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A rare case of isolated castrate resistant bilateral testicular metastases in advanced prostate cancer

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Asian Journal of Urology 2018年第2期5卷 127-130页

作者： Jiarui Su Edwin Jonathan Aslim Hakan Aydin Puay hoon Tan henry sun sien ho Department of Urology Singapore General HospitalSingapore Department of Anatomical Pathology Singapore General HospitalSingapore Division of Pathology Singapore General HospitalSingapore

Testicular metastasis is rare with the prostate being the most common site of primary *** report a case of a 72-year-old man with castration-resistant prostate cancer(CRPC)and known metastases to bone and lymph nodes,who developed bilateral painful swollen testes 3 years after the initial diagnosis of prostate *** had first presented with lower urinary tract symptoms(LUTS)with suspicious findings on digital rectal examination of the prostate,and an elevated serum prostate specific antigen(PSA)level of 129 ng/*** prostate biopsy revealed Gleason 4þ5 *** staging showed locally advanced prostate cancer with extensive metastases to bone and pelvic and retroperitoneal lymph *** was given hormonal therapy for over 2 years until progression to *** months later he developed painful bilateral testicular swellings,and serum markers for testicular germ cell cancer were *** orchiectomy was performed,showing metastatic prostate cancer(Gleason 4þ5)on *** month postoperatively his PSA level dropped to 0.1 ng/mL from a presurgery level of 6.24 ng/mL.

关键词： Castration-resistant prostate cancer Metastases Testicular tumor Orchiectomy

Benign prostatic hyperplasia and male lower urinary symptoms:A guide for family physicians

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Asian Journal of Urology 2017年第3期4卷 181-184页

作者： Farhad Fakhrudin Vasanwala Michael Yuet Chen Wong henry sun sien ho Keong Tatt Foo Department of Family Medicine Sengkang Hospital at Alexandra HospitalSingHealthSingapore International Urology Fertility and Gynaecology CentreMount Elizabeth Medical CentreSingapore Department of Urology Singapore General HospitalSingHealthSingapore

Male patients with lower urinary tract symptoms(LUTS)and benign prostatic hyperplasia(BPH)are increasingly seen by family physicians worldwide due to ageing demographics.A systematic way to stratify patients who can be managed in the community and those who need to be referred to the urologist is thus very *** history taking,physical examination,targeted blood or urine tests,and knowing the red flags for referral are the mainstay of stratifying these *** selection is always key in clinical practice and in the setting of the family *** best patient to manage is one above 40 years of age,symptomatic with nocturia,slower stream and sensation of incomplete voiding,has a normal prostatespecific antigen level,no palpable bladder,and no haematuria or pyuria on the *** roles of α blockers,5-α reductase inhibitors,and antibiotics in a primary care setting to manage this condition are also discussed.

关键词： Benign prostatic hyperplasia Male lower urinary tract symptoms Guideline Family physicians

Peak stent discomfort occurs early and ureteral stent with distal loop design has less paineA pilot prospective randomised singleblinded trial over 2 weeks

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Asian Journal of Urology 2020年第4期7卷 357-362页

作者： Kheng Sit Lim Zhi Wei Law Marcus Way Lunn Chow Allen Soon Phang Sim henry sun sien ho Department of Urology Singapore General HospitalSingapore Department of Urology Tan Tock Seng HospitalSingapore

Objectives:The Polarisloop ureteric stent reduces the severity of stent discomfort by minimising stent material in the *** impact of ureteral stenting on quality of life(QoL)within 1 week remains *** usefulness of the patient-administered ureteral stent symptoms questionnaire(USSQ)during this period of stent insertion was *** this pilot single-blinded prospective randomised study,we investigate 1)the presence of early(within the 1st week)stent discomfort via the visual analog scale(VAS);2)determine the QoL of the loop stent against conventional ***:Forty adults requiring retrograde unilateral ureteral stent placements were *** with single ureteric stone or benign stricture were *** were randomised in 1:1 ratio to the loop and pigtail *** USSQ was administered before placement(baseline),USSQ and VAS were administered on Day 3,7,and ***:There were no significant differences between the USSQ *** pain scores on Day 3 were lower in the loop stent group(2.9 vs.4.0,pZ0.047).There was a significant reduction in pain from Day 3e7(0 vs.1,pZ0.016)in the pigtail ***:Our results suggest that peak stent discomfort occurs but resolves quickly within 1 week of post-stent *** loop stent offers a better pain profile compared with conventional stents at Day 3 but no difference in *** loop stent reduces early pain experience post-stent insertion and may have a role in the care of patients who experience significant stent discomfort previously.

关键词： Quality of life Stent discomfort Ureteral stent symptoms questionnaire Ureteric stents

Multiparametric MRI reporting using Prostate Imaging Reporting and Data System version 2.0 (PI-RADSv2) retains clinical efficacy in a predominantly post-biopsy patient population

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Asian Journal of Urology 2019年第3期6卷 256-263页

作者： Edwin Jonathan Aslim Yan Mee Law Puay hoon Tan John Carson Allen Jr Lionel Tim-Ee Cheng Viswanath Anand Chidambaram Li Yan Khor Benjamin Yongcheng Tan Ernest Wencong Eu Christopher Wai Sam Cheng John Shyi Peng Yuen henry sun sien ho Lui Shiong Lee Department of Urology Singapore General HospitalSingapore Department of Diagnostic Radiology Singapore General HospitalSingapore Division of Pathology Singapore General HospitalSingapore Centre of Quantitative Medicine DUKE-NUS Medical SchoolSingapore Department of Anatomical Pathology Singapore General HospitalSingapore

Objective:To evaluate the efficacy of multiparametric magnetic resonance imaging(mp-MRI)using Prostate Imaging Reporting and Data System version 2.0(PI-RADSv2)definitions in detecting organ-confined prostate ***:All patients who underwent radical prostatectomy between January 1,2014 and December 30,2014 were *** underwent mp-MRI within 180 days before *** with prior pelvic irradiation or androgen deprivation therapy were *** embedded,whole-mount histopathology was centrally reviewed and correlated with imaging for tumour location,Gleason score(GS)and ***:There were 39 patients included,of which 35(90%)had mp-MRI done post-biopsy.A total of 93 cancer foci were identified on whole-mount pathology,of which mp-MRI detected 63(68%).Of those detected by mp-MRI,14 were PI-RADS 3(n=6 for GS 6,n=8 for GS 7,no GS≥8)and 49 were PI-RADS 4e5(nZ7 for GS 6,nZ33 for GS 7,and nZ9 for GS≥8).There were 30(32%)cancer foci missed by mp-MRI(n=15 for GS 6,n=13 for GS 7 and n=2 for GS≥8).A lesion classified as PI-RADS 4e5 predicted a higher grade cancer on pathology as compared to PI-RADS 3(for GS 7 lesions,odds ratio[OR]=3.53,95%CI:0.93e13.45,p=0.064).The mp-MRI size detection limit was 20 mm2 and 100 mm2 for 50%and 75%probability of cancer,*** associating with radiological and pathologic stage,the weighted Kappa value was 0.69(phort,mp-MRI using PI-RADSv2 reporting has a reasonably high diagnostic accuracy in detecting clinically significant prostate cancer.

关键词： Gleason score Histopathology Magnetic resonance imaging Prostatectomy Prostatic cancer

都铎早期英格兰地权冲突与立法应对——以用益授予为中心的考察

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山东师范大学学报（社会科学版） 2024年第3期69卷 68-81页

作者：孙小娇山东师范大学历史文化学院山东济南250358

诺曼征服后,英格兰进入封建社会,形成了以封土为纽带的封君封臣关系。封臣需要向封君履行封建义务且不能自由处分土地。到中世纪后期,封臣广泛借助用益授予进行规避,产生并激化了双方之间的地权冲突。都铎早期英格兰处于封建王国向民族... 详细信息

诺曼征服后,英格兰进入封建社会,形成了以封土为纽带的封君封臣关系。封臣需要向封君履行封建义务且不能自由处分土地。到中世纪后期,封臣广泛借助用益授予进行规避,产生并激化了双方之间的地权冲突。都铎早期英格兰处于封建王国向民族国家转变的重要阶段,国王亨利八世在对外摆脱教会控制、对内加强国家控制之时,借助议会之手全面规范用益授予以控制土地流动,获取封建权益,树立国王权威。土地立法进程相当曲折,国王通过分化议员与输送利益的方式推动了《用益法》和《登记法》的颁布,很快又因为普遍不满和国内暴动进行了妥协。尽管土地立法效果未如国王所愿,但用益授予获得了合法地位,用益主体之间的信义关系亦得到承认。

关键词：都铎早期英格兰用益授予地权冲突土地立法

情感体验的语言——论米歇尔·亨利的语言现象学

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文学评论 2024年第1期 79-87页

作者：孙云霏北京师范大学文学院

语言现象学在语言研究领域中的独特性在于,它主张语言的意义不是既成的,而是在活生生的体验中创生出的,因此“体验”对语言来说十分重要,如经典现象学认为语言是从意识体验、生存体验里生发的。然而,法国现象学家米歇尔·亨利指出,经典... 详细信息

语言现象学在语言研究领域中的独特性在于,它主张语言的意义不是既成的,而是在活生生的体验中创生出的,因此“体验”对语言来说十分重要,如经典现象学认为语言是从意识体验、生存体验里生发的。然而,法国现象学家米歇尔·亨利指出,经典现象学所重视的体验并非真实的体验,只是意向性或存在对物质的揭示,可物质之实存却在被揭示中消自身,语言发挥的正是这种揭示作用。他针对经典现象学的“世界的语言”提出“生命的语言”,目的是在语言中体验物质之实存、体验生命生成、体验活泼泼的情感,由此开启新的世界。文学是通过语言进入情感体验从而激生新意义的典型场域。

关键词：语言体验实存情感物质

Gating System Design for a Magnesium Alloy Casting

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Journal of Materials Science & Technology 2008年第1期24卷 93-95页

作者： Zhizhong sun henry HU Xiang CHEN Qigui WANG Wenying YANG Department of Mechanical Automotive ＆ Materials Engineering University of Windsor Windsor Ontario Canada N9B 3P4 Canada Department of Electrical ＆： Computer Engineering University of Windsor Windsor Ontario Canada N9B 3P4 Canada General Motors Corporation Pontiac MI 48340 USA

The gating system of a cylindrical magnesium casting has been designed by using multiple objective optimiza- tion and Taguchi *** filling and solidification processes were simulated by using MAGMASOFT（？）. The simulation results indicate that the gating system design has a significant effect on the quality of magne- sium *** an effort to obtain the optimal design of gating system,the signal-to-noise （S/N） ratio was used to analyze the effect of various gating designs on cavity filling and casting quality by using a weighting method based on the design of an orthogonal *** gating system parameters,namely,ingate height, ingate width,runner height,runner width,were optimized with a consideration of multiple objective criteria including filling velocity,shrinkage porosity and product yield.

关键词： Gating system Magnesium casting Optimization Taguchi method

Section thickness-dependent tensile properties of squeeze cast magnesium alloy AM60

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China Foundry 2012年第2期9卷 178-183页

作者： Xuezhi Zhang Meng Wang Zhizhong sun henry Hu Department of Mechanical Automotive and Materials Engineering University of Windsor Windsor Ontario N9B 3P4 Canada

The development of alternative casting processes is essential for the high demand of light weight magnesium components to be used in the automotive industry, which often contain different section thicknesses. Squeeze casting with its inherent advantages has been approved for the capability of minimizing the gas porosity in magnesium alloys. For advanced engineering design of light magnesium automotive applications, it is critical to understand the effect of section thickness on mechanical properties of squeeze cast magnesium alloys. In this study, magnesium alloy AM60 with different section thicknesses of 6, 10 and 20 mm squeeze cast under an applied pressure of 30 MPa was investigated. The prepared squeeze cast AM60 specimens were tensile tested at room termperature. The results indicate that the mechanical properties including yield strength （YS）, ultimate tensile strength （UTS） and elongation （A） decrease with an increase in section thickness of squeeze cast AM6O. The microstructure analysis shows that the improvement in the tensile behavior of squeeze cast AM60 is primarily attributed to the low-gas porosity level and fine grain strucuture which result from the variation of cooling rate of different section thickness. The numerical simulation （Magmasoft） was employed to determine the solidification rates of each step, and the simulated results show that the solidification rate of the alloy decreases with an increase in the section thickness. The computed solidification rates support the experimental observation on grain structural development.

关键词： squeeze casting magnesium alloy AM60 tensile properties section thickness

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关于明清时期桂西土司地区城头组织的考察

中国边疆史地研究 2024年第1期34卷 94-105,215页

作者：孙剑伟广西财经学院新闻与文化传播学院南宁市530007

明代桂西地区田州和思恩府土司地区普遍设立城头组织,存续至清末民国。城头组织与赋役制度密切配合,使土司能够有效地征派赋税和差。土司辖区内的“边缘”群体不断被吸纳到城头组织当中,不同地域和群体之间的经济、文化差异逐渐缩小,社... 详细信息

明代桂西地区田州和思恩府土司地区普遍设立城头组织,存续至清末民国。城头组织与赋役制度密切配合,使土司能够有效地征派赋税和差。土司辖区内的“边缘”群体不断被吸纳到城头组织当中,不同地域和群体之间的经济、文化差异逐渐缩小,社会整合程度越来越高。明代田州和思恩府的城头组织除了赋役征派的功能外,还具有突出的军事功能。到了清代,城头组织的军事功能逐渐褪去,赋役征派功能更加突出,其运作方式越来越类似于流官地区的“里(图)甲”。

关键词：城头土司田州思恩府