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Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

Bioactive Materials 2023年第11期29卷 151-176页

作者： Filipe V.Ferreira Alana G.souza Rubina Ajdary Lucas P.de souza Jo˜ao H.Lopes Daniel s.Correa Gilberto siqueira hernane s.barud Derval dos s.Rosa Luiz H.C.Mattoso Orlando J.Rojas Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa Instrumentation-Rua XV de Novembro1452S˜ao CarlosSP13560-979Brazil Center for Engineering Modelingand Applied Social Sciences(CECS)Federal University of ABC(UFABC)Santo Andr´eBrazil Department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityP.O.Box 16300AaltoEspooFIN-00076Finland College of Engineering and Physical sciences Aston Institute of Materials ResearchAston UniversityBirminghamUK Department of Chemistry Division of Fundamental Sciences(IEF)Technological Institute of Aeronautics(ITA)S˜ao Jose dos CamposSPBrazil Laboratory for Cellulose&Wood Materials Empa-Swiss Federal Laboratories for Materials Science and TechnologyÜberlandstrasse 1298600DübendorfSwitzerland Biopolymers and Biomaterials Laboratory(BIOPOLMAT) University of Araraquara(UNIARA)Araraquar114801-340S˜ao PauloBrazil Bioproducts Institute Department of Chemical&Biological EngineeringDepartment of Chemistry andDepartment of Wood ScienceThe University of British Columbi12360 East MallVancouverBCV6T 1Z3Canada

We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure-property-function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

关键词： Cellulose nanofibrils Cellulose nanocrystals Regenerative medicine Biomaterial sustainable materials Green nanomaterials

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Information and Knowledge Flows in the Network of the Education through Work for Family Health Program

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social Networking 2014年第2期3卷 119-126页

作者： Ana Aurea Alécio de Oliveira Rodrigues Claudia Ribeiro santos Lopes Eliane santos souza Inacio de sousa Fadigas hernane Borges de Barros Pereira Universidade Estadual de Feira de santana Feira de SantanaBrazil Programa de Difusao do Conhecimento DMMDC/UFBASalvadorBrazil Universidade Estadual do sudoeste da Bahia JequiéBrazil Universidade Federal da Bahia SalvadorBrazil Universidade do Estado da Bahia SalvadorBrazil Programa de Modelagem Computacional SENAI CimatecSalvadorBrazil

The Education through Work for Family Health Program (PET saúde, in Portuguese) created by the Ministries of Education and Health is a proposal to integrate service, learning and community. The goal of PET saúde is to foster the formation of learning groups within the Family Health strategy scope. While being studied at the city of Feira de santana, the program was structured with one coordinator and eleven tutorial groups, distributed in 27 family health offices, which constituted a social network where the construction and knowledge diffusion occur. This article proposes the analysis of the information and knowledge flows of this network through the social networks analysis. This study highlights the play of PET saúde’s coordinator in the processes of organization and articulation as central vertex of the network, and some scholars in the articulation of different tutorial groups. The results show a fragmentation in the PET saúde network when the coordinator vertex is removed, whereas 5 components are generated where 4 tutorial groups appear isolated.

关键词： social Networks Education-service Interaction Health Information Knowledge

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