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Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan Grace gar.Lee Yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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Knowledge discovery for geographical cellular automata

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Science China Earth Sciences 2005年第10期48卷 1758-1767页

作者： Anthony gar.On Yeh Centre of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

This paper proposes a new method for geographical simulation by applying data mining techniques to cellular automata. CA has strong capabilities in simulating complex systems. The core of CA is how to define transition rules. There are no good methods for defining these transition rules. They are usually defined by using heuristic methods and thus subject to uncer-tainties. Mathematical equations are used to represent transition rules implicitly and have limita-tions in capturing complex relationships. This paper demonstrates that the explicit transition rules of CA can be automatically reconstructed through the rule induction procedure of data mining. The proposed method can reduce the influences of individual knowledge and preferences in de-fining transition rules and generate more reliable simulation results. It can efficiently discover knowledge from a vast volume of spatial data.

关键词： knowledge discovery, cellular automata, geographical simulation, geographical information systems.

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Multi-agent systems for simulating spatial decision behaviors and land-use dynamics

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Science China Earth Sciences 2006年第11期49卷 1184-1194页

作者： Anthony gar.On Yeh Center of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

A new method to simulate urban land-use dynamics is proposed based on multi-agent systems (MAS). The model consists of a series of environmental layers and multi-agent layers, which can interact with each other. It attempts to explore the interactions between different players or agents, such as residents, property developers, and governments, and between these players and the envi- ronment. These interactions can give rise to urban macro-spatial patterns. This model is used to simulate the land-use dynamics of the Haizhu district of Guangzhou City in 1995―2004. Cellular automata (CA) were also used for the simulation of land use changes as a comparison. The study indicates that MAS has better performance for simulating complex cities than CA.

关键词： multi-agent systems, cellular automata, complex systems, cities, land use.

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Resection of hepatitis B virus-related hepatocellular carcinoma:Evolving strategies and emerging therapies to improve outcome

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World Journal of Gastroenterology 2014年第35期20卷 12473-12484页

作者： gar.Yang Chau Division of General Surgery Department of SurgeryTaipei Veterans General Hospitaland School of MedicineNational Yang-Ming University

The incidence of hepatocellular carcinoma(HCC) is increasing worldwide,largely due to hepatitis B virus(HBV),hepatitis C virus and liver *** HBV infection is estimated to cause 55%-60% of the cases of HCC worldwide and over 70% in Asian *** resection is currently the mainstay of treatment due to the low surgical mortality,a wider treatment indication,and simplicity of post-treatment *** is an ever-increasing demand on surgeons to perform curative liver resection in HCC,with the hope of avoiding tumor *** B-related-HCC has distinct clinicopathological features,which should be considered when treating the *** author presents a review of the recently evolving strategies and emerging therapies to improve HCC postresectional outcomes and focus on perioperative measures to improve patient outcome,with particular reference to the current status of adjuvant therapies in HCC patients after liver resection.

关键词： Hepatocellular carcinoma Hepatitis B virus Hepatic resection Outcome Adjuvant therapy

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向多平台传送数字电视

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世界广播电视 2000年第6期14卷 22-25,70页

作者： gar.,PAO

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进退两难的前列腺癌问题

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科学（中文版） 1994年第8期 30-37页

作者： gar.,MB 颂平

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Integration of Neural Networks and Cellular Automata for Urban Planning

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Geo-Spatial Information Science 2004年第1期7卷 6-13页

作者： Anthony gar.on Yeh Centre of Urban Planning and Environmental Management The University of Hong Kong

This paper presents a new type of cellular automa ta (CA) model for the simulation of alternative land development using neural netw orks for urban planning. CA models can be regar.ed as a planning tool because th ey can generate alternative urban growth. Alternative development patterns can b e formed by using different sets of parameter values in CA simulation. A critica l issue is how to define parameter values for realistic and idealized simulation . This paper demonstrates that neural networks can simplify CA models but genera te more plausible results. The simulation is based on a simple three-layer netw ork with an output neuron to generate conversion probability. No transition rule s are required for the simulation. Parameter values are automatically obtained f rom the training of network by using satellite remote sensing data. Original tra ining data can be assessed and modified according to planning objectives. Altern ative urban patterns can be easily formulated by using the modified training dat a sets rather than changing the model.

关键词： neural networks cellular automata GIS urban simulation urban planning

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Use of Sentinel-1 imagery for flood management in a reservoir-regulated river basin

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Frontiers of Earth Science 2018年第3期12卷 506-520页

作者： T. PERROU A. gar.OUD I. PARCHARIDIS Department of Geography Harokopio University of Athens Athens Greece European Space Agency/ESRIN Frascati Rome Italy Department of Geography University Paris Diderot Paris France

Flood hazard monitoring and mapping is of great importance because it represents a significant contribution to risk management. The present study investigated the flood event that occurred downstream from the transboundary Strymon River basin, more specifically at Serres basin-a reservoir-regulated basin, in the beginning of 2015. The focus of this study was to better understand the spatio-temporal dynamic of the flood and the causes that initiated the hazard. Within the Serres basin, the Strymon transboundary river outflows to Lake Kerkini, which regulates water flow downstream for irrigation purposes and flood protection. For this research, a dataset of Sentinel-1 SAR GRD images was collected and processed covering the period of October 2014-October 2015 to investigate the water level changes in Lake Kerkini. Based on SAR images, binary water/non-water products and multitemporal RGB amplitude images were generated and interpreted. Sentinel-1 products have proved to be an effective tool on flood hazard dynamic extension mapping and estimation of water extent bodies retained by small reservoirs. In agreement with hydro-meteorological data and the high-resolution DEM, it was conceived that the flood event occurred due to the water volume flowing from upstream in the reservoir and the large amount of water draining from the tributaries into nearby sub-basins. Moreover, inefficient water management of the overwhelming water flow through the dam could further strengthen the flood event. The proposed approach, which is entirely based on open access remotely sensed data and processing tools, could be implemented in the same area for past flood events to produce archive retrospective data, as well as in other similar reservoir-regulated river basins in terms of water management and flood risk management.

关键词： flood mapping Sentinel-1 SAR binary images multitemporal image river basin

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玻璃纤维熔窑用新型耐火材料

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国外耐火材料 1990年第8期15卷 44-47页

作者： gar.,CNM 郭海珠

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速度变化对AVO及其解释的影响

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石油勘探开发情报 1994年第4期 31-35页

作者： gar.,GHF 夏子煌

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