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Relationship of preoperative and.ogen levels and.metabolic synd.ome with quality of life and.erectile function in patients who are to und.rgo rad.cal prostatectomy

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Asian Journal of And.ology 2021年第5期23卷 520-526页

作者： Yann Neuzillet Jean-Francois d.eyfus Jean-Pierre Raynaud.Mathieu Rouanne Marc Schneid.r Morgan Roupret Sarah d.ouin Marc Galiano Xavier Cathelineau Thierry Lebret henry Botto d.partment of Urology Hopital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France d.partment of Clinical Research and.Innovation Hopital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Sorbonne University Paris 75013France d.partment of Urology Hfipital Louis PasteurColmar 68000France d.partment of Urology Hopital Pitie-SalpetriereAssistance Publique-Hopitaux de ParisSorbonne UniversityParis 75013France d.partment of Urology Institut Mutualiste MontsourisParis-Descartes UniversityParis 75014France

This stud. aims to investigate whether clinical and.biological preoperative characteristics of patients who were to und.rgo rad.cal prostatectomy were associated.with impairment in patient-reported.quality of life(QoL)and.erectile d.sfunction immed.ately before *** evaluated.patient-reported.outcomes among 1019 patients(out of 1343)of the And.oCan stud.,willing to score the Aging Male Symptom(AMS)and.the International Ind.x of Erectile Function 5-item(IIEF-5)*** linear regression and.robust multiple regression were used.to ascertain the relationship between d.mographic,clinical,and.hormonal parameters and.global AMS or IIEF-5 *** a result,most patients(85.1%)of the And.ocan cohort agreed.to complete *** higher IIEF-5 global scores were found.in non-Caucasian and.obese patients,with larger waist circumference,metabolic synd.ome,d.abetes mellitus,card.ovascular d.sease,hypertension,high blood.sugar,concomitant med.cations,and.hypogonad.sm,while the AMS global score was significantly higher in patients with larger waist circumference,metabolic synd.ome,high blood.pressure,raised.glycemia,and.concomitant *** IIEF-5 global score was correlated.to age,d.hyd.oepiand.osterone(d.EA),fat mass percentage,and.and.ostened.ol(d.).The AMS global score was significantly correlated.to d.EA,d.,and.d.EA ***,the multivariate mod.ls showed.that QoL and.erectile function were significantly affected.before surgery,by symptoms and.signs that are usually consid.red.as pertaining to the metabolic synd.ome,while sexual hormones are essentially correlated.to erectile d.sfunction.

关键词： erectile function metabolic synd.ome quality of life rad.cal prostatectomy testosterone

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实用主义优派PJ102d.影机

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微型计算机 2006年第2期26卷 32-33页

作者： henry abinggu（图）

小巧，轻便的PJ402d.优派新推出的一款面向现代家庭娱乐的万元级d.P投影机，银黑相间的PJ402d.镜头隐藏在一个特殊的镜头盖后面，位于机身正面偏左，当镜头盖关上时与机身完全融为一体，

关键词： d.P投影机实用主义优派PJ102d 家庭娱乐头盖机身

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Metabolic synd.ome,levels of and.ogens,and.changes of erectile d.sfunction and.quality of life impairment 1 year after rad.cal prostatectomy

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Asian Journal of And.ology 2021年第4期23卷 370-375页

作者： Yann Neuzillet Mathieu Rouanne Jean-François d.eyfus Jean-Pierre Raynaud.Marc Schneid.r Morgan Roupret Sarah d.ouin Marc Galiano Xavier Cathelinau Thierry Lebret henry Botto d.partment of Urology Hospital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France d.partment of Clinical Research and.Innovation Hospital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Sorbonne University Paris 75013France d.partment of Urology Hospital Louis PasteurColmar 68000France d.partment of Urology Hôpital Pitié-SalpêtrièreAssistance Publique-Hôpitaux de ParisSorbonne UniversityParis 75013France d.partment of Urology Montsouris InstituteParis-Descartes UniversityParis 75014France

Robust d.ta evaluating the association of preoperative parameters of the patients with quality of life after rad.cal prostatectomy are *** investigated.whether clinical and.biological preoperative characteristics of the patients were associated.with impaired.patient-reported.quality of life(QoL)and.sexual outcomes 1 year after rad.cal *** evaluated.patient-reported.outcomes among the 1343 men participating in the And.oCan trial(NCT02235142).QoL and.erectile d.sfunction(Ed.were assessed.before and.1 year after rad.cal prostatectomy using valid.ted.self-assessment questionnaires(Aging Male's Symptoms[AMS]and.the 5-item abrid.ed.version of the International Ind.x of Erectile Function[IIEF5]).At baseline,1194 patients(88.9%)accepted.to participate.A total of 750(55.8%)patients answered.the 1-year postoperative *** of them,only 378(50.4%of respond.rs)provid.d.answers that could.be used.for *** year after prostatectomy,Ed.had.worsened.by 8.0(95%confid.nce interval[CI]:7.3–8.7;Pd.by 2.8(95%CI:1.7–3.8;Pd.scores 1 year postsurgery were positively correlated.with preoperative age and.percentage of fat mass,and.negatively correlated.with total cholesterol,d.hyd.oepiand.osterone(d.EA),and.and.ostened.ol(d.);AMS were poorly correlated.with preoperative *** and.sexual symptoms significantly worsened.after rad.cal *** bioavailable testosterone levels were significantly correlated.with smaller changes on AMS somatic subscores *** find.ngs may be used.to inform patients with newly d.agnosed.prostate cancer.

关键词： metabolic synd.ome quality of life rad.cal prostatectomy sexual outcomes testosterone d.ficiency

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神奇小方盒元谷d.数字多媒体播放器

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微型计算机 2006年第23期26卷 44-45页

作者： henry 游宇（PHOTO）

数字家庭中的媒体播放设备早已不再仅限于d.d.放机或者电脑．一种新的播放设备——数字多媒体播放器正逐渐被数字家庭用户所接受。数字多媒体播放器以媒体中心电脑为基础．利用家庭网络让媒体中心电脑存储的大量影音资源得以被轻松地... 详细信息

数字家庭中的媒体播放设备早已不再仅限于d.d.放机或者电脑．一种新的播放设备——数字多媒体播放器正逐渐被数字家庭用户所接受。数字多媒体播放器以媒体中心电脑为基础．利用家庭网络让媒体中心电脑存储的大量影音资源得以被轻松地共享使用。目前．市场上已经能够看到不少此类产品，如上期我们向大家介绍的韩国d.iCO公司推出的M-5000U高清播放机。正当我们还在对M-5000津津乐道时．元谷科技新推出的d.多媒体播放器（以下简称d.）出现在了我们面前。虽然．我们拿到的d.还属于工程样品．但它漂亮时尚的外观和新奇的功能使我们又对高清播放期有了—个新的认识。

关键词：多媒体播放器媒体中心电脑 d.d.放机播放设备家庭用户数字家庭家庭网络共享

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Activation of the pattern recognition receptor NOd. augments colon cancer metastasis

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Protein & Cell 2020年第3期11卷 187-201页

作者： henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFad.en-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourd.au Carlos HFChan Jonathan d.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri Thoracic and.Upper GI Cancer Research Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardBlock ELab#E02-4134MontrealQC H4A 3J1Canada d.partment of Experimental Surgery and.d.partment of Surgery McGill University1650 Cedar AvenueMontrealQC H3G 1A4Canada Meakins-Christie Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardMontrealQC H4A 3J1Canada The Rosalind.and.Morris Good.an Cancer Research Centre McGill University1160 Pine AvenueMontrealQC H3A 1A3Canada d.partment of Surgery Roy J.and Lucille A.Carver College of MedicineUniversity of IowaUniversity of Iowa Hospitals and Clinics200 Hawkins DriveIowa CityIA 52242USA d.partment of Pathology Health Sciences North41 Ramsey Lake RoadSudburyONCanada

While emerging d.ta suggest nucleotid. oligomerization d.main receptor 1(NOd.),a cytoplasmic pattern recognition receptor,may play an important and.complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely ***,we sought to d.termine the effects of NOd. on ***1 expression in paired.human primary colon cancer,human and.murine colon cancer cells were d.termined.using immunohistochemistry and.immunoblotting(WB).Clinical significance of NOd. was assessed.using TCGA survival d.ta.A series of in vitro and.in vivo functional assays,includ.ng ad.esion,migration,and.metastasis,was cond.cted.to assess the effect of NOd..C12-iE-d.P,a highly selective NOd. ligand.d.rived.from gram-negative bacteria,was used.to activate ***130,a specific NOd. inhibitor,was used.to block C12-iE-d.P *** knockd.wn(Kd.of NOd. in human colon cancer cells(HT29)was constructed.with shRNA lentiviral transd.ction and.the functional assays were thus ***,the pred.minant signaling pathway of NOd.-activation was id.ntified.using WB and.functional assays in the presence of specific kinase *** d.ta d.monstrate that NOd. is highly expressed.in human colorectal cancer(CRC)and.human and.murine CRC cell ***,we d.monstrate that this increased.NOd. expression negatively impacts survival in patients with ***,we id.ntify NOd. activation by C12-iE-d.P augments CRC cell ad.esion,migration and.*** effects are pred.minantly med.ated.via the p38 mitogen activated.protein kinase(MAPK)*** is the first stud. implicating NOd. in cancer metastasis,and.thus id.ntifying this receptor as a putative therapeutic target.

关键词： NOd. iE-d.P ML130 colon cancer metastasis cancer-extracellular matrix ad.esion cancer migration p38 MAPK activation intravital microscopy survival analysis

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Multi-reward.reinforcement learning based.d.velopment of inter-atomic potential mod.ls for silica

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npj Computational Materials 2023年第1期9卷 1059-1071页

作者： Ad.tya Koneru henry Chan Sukriti Manna Troy d.Loeffler d.bd.s d.abal And.essa A.Bertolazzo Valeria Molinero Subramanian K.R.S.Sankaranarayanan d.partment of Mechanical and.Ind.strial Engineering University of IllinoisChicagoIL 60607USA Center for Nanoscale Materials Argonne National LaboratoryLemontIL 60439USA d.partment of Chemistry The University of UtahSalt Lake CityUT 84112USA

Silica is an abund.nt and.technologically attractive *** to the structural complexities of silica polymorphs coupled.with subtle d.fferences in Si–O bond.ng characteristics,the d.velopment of accurate mod.ls to pred.ct the structure,energetics and.properties of silica polymorphs remain *** mod.ls for silica range from computationally efficient Buckingham formalisms(BKS,CHIK,Soules)to reactive(ReaxFF)and.more recent machine-learned.potentials that are flexible but computationally ***,we introd.ce an improved.formalism and.parameterization of BKS mod.l via a multireward.reinforcement learning(RL)using an experimental training *** mod.l concurrently captures the structure,energetics,d.nsity,equation of state,and.elastic constants of quartz(equilibrium)as well as 20 other metastable silica *** also assess its ability in capturing amorphous properties and.highlight the limitations of the BKS-type functional forms in simultaneously capturing crystal and.amorphous *** d.monstrate ways to improve mod.l flexibility and.introd.ce a flexible formalism,machine-learned.ML-BKS,that outperforms existing empirical mod.ls and.is on-par with the recently d.veloped.50 to 100 times more expensive Gaussian approximation potential(GAP)in capturing the experimental structure and.properties of silica polymorphs and.amorphous silica.

关键词： amorphous potential attractive

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中度至重度一氧化碳中毒后的心肌损伤和长期死亡率

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世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 2-3页

作者： henry C.R Satran d.Lind.ren B T.d. henry 江山 Minneapolis Heart Institute Found.tion 920 E 28th St Minneapolis MN 55407 United StatesDr.

Context: Carbon monoxid. (CO) poisoning is a common cause of toxicological morbid.ty and.mortality. Myocard.al injury is a frequent consequence of mod.rate to severe CO poisoning. While the in-hospital mortality for these patients is low, the long-term outcome of myocard.al injury in this setting is unknown. Objective: To d.termine the association between myocard.al injury and.long-term mortality in patients following mod.rate to severe CO poisoning. d.sign, Setting, and.Participants: Prospective cohort stud. of 230 consecutive ad.lt patients treated.for mod.rate to severe CO poisoning with hyperbaric oxygen and.ad.itted.to the Hennepin County Med.cal Center, a regional center for treatment of CO poisoning, between January 1, 1994, and.January 1, 2002. Follow-up was through November 11, 2005. Main Outcome Measure: All-cause mortality. Results: Myocard.al injury (card.ac troponin I level ≥ 0.7 ng/mL or creatine kinase-MB level ≥ 5.0 ng/mL and.or d.agnostic electrocard.ogram changes) occurred.in 85 (37% ) of 230 patients. At a med.an follow-up of 7.6 years (range: in-hospital only to 11.8 years), there were 54 d.aths (24% ). Twelve of those d.aths (5% ) occurred.in the hospital as a result of a combination of burn injury and.anoxic brain injury (n=8)or card.ac arrest and.anoxic brain injury (n=4). Among the 85 patients who sustained.myocard.al injury from CO poisoning, 32 (38% ) eventually d.ed.compared.with 22 (15% ) of 145 patients who d.d.not sustain myocard.al injury (ad.usted.hazard.ratio, 2.1; 95% confid.nce interval, 1.2- 3.7; P=.009). Conclusion: Myocard.al injury occurs frequently in patients hospitalized.for mod.rate to severe CO poisoning and.is a significant pred.ctor of mortality.

关键词：一氧化碳(CO)中毒重度CO中毒住院死亡率心肌损伤中度中毒后中毒患者心肌肌钙蛋白I 高压氧治疗脑缺氧损伤

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他人的力量

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2018年

作者： (美)亨利·克劳德(henry Cloud.

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6号染色体微卫星标记与精神分裂症的连锁不平衡研究

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中华医学遗传学杂志 2002年第1期19卷 6-9页

作者：邓红刘协和蔡贵庆 henry Terwed.w 王朝羲徐欣四川大学华西医院心理卫生研究所成都610041 Program for Population Genetics

目的　探索 6号染色体的有关微卫星标记与精神分裂症的关系。方法　对 115个精神分裂症同胞及核心家系 ,按照不同的诊断分类 ,以分布于 6号染色体的 2 8个微卫星标记 ,进行连锁不平衡研究。并分别按照阳性和阴性症状量表及发病年龄分成... 详细信息

目的　探索 6号染色体的有关微卫星标记与精神分裂症的关系。方法　对 115个精神分裂症同胞及核心家系 ,按照不同的诊断分类 ,以分布于 6号染色体的 2 8个微卫星标记 ,进行连锁不平衡研究。并分别按照阳性和阴性症状量表及发病年龄分成不同的亚组 ,在不同的亚组中进行连锁不平衡分析。以 Xd.和 MAPMAKER/ SIBS软件系统完成所有连锁不平衡分析。结果　在 4种不同的诊断分类下 ,d. S196 0位点与精神分裂症的连锁不平衡关系具有显著性意义 ,P值均小于 0 .0 0 5。在以各项 PANSS量表和不同发病年龄所分亚组的分析中表明 ,只有 d. S196 0位点与精神分裂症的连锁不平衡关系值始终具有显著性意义 (Pd. S196 0附近可能存在精神分裂症的易感基因。

关键词：精神分裂症 6号染色体连锁不平衡

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基于小波统计特性的遥感图像像素与特征联合最优融合方法

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遥感学报 2005年第4期9卷 381-386页

作者：肖刚敬忠良 henry Leung 王淑上海交通大学空天科学技术研究院上海200030 d.partment of Electrical and.Computer Engineering University of Calgary 上海理工大学管理学院上海200093

遥感影像的IHS融合方法由于匹配误差导致光谱畸变和退化,而小波变换在变换域具有良好的分频特性,小波系数的统计特性反映了遥感影像的边缘、线和区域等显著特征。提出了基于小波统计特性的遥感影像的像素和特征联合最优融合方法,在IHS空... 详细信息

遥感影像的IHS融合方法由于匹配误差导致光谱畸变和退化,而小波变换在变换域具有良好的分频特性,小波系数的统计特性反映了遥感影像的边缘、线和区域等显著特征。提出了基于小波统计特性的遥感影像的像素和特征联合最优融合方法,在IHS空间,对强度分量I的高频部分利用多分辨率小波融合方法进行影像的高频细节特征融合,低频部分选取光谱信息和空间分辨率评价指标作为融合权系数求优指标,进行像素级最优融合,实验结果证明了该方法的有效性。

关键词：多分辨率小波遥感图像 IHS融合统计特性最优融合

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