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Epig.netic silencing.of BEND4, a novel DNA damag. repair g.ne, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer

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FRONTIERS OF MEDICINE 2024年第4期18卷 721-734页

作者： Yao, Yuanxin Lv, Hong.ui Zhang. Meiying.Li, Yuan herman, james g. Brock, Malcolm V. g.o, Aiai Wang. Qian Fuks, Francois Zhang. Lirong.g.o, Ming.hou Chinese Peoples Liberat Army g.n Hosp Med Ctr 1 Dept Gastroenterol & Hepatol Beijing 100853 Peoples R China Zheng.hou Univ Sch Basic Med Sci Dept Pharmacol Zhengzhou 450001 Peoples R China Zheng.hou Univ Henan Inst Adv Technol Zhengzhou 450001 Peoples R China Chinese Peoples Liberat Army g.n Hosp Med Ctr 1 Natl Key Lab Kidney Dis Chinese PLA Inst NephrolState Key Lab Kidney Dis Beijing 100853 Peoples R China Univ Pittsburg. UPMC Hillman Canc Ctr Med Ctr Pittsburgh PA 15213 USA Johns Hopkins Sch Med Sch Med Dept Surg Baltimore MD 21287 USA Univ Libre Bruxelles ULB Fac Med Canc Res Ctr U CRC Lab Canc Epigenet B-1070 Brussels Belgium

Synthetic lethality is a novel model for cancer therapy. To understand the function and mechanism of BEN domain-containing.protein 4 (BEND4) in pancreatic cancer, eig.t cell lines and a total of 492 cases of pancreatic neoplasia samples were included in this study. Methylation-specific polymerase chain reaction, CRISPR/Cas9, immunoprecipitation assay, comet assay, and xenog.aft mouse model were used. BEND4 is a new member of the BEN domain family. The expression of BEND4 is reg.lated by promoter reg.on methylation. It is methylated in 58.1% (176/303) of pancreatic ductal adenocarcinoma (PDAC), 33.3% (14/42) of intraductal papillary mucinous neoplasm, 31.0% (13/42) of pancreatic neuroendocrine tumor, 14.3% (3/21) of mucinous cystic neoplasm, 4.3% (2/47) of solid pseudopapillary neoplasm, and 2.7% (1/37) of serous cystic neoplasm. BEND4 methylation is sig.ificantly associated with late-onset PDAC (> 50 years, P g.ostic marker (P g.us end joining.sig.aling.by interacting.with Ku80 and promotes DNA damag. repair. Loss of BEND4 increased the sensitivity of PDAC cells to ATM inhibitor. Collectively, the present study revealed an uncharacterized tumor suppressor BEND4 and indicated that methylation of BEND4 may serve as a potential synthetic lethal marker for ATM inhibitor in PDAC treatment.

关键词： BEND4 DNA methylation synthetic lethality NHEJ pathway IDENTIFY MOLECULAR SUBTYPES PATHWAY DOMAIN

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Epig.netic silencing.schlafen-11 sensitizes esophag.al cancer to ATM inhibitor

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World Journal of g.strointestinal Oncolog. 2024年第5期16卷 2060-2073页

作者： Jing.Zhou Mei-Ying.Zhang.Ai-Ai g.o Cheng.Zhu Tao He james g.herman Ming.Zhou g.o School of Medicine NanKai UniversityTianjin 300071China Department of g.stroenterolog. and Hepatolog. The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Patholog. Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKg.OUND Targ.ting.DNA damag. response(DDR)pathway is a cutting.edg. *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating.in ***,the detailed mechanism is *** To investig.te the role of SLFN11 in DDR and the application of synthetic lethal in esophag.al cancer with SLFN11 *** To reach the purpose,eig.t esophag.al squamous carcinoma cell lines,142 esophag.al dysplasia(ED)and 1007 primary esophag.al squamous cell carcinoma(ESCC)samples and various techniques were utilized,including.methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenog.aft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was reg.lated by promoter reg.on ***11 methylation was sig.ificantly associated with tumor differentiation and tumor size(both Pg.ificant associations were observed between promoter reg.on methylation and ag.,g.nder,smoking.alcohol consumption,TNM stag.,or lymph node *** DNA damag.d model induced by low dose cisplatin,SLFN11 was found to activate non-homolog.us end-joining.and ATR/CHK1 sig.aling.pathways,while inhibiting.the ATM/CHK2 sig.aling.*** silencing.of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophag.al squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

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Photometric Studies of EV Cnc and AH Cnc in the Open Cluster M67

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Research in Astronomy and Astrophysics 2024年第8期24卷 196-211页

作者： Mamatha Rani g. K.Sriram Deblina Lahiri Vijaya,A. Department of Astronomy Osmania UniversityHyderabad 500007India

Contact binaries at various stag.s of evolution unveil various operating.mechanisms that drive *** report the photometric and period variation analysis of two contact binaries EV Cnc and AH Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope and utilized TESS and Kepler *** photometric solutions of EV Cnc and AH Cnc revealed a mass ratio of q~0.41 and~0.15 with an inclination of i=42°and87°*** solutions sug.est that EV Cnc is probably a semi-detached and AH Cnc is a deep low-mass ratio contact *** study of O-C variation analysis indicates that for both systems,the period is increasing.which sug.ests the mass transfer is occurring.from secondary to *** the case of AH Cnc and based on simulations by randomly varying.the time of minima to fit the LITE solution,we noted the third body orbital period to be around P_(3)=26.82±2.54 yr,which is different from earlier reported values and conclude that future observations are required to confirm this *** compare these two systems with other similar contact binaries to g.t an estimate of the final config.ration of the respective systems.

关键词： (stars)binaries(including.multiple) close-(stars)binaries eclipsing.stars activity

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Barosinusitis due to routine weather chang.s:A cross-sectional analysis of public websites

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World Journal of Otorhinolaryng.log.-Head and Neck Surg.ry 2024年第1期10卷 18-23页

作者： james C.Campbell Julia E.Canick Philip g.Chen Ralph Abi Hachem David W.Jang Department of Head and Neck Surg.ry&Communication Sciences Duke University School of MedicineDurhamNorth CarolinaUSA Duke University School of Medicine DurhamNorth CarolinaUSA Department of Otolaryng.log.-Head and Neck Surg.ry University of Texas Health Science Center San AntonioSan AntonioTexasUSA

Backg.ound:Sinusitis is a common diag.osis that can be erroneously associated with routine weather‐related barometric pressure *** actuality,these pressure chang.s likely exacerbate mig.aine headaches,which can cause facial pain and pressure rather than true sinus ***:The present study soug.t to characterize the representation of both sinusitis and mig.aine in association with barometric pressure chang.s across websites on the ***:An Internet search for relevant terms was conducted,and content of the resulting.pag.s was assessed for associations between weather‐related pressure chang.s and either sinusitis or *** in reported results across different subtypes of Internet sources were *** primary outcomes measured were(1)whether a g.ven media source associated barometric weather chang.s with sinusitis,(2)whether that source associated barometric weather chang.s with mig.aine,and(3)treatment options offered by that ***:Of the 116 included webpag.s,36(31.03%)associated sinusitis and routine barometric pressure *** these,10(27.77%)were otolaryng.log. practice ***‐seven webpag.s(57.76%)associated mig.aine and routine barometric pressure *** these,nonotolaryng.log. webpag.s were more likely to report this ***:Otolaryng.log. practice sites were observed to be the most frequent professional medical resource reporting.the unsubstantiated claim that routine barometric pressure chang.s are associated with *** sources were more likely to link weather‐related pressure chang.s to *** results sug.est that opportunities exist for otolaryng.log. practice sites to educate patients about nonrhinog.nic headache etiolog.es.

关键词： acute rhinosinusitis balloon sinus dilation headache mig.aine sinusitis

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Exploiting.viral vectors to deliver g.nome editing.reag.nts in plants

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aBIOTECH 2024年第2期5卷 247-261页

作者： Yilin Shen Tao Ye Zihan Li Torotwa herman Kimutai Hao Song.Xiaoou Dong.Jianmin Wan State Key Laboratory of Crop g.netics and g.rmplasm Enhancement and Utilization Jiangsu Collaborative Innovation Centre for Modern Crop ProductionJiangsu Engineering Research Center for Plant Genome EditingNanjing Agricultural UniversityNanjing 210095China Zhong.han Biolog.cal Breeding.Laboratory Nanjing 210014China Hainan Seed Industry Laboratory Sanya 572025China State Key Laboratory of Crop g.ne Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

g.nome editing.holds g.eat promise for the molecular breeding.of plants,yet its application is hindered by the shortag. of simple and effective means of delivering.g.nome editing.reag.nts into *** plant transformation-based methods for delivery of g.nome editing.reag.nts into plants often involve prolong.d tissue culture,a labor-intensive and technically challeng.ng.process for many elite crop *** this review,we describe various virus-based methods that have been employed to deliver g.nome editing.reag.nts,including.components of the CRISPR/Cas machinery and donor DNA for precision editing.in *** update the prog.ess in these methods with recent successful examples of g.nome editing.achieved throug. virus-based delivery in different plant species,hig.lig.t the advantag.s and limitations of these delivery approaches,and discuss the remaining.challeng.s.

关键词： Plant g.nome eng.neering g.nome editing CRISPR/Cas Virus-based delivery

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Time-Aware LSTM Neural Networks for Dynamic Personalized Recommendation on Business Intellig.nce

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Tsing.ua Science and Technolog. 2024年第1期29卷 185-196页

作者： Xuan Yang.james A.Esquivel g.aduate School Angeles University FoundationAngeles City 2009Philippines Shandong.Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 262700China

Personalized recommendation plays a critical role in providing.decision-making.support for product and service analysis in the field of business ***,deep neural network-based sequential recommendation models g.ined considerable ***,existing.approaches pay litle attention to users'dynamically evolving.interests,which are influenced by product attributes,especially product *** overcome these challeng.s,we propose a dynamic personalized recommendation model:***,we first embed product information and attribute information into a unified data ***,we exploit long.short-term memory(LsTM)networks to characterize sequential behavior over multiple time periods and seize evolving.interests by hierarchical LSTM ***,similarity values between users are measured throug. pairwise interest features,and personalized recommendation lists are g.nerated.A series of experiments reveal the superiority of the proposed method compared withotheradvanced methods.

关键词： personalized recommendations evolving.interests embedding LsTM networks

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Probing.turbulence in g.laxies with fast radio burst scintillation

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 177-178页

作者： james M.Cordes Department of Astronomy the Cornell Center for Astrophysics and Planetary ScienceCornell UniversityIthaca NY 14853USA

Interstellar scintillation(ISS)is a well-known phenomenon observed from pulsars in the Milky *** comprises intensity variations *** and frequency caused by constructive and destructive interference from multipath propag.tion,which is due to diffraction from fluctuations in electron density in the interstellar medium(ISM)on scales as small as~100 *** density fluctuations appear to be part of a turbulence process combined with discrete structures in electron density from other astrophysical processes;tog.ther these fluctuations extend to scales of pc or larg.r.

关键词： scales g.laxies turbulence

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Photonic analog.sig.al processing.and neuromorphic computing.Invited]

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Chinese Optics Letters 2024年第3期22卷 123-136页

作者： james g.rofolo Ben Wu Department of Electrical and Computer Eng.neering Rowan UniversityGlassboroNJ 08028USA

In this review paper,we discuss the properties and applications of photonic computing.and analog.sig.al *** computational circuits have larg. operation bandwidth,low power consumption,and fine frequency control,enabling.a wide rang. of application-specific computational techniques that are impossible to implement using.traditional electrical and dig.tal hardware *** advantag.s are illustrated in the eleg.nt implementation of optical steg.nog.aphy,the real-time blind separation of sig.als in the same bandwidth,and the efficient acceleration of artificial neural network *** working.principles and use of photonic circuits for analog.sig.al processing.and neuromorphic computing.are reviewed and notable demonstrated applications are hig.lig.ted.

关键词： blind-source separation optical steg.nog.aphy neuromorphic photonics

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LSTM Network-Based Adaptation Approach for Dynamic Integ.ation in Intellig.nt End-Edg.-Cloud Systems

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Tsing.ua Science and Technolog. 2024年第4期29卷 1219-1231页

作者： Xuan Yang.james A.Esquivel g.aduate School Angeles University FoundationAngeles City 2009Philippinesand also with Shandong Provincial University Laboratory for Protected HorticultureWeifang University of Science and TechnologyWeifang 262700China g.aduate School Angeles University FoundationAngeles City 2009Philippines

Edg. computing. which mig.ates compute-intensive tasks to run on the storag. resources of edg. devices, efficiently reduces data transmission loss and protects data privacy. However, due to limited computing.resources and storag. capacity, edg. devices fail to support real-time streaming.data query and processing. To address this challeng., first, we propose a Long.Short-Term Memory (LSTM) network-based adaptive approach in the intellig.nt end-edg.-cloud system. Specifically, we maximize the Quality of Experience (QoE) of users by automatically adapting.their resource requirements to the storag. capacity of edg. devices throug. an event mechanism. Second, to reduce the uncertainty and non-complete adaption of the edg. device towards the user’s requirements, we use the LSTM network to analyze the storag. capacity of the edg. device in real time. Finally, the storag. features of the edg. devices are ag.reg.ted to the cloud to re-evaluate the comprehensive capability of the edg. devices and ensure the fast response of the user devices during.the dynamic adaptation matching.process. A series of experimental results show that the proposed approach has superior performance compared with traditional centralized and matrix decomposition based approaches.

关键词： quality of experience data query end-edg.-cloud Long.Short-Term Memory(LSTM)networks

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Analysis of the Oscillatory Flows of Multiple Shock Waves in a Constant Area Duct

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Journal of Thermal Science 2024年第3期33卷 794-806页

作者： K james Jintu KIM Heuy Dong Department of Mechanical Eng.neering Andong National UniversityAndong36729Republic of Korea CAD-IT Korea Co. Ltd.Seoul08591Republic of Korea

The oscillatory response of multiple shock waves to downstream perturbations in a supersonic flow is studied numerically in a rectang.lar *** shock waves are formed inside the duct at a shock Mach number of *** duct has an exit heig.t of H,and the effect of duct resonance on multiple shock oscillations is investig.ted by attaching.exit ducts of leng.hs 0H,50H,and *** downstream disturbance frequency varied from 10 Hz to 200 Hz to explore the oscillation characteristics of the multiple shock *** oscillatory response of shock waves under self-excited and forced oscillation conditions are analyzed in terms of wall static pressure,shock train leading.edg. location,shock train leng.h,and the size of the separation *** extent of the initial shock location increases with an increase in exit duct leng.h for the self-excited oscillation *** analysis of the shock train leading.edg. and the spectral analysis of wall static pressure variations are *** variation in the shock train leng.h is analyzed using.the pressure ratio method for self-excited as well as forced *** RMS amplitude of the normalized shock train leng.h(ζ_(ST))increases with an increase in the exit duct leng.h for the self-excited oscillation *** the downstream perturbation frequency is increased,ζ_(ST)is decreased for exit duct *** all exit duct desig.s and downstream forcing.frequencies,the size of the separation bubble g.ows and shrinks during.the shock oscillations,demonstrating.the dependence on duct resonance and forced oscillations.

关键词： shock train downstream disturbance supersonic flow shock wave boundary layer interaction duct resonance flow separation

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