检索结果-南通市图书馆

The Temporal Variability of the Freshwater Discharge and Water Levels at the Patos Lagoon,Brazil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Geosciences 2012年第4期3卷 758-766页

作者： Wiliam correa Marques Instituto de Matematica Estatistica e FisicaUniversidade Federal do Rio GrandeRio Grande do SulBrazil

The direct influence of freshwater discharge along the coastal regions is observed in several processes following a wide spectrum on spatial and temporal variability. The knowledge of relative importance of this physical forcing is fundamental by the correct management of the coastal sites and the understanding of consequences associated with processes of climatic order is one point deserves some investigation. The major part of the studies in the Patos Lagoon, located in the southernmost part of Brazil, is limited to investigate the effects in synoptic time scales. In this way, the objective of this study is to investigate the long term variability pattern of the Patos Lagoon discharge and water levels indentifying long term trends through wavelet analysis. The results indicated that El Ni?o (La Ni?a) events promote the intensification (decrease) of the freshwater intensity in the principal river tributaries of the Patos Lagoon following scales from 16 to 120 months (from 1.3 to 10 years). The most energetic cycle is centered in periods of 64 months (5.3 years). The longer events reflect the long term response of the non linear dynamics in Equatorial Pacific changing the precipitation pattern, principally during winter and at the end of spring and early autumn. The non-linear long term trend indicates a pattern with values of discharge normally above (below) the mean after (before) 1970’s. An increasing trend starting after 1970 possibly indicates a longer term cycle influencing the interannual variability of the Patos Lagoon discharge. The seasonality is maintained in climatic monthly means obtained after and before 1970’s, but, with mean increase around 364 m3·s?1 in freshwater discharge with reduced amplitude of the seasonal cycle.

关键词： Freshwater Discharge El Nino La Nina Wavelet Analyzes

Hybrid Security Assessment Methodology for Web Applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2021年第1期126卷 89-124页

作者： Roddy A.correa Juan Ramon Bermejo Higuera Javier Bermejo Higuera Juan Antonio SiciliaMontalvo Manuel Sanchez Rubio A.Alberto Magrenan Universidad Tecnica Particular de Loja San Cayetano AltoLojaEcuador Escuela Superior de Ingenieria y Tecnologia Universidad Internacional de La RiojaLogrono26006Spain Universidad de la Rioja Logrono26006Spain

This study presents a methodology to evaluate and prevent security vulnerabilities issues for web *** analysis process is based on the use of techniques and tools that allow to perform security assessments of white box and black box,to carry out the security validation of a web application in an agile and precise *** objective of the methodology is to take advantage of the synergies of semi-automatic static and dynamic security analysis tools and manual *** one of the phases contemplated in the methodology is supported by security analysis tools of different degrees of coverage,so that the results generated in one phase are used as feed for the following phases in order to get an optimized global security analysis *** methodology can be used as part of other more general methodologies that do not cover how to use static and dynamic analysis tools in the implementation and testing phases of a Secure Software Development Life Cycle(SSDLC).A practical application of the methodology to analyze the security of a real web application demonstrates its effectiveness by obtaining a better optimized vulnerability detection result against the true and false positive *** analysis with manual checking is used to audit the results,24.6 per cent of security vulnerabilities reported by the static analysis has been checked and it allows to study which vulnerabilities can be directly exploited *** phase is very important because it permits that each reported vulnerability can be checked by a dynamic second tool to confirm whether a vulnerability is true or false positive and it allows to study which vulnerabilities can be directly exploited *** analysis finds six(6)additional critical *** control analysis finds other five(5)important vulnerabilities such as Insufficient Protected Passwords or Weak Password Policy and Excessive Authentication Attacks,two vulnerabilities that permit brute force at

关键词： Web applications security vulnerability weakness security analysis white box black box interactive application security testing static application security testing dynamic application security testing

Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2016年第5期7卷 340-351页

作者： Zain A Sobani Ashwin Sawant Mikram Jafri Amit Keith correa Ibrahim Halil Sahin Department of Medicine Maimonides Medical Center Department of Medicine Icahn School of Medicine at Mount Sinai St Luke’s Roosevelt Hospital Center Department of Medicine Albany Stratton Veterans Hospital

Epidermal growth factor receptor(EGFR) has been an attractive target for treatment of epithelial cancers, including colorectal cancer(CRC). Evidence from clinical trials indicates that cetuximab and panitumumab(antiEGFR monoclonal antibodies) have clinical activity in patients with metastatic CRC. The discovery of intrinsic EGFR blockade resistance in Kirsten RAS(KRAS)-mutant patients led to the restriction of anti-EGFR antibodies to KRAS wild-type patients by Food and Drug Administration and European Medicine Agency. Studies have since focused on the evaluation of biomarkers to identify appropriate patient populations that may benefit from EGFR blockade. Accumulating evidence suggests that patients with mutations in EGFR downstream signaling pathways including KRAS, BRAF, PIK3CA and PTEN could be intrinsically resistant to EGFR blockade. Recent whole genome studies also suggest that dynamic alterations in signaling pathways downstream of EGFR leads to distinct oncogenic signatures and subclones which might have some impact on emerging resistance in KRAS wild-type patients. While anti-EGFR monoclonal antibodies have a clear potential in the management of a subset of patients with metastatic CRC, further studies are warranted to uncover exact mechanisms related to acquired resistance to EGFR blockade.

关键词： Epidermal growth factor receptor Oncogenic signature Kirsten RAS BRAF Cetuximab Panitumumab Epidermal growth factor receptor blockade resistance

QTL mapping and identification of SNP-haplotypes affecting yield components of Theobroma cacao L.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture Research 2020年第1期7卷 2444-2461页

作者： Luciel dos Santos Fernandes Fábio M.correa Keith TIngram Alex-Alan Furtado de Almeida Stefan Royaert Mars Center for Cocoa Science CP 55ItajuípeBA CEP 45.630-000Brazil Departamento de Ciências Biológicas Universidade Estadual de Santa CruzRodovia Ilhéus-ItabunaKm 16Bairro SalobrinhoIlhéusBA CEP 45.662-900Brazil Mars Incorporated13601 Old Cutler RoadMiamiFL 33158USA

Cacao is a crop of global relevance that faces constant demands for improved bean ***,little is known about the genomic regions controlling the crop yield and genes involved in cacao bean ***,to identify the quantitative trait loci(QTL)associated with cacao yield and bean filling,we performed a QTL mapping in a segregating mapping population comprising 459 trees of a cross between‘TSH 1188’and‘CCN 51’.All variables showed considerable phenotypic variation and had moderate to high heritability *** identified 24 QTLs using a genetic linkage map that contains 3526 single nucleotide polymorphism(SNP)*** analysis at the significant QTL region on chromosome IV pointed to the alleles from the maternal parent,‘TSH 1188’,as the ones that affect the cacao yield components the *** recombination events identified within these QTL regions allowed us to identify candidate genes that may take part in the different steps of pod growth and bean *** candidate genes seem to play a significant role in the source-to-sink transport of sugars and amino acids,and lipid metabolism,such as fatty acid *** SNP markers mapped in our study are now being used to select potential highyielding cacao varieties through marker-assisted selection in our existing cacao-breeding experiments.

关键词： breeding mapping linkage

Association of swine influenza H1N1 pandemic virus(SIV-H1N1p) with porcine respiratory disease complex in sows from commercial pig farms in Colombia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2014年第4期29卷 242-249页

作者： Luisa Fernanda Mancipe Jiménez Gloria Ramírez Nieto Victor Vera Alfonso Jairo Jaime correa Laboratory of Animal Virology Faculty of Veterinary Medicine and Animal Science National University of Colombia

Porcine respiratory disease complex(PRDC) is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus(PRRSV), swine influenza virus(SIV), Mycoplasma hyopneumoniae(Myh), Actinobacillus pleuropneumoniae(APP), Pasteurella multocida and Porcine circovirus 2(PCV2). To characterize the specific role of swine influenza virus in PRDC presentation in Colombia, 11 farms from three major production regions in Colombia were examined in this study. Nasal swabs, bronchial lavage and lung tissue samples were obtained from animals displaying symptoms compatible with SIV. Isolation of SIV was performed in 9-day embryonated chicken eggs or Madin-Darby Canine Kidney(MDCK) cells. Positive isolates, identified via the hemagglutination inhibition test, were further analyzed using PCR. Overall, 7 of the 11 farms were positive for SIV. Notably, sequencing of the gene encoding the hemagglutinin(HA) protein led to grouping of strains into circulating viruses identified during the human outbreak of 2009, classified as pandemic H1N1-2009. Serum samples from 198 gilts and multiparous sows between 2008 and 2009 were obtained to determine antibody presence of APP, Myh, PCV2 and PRRSV in both SIV-H1N1p-negative and-positive farms, but higher levels were recorded for SIV-H1N1p-positive farms. Odds ratio(OR) and P values revealed statistically significant differences(p<0.05) in PRDC presentation in gilts and multiparous sows of farms positive for SIV-H1N1 p. Our findings indicate that positive farms have increased risk of PRDC presentation, in particular, PCV2, APP and Myh.

关键词：猪呼吸道疾病综合征猪流感病毒经产母猪哥伦比亚商品猪场猪繁殖与呼吸综合征病毒胸膜肺炎放线杆菌支气管肺泡灌洗液

Prediction of hospital mortality in intensive care unit patients from clinical and laboratory data: A machine learning approach

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Critical Care Medicine 2022年第5期11卷 317-329页

作者： Elena Caires Silveira Soraya Mattos Pretti Bruna Almeida Santos Caio Fellipe Santos correa Leonardo Madureira Silva Fabricio Freire de Melo Multidisciplinary Institute of Health Federal University of BahiaVitória da Conquista 45-029094Brazil

BACKGROUND Intensive care unit(ICU)patients demand continuous monitoring of several clinical and laboratory parameters that directly influence their medical progress and the staff’s *** data are vital in the assistance of these patients,being already used by several scoring *** this context,machine learning approaches have been used for medical predictions based on clinical data,which includes patient *** To develop a binary classifier for the outcome of death in ICU patients based on clinical and laboratory parameters,a set formed by 1087 instances and 50 variables from ICU patients admitted to the emergency department was obtained in the“WiDS(Women in Data Science)Datathon 2020:ICU Mortality Prediction”*** For categorical variables,frequencies and risk ratios were *** variables were computed as means and standard deviations and Mann-Whitney U tests were *** then divided the data into a training(80%)and test(20%)*** training set was used to train a predictive model based on the Random Forest algorithm and the test set was used to evaluate the predictive effectiveness of the *** A statistically significant association was identified between need for intubation,as well predominant systemic cardiovascular involvement,and hospital death.A number of the numerical variables analyzed(for instance Glasgow Coma Score punctuations,mean arterial pressure,temperature,pH,and lactate,creatinine,albumin and bilirubin values)were also significantly associated with death *** proposed binary Random Forest classifier obtained on the test set(n=218)had an accuracy of 80.28%,sensitivity of 81.82%,specificity of 79.43%,positive predictive value of 73.26%,negative predictive value of 84.85%,F1 score of 0.74,and area under the curve score of *** predictive variables of the greatest importance were the maximum and minimum lactate values,adding up to a predictive importance of 15.54%.CONCLUSIO

关键词： Hospital mortality Machine learning Patient outcome assessment Routinely collected health data Intensive care units Critical care outcomes

Gait Analysis of a Subject with Total Hip Arthroplasty

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2022年第10期10卷 135-143页

作者： Carlos Díaz Novo Micaela González Castillo Juan Bentos Dupuy Maximiliano Vespa correa Martín Machado López Felipe Gorla Gargano Biomedical Engineering Program Technological University of Uruguay UTEC Fray Bentos Uruguay

Introduction: gait analysis of a subject with total hip replacement is described. Objective: instrumental gait analysis of a subject 12 years after the total hip arthroplasty. Materials and Methods: in a movement analysis laboratory, locomotion studies were carried out at freely chosen walking speed by a 64-year-old subject, obtaining kinematic, kinetic and surface electromyographic data in time and space. All measurements were assessments by applying walking protocols on a straight surface of 8 m long. Results: abnormal slight activations of semitendinosus and tibialis anterior muscles, of the left limb, were observed throughout the gait cycle, no spatiotemporal parameters far from normal values were detected. Conclusions: it was possible to obtain an exhaustive analysis of the parameters associated with the gait of a subject after 12 years of total hip arthroplasty.

关键词： Total Hip Arthroplasty Kinetics Kinematics Surface Electromyography Motion Analysis Laboratory Pathological

Maternal antibiotic treatment affects offspring gastric sensing for umami taste and ghrelin regulation in the pig

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2021年第3期12卷 1031-1041页

作者： P.Trevisi D.Luise F.correa S.Messori M.Mazzoni J.P.Lallès P.Bosi Department of Agricultural and Food Sciences University of BolognaViale G.Fanin 4640127 BolognaItaly Present Address:World Organisation for Animal Health(OIE) Scientific Secretariat for the STAR-IDAZ International Research Consortium on animal health12 rue de Prony75017 ParisFrance Department of Veterinary Sciences University of BolognaVia Tolara di SopraOzzano nell’Emilia(BO)BolognaItaly INRAE Human Nutrition DivisionSite of Theix63122 Saint-Genès-ChampanelleFrance

Background:Scarce is knowledge on the process regulating the development of acid secretion,orexigenic signaling,and chemosensing in the stomach of young *** of early microbial encounters by suckling pigs can interact with the gut maturation,by the induction of different molecular *** goal was to assess if the age of offspring and the maternal environment,influenced by sow antibiotic treatment peripartum,could affect gastric morphology and the expression of genes involved in the control of hydrochloric secretion,feed intake,taste,and inflammation in offspring ***:84 pigs from sows fed a diet with amoxicillin(on-d10 to+d21 from farrowing,ANT)or without(CON)were sacrificed at d14,d21,d28(weaning)or *** of oxyntic(OXY),pyloric(PY)and cardiac mucosae close to OXY were collected and parietal and enteroendocrine cells(EECs)were *** gene expression of a set of 11 key genes(ATP4A,SSTR2,GAST,GHRL,MBOAT4,PCSK1,GNAT1,TAS1R1,TAS1R3,IL8 and TNF)was assessed by *** addition,40 offspring obtained from the same ANT and CON sows were offered a normal or a fatenriched diet for 4 weeks between 140 and 169 d of age,and then OXY and PY were ***:The number of parietal and EECs increased with age(P<0.001).ATP4A increased with age(within suckling,P=0.043,post-weaning ***,P<0.001),SSTR2 increased only after weaning(P<0.001).In OXY,GHRL increased during suckling(P=0.012),and post-weaning as a trend(P=0.088).MBOAT4 tended to increase during suckling(P=0.062).TAS1R1 increased from suckling to post-weaning period(P=0.001)and was lower in ANT offspring(P=0.013).GNAT1 in PY was higher in ANT offspring(P=0.041).Antibiotic treatment of sows peripartum increased expression of GHRL and MBOAT4 in OXY of growing-finishing offspring aged 5 ***:Data show that sensing for umami taste and ghrelin regulation can be affected by maternal environment,but the development of acid secretion,orexigenic signaling and taste

关键词： Enteroendocrine cell Gastrin Ghrelin Parietal cell Stomach Taste receptor

Benzyl Amino Purine and Gibberellic Acid Coupled to Nitrogen-Limited Stress Induce Fatty Acids,Biomass Accumulation,and Gene Expression in Scenedesmus Obliquus

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2021年第2期90卷 515-531页

作者： Hans Christian correa-Aguado Gloria Viviana Cerrillo-Rojas Alejandro Rocha-Uribe Ruth Elena Soria-Guerra JoséFrancisco Morales-Domínguez Departamento de Química Centro de Ciencias BásicasUniversidad Autónoma de AguascalientesAguascalientes20131México Facultad de Ciencias Químicas Universidad Autónoma de San Luis PotosíSan Luis Potosí78210México Instituto Politécnico Nacional Unidad Profesional Interdisciplinaria de Ingeniería Campus ZacatecasBlvd.del Bote 202Cerro del Gato Ejido La EscondidaCol.Ciudad AdministrativaZacatecasZAC 98160Mexico

The need for renewable energy sources makes microalgae an essential feedstock for biofuels *** molecular aspects and the response to nitrogen(N)-limited conditions with a phytohormone stimulus in microalgae have been slightly *** this work,Scenedesmus obliquus was used as a study model to analyze the effect of benzyl amino purine(BAP)and gibberellic acid(GA)coupled to nitrogen limitation on cell growth,biomass and fatty *** selected 10^(-5)M BAP increased the biomass by 1.44-fold,and 10^(-6)M GA by *** total lipids also increased by 2.8 and 1.11-fold,*** 10^(-5)M BAP and 10^(-6)M GA addition to *** cultures at different initial nitrogen percentages(N-0,N-25,and N-50)showed a significant increase in cell growth and biomass productivity compared to the unstimulated *** N-0 and GA N-0 produced the highest lipid yields with 55%and 50%,*** lipid profile analysis revealed an increase,particularly in C18:1 and C16:0 fatty *** expression analysis showed an over-expression of acyl carrying protein(ACP),stearoyl-ACP desaturase(SAD),fatty acid acyl-ACP thioesterase(FATA),and diacylglycerol acyltransferase(DGAT)genes,which were mainly induced by nitrogen ***,BAP and GA produced a significant over-expression on these genes in the N-replete *** study shows that BAP and GA,coupled to N limitation stress,can be used to increase the biomass and lipid production in *** for sustainable biofuels.

关键词： Biodiesel gene expression lipids microalgae nitrogen deficiency phytohormones