the two grating segments.

关键词： Improved optical enhancement using double-width plasmonic gratings with nanogaps nm

the secrets to running economy

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journal of Sport and Health Science 2022年第3期11卷 273-274页

作者： Walter herzog Human Performance Laboratory Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada

Every once in a while,a sport is revolutionized by a discovery or a new *** the mid-1980s,cross-country skiing was changed forever by the introduction of the skating *** Fosbury revolutionized high-jumping when he won the Olympic Games by crossing the bar“backwards”,and the development of the“klapp-skate”led to vast improvements of world records in speed skating.

关键词： technique. backward revolution

Eccentric vs. concentric muscle contraction： that is the question

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journal of Sport and Health Science 2017年第2期6卷 128-129页

作者： Walter herzog Human Performance Laboratory Faculty of KinesiologyUniversity of Calgary

In their recent papers in the journal of Sport and Health Science on hamstring injuries in sprinting,^(1,2)and their corresponding commentaries on each other's research,3,4Yu et *** Liu et *** different views of the mechanisms of muscle injuries in general,and hamstring injuries in sprinting *** Yu et al.^(1,3)argued that muscle injuries are primarily,if not exclusively,caused by muscle strain magnitude in eccentric contractions,and thus hamstring injuries occur primarily

关键词：心肌收缩偏心肌肉损伤收缩应变受伤短跑

Editorial re:Could sport be part……by Ring-Dimitriou et al.

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journal of Sport and Health Science 2019年第4期8卷 348-349页

作者： Walter herzog Human Performance Laboratory Faculty of KinesiologyUniversity of Calgary

Childhood obesity has become a concern in most economically developing *** reasons for this seem clear:too much food and not enough *** dilemma has received much scientific attention,and the question arises:How do we get children to move and make good eating choices?In their opinion piece in this issue of the journal of Sport and Health Science(jSHS),Ring-Dimitriou et al.1 make an argument that playing structured and supervised traditional sports will help children with obesity,where traditional sports include football,handball,gymnastics,athletics,and martial arts.

关键词： Ring-Dimitriou journal of Sport and Health Science(jSHS) economically developing countries

Do recreational team sports provide fitness and health benefits?

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journal of Sport and Health Science 2018年第2期7卷 127-128页

作者： Walter herzog Human Performance Laboratory Faculty of KinesiologyUniversity of Calgary

In many countries,sedentary lifestyle has led to a number of epidemic health problems,including obesity,metabolic syndrome,and associated *** have performed self-evaluations of the fitness status of their people:child... 详细信息

关键词：健康问题运动娱乐生活方式新陈代谢自我评估症候群成年人