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Dopaminergic effects on in vitro osteogenesis

Bone Research 2015年第3期3卷 130-139页

作者： Dong Joon lee henry C Tseng Sing Wai Wong Zhengyan Wang Meng Deng Ching-Chang Ko NC Oral Health Institute School of Dentistry University of North Carolina Duke Eye Center and Department of Ophthalmology Duke University Medical Center Oral Biology Program School of Dentistry University of North Carolina Department of Pediatric Dentistry School of Dentistry University of North Carolina Department of Orthodontics School of Dentistry University of North Carolina

Multiple growth factors（e.g., BMP2, TGF-b1, FGF2） and isolated genes have been shown to improve osteoblastic proliferation and mineralization, advancing bone tissue engineering. Among these factors, both polydopamine（PDA） and dopamine（DA） monomer have recently been reported to increase osteoblast proliferation and mineralization in vitro. Although a well-characterized neurotransmitter, DA＇s role in the bone is unknown. We hypothesize that DA can directly act on osteoblasts, and examined whether osteoblasts express DA receptors that respond to exogenous DA. m RNAs and protein cell lysates were obtained from MC3T3-E1 cells during osteogenic differentiation phase. Reverse transcription polymerase chain reaction and western blot analysis were used to examine the expression of DA receptors, D1–D5. Dose-response effect and time course of DA treatment on cell proliferation, mineralization, and osteogenic differentiation were investigated at pre-determined days. Real-time PCR was performed to investigate whether DA affects osteogenic gene expression（ALP, BSP, OC, OSX, RUNX2, and Collagen1a2） with or without receptor antagonists（SCH233390 and GR103691）. Two-way ANOVA was used for statistical analysis. All five DA receptors（D1, D2, D3, D4, and D5） m RNAs and proteins were expressed in MC3T3-E1 cells. DA treatment increased cell proliferation for up to 7 days（P, 0.05）. Osteogenic mineralization was significantly greater in the DA-treated group than control group（P, 0.05）. Finally, expression of all the osteogenic genes was inhibited by DA receptor antagonists for D1, D3, and D5. Our findings suggest that MC3T3-E1 osteoblasts express functional DA receptors that enhance proliferation and mineralization. PDA is not biologically inert and has important implications in orthopedic applications. Furthermore, osteoblast differentiation might be regulated by the nervous system, presumably during bone development, remodeling, or repair.

关键词： DIFFERENTIATION RECEPTORS CYTOTOXICITY INNERVATION EXPRESSION DELETION TISSUE

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An update on transurethral surgery for benign prostatic obstruction

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Asian Journal of Urology 2017年第3期4卷 195-198页

作者： Jonathan Shunming Teo Yee Mun lee henry Sun Sien Ho Department of Urology Singapore General HospitalSingapore Department of Urology Tan Tock Seng HospitalSingapore

Clinical benign prostatic hyperplasia(BPH)is one of the most common cause of lower urinary tract symptoms and transurethral resection of prostate(TURP)has been the gold standard technique for surgical treatment of benign prostate obstruction(BPO)over the last 2 *** monopolar TURP is considered a safe and effective option for surgical management of BPO,there are some disadvantages,namely bleeding,transurethral resection syndrome,incompleteness of *** review aims to highlight these problems,and describe the advances in technology and techniques that have evolved to minimise such *** the advent of lasers and bipolar technology,as well as enucleative techniques to remove the prostatic adenoma/adenomata,the problems of bleeding,transurethral resection syndrome and incomplete treatment are significantly *** TURPwill likely be replaced by such technology and techniques in the near future such that transurethral surgery of the prostate remain a safe and effective option in alleviating the harmful effects of BPO.

关键词： Transurethral resection of prostate Benign prostatic obstruction Bleeding Prostatectomy

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Site-selective oral delivery of therapeutic antibodies to the inflamed colon via a folic acid-grafted organic/inorganic hy brid nanocomposite system

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Acta Pharmaceutica Sinica B 2022年第11期12卷 4249-4261页

作者： Sang Hoon lee Jae Geun Song hyo-Kyung Han College of Pharmacy Dongguk University-SeoulGoyang 10326South Korea

This study aimed to develop a pH-responsive folic acid-grafted organic/inorganic hybrid nanocomposite system for site-selective oral delivery of therapeutic antibodies. A folic acid-grafted aminoclay(FA-AC) was prepared via an in situ sol-gel method. Then, a drug-loaded nanocomplex was prepared via the electrostatic interaction of FA-AC with infliximab(IFX), a model antibody, and coated with Eudragit? S100(EFA-AC-IFX). FA-AC exhibited favorable profiles as a drug carrier including low cytotoxicity, good target selectivity, and capability to form a nanocomplex with negatively charged macromolecules. A pH-responsive FA-AC-based nanocomplex containing IFX(EFA-AC-IFX) was also obtained in a narrow size distribution with high entrapment efficiency(>87%). The conformational stability of IFX entrapped in EFA-AC-IFX was well maintained in the presence of proteolytic enzymes. EFA-ACIFX exhibited pH-dependent drug release, minimizing premature drug release in gastric conditions and the upper intestine. Accordingly, oral administration of EFA-AC-IFX to colitis-induced mice was effective in alleviating the progression of ulcerative colitis, while oral IFX solution had no efficacy. These results suggest that a pH-responsive FA-AC-based nanocomposite system can be a new platform for the site-selective oral delivery of therapeutic antibodies.

关键词： Infliximab Aminoclay Colonic delivery:TNF-x Infammation Folate rceptor Anibody Nanocomposite

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Burn injury prevention in low-and middleincome countries:scoping systematic review

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Burns & Trauma 2021年第1期9卷 123-144页

作者： Kate Price Kwang Chear lee Katherine E.Woolley henry Falk Michael Peck Richard Lilford Naiem Moiemen College of Medical and Dental Sciences University of BirminghamEdgbastonBirminghamB152TTUK University Hospital Birmingham NHS Foundation Trust Queen Elizabeth Hospital BirminghamMindelsohn WayEdgbastonBirminghamB152WBUK Institute of Applied Health Research University of BirminghamEdgbastonBirminghamB152TTUK Adjunct Professor of Environmental Health Emory UniversityRollins School of Public HealthAtlantaGA 30322US Clinical Professor of Surgery University of Arizona College of MedicinePhoenixAZ 85004US

Background:Burn injuries are a leading cause of morbidity and disability,with the burden of disease being disproportionately higher in low-and middle-income countries(LMIC).Burn prevention programmes have led to significant reductions in the incidence of burns in high-income ***,a previous systematic review published in 2015 highlighted that implementation and evaluation of similar programmes has been limited in *** objective of this scoping review and narrative synthesis was to summarise and understand the initiatives that have been carried out to reduce burn injuries in LMIC and their ***:We aimed to identify publications that described studies of effectiveness of burn prevention interventions applied to any population within a LMIC and measured burn incidence or burns-related *** publications were identified from three ***,data was extracted from manuscripts identified in the systematic review published by Rybarczyk et *** then performed a search for manuscripts on burn prevention interventions published between January 2015 and September ***,we extracted data from two systematic reviews where burn evidence was not the primary outcome,which were identified by senior authors.A quality assessment and narrative synthesis of included manuscripts were ***:In total,24 manuscripts were identified and categorized according to intervention *** majority of manuscripts(n=16)described education-based *** manuscripts focused on environmental modification interventions and four adopted a mixedmethods *** of the education-based initiatives demonstrated improvements in knowledge relating to burn safety or first aid,however few measured the impact of their intervention on burn *** manuscripts described population-based educational interventions and noted reductions in burn *** one of the four manuscripts describing environmental modification i

关键词： Burns Prevention Low-and-middle income countries Systematic review

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Can intravesical prostatic protrusion predict bladder outlet obstruction even in men with good flow?

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Asian Journal of Urology 2016年第1期3卷 39-43页

作者： Alvin lee Han Jie lee Kok Bin Lim Hong Hong Huang henry Ho Keong Tatt Foo Department of Urology Singapore General HospitalSingapore Urology Centre Raffles HospitalSingapore

Objective:Men with benign prostate hyperplasia(BPH)with good urinary flow may still have bladder outlet obstruction(BOO).Intravesical prostatic protrusion(IPP)has been shown to be able to predict *** aim to investigate the use of IPP to predict BOO in men with good urinary ***:One hundred and fourteen consecutive men(>50 years old)presenting with lower urinary tract symptoms suggestive of BPH were recruited in 2001 and *** were evaluated with serum prostate specific antigen(PSA),uroflowmetry and transabdominal ultrasound measurement of IPP and prostate volume(PV).Pressure-flow urodynamic studies were performed on all men and BOO was defined by BOO index>*** with Qmax12.0 mL/s were considered to have good ***:Among the 114 men,61 patients had good urinary *** median age,PV and Qmax were 66 years,32.9 mm3 and 14.5 mL/s respectively.14/61(23.0%)patients had BOO and their distribution of IPP were as follows:Grade 1 e 0/20(0%)obstructed,Grade 2 e 6/22(27.3%)and Grade 3 e 8/19(42.1%).Sensitivity of Grade 2/3 IPP for BOO was 100% while specificity of Grade 3 IPP was 76.6%.The area-under-curve(AUC)for IPP was greater than that for PV(0.757 vs.0.696).Conclusion:Even in men with good flow,high grades of IPP were more likely to have BOO and hence,may be a useful adjunct to predict BOO.

关键词： Male Prostate hyperplasia Pathology Ultrasonography Urinary bladder Urodynamics

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CLINICAL SIGNIFICANCE OF COMBINED ANTINUCLEAR AND ANTICYTOPLASMIC ANTIBODIES DETECTED BY IMMUNOFLUORESCENCE

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中华医学杂志(英文版) 1989年第12期102卷 915-915页

作者： Tung-Kwang lee henry Rothberger DepartmentofRadiationOncology EastCarolinaUniversitySchoolofMedicine Greenville NorthCarolina27858 USA SectionofRheumatology DepartmentofMedicine BowmanGraySchoolofMedicineofWakeForestUniversity Winston-Salem NorthCar7103 USA

Anti-nuclear antibodies (ANA) combined with anti-cytoplasmic antibodies (ACA) in 0.6% (n=43) of 7 121 consecutive patients referred for ANA screening were observed. Homogeneous/cytoplasmic was the most frequently combined ANA/ACA pattern among 6 different indirect immunofluorescent (IF) combinations. Distribution of diseases was similar in patients with ANA/ACA and those controls with ANA alone. However, the ANA/ACA results were often transitory, especially in systemic lupus erythromatosus (SLE). The appearance of transitory ANA/ACA combinations on serial ANA testing may be useful as a serologic marker for SLE.

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2D/2D BiOIO_(3)/g-C_(3)N_(4) S-scheme hybrid heterojunction with face-to-face interfacial contact for effective photocatalytic H_(2) production and norfloxacin degradation

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Journal of Materials Science & Technology 2023年第17期148卷 19-30页

作者： Dong-Eun lee Satyanarayana Moru KasalaPrabhakar Reddy Wan-Kuen Jo Surendar Tonda School of Architecture CivilEnvironmental and Energy EngineeringKyungpook National University80 Daehak-roBuk-guDaegu 41566Republic of Korea School of Advanced Sciences Vellore Institute of Technology-Andhra Pradesh(VIT-AP University)AmaravatiAndhra Pradesh 522237India Department of Chemistry and Biochemistry University of South Carolina631 Sumter StreetColumbiaSC 29208United States

A two-dimensional(2D)/2D hybrid heterojunction with face-to-face interfacial assembly is a desirable dimensionality design with significant potential for various photocatalytic applications due to the large interfacial contact area,which facilitates charge migration and ***,we developed an ef-ficient 2D/2D hybrid heterojunction consisting of BiOIO 3 nanoplates(BIO)and g-C_(3)N_(4) nanosheets(CN)using a simple but effective in situ growth method for photocatalytic aqueous antibiotic degradation and H_(2) *** face-to-face interfacial assembly of the BIO and CN components in the BIO/CN hy-brid heterojunction was verified using electron ***,the BIO/CN hybrid heterojunc-tion outperformed both the BIO and CN counterparts in terms of norfloxacin degradation and H_(2) gen-eration under simulated solar light ***,the photocatalytic performance of the hybrid catalyst remained nearly unchanged throughout five consecutive test *** exceptional performance and stability of the hybrid catalyst are attributable to its extended optical absorption range,large interfa-cial contact area provided by the face-to-face assembly in the 2D/2D hybrid configuration,and enhanced photoexcited charge separation efficiency and redox power of the separated charges,which are supported by an efficient S-scheme charge transfer *** study illuminates the rational construction of novel 2D/2D S-scheme hybrid heterojunction photocatalysts with practical applications in environmental remediation and sustainable energy generation.

关键词： g-C_(3)N_(4) BiOIO_(3) Face-to-face interface 2D/2D heterojunction S-scheme charge transfer Solar energy conversion

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The Irony of Flood Risks in African Dryland Environments: Human Security in North Cameroon

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World Journal of Engineering and Technology 2017年第3期5卷 109-121页

作者： henry Bang lee Miles Richard Gordon Disaster Management Centre Faculty of Management Bournemouth University Bournemouth United Kingdom

North Cameroon, though located in an arid environment, ironically also suffers from the serious threat of flooding in the region. This article examines contemporary challenges resulting from frequent flooding in North Cameroon. Using Cutter’s “Hazard of Place Model” of vulnerability as the conceptual basis, the article triangulates data from a variety of sources to analyze environmental risks, social and biophysical vulnerability and flood impact, including flood risk management in North Cameroon. The findings reveal that North Cameroon is vulnerable to frequent flooding due to a combination of environmental, socio-economic, and geographic factors further compounded by low organizational resilience to flooding with dire consequences for livelihoods. We argue that, if not handled appropriately, the impact of flooding in North Cameroon risks trapping the population in a permanent and vicious cycle of destitution and poverty. The government urgently needs to review its disaster management policies to be more proactive and strategic in flood management in order to enhance human security and prevent permanent damage to the livelihoods and the micro-economy of the region. Lessons learned from this research, when applied, can help to reduce the vulnerabilities of the poverty-stricken population and enhance resilience to flood risks.

关键词： Frequent Flooding North Cameroon Vulnerability Flood Management

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作者： henry C lee

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Hurricane Occurrence and Seasonal Activity: An Analysis of the 2017 Atlantic Hurricane Season

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American Journal of Climate Change 2019年第4期8卷 454-481页

作者： henry Ngenyam Bang lee Stuart Miles Richard Duncan Gordon Disaster Management Centre Bournemouth University Dorset Talbot Campus Fern Barrow Poole UK

This article provides a reckoning of the 2017 Atlantic Hurricane Season’s place in history to ascertain how unique it was from other hurricane seasons. A research strategy involving qualitative, descriptive and analytical research approaches, including content analysis, sequential description of events and comparative analysis, were used to assess how and why the 2017 AHS season is distinct from others. Findings reveal that the 2017 AHS was extraordinary by all meteorological standards—in many ways, being hyperactive, and producing a frenetic stretch of huge, long-lived and dramatic, tropical storms including 10 hurricanes. The season was, arguably, the most expensive in history and will be remembered for the unprecedented devastation caused by the season’s major hurricanes (Harvey, Irma and Maria). While the extremely active season can be attributed to anomalously high, climate change induced, hurricane friendly environmental conditions in the Atlantic basin, early forecasts did not also predict the hyperactivity of the season. This article, therefore, advances for a more strategic anticipatory and proactive approach in dealing with these severe storms, underpinned by effective mitigation of their effects. Furthermore, the article adds value to the literature examining extreme natural forces, particularly in understanding variations in the ferocity of the meteorological events associated with hurricane seasons.

关键词： Hurricanes Disaster Hurricane Season Tropical Cyclones Seasonal Activity

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