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Risk of colon cancer in heredit.ry non-polyposis colorect.l cancer pat.ent. as predict.d by fuzzy modeling:Influence of smoking

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World Journal of Gast.oent.rology 2006年第28期12卷 4485-4491页

作者： Rhonda M Brand David D Jones henry t.Lynch Randall E Brand Pat.ice Wat.on Ramesh Ashwat.nayaran Hemant.K Roy Depart.ent.of Int.rnal Medicine Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern UniversityEvanston ILUinted States Depart.ent.of Biological Syst.ms Engineering University of Nebraska-LincolnLincoln NEUinted States Heredit.ry Cancer Inst.t.t. Creighton UniversityUinted States

AIM： t. invest.gat. whet.er a fuzzy logic model could predict.colorect.l cancer （CRC） risk engendered by smoking in heredit.ry non-polyposis colorect.l cancer （HNPCC） pat.ent.. MEt.ODS： t.ree hundred and fort. HNPCC mismat.h repair （MMR） mut.t.on carriers from t.e Creight.n Universit. Heredit.ry Cancer Inst.t.t. Regist.y were select.d for modeling. Age-dependent.curves were generat.d t. elucidat. t.e joint.effect. bet.een gene mut.t.on （hMLH1 or hMSH2）, gender, and smoking st.t.s on t.e probabilit. of developing CRC. RESULt.： Smoking significant.y increased CRC risk in male hMSH2 mut.t.on carriers （P 〈 0.05）. hMLH1 mut.t.ons augment.d CRC risk relat.ve t. hMSH2 mut.t.on carriers for males （P 〈 0.05）. Males had a significant.y higher risk of CRC t.an females for hMLH1 non smokers （P 〈 0.05）, hMLH1 smokers （P 〈 0.1） and hMSH2 smokers （P 〈 0.1）. Smoking promot.d CRC in a dose-dependent.manner in hMSH2 in males （P 〈 0.05）. Females wit. hMSH2 mut.t.ons and bot. sexes wit. t.e hMLH1 groups only demonst.at.d a smoking effect.aft.r an ext.nsive smoking hist.ry （P 〈 0.05）. CONCLUSION： CRC promot.on by smoking in HNPCC pat.ent. is dependent.on gene mut.t.on, gender and age. t.ese dat. demonst.at. t.at.fuzzy modeling may enable formulat.on of clinical risk scores, t.ereby allowing individualizat.on of CRC prevent.on st.at.gies.

关键词： Heredit.ry non-polyposis colorect.l cancer Lynch syndrome Smoking Colorect.l cancer Fuzzy modeling Risk assessment

Report.of t.e rest.dy of t.e defined global st.at.t.pe of t.e base of t.e Silurian Syst.m

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Episodes 2008年第3期31卷 315-318页

作者： Jiayu Rong Michael Melchin S. henry Williams t.t.ana N. Koren Jacques Verniers SKL Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences 210008 Nanjing PRC Depart.ent.of Geology St. Francis Xavier University Antigonish NS B2G 2W5 Canada Pet.o-Canada Oil and Gas 150 - 6th Avenue SW Calgary AB T2P 3E3 Canada All Russian Geological Research Insfit.t.-VSEGEI Sredny pr. 74 199026 St. Petersburg Russia Research Unit.Palaeont.logy Ghent University Krijgslaan 281/S 8 2000 Ghent Belgium

t.e Global St.at.t.pe Sect.on and Point.（GSSP） for t.e base of t.e Silurian Syst.m was defined in 1985. Since t.at.t.me, a number of researchers have suggest.d t.at.t.is sect.on has serious deficiencies for use as a GSSP. As a result. in 2000, t.e Subcommission on Silurian St.at.graphy （SSS） proposed undert.king a formal rest.@ of t.is GSSP, which was subsequent.y approved by t.e Int.rnat.onal Commission of St.at.graphy （ICS）. t.e result.of t.is rest.dy was t.e formal proposal t.at.t.e current.GSSP, at.1.6 m above t.e base of t.e Birkhill Shale, at.Dob＇s Linn, Scot.and, should be maint.ined as t.e same localit. and st.at.graphic level, but.t.e bios- t.at.graphical definit.on of t.e boundary should be revised. t.e previously defined, basal Silurian grapt.- lit. zone, t.e Parakidograpt.s acuminat.s Zone, should be subdivided int. a lower Akidograpt.s ascensus Zone and a higher E acuminat.s Zone. t.e base of t.e A. ascensus Zone, marked by t.e first.appearance of A. ascensus, should be regarded as t.e biost.at.graphic mark for t.e base of t.e Silurian. t.is proposal has now been formally approved by t.e SSS and ICS, and rat.fied by Int.rnat.onal Union of Geological Sciences. t.is is t.e first.GSSP t. undergo formal rest.dy and redefini- t.on, and t.e proposal also included a recommended procedure for rest.dy of GSSPs.

关键词：全球层形志留纪地质学研究项目

Ident.ficat.on and confirmat.on of novel Qt.s for aluminum t.lerance conferring t.ssue t.lerance mechanism in soybean

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Identification and confirmation of novel QTLs for aluminum t...

Cyst.c lymphangioma of t.e pancreas

江苏省遗传学会2019年学术研讨会

作者：李阳 Heng Ye t.i Vuong 李艳 henry t.Nguyen Nat.onal Key Laborat.ry of Crop Genet.cs and Germplasm Enhancement National Center for Soybean Improvement Nanjing Agricultural University Division of Plant.Sciences University of Missouri

Aluminum(Al) t.xicit. is a major abiot.c st.ess limit.ng crop yield in acidic soil. Al t.xicit. inhibit. plant.root.growt. and development. leading t. insufficient.upt.ke of wat.r and nut.ient.from soil. Soybean is sensit.ve t. Al t.xicit., exhibit.ng impaired root.growt. under elevat.d Al concent.at.ons. In t.is research, t.o soybean lines(Magellan and PI 567731) were ident.fied t. differ in Al t.lerance represent.d by primary root.lengt. rat.o(PRLat.o), t.t.l root.lengt. rat.o(t.Lat.o), and root.t.p number rat.o(Rt.at.o) under 25 μM Al3+. t.e recombinant.inbred line(RIL) populat.on derived from t.e cross of t.ese t.o lines exhibit.d high inherit.nce(0.65 t. 0.85) in Al t.lerance-relat.d t.ait.. t.e quant.t.t.ve t.ait.loci(Qt.) mapping ident.fied t.ree Qt. on chromosome(Chr.) 3, 13 and 20 associat.d wit. Al t.lerancerelat.d t.ait.. qAlm20 explained t.e largest.phenot.pic variat.on of ～ 27.4% and mainly played roles in maint.ining root.elongat.on. qAlm03 and q Alm13 were mapped as novel Al t.lerance loci and predict.d t. be mainly involved in maint.ining root.t.p init.at.on or root.elongat.on under Al st.ess, respect.vely. Furt.ermore, t.e t.o major Qt.(qAlm13 and qALm20) were confirmed using nearisogenic lines(NILs), and t.ey seemed t. regulat. Al t.lerance in t.ssue t.lerance pat.way inst.ad of Al3+ exclusion or t.ansport. t.e t.lerant.allele of qALm20 was ident.fied as a rare allele, which has not.been widely ut.lized in soybean breeding. Our result. not.only provided novel genet.c resources for breeding Al t.lerant.soybean variet.es, but.also confirmed Al t.lerance Qt. in t.e NIL background and proposed t.e possible mechanisms underlying t.em.

关键词： Aluminum t.lerance Near-isogenic lines Qt. mapping Root.lengt. Soybean

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World Journal of Gast.oent.rology 2008年第44期14卷 6873-6875页

作者： Radoje B Colovic Nikica M Grubor Marjan t.Micev henry Dushan E At.inson Vit.mir I Rankovic Mihajlo M Jagodic Inst.t.t. for Digest.ve Diseases Clinical Center of SerbiaFirst Surgical ClinicKoste Todorovica 6Belgrade11000Serbia Imperial College School of Medicine St Mary's HospitalPraed StreetLondon W21NYUnited Kingdom

Lymphangioma of t.e pancreas is an ext.emely rare benign t.mour of lymphat.c origin, wit. fewer t.an 60 published cases. Hist.logically, it.is polycyst.c, wit. t.e cyst. separat.d by t.in sept. and lined wit. endot.elial cells. t.ough congenit.l, it.can affect.all age groups, and occurs more frequent.y in females. Pat.ent. usually present.wit. epigast.ic pain and an associat.d palpable mass. Complet. excision is curat.ve, even t.ough, depending on t.e t.mour locat.on, surgery may be simple or involve ext.nsive pancreat.c resect.on and anast.moses. t.e aut.ors present.a 49-year-old woman in whom a polycyst.c sept.t.d mass, 35 mm× 35 mm in size, was discovered by ult.asonography （US） in t.e body of t.e pancreas during invest.gat.ons for epigast.ic pain and nausea. At.surgery, a well circumscribed polycyst.c t.mor was complet.ly excised, wit. preservat.on of t.e pancreat.c duct. t.e post.perat.ve recovery was unevent.ul. Hist.logy confirmed a microcyst.c lymphangioma of t.e pancreas. Immunohist.chemist.y showed cyst.c endot.elial cells react.vit. t. fact.r Ⅷ -RA （＋＋）, CD31 （＋＋＋） and CD34 （-）. Post.perat.vely, abdominal pain disappeared and t.e pat.ent.remained sympt.mfree for 12 mo unt.l now. Alt.ough ext.emely rare, lymphangioma of t.e pancreas should be t.ken int. considerat.on as a different.al diagnosis of a pancreat.c cyst.c lesion, especially in women.

关键词： Pancreas Cyst.c lymphangioma Localsurgical excision

Perigast.ic ext.askelet.l Ewing's sarcoma: A case report

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World Journal of Gast.oent.rology 2009年第2期15卷 245-247页

作者： Radoje B Colovic Nikica M Grubor Marjan t.Micev Slavko V Mat.c henry Dushan Edward At.inson St.jan M Lat.ncic Inst.t.t. for Digest.ve Diseases Clinical Center of Serbia Koste Todorovica 6 Belgrade 11000 Serbia Imperial College School of Medicine St Mary's Hospital Praed Street London W2 1NY United Kingdom

Ewing's sarcoma (ES) is a neoplasm of undifferent.at.d small round cells, which occurs in t.e bones and deep soft.t.ssues of children and adolescent.. We present.a rare case of a 44-year-old woman wit. gast.ic ES present.ng wit. epigast.ic pain and weight.loss. Ult.asound and comput.d t.mography scans indicat.d a solid/cyst.c mass in t.e pancreat.c t.il. At.laparot.my, t.e t.mor was found at.ached t. t.e post.rior surface of t.e st.mach, complet.ly free from t.e pancreas, wit. no lymphadenopat.y or local met.st.ses. t.e polynodal, part.y pseudocyst.c, dark-red soft.t.mor was excised. Hist.pat.ology revealed an anaplast.c small-round-cell t.mor wit. st.ong membranous CD99 immunoexpression. Addit.onally, t.ere was pat.hy immunost.ining for S-100 prot.in, viment.n, prot.in gene product.(PGP) 9.5 and neuron-specifi c enolase, and weak focal CD117 cyt.plasmic immunoreact.vit.. t.e pat.ent.had no adjuvant.chemot.erapy; her post.perat.ve recovery was unevent.ul, and she remains sympt.m-free, and wit.out.any sign of recurrence at.20 mo. t. t.e best.of our knowledge, t.is is only t.e t.ird ever case of gast.ic ES.

关键词： St.mach Ext.askelet.l Ewing's sarcoma

Nat.re:特殊抗菌蛋白或有望治疗机体炎症

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现代生物医学进展 2017年第6期17卷 I0003-I0004页

作者： Mart.na Sassone-Corsi, Sean-Paul Nuccio, henry Liu, Dulcemaria Hernandez, Christ.ne t. Vu, Amy A. t.kahashi Manuela Raffat.llu Mart.na Sassone-Corsi, Sean-Paul Nuccio, Robert.A. Edwards Manuela Raffat.llu Robert.A. Edwards Depart.ent.of Microbiology and Molecular Genet.cs University of California Irvine Irvine California 92697 USA Inst.t.t. for Immunology University of California Irvine Irvine California 92697 USA Depart.ent.of Pat.ology and Laborat.ry Medicine University of California Irvine California 92697 USA

近日，刊登在国际杂志Nat.re上的一项研究报告中，来自加利福尼亚大学的研究人员通过研究发现，将一种名为小菌素的抗菌蛋白引入到肠道发炎的小鼠机体中或许就能够降低小鼠肠道的发炎程度，同时研究者还发现小菌素或许能够调解肠道中不... 详细信息

近日，刊登在国际杂志Nat.re上的一项研究报告中，来自加利福尼亚大学的研究人员通过研究发现，将一种名为小菌素的抗菌蛋白引入到肠道发炎的小鼠机体中或许就能够降低小鼠肠道的发炎程度，同时研究者还发现小菌素或许能够调解肠道中不同类型细菌的关系。

关键词：抗菌蛋白机体加利福尼亚大学炎症治疗研究人员肠道小鼠

Nanot.chnology-based approach for safer enrichment.of semen wit. best.spermat.zoa

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Journal of Animal Science and Biot.chnology 2019年第2期10卷 390-401页

作者： Casey L.Durfey Sabrina E.Swist.k Shengfa F.Liao Mark A.Crenshaw henry J.Clement. Rooban V.K.G.t.irumalai Christ. S.St.adman Pet.r L.Ryan Scot. t.Willard Jean M.Feugang Depart.ent.of Animal and Dairy Sciences Mississippi State UniversityMississippi StateMSUSA Depart.ent.of Biochemist.y Molecular BiologyEntomology and Plant PathologyMississippi StateMSUSA Clement. Associat.s MadisonCTUSA Inst.t.t. of Imaging and Analyt.c t.chnology(I2At. Mississippi State UniversityMississippi StateMSUSA Depart.ent.of Pat.obiology and Populat.on Medicine Biochemist.y Mississippi State UniversityMississippi StateMSUSA.

Background: Advances in nanot.chnology have permit.ed molecular-based t.rget.ng of cells t.rough safe and biocompat.ble magnet.c nanopart.cles(MNP). t.eir use t. det.ct.and remove damaged spermat.zoa from semen doses could be of great.int.rest. Here, MNP were synt.esized and t.st.d for t.eir abilit. t. t.rget.apopt.t.c(annexin V) and acrosome-react.d(lect.n) boar spermat.zoa, for high-t.roughout.ret.ieval in a magnet.c field(nanoselect.on). t.e pot.nt.al impact. of nanoselect.on on sperm funct.ons and performance of offspring sired by sperm subject.d t. nanoselect.on were det.rmined. Fresh harvest.d and ext.nded boar semen was mixed wit. various amount.(0, 87.5, and 175 μg) of MNP-conjugat.s(Annexin V-MNP or Lect.n-MNP) and incubat.d(10 t.15 min) for 37 °C in Exp. 1. In Exp. 2, ext.nded semen was mixed wit. opt.mal concent.at.ons of MNP-conjugat.s and incubat.d(0, 30, 90, or 120 min). In Exp. 3, t.e synergist.c effect. of bot. MNP-conjugat.s(87.5 μg– 30 min)on spermat.zoa was evaluat.d, followed by sperm fert.lit. assessment. t.rough pregnancy of inseminat.d gilt. and performance of neonat.l offspring. Sperm mot.on, viabilit., and morphology charact.rist.cs were evaluat.d in all ***: t.ansmission elect.on microscopy, at.mic force microscopy, and hyperspect.al imaging t.chniques were used t. confirm at.achment.of MNP-conjugat.s t. damaged spermat.zoa. t.e mot.lit. of nanoselect.d spermat.zoa was improved(P t.e viabilit. of boar sperm, as assessed by t.e abundance of react.ve oxygen species and t.e int.grit. of t.e acrosome, plasma membrane, and mit.chondrial membrane was not.different.bet.een nanoselect.d and cont.ol spermat.zoa. t.e fert.lit. of gilt. inseminat.d wit. cont.ol or nanoselect.d spermat.zoa, as well as growt. and healt. of t.eir offspring were not.different.bet.een(P > 0.05).Conclusions: t.e findings revealed t.e benefit.of magnet.c nanoselect.on for high-t.roughput.t.rget.ng of damaged sperm, for removal and rapid and effort.es

关键词： Acrosome react.on Apopt.sis Art.ficial inseminat.on Boar Iron oxide nanopart.cles Nanopurificat.on Nanoselect.on Nanot.chnology Reproduct.on Swine

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实用工艺工程设计工作方法

丛书名：书名原文∶Pract.cal process engineering a working approach t. plant.design

1992年

作者：（美）桑德勒（Sandler henry J.）（美）卢奇威斯（Luckiewicz Edward t.）朱康福等译

书名原文∶Pract.cal process engineering a working approach t. plant.design:本书阐述了工艺工程的作用与职责、工程项目的经济评价与分析、工艺流程设计的全过程等。

ISBN: (纸本)7800432416

关键词：工艺设计

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大型装配式自复位剪力墙结构振动台试验研究

土木工程学报 2020年第10期53卷 62-71页

作者：周颖顾安琪鲁懿虬宋戈 Richard henry Geoffrey Rodgers 同济大学土木工程防灾国家重点实验室上海200092 奥克兰大学奥克兰1010新西兰坎特伯雷大学基督城8140新西兰

为研究装配式自复位剪力墙结构在地震作用下的低损伤特性以及新型节点连接形式的有效性,同济大学ILEE联合实验室与新西兰QuakeCoRE研究中心联合开展了大型装配式自复位剪力墙结构振动台试验研究。试验对象为二层足尺装配式结构,结构体... 详细信息

为研究装配式自复位剪力墙结构在地震作用下的低损伤特性以及新型节点连接形式的有效性,同济大学ILEE联合实验室与新西兰QuakeCoRE研究中心联合开展了大型装配式自复位剪力墙结构振动台试验研究。试验对象为二层足尺装配式结构,结构体系主要由承受重力荷载的外围框架和承担水平荷载的自复位剪力墙构成。框架柱为重力柱,梁柱节点为开槽梁节点,可减少梁伸长效应带来的楼板损伤;自复位剪力墙与楼板的连接,长边方向为柔性连接、短边方向为隔离式连接;一层楼板采用双t.,二层楼板采用压型钢板组合楼板;节点连接处设有钢、铅、黏滞等三类阻尼器。在振动台试验中考虑了不同地震水准、地震动输入、结构设计等对结构动力响应的影响。试验结果表明,该结构在1g地震动输入下仍具有低损伤、自复位特性,试验间多次更换阻尼器,成功实现了关键部件的可更换性。

关键词：自复位剪力墙结构装配式振动台试验低损伤可更换