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THE Hp-VERSION OF BEM-FAST CONVERGENCE,ADApTIVITY And EFFICIENT pRECOndITIONING

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Journal of Computational Mathematics 2009年第2期27卷 348-359页

作者： Ernst p.Stephan Institute of Applied Mathematics Leibniz University HannoverGermany

In this survey paper we report on recent developments of the hp-version of the boundary element method （BEM）. As model problems we consider weakly singular and hypersingular integral equations of the first kind on a planar, open surface. We show that the Galerkin solutions （computed with the hp-version on geometric meshes） converge exponentially fast towards the exact solutions of the integral equations. An hp-adaptive algorithm is given and the implementation of the hp-version BEM is discussed together with the choice of efficient preconditioners for the ill-conditioned boundary element stiffness matrices. We also comment on the use of the hp-version BEM for solving Signorini contact problems in linear elasticity where the contact conditions are enforced only on the discrete set of Gauss-Lobatto points. Numerical results are presented which underline the theoretical results.

关键词： hp-version of the boundary element method Adaptive refinement preconditioning Signorini contact

Glucosamine increases the expression of YKL-40 and osteogenic marker genes in hMSC during osteogenic differentiation

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Natural products and Bioprospecting 2012年第2期2卷 87-91页

作者： Ramona LIEDER Sigrídur Thóra REYNISDOTTIR Finnbogi THORMÓDSSON Chuen-How NG Jon Magnús EINARSSON Jóhannes GÍSLASON Jóhannes BJORNSSON Sveinn GUDMUndSSON pétur henry pETERSEN Olafur Eysteinn SIGURJONSSON The Blood Bank Landspitali University HospitalSnorrabraut 60105 ReykjavikIceland School of Science and Engineering Reykjavik UniversityMenntavegi 1101 ReykjavikIceland Genis ehf Vatnagördum 18104 ReykjavikIceland Biomedical Center University of IcelandVatnsmyrarvegi 16101 ReykjavikIceland Department of Anatomy Medical FacultyUniversity of IcelandVatnsmyrarvegi 16101 ReykjavikIceland Department of pathology Landspitali University HospitalBaronsstig101 ReykjavikIceland

Human mesenchymal stem cells(hMSC)can be expanded in vitro and differentiated towards osteogenic,chondrogenic or adipogenic lineages,making them an attractive source for tissue engineering and regenerative ***-like-proteins(CLps)belong to the family 18 glycosyl hydrolases and are believed to play a role in inflammation and tissue *** aim of this study was to determine the effect of the aminosugar glucosamine on the expression of the CLp YKL-40 during osteogenic differentiation of *** did not affect multipotency of hMSC nor proliferation rate of undifferentiated ***-40 was expressed during both expansion of undifferentiated hMSC and during osteogenic differentiation.A slight but non-significant increase in YKL-40 expression was observed with glucosamine,accompanied by a pH-dependent delay in ***,glucosamine induced higher expression of osteogenic marker genes.

关键词： YKL-40 mesenchymal stem cells osteogenic differentiation chitinase-like-protein

Evolution of Biochemical, Hematological, Inflammatory and Immunological Markers among person Living with HIV-1 on ART in Burkina Faso

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Advances in Infectious Diseases 2021年第2期11卷 104-121页

作者： S. Rokiatou henry Yeri Esther Hien S. Guillaume Sanou Appollinaire Kima p. Denise Ilboudo Elie Kabre Yves Traore Laboratoire National de Santé publique (LNSp) Boulevard des Tensoba Ouagadougou Burkina Faso Laboratoire de Biochimie et d’Immunologie Appliquée (LABIA) Unité de Formation et de Recherche en Science de la Vie et de la Terre Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Centre National de Recherche et de Formation sur le paludisme (CNRFp) Ouagadougou Burkina Faso Medecin Referent Communuty Association ALAVI Ouagadougou Burkina Faso Université de Fada N’Gourma Fada N’Gourma Burkina Faso

In Human immunodeficiency virus infected (HIV+) patients, deregulation of regulatory T (Treg) cells can be deleterious for the development of an efficient anti-HIV specific immune response with an inappropriate immune activation despite anti-retroviral therapy (ART). In addition, infection and ART have the potential to cause hematological and biochemical abnormalities that can lead to the discontinuation of ART. The aim of this study was to assess hematological, biochemical and immunological abnormalities in HIV+ patients’ naïve to ART and 6 months after ART initiation. In a cross-sectional study, 11 HIV+ patients and 09 healthy individuals (control group) were voluntarily recruited. At inclusion, blood samples were taken before administration of ART. All hematological, biochemical, immunological parameters and viral load were measured and assessed at inclusion (M0) and three and/or six months later (M3, M6). Higher level of white blood cells and CD4+ T lymphocytes (p = 0.032, 0.038 respectively) were observed in HIV+ patients. ART also had significantly effect on the level of red blood cells (p = 0.04) and Hb (p = 0.015). The inflammatory markers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRp) that were significantly increased by HIV infection, tended to decrease for ESR and revert to levels similar to those of control for CRp. Analysis of CD4+CD25+ cells and CD4+Foxp3+CD25+ showed significantly elevated levels of activated form of all CD4+ cells and Treg cells. Interestingly, six months after initiation of ART, the average percentage of CD4+CD25+ was not significantly different from control group (p = 0.382). Our study provides information about the evolution of the activated form of all CD4 cells and Treg cells and points out the necessity to monitor hematological and biochemical parameters in order to detect and prevent toxicity, improve the quality of life and reduce the risk of mortality.

关键词： Biological Markers TReg ART HIV Burkina Faso

rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study

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World Journal of Gastroenterology 2017年第47期23卷 8405-8414页

作者： henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu pons Joan B Gornals David Nicolás-pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles pons Enrique pérez-Cuadrado-Robles Orlando García-Bosch Michel papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach Endoscopy Unit.Institut de Malalties Digestives Hospital ClínicIDIBAPSCIBERehdUniversitat de Barcelona Digestive Endoscopy Unit Digestive Diseases DepartmentGastrointestinal Endoscopy Research GroupIISLa Fe Polytechnic University Hospital Hospital Universitari Mútua de Terrassa CIBERehd Hospital Reina Sofía Hospital Del Mar Hospital Universitari de Bellvitge IDIBELLUniversitat de BarcelonaHospitalet de Llobregat Hospital Universitario de Canarias Hospital Santos Reyes Aranda de Duero Hospital San Jorge Consorci Hospitalari de Vic Universitat de Vic Hospital de Viladecans Hospital Morales Meseguer Hospital Moisès Broggi Sant Joan Despí Hospital Joan XXIII Complejo Hospitalario de pontevedra

AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of *** Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location.

关键词： polypectomy Bleeding Adverse events protruded polyps Gastroduodenal Foregut

Epidemiological, Clinical and Outcome Aspects of Care-Related Tetanus in Dakar, Senegal

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Advances in Infectious Diseases 2022年第2期12卷 230-240页

作者： Viviane Marie pierre Cisse ndèye Fatou Ngom Gueye Louise Fortes Imelda Mickelina Thoo Aminata Massaly Khardiata Diallo Mbaye Daye Ka ndèye Aissatou Lakhe Assane Diouf ndèye Maguette Fall Daouda Thioub Aboubakry Sidikh Badiane Latyr Junior Diouf Alassane Sarr Sylvie Audrey Diop Cheikh Tidiane ndour Masserigne Soumaré Moussa Seydi Infectious and Tropical Diseases Department Fann Teaching University Hospital Dakar Senegal Department of Community Health Alioune Diop University Bambey Senegal Department of Health Thies University Thies Senegal

Introduction: Tetanus portals of entry are numerous. Amongst these, the carerelated portals of entry are rarely reported. The aim of the study was to describe the epidemiological, clinical and outcome aspects and identify the factors associated with death from care-related tetanus. patients and Methods: This is a retrospective study of descriptive and analytical purposes. Data were collected from the medical records of patients admitted to the Infectious and Tropical Diseases Department of the National University Hospital Center (CHNU) of Fann in Dakar for care-related tetanus during the period ranging from 1 January 2009 to 31 December 2016. Care-related tetanus was defined as any case of tetanus occurring after a surgical procedure, including circumcisions performed even outside a health facility. Results: In eight years, 50 cases of care-related tetanus were recorded. Care-related tetanus accounted for 6.7% of hospitalized tetanus cases. The mean age of patients was 21 ± 22 years, with a male predominance (sex ratio: 6.14). The procedure had been performed in most cases, either in a health facility in 22 patients (44%) or at home in 16 patients (32%), and occurred after circumcision. In 62% of cases the portal of entry was urological, followed by orthopedic surgery (14%) and visceral surgery (10%). The procedures performed were dominated by circumcision (31 cases), limb amputation (3 cases) and inguinal hernia repair (2 cases). Tetanus was immediately generalized on admission in all patients. Eighty-four percent (84%) of patients were admitted with Mollaret stage II. Cardiovascular (11 cases), infectious (10 cases) and respiratory (9 cases) complications were the most frequent. The hospital case fatality rate was 24%. Factors associated with death were female gender (p = 0.03), age between 15 - 60 years (p = 0.02), incubation time Conclusion: Care-related tetanus remains a concern in poor income countries, particularly in Senegal. The drop of these cases will req

关键词： Tetanus Care Surgery Dakar Senegal

Band-gap engineering of La1-xndxAlO3(x = 0,0.25,0.50,0.75,1)perovskite using density functional theory：A modified Becke Johnson potential study

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Chinese physics B 2016年第6期25卷 376-382页

作者： Sandeep D p Rai A Shankar M p Ghimire Anup pradhan Sakhya T p Sinha R Khenata S Bin Omran R K Thapa Department of physics Mizoram University Aizawl-796004 India Department of physics Pachhunga University College Aizawl-796001 India Department of physics University of North Bengal Darjeeling-734013 India IFW Dresden e. V. P. O. Box 270116 D-01171 Dresden Germany Department of physics Bose Institute 93/1 Acharya Prafulla Chandra Road Kolkata 700009 India Laboratoire de physique Quantique et de Modelisation Mathematique (LpQ3M) Department de Technologie Universite de Mascara 29000 Mascara Algerie Algeria Department of physics and Astronomy College of Science King Saud University P. O: Box 2455 Riyadh 11451 Saudi Arabia

The structural,electronic,and magnetic properties of the nd-doped Rare earth aluminate,La1-xndxAlO3（x = 0%to 100%） alloys are studied using the full potential linearized augmented plane wave（Fp-LApW） method within the density functional *** effects of the nd substitution in La AlO3 are studied using the supercell *** computed electronic structure with the modified Becke–Johnson（m BJ） potential based approximation indicates that the La1-xndxAlO3 alloys may possess half-metallic（HM） behaviors when doped with nd of a finite density of states at the Fermi level（EF）.The direct and indirect band gaps are studied each as a function of x which is the concentration of nddoped La *** calculated magnetic moments in the La1-xndxAlO3 alloys are found to arise mainly from the nd-4f state.A probable half-metallic nature is suggested for each of these systems with supportive integral magnetic moments and highly spin-polarized electronic structures in these doped systems at *** observed decrease of the band gap with the increase in the concentration of nd doping in La AlO3 is a suitable technique for harnessing useful spintronic and magnetic devices.

关键词： density functional theory rare earth aluminates perovskites electronic structures

硅表面有机单分子膜的新表征方法──界面微分电容测量法

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高等学校化学学报 2003年第1期24卷 86-90页

作者：孙乔玉 Catherine henry de Villeneuve 力虎林 philippe A llongue 兰州大学化学化工学院 Laboratoire de physique des Liquides et Electrochimie CNRS-UPR 15 Conventionnée avec l'Université P & M Curie 4 place Jussieu Tour 22 75005 Paris

提出一种表征硅表面有机单分子膜的新方法界面微分电容测量法 .通过对新制备的 H-Si( 1 1 1 )表面和一系列烯烃分子修饰的硅表面 /电解液界面的微分电容的研究 ,建立了硅表面有机膜结构和性质与界面电容之间的联系 .实践证明这是一个简... 详细信息

提出一种表征硅表面有机单分子膜的新方法界面微分电容测量法 .通过对新制备的 H-Si( 1 1 1 )表面和一系列烯烃分子修饰的硅表面 /电解液界面的微分电容的研究 ,建立了硅表面有机膜结构和性质与界面电容之间的联系 .实践证明这是一个简便、快速和有效的实验技术 ,为硅表面化学修饰与功能化研究提供了一个非常有力的工具 .

关键词：硅表面有机单分子膜界面微分电容测量法表征方法膜结构

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目前应激理论的概念

心理学动态 1984年第2期 41-48页

作者： J.p.henry 汤慈美

应激领域中的争论二十世纪早期Cannon进行了机体在疼痛、饥饿、恐惧和愤怒时身体改变的开拓性研究。他工作的目的是研究应激是如何导致疾病的。他集中于交感-肾上腺髓质系统,研究表明这种机制除了与对生理刺激如失血等的反应有关外,也... 详细信息

应激领域中的争论二十世纪早期Cannon进行了机体在疼痛、饥饿、恐惧和愤怒时身体改变的开拓性研究。他工作的目的是研究应激是如何导致疾病的。他集中于交感-肾上腺髓质系统,研究表明这种机制除了与对生理刺激如失血等的反应有关外,也与精神刺激如一只猫面对一只吠叫的狗挑战时的反应也有关。

关键词：皮质醇婴猴 ACTH 战斗肾上腺素肾上腺能α-受体兴奋药应激反应肾上腺皮质激素激素类药物交感肾上腺系统皮质酮儿茶酚胺苯胺应激理论概念思维形式

6号染色体微卫星标记与精神分裂症的连锁不平衡研究

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中华医学遗传学杂志 2002年第1期19卷 6-9页

作者：邓红刘协和蔡贵庆 henry Terwedow 王朝羲徐欣四川大学华西医院心理卫生研究所成都610041 program for population Genetics

目的　探索 6号染色体的有关微卫星标记与精神分裂症的关系。方法　对 115个精神分裂症同胞及核心家系 ,按照不同的诊断分类 ,以分布于 6号染色体的 2 8个微卫星标记 ,进行连锁不平衡研究。并分别按照阳性和阴性症状量表及发病年龄分成... 详细信息

目的　探索 6号染色体的有关微卫星标记与精神分裂症的关系。方法　对 115个精神分裂症同胞及核心家系 ,按照不同的诊断分类 ,以分布于 6号染色体的 2 8个微卫星标记 ,进行连锁不平衡研究。并分别按照阳性和阴性症状量表及发病年龄分成不同的亚组 ,在不同的亚组中进行连锁不平衡分析。以 XDT和 MApMAKER/ SIBS软件系统完成所有连锁不平衡分析。结果　在 4种不同的诊断分类下 ,D6 S196 0位点与精神分裂症的连锁不平衡关系具有显著性意义 ,p值均小于 0 .0 0 5。在以各项 pANSS量表和不同发病年龄所分亚组的分析中表明 ,只有 D6 S196 0位点与精神分裂症的连锁不平衡关系值始终具有显著性意义 (p<0 .0 5 )。结论　 6号染色体短臂 D6 S196 0附近可能存在精神分裂症的易感基因。

关键词：精神分裂症 6号染色体连锁不平衡