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Asian Pacific journal of Tropical Medicine 2013年第10期6卷 780-784页

作者： herbert j sa.tos Windell L Rivera Institute of Biology College of ScienceUniversity of the Philippines Molecular Protozoology Laboratory Natural Sciences Research InstituteUniversity of the Philippines

Objective:To compare the sensitivity and specificity of direct fecal smear microscopy,culture,and polymerase chain reaction in the detection of Blastocystis *** human ***:Human stool samples were collected from a community in san Isidro,Rodriguez,Rizal,*** samples were subjected to direct fecal smear microscopy,culture and polymerase chain reaction to detect the presence of Blastocystis ***:Of the 110 stool samples collected,28(25%)were detected positive for the presence of Blastocystis *** two or more *** method detected the highest number of Blastocystis-positive stool samples(n=36),followed by PCR of DNA extracted from culture(n=26),PCR of DNA extracted from stool(n=10),and direct fecal smear(n=9).Compared to culture,the sensitivity of the other detection methods were 66.7%for PCR from culture and 19.4%for both PCR from stool and direct fecal *** of the methods was high,with PCR from culture and direct fecal smear having97.3%,while PCR from stool at 95.9%.Conclusions:In this study,in vitro culture is the best method for detecting Blastocystis *** human stool samples.

关键词： Blastocystis sp. Direct fecal smear Culture Polymerase chain reaction(PCR) Human stool Sensitivity Specificity

Blood rheology and aging

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journal of Geriatric Cardiology 2013年第3期10卷 291-301页

作者： Michael j. Simmonds herbert j. Meiselman Oguz K. Baskurt Heart Foundation Research Centre Griffith Health Institute Griffith University Gold Coast QLD 4222 Australia Department of Physiology and Biophysics Keck School of Medicine University of Southern California Los Angeles CA 9033 USA Koc University School of Medicine Istanbul Turkey

The flow properties of blood play significant roles in tissue perfusion by contributing to hydrodynamic resistance in blood vessels. These properties are influenced by pathophysiological processes, thereby increasing the clinical relevance of blood rheology information. There is well-established clinical evidence for impaired blood fluidity in humans of advanced age, including enhanced plasma and whole blood viscosity, impaired red blood cell (RBC) deformability and enhanced RBC aggregation. Increased plasma fibrinogen concentration is a common finding in many studies owing to the pro-inflammatory condition of aged individuals;this finding of increased fibrinogen concen-tration explains the higher plasma viscosity and RBC aggregation in elderly subjects. Enhanced oxidant stress in advanced age is also known to contribute to altered blood fluidity, with RBC deformability being an important determinant of blood viscosity. Several studies have shown that physical activity may improve the hemorheological picture in elderly subjects, yet well-designed observational and mechanistic studies are required to determine the specific effects of regular exercise on hemorheological parameters in healthy and older individuals.

关键词： Aggregation Deformability Elderly Erythrocyte Red blood cell Viscosity

Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review

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World journal of Gastroenterology 2016年第29期22卷 6742-6756页

作者： Tyler j Severson Siddesh Besur herbert L Bonkovsky Department of Gastroenterology and Hepatology Wake Forest University NC Baptist Medical Center Abdominal Transplant Program Aurora St Luke’s Medical Center

AIM: To investigate roles of genetic polymorphisms in non-alcoholic fatty liver disease (NAFLD) onset, severity, and outcome through systematic literature ***: The authors conducted both systematic and specific searches of PubMed through December 2015 with special emphasis on more recent data (from 2012 onward) while still drawing from more historical data for background. We identified several specific genetic polymorphisms that have been most researched and, at this time, appear to have the greatest clinical significance on NAFLD and similar hepatic diseases. These were further investigated to assess their specific effects on disease onset and progression and the mechanisms by which these effects ***: We focus particularly on genetic polymorphisms of the following genes: PNPLA3, particularly the p. I148M variant, TM6SF2, particularly the p. E167K variant, and on variants in FTO, LIPA, IFNλ4, and iron metabolism, specifically focusing on HFE, and HMOX-1. We discuss the effect of these genetic variations and their resultant protein variants on the onset of fatty liver disease and its severity, including the effect on likelihood of progression to cirrhosis and hepatocellular carcinoma. While our principal focus is on NAFLD, we also discuss briefly effects of some of the variants on development and severity of other hepatic diseases, including hepatitis C and alcoholic liver disease. These results are briefly discussed in terms of clinical application and future potential for personalized ***: Polymorphisms and genetic factors of several genes contribute to NAFLD and its end results. These genes hold keys to future improvements in diagnosis and management.

关键词： Genetic polymorphisms Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis PNPLA3 TM6SF2 FTO Cirrhosis Iron metabolism

Pillararene-based fluorescent sensors for the tracking of organic compounds

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Chinese Chemical Letters 2019年第10期30卷 1758-1766页

作者： Derong Cao herbert Meier School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510641China Institute of Organic Chemistry University of MainzD-55099 MainzGermany

Fluorescent chemosensors based on pillararene complexes represent a new, promising branch in sensor technology. Because of CH-π interactions, aliphatic chains are well suited for the columnar cavities of pillararenes and bulky or sheet-like(sub)structures can be arranged on the portals. Thus, pillararenes form versatile receptors and an alteration of the fluorescence behavior upon complexation ensures the function of these chemosensors as the reporter. Although this field of research exists only since a few years, remarkable chemosensors were developed for substances as diverse as medical drugs,biochemicals, herbicides and explosives.

关键词： Pillararene Fluorescent chemosensor Complex Host-guest Fluorescent cavity

Potential Secretory Transporters and Biosynthetic Precursors of Biological Nitrification Inhibitor 1,9-Decanediol in Rice as Revealed by Transcriptome and Metabolome Analyses

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Rice science 2024年第1期31卷 87-102页

作者： DI Dongwei MA Mingkun ZHANG Xiaoyang LU Yufang herbert j.KRONZUCKER SHI Weiming State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China School of Food Science and Engineering Foshan UniversityFoshan 528000China School of BioSciences The University of MelbourneParkvilleVIC 3010Australia University of Chinese Academy of Sciences Beijing 100049China

Biological nitrification inhibitors(BNIs)are released from plant roots and inhibit the nitrification activity of microorganisms in soils,reducing NO_(3)^(‒)leaching and N2O emissions,and increasing nitrogenuse efficiency(NUE).Several recent studies have focused on the identification of new BNIs,yet little is known about the genetic loci that govern their biosynthesis and *** applied a combined transcriptomic and metabolomic analysis to investigate possible biosynthetic pathways and transporters involved in the biosynthesis and release of BNI 1,9-decanediol(1,9-D),which was previously identified in rice root *** results linked four fatty acids,icosapentaenoic acid,linoleate,norlinolenic acid,and polyhydroxy-α,ω-divarboxylic acid,with 1,9-D biosynthesis and three transporter families,namely the ATP-binding cassette protein family,the multidrug and toxic compound extrusion family,and the major facilitator superfamily,with 1,9-D release from roots into the soil *** finding provided candidates for further work on the genes implicated in the biosynthesis and secretion of 1,9-D and pinpoint genetic loci for crop breeding to improve NUE by enhancing 1,9-D secretion,with the potential to reduce NO_(3)^(‒)leaching and N2O emissions from agricultural soils.

关键词： 1,9-decanediol biological nitrification inhibitor metabolomic analysis nitrogen-use efficiency transcriptomic analysis

Profiles of Entamoeba histolytica—specific imunoglobulins in human sera

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Asian Pacific journal of Tropical Medicine 2012年第3期5卷 234-238页

作者： Windell L Rivera herbert j sa.tos Vanissa A Ong Lara jessica G Murao Institute of Biology College of ScienceUniversity of the PhilippinesDilimanQuezon City 1101Philippines Molecular Protozoology Laboratory Natural Sciences Research InstituteUniversity of the PhilippinesDilimanQuezon City 1101Philippines

Objective:To determine the profdes of anti-Entamoeba histolytica(***) ***. and IgM in sera of diarrheic and non-diarrheic individuals and partially characterize target ***:Serum samples from thirty diarrheic and thirty non-diarrheic individuals were subjected to IgA,IgG,and IgM profiling through enzyme-linked immunosorbent assay (***),flow cytometry,and ***:ELBA titer results showed that both diarrheic and non-diarrheic individuals possess high levels of ***-specific IgG compared to IgA and *** cytometry data showed that diarrheic serum samples had higher mean reaction percentages against *** cells compared to non-diarrheic *** *** proteins with molecular weights ranging belween 7 kDa and 292 kDa were recognized by diarrheic serum IgG,and 170 kDa and 250 kDa by non-diarrheic serum IgG. Conclusions:Our findings suggest that serum *** IgG,compared with serum *** IgA and IgM responses,was generally high in both diarrheic and nondiarrheic sera,indicating a past exposure to the organism both in symptomatic patients as well as in asymptomatic carriers,*** addition,serum IgG from diarrheic and non-diarrheic patients were able to detect immunogenic *** proteins.

关键词： Entamoeba histolytica IgA IgG IgM ELIsa immunoblot flow cytometry

Oil-bearing fluid inclusions from the Palaeoproterozoic:A review of biogeochemical results from time-capsules >2.0 Ga old

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Science China Earth Sciences 2009年第1期52卷 1-11页

作者： Simon C. GEORGE Adriana DUTKIEWICZ herbert VOLK john RIDLEY David j. MOSSMAN Roger BUICK Department of Earth and Planetary Sciences Macquarie University School of Geosciences University of Sydney CSIRO Petroleum Department of Geosciences Colorado State University Department of Geography Mount Allison University Department of Earth and Space Sciences & Astrobiology Program University of Washington

The observation of oil inclusions trapped prior to 2.0 Ga in Palaeoproterozoic rocks and the ability to obtain detailed molecular geochemical information from them provide a robust way for understanding the early biog... 详细信息

关键词： Palaeoproterozoic fluid inclusion oil biomarker blank

Liver stiffness in pregnant women with intrahepatic cholestasis of pregnancy:A case control study

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World journal of Hepatology 2023年第7期15卷 904-913页

作者： juliane Nees Franziska j Ammon johannes Mueller herbert Fluhr Sebastian Mueller Department of Gynecology and Obstetrics University Hospital HeidelbergHeidelberg 69120Germany Center for Alcohol Research University Hospital HeidelbergHeidelberg 69120Germany Division of Obstetrics Department of Obstetrics and GynecologyMedical University of GrazGraz 8036Austria

BACKGROUND Intrahepatic cholestasis of pregnancy(ICP)is a rare but severe complication for both the mother and the unborn *** diagnosis is primarily based on elevated serum levels of bile *** a large ICP cohort,we here study in detail liver stiffness(LS)using transient elastography(TE),now widely used to noninvasively screen for liver cirrhosis within *** To specifically explore LS in a large cohort of women with ICP compared to a control group with uncomplicated *** LS and hepatic steatosis marker controlled attenuation parameter(CAP)were measured in 100 pregnant women with ICP using TE(Fibroscan,Echosens,Paris,France)between 2010 and *** 17 cases,LS could be measured postpartum.450 women before and 38 women after delivery with uncomplicated pregnancy served as control *** laboratory,levels of bile acids and apoptosis marker caspase-cleaved cytokeratin 18 fragment(M30)were also *** Women with ICP had significantly elevated transaminases but normal gammaglutamyl transferase(GGT).Mean LS was significantly increased at 7.3±3.0 kPa compared to the control group at 6.2±2.3 kPa(Ptosis marker M30,LS and levels of alanine aminotransferase,aspartate aminotransferase,and *** multivariate analysis,LS remained the sole parameter that was independently associated with elevated bile *** In conclusion,LS is significantly elevated in ICP which is most likely due to toxic bile acid accumulation and hepatocyte *** association with conventional laboratory markers,LS provides additional non-invasive informati

关键词： Intrahepatic cholestasis of pregnancy Transient elastography Bile acids Liver stiffness High risk pregnancy

Cytokines and fatty liver diseases

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Liver Research 2018年第1期2卷 14-20页

作者： Lukas Niederreiter herbert Tilg Department of Internal Medicine I GastroenterologyEndocrinology&MetabolismMedical University InnsbruckInnsbruckAustria

Cytokines are considered crucial players in inflammatory-associated disorders throughout the *** liver diseases such as alcoholic liver disease(ALD)and non-alcoholic fatty liver disease(NAFLD)are commonly characterized by lipid accumulation and in a substantial subset of patients with inflammation in the *** of inflammation affects long-term outcome of liver disease including evolution of liver fibrosis,cirrhosis and hepatocellular *** the pro-inflammatory cytokines Interleukin(IL)-1(αandβ)and tumor necrosis factor(TNF)αplay a central role in many stages of liver diseases mediating fundamental aspects of those diseases including acute phase protein synthesis,lipid metabolism,cholestasis and degree of *** key cytokines released mainly by mononuclear cells affect all liver cell types and orchestrate the production of many other mediators relevant in chronic liver *** cytokines also regulate crucially the development of insulin resistance,a key component of *** these critical mediators of inflammation by specific antibodies,especially TNFα,has so far not been proven successful in alcoholic steatohepatitis,a cytokine-driven *** summary,inflammatory cytokines are continuously present locally and systemically in patients with advanced fatty liver diseases,mediating and affecting the clinical phenotype and many features of these disorders.

关键词： Alcoholic hepatitis(AH) Cytokines Inflammation Interleukin(IL)-1 Alcoholic liver disease(ALD) Non-alcoholic fatty liver disease(NAFLD) Tumor necrosis factor(TNF)α

A digital twins enabled underwater intelligent internet vehicle path planning system via reinforcement learning and edge computing

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Digital Communications and Networks 2024年第2期10卷 282-291页

作者： jiachen Yang Meng Xi jiabao Wen Yang Li Houbing herbert Song School of Electrical and Information Engineering Tianjin UniversityTianjin300072China Security and Optimization for Networked Globe Laboratory(SONG Lab) Embry-Riddle Aeronautical UniversityDaytona BeachFL32114USA

The Autonomous Underwater Glider(AUG)is a kind of prevailing underwater intelligent internet vehicle and occupies a dominant position in industrial applications,in which path planning is an essential *** to the complexity and variability of the ocean,accurate environment modeling and flexible path planning algorithms are pivotal *** traditional models mainly utilize mathematical functions,which are not complete and *** existing path planning algorithms depend on the environment and lack *** overcome these challenges,we propose a path planning system for underwater intelligent internet *** applies digital twins and sensor data to map the real ocean environment to a virtual digital space,which provides a comprehensive and reliable environment for path *** design a value-based reinforcement learning path planning algorithm and explore the optimal network structure *** path simulation is controlled by a closed-loop model integrated into the terminal vehicle through edge *** integration of state input enriches the learning of neural networks and helps to improve generalization and *** task-related reward function promotes the rapid convergence of the *** experimental results prove that our reinforcement learning based path planning algorithm has great flexibility and can effectively adapt to a variety of different ocean conditions.

关键词： Digital twins Reinforcement learning Edge computing Underwater intelligent internet vehicle Path planning