检索结果-南通市图书馆

Adaptation of international coronavirus disease 2019 and breast cancer guidelines to local context

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2021年第1期12卷 31-42页

作者： Guillermo Arturo Valencia Silvia Neciosup henry l Gómez Maria Del Pilar Benites Silvia Falcón David Moron Karin Veliz Mike Maldonado Rodrigo Auqui Department of Medical Oncology Instituto Nacional de Enfermedades Neoplásicas(INEN)Surquillo 15000LimaPeru Clínica Oncosalud–AUNA Surquillo 15000LimaPeru Breast Cancer Unit Hospital Nacional Edgardo Rebagliati MartinsLima 15000Peru Department of Medical Oncology Centro Oncológico AliadaLima 15000Peru Department of Medical Oncology Hospital Nacional Carlos Alberto Seguín EscobedoArequipa 04001Peru Department of Medical Oncology Hospital Nacional Ramiro PrialéPrialéHuancayo 12000Peru Department of Medical Oncology Instituto Regional de Enfermedades Neoplásicas(IREN)Trujillo 13001Peru Department of Medical Oncology Hospital Nacional Almanzor Aguinaga AsenjoChiclayo 14001Peru

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(a novel coronavirus),which was first identified amid an outbreak of respiratory illness cases in Wuhan,China and declared a global health emergency,is currently considered an additional challenge in the management of patients with breast cancer(BC).Cancer patients are more vulnerable to becoming infected with severe acute respiratory syndrome coronavirus 2 and are more likely to suffer additional complications that can increase *** those BC patients who require more urgent therapy than others in the current situation is *** recommendations are based on and have been adapted from those similarly published by international scientific societies for BC *** are divided mainly by clinical stage(early,advanced),subtype[luminal,human epidermal growth factor receptor 2(HER2),triple-negative],or type of medical treatment and setting(neoadjuvant,adjuvant,metastatic).Recommendations for HER2 and triplenegative subtypes are similar,whereas in luminal subtype there are various options of *** objective is to adapt guidelines to local context through relevant decision-makers,avoiding duplication of efforts and optimizing use or *** hope that these recommendations will help medical oncologists provide the best quality care to BC patients during the COVID-19 pandemic with information tailored to our healthcare *** To establish and adapt recommendations from those published by international scientific societies for BC *** The Peruvian Society of Medical Oncology developed a consensus and propose here a manuscript with recommendations for oncological medical treatment of BC during the COVID-19 *** Peruvian Society of Medical Oncology invited a panel of experts and opinion leaders on BC working in major health care systems around *** experts selected three international clin

关键词： Breast cancer COVID-19 Guidelines Recommendations Oncology Medical treatment

人类多形核白细胞及血清在无氧条件下对牙髓致病菌的杀菌作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代口腔医学杂志 1990年第4期4卷 218-219页

作者：吴民凯 C.A.henry J.l.Gutmann 北京医科大学口腔医学院牙体牙髓科美国Baylor牙医学院微生物科美国Baylor牙医学院牙髓科

本文对人类PMNS及血清在无氧条件下对6种常见的牙髓致病菌的杀菌作用进行观察和比较。研究结果表明:PMNS在40分钟内能杀死放线菌,20％的血清在2小时内也不能将其杀死。消化链球菌对宿主的防卫系统也表现出很强的抵抗力,既使95％的血清在... 详细信息

本文对人类PMNS及血清在无氧条件下对6种常见的牙髓致病菌的杀菌作用进行观察和比较。研究结果表明:PMNS在40分钟内能杀死放线菌,20％的血清在2小时内也不能将其杀死。消化链球菌对宿主的防卫系统也表现出很强的抵抗力,既使95％的血清在2小时内也未能将其杀死,本研究还表明其它几种细菌对机体防卫系统也表现出一定程度的抵抗力。

关键词：多形核白细胞牙髓致病菌杀菌

间断或持续PTH刺激对骨及间充质干细胞的不同分化作用

在线全文

学校读者我要写书评

暂无评论

中华医学杂志 2018年第10期98卷 781-787页

作者：张瀶曦 Deepak H. Balani Sophia Trinh henry M. Kronenberg 母义明解放军总医院内分泌科北京100853 Endocrine Unit Massachusetts General Hospital and Harvard Medical School Boston 02114 USA

目的探讨不同甲状旁腺素（PTH）给药情况下及撤药后，骨及间充质干细胞的不同分化作用机制。方法6周龄雄性C57/Bl6J小鼠，基因型为SOX9－creERT/Td－Tomato/Osteocalcin－GFP，分为间断PTH刺激及撤药组（PTH 500 μg·kg^－1·d^－1，... 详细信息

目的探讨不同甲状旁腺素（PTH）给药情况下及撤药后，骨及间充质干细胞的不同分化作用机制。方法6周龄雄性C57/Bl6J小鼠，基因型为SOX9－creERT/Td－Tomato/Osteocalcin－GFP，分为间断PTH刺激及撤药组（PTH 500 μg·kg^－1·d^－1，皮下注射）、持续PTH刺激及撤药组（PTH泵，80 μg·kg^－1·d^－1，速度0.25 μl/h，皮下埋入）、空白对照组及撤药对照组，共6组，每组8只。分别于给药2周及撤药2周时观察小鼠血清中钙离子浓度及骨密度，并取小鼠胫骨骨骼分别进行病理及免疫荧光染色。结果间断PTH刺激组血清钙离子浓度一过性升高，达（1.36±0.03）mmol/l。持续PTH泵刺激组血清中钙离子浓度逐渐升高，48 h达高峰[（2.33±0.03）mmol/l]，2周后恢复正常（1.12～1.27 mmol/l）。PTH刺激2周后，间断组[（0.047±0.002）g/cm2]和持续组[（0.046±0.001）g/cm2]骨密度均高于对照组[（0.044±0.001）g/cm2]，但间断组和持续组差异无统计学意义。停药2周后，三组间BMD差异无统计学意义。股骨病理可见间断组骨皮质不明显，大量的骨小梁增生，伴少量纤维组织增生；持续PTH刺激大片纤维组织增生，尤以骨皮质内侧显著，撤药后纤维化消失。间断PTH刺激后骨细胞和成骨细胞明显升高，撤药后明显下降；衬里细胞数量骤减，撤药后有所增加；破骨细胞给药及撤药后差异均无统计学意义。持续PTH刺激破骨细胞增多，衬里细胞骤减，撤药后破骨细胞和衬里细胞增加，成骨细胞减少。腓骨干骺端免疫荧光显示，间断PTH刺激组大量未分化的Td－tomato间充质干细胞，撤药后较前明显减少。持续PTH组少量未分化的Td－tomato间充质干细胞增生，撤药后较前减少。结论间断PTH刺激可通过增加未分化的间充质干细胞和成骨细胞数量，将衬里细胞转换为骨细胞和成骨细胞，进而促进骨生成；持续PTH刺激可使少量未分化的间充质干细胞、成骨细胞和骨细胞增生，伴大量纤维化增生和破骨细胞数量骤增，最终可能导致代谢性骨病，撤药后衬里细胞明显增加，或有利于代谢性骨病的缓解。

关键词：甲状旁腺素间充质干细胞骨成骨细胞破骨细胞

MicroRNA in pancreatic ductal adenocarcinoma and its precursor lesions

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2016年第1期8卷 18-29页

作者： yasmin g hernandez aimee l lucas department of internal medicine icahn school of medicine at mount sinaiNew YorkNY 10029United States henry janowitz division of gastroenterology icahn school of medicine at mount sinaiNew YorkNY 10029United States

Pancreatic ductal adenocarcinoma(PDAC) is the 4^(th) deadliest cancer in the United States, due to its aggressive nature, late detection, and resistance to chemotherapy. The majority of PDAC develops from 3 precursor lesions, pancreatic intraepithelial lesions(PanIN), intraductual papillary mucinous neoplasm(IPMN), and mucinous cystic neoplasm. Early detection and surgical resection can increase PDAC 5-year survival rate from 6% for Stage Ⅳ to 50% for Stage Ⅰ. To date, there are no reliable biomarkers that can detect PDAC. MicroRNAs(miRNA) are small noncoding RNAs(18-25 nucleotides) that regulate gene expression by affecting translation of messenger RNA(mRNA). A large body of evidence suggests that miRNAs are dysregulated in various types of cancers. MiRNA has been profiled as a potential biomarker in pancreatic tumor tissue, blood, cyst fluid, stool, and saliva. Four mi RNA biomarkers(miR-21, miR-155, miR-196, and miR-210) have been consistently dysregulated in PDAC. MiR-21, miR-155, and miR-196 have also been dysregulated in IPMN and PanIN lesions suggesting their use as early biomarkers of this disease. In this review, we explore current knowledge of miRNA sampling, miR NA dysregulation in PDAC and its precursor lesions, and advances that have been made in using miRNA as a biomarker for PDAC and its precursor lesions.

关键词： Pancreatic cancer MicroRNA Biomarkers Pancreatic intraepithelial lesions Intraductal papillarymucinous neoplasm

Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2020年第6期22卷 590-601页

作者： Chen Chu lu Yu Joelle henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-li Guo Zhao-liang Fei lan-Tao Gou Qiang liu Samanta Sharma Yu Zhou Mo-Fang liu Charlie Degui Chen Andrew l Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-lian Zhang State Key laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Genetics Reproduction and Development laboratory CNRS UMR 6293-INSERM U1103-Universite Clermont AuvergneClermont-Ferrand 63001France Institute of Neuroscience State Key Laboratory of NeuroscieneeShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Key laboratory of Agricultural Animal Genetics Breedingand Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of the Ministry of AgricultureHuazhong Agricultural UniversityWuhan 430070China Department of Cellular and Molecular Medicine University of CaliforniaSan DiegoLa JollaCA 92093-0651USA Department of Anatomy Histology and EmbryologyShanghai Jiao long University School of MedicineShanghai Key Laboratory of Reproductive MedicineShanghai 200025China department of Cancer Biology Dana-Farber Cancer InstituteBostonMA 02215USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Priority Research Centre for Reproductive Sciences School of Environmental and Life SciencesThe University of NewcastleCallaghanNSW 2308Australia.

The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various *** foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic *** mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal ***,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 *** explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m *** analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-*** agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIl1 and *** absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-***,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses.

关键词： epididymis GPX5 oxidative stress piRNA PIWI-interacting RNA small noncoding RNA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

柠檬酸对黄龙碳酸钙矿化影响的模拟实验研究

矿物岩石地球化学通报 2015年第2期34卷 294-300页

作者：李琼芳董发勤李骐言代群威安德军 TENG HUI henry 西南科技大学生命科学与工程学院四川绵阳621010 固体废物处理与资源化教育部重点实验室四川绵阳621010 黄龙国家级风景名胜区管理局四川松潘623300 美国乔治华盛顿大学化学系

为探索生物因素在黄龙钙华沉积过程中的作用及参与程度,本研究以黄龙水体中2株嗜冷细菌胞外特征有机酸组分——柠檬酸为研究对象,通过模拟黄龙常年水温和p H值,结合碳酸钙晶体晶型和形貌,探讨柠檬酸钙化体系中的钙化过程及柠檬酸对碳酸... 详细信息

为探索生物因素在黄龙钙华沉积过程中的作用及参与程度,本研究以黄龙水体中2株嗜冷细菌胞外特征有机酸组分——柠檬酸为研究对象,通过模拟黄龙常年水温和p H值,结合碳酸钙晶体晶型和形貌,探讨柠檬酸钙化体系中的钙化过程及柠檬酸对碳酸钙晶型和形貌的影响。结果表明:1柠檬酸浓度高、p H值低和温度低都会一定程度地抑制碳酸钙沉积;2柠檬酸浓度(20、40、80、160mg/l)对碳酸钙晶型影响不大,主要合成方解石型碳酸钙,但随着浓度的增加,伴随有花瓣状形貌的生成;3随着p H值的增大,棱柱体形貌转变为边缘较为圆滑的椭球体。综上可见,柠檬酸对碳酸钙的钙化速率、晶型和形貌具有一定的影响和调控作用,其结果可为黄龙钙华生物成因的探究提供理论基础。

关键词：碳酸钙沉积黄龙柠檬酸钙化晶型和形貌

Scoring Cercospora leaf Spot on Sugar Beet:Comparison of UGV and UAV Phenotyping Systems

在线全文

学校读者我要写书评

暂无评论

Plant Phenomics 2020年第1期2卷 225-242页

作者： S.Jay A.Comar R.Benicio J.Beauvois D.Dutartre G.Daubige W.li J.labrosse S.Thomas N.henry M.Weiss F.Baret INRAE UMR 114 EMMAHUMT CAPTEF-84914 AvignonFrance HIPHEN SAS 84000 AvignonFrance ARVAlIS-Institut du végétal 84000 AvignonFrance Florimond Desprez 59242 Capelle-en-PévèleFrance

Selection of sugar beet(Beta vulgaris l.)cultivars that are resistant to Cercospora leaf Spot(ClS)disease is critical to increase *** selection requires an automatic,fast,and objective method to assess ClS severity on thousands of cultivars in the *** this purpose,we compare the use of submillimeter scale RGB imagery acquired from an Unmanned Ground Vehicle(UGV)under active illumination and centimeter scale multispectral imagery acquired from an Unmanned Aerial Vehicle(UAV)under passive *** variables are extracted from the images(spot density and spot size for UGV,green fraction for UGV and UAV)and related to visual scores assessed by an *** show that spot density and green fraction are critical variables to assess low and high ClS severities,respectively,which emphasizes the importance of having submillimeter images to early detect ClS in field *** sensitivity to ClS can then be accurately retrieved based on time integrals of UGV-and UAV-derived *** UGV shows the best estimation performance,UAV can show accurate estimates of cultivar sensitivity if the data are properly *** and limitations of UGV,UAV,and visual scoring methods are finally discussed in the perspective of high-throughput phenotyping.

关键词： illumination millimeter critical

Crack Prediction Model for Concrete Affected by Reinforcement Corrosion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Materials Sciences and Applications 2019年第6期10卷 475-495页

作者： Jeb M. Stefan luz M. Calle Sven E. Eklund Mark R. Kolody Kunal Kupwade-Patil Eliza l. Montgomery henry E. Cardenas University of Texas in Austin Austin USA NASA John F. Kennedy Space Center Kennedy Space Center Merritt Island USA louisiana Tech University Ruston USA Department of Civil and Environmental Engineering Massachusetts Institute of Technology Cambridge USA

The purpose of this study was to develop an analytical model to predict the time required for cracking of concrete due to corrosion of the iron reinforcement. The concrete and cement specimens used for this study were batched with cover material ranging from 0.75 to 1.3 in (1.91 to 3.30 cm). The extent of cover material was not formulated into the model under the assumption that crack initiation would tend to produce visible cracking within a relatively short time period. The model was derived using both Hooke’s law and the volume expansion induced by the corrosion oxides. Correlation achieved with specimen cracking data from the literature was relatively good with a 95% level of confidence. This model presents a key benefit to facility and infrastructure managers by enabling them to plan the time when corrosion mitigating actions are required. It also provides a significant convenience as the condition of the concrete structure or its environment changes over time. The only parameter that needs to be updated over time is the corrosion rate measurement. This single parameter captures the most influential impact that stems from several other parameters which tend to be required in models that are more mechanistically definitive.

关键词： Cracking Model Concrete Corrosion Marine Pore Band Green Rust