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Adjunctive platelet-rich plasma and hyaluronic acid injection after arthroscopic debridement in Kellgren-Lawrence grade 3 and 4 knee osteoarthritis

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World Journal of Orthopedics 2022年第10期13卷 911-920页

作者： henry tirtosuharto I Gede Eka Wiratnaya Putu Astawa Department of Orthopaedic and Traumatology Faculty of Medicine Udayana University/Sanglah HospitalDenpasar 80113BaliIndonesia

BACKGROUND Osteoarthritis(OA)is the most common cause of pain and disability,predominantly affecting the *** current management of knee OA falls short of completely stopping disease progression,particularly in Kellgren-Lawrence(KL)grade 3 and 4 knee *** such,joint replacement is often recommended,although only 15%-33%of candidates accept *** therapeutic options are still needed to prevent the progression of joint damage and delay the need for knee *** To investigate the effect of adjunctive platelet rich plasma(PRP)and hyaluronic acid(HA)after arthroscopic debridement in KL grade 3 and 4 knee *** This retrospective cohort study used the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score and WOMAC sub-scores(pain,stiffness,and function)to assess 21 patients,grouped according to medical record data of treatment received:Arthroscopic debridement(n=7);arthroscopic debridement with PRP(n=7);or arthroscopic debridement with HA(n=7).WOMAC scores and sub-scores at baseline and at 3 mo and 5 mo posttreatment were *** three-group data were statistically analyzed using the tests of paired t,one-way analysis of variance,and post hoc least significant *** All three treatment groups showed significant improvements in WOMAC score and sub-scores from before treatment to 3 mo and 5 mo after ***,the arthroscopic debridement with PRP treatment group,in particular,showed a significantly lower WOMAC pain score than the group who received arthroscopic debridement alone at 5 mo after the procedure(P=0.03).CONCLUSION Compared to arthroscopic debridement alone,adjunctive PRP after arthroscopic debridement significantly lessened the patients’pain symptom.

关键词： Arthroscopic debridement Hyaluronic acid Osteoarthritis Platelet-rich plasma Western Ontario and McMaster Universities Osteoarthritis Index WOMAC score

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