检索结果-南通市图书馆

Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja malm Xiaobo mao Joaquim miguel Oliveira mike m.modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou marietta Zille Colin L.masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-macao Institute of CNS Regeneration(GHmICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of molecular Neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life Sciences University of NottinghamNottinghamUK Brain and mind Centre&School of medical Sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for molecular Sciences University of Eastern FinlandKuopioFinland Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear medicine University of Maryland School of MedicineBaltimoreMarylandUSA University of Chinese Academy of Sciences BeijingChina State Key Laboratory of membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic *** metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβ***,the cognitive benefits of the current treatments are *** etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive ***,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve *** attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD *** Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat *** aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective

Urban Cemeteries in Southern Brazil: An Analysis of Planimetric Variations, Vegetation Indices and Temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Civil engineering and Architecture 2020年第11期14卷 617-624页

作者： Paloma Carollo Toscan Alcindo Neckel Cleiton Korcelski Laércio Stolfo maculan Daniela maroni Tania michel Fuga Laura Pasa Cambrussi henrique Aniceto Kujawa eliane Thaines Bodah Brian William Bodah Stricto Sensu Postgraduate Program in Architecture and Urbanism of ImeD(PPGARQ-ImeD) Group of Studies and Research on Urban Mobility(NEPMOUR)Passo Fundo/RS 99070-220Brazil University of Perugia Piazza Università1Perugia 06123Italy State University of New York Onondaga Community College4585 West Seneca TurnpikeSyracuseNY 13215USA Thaines and Bodah Center for education and Development 840 South Meadowlark LaneOthelloWA 99344USA

Urban cemeteries have the potential to negatively impact the quality of health of populations in their immediate ***,it becomes important to understand the factors influencing the potential to disperse *** study examined the altimetry,Normalized Difference Vegetation Index(NDVI)and Land Surface Temperature(LST)in five urban cemeteries in the City of Passo Fundo/RS,in the south of Brazil,and the possible potential for the proliferation of contaminating agents present in these cemetery spaces in relation to a radius of 300 meters(m).The methodologies used Landsat 8 satellite images to sample the altimetry,NDVI and LST,applied to a regression model,to analyze the dispersion factors of the correlation of collected *** results showed a trend of contamination of the environment by urban cemeteries in Passo Fundo,in the regions with the highest population density and the lowest vegetative cover.

关键词： Contamination potential remote sensing urban cemeteries urban population

Simulations of Carbon Dioxide emissions Related to the Use of Public Transport for Students in a Higher education Institution in Southern Brazil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Civil engineering and Architecture 2021年第1期15卷 28-34页

作者： Carla Gabriela Carlot Zorzi Tauana Bertoldi Alcindo Neckel Laércio Stolfo maculan Laura PasaCambrussi Kleber Augusto medeiros Georgea marthina Pedott Julian Grub henrique Aniceto Kujawa Leila Dal moro Postgraduate Program in Architecture and Urbanism(PPGArq-ImeD) Group of Studies and Research on Urban Mobility(NEPMOUR)Passo Fundo/RS 99070-220Brazil Postgraduate Program in Architecture and Urbanism(PPG Arq e Urb—UNISINOS) São Leopoldo/RS 93022-750Brazil University of Perugia Piazza Università1Perugia 06123Italy Stricto Sensu Postgraduate Program in Administration of ImeD Faculty(PPGA-ImeD) Passo Fundo/RS 99070-220Brazil

Carbon dioxide(CO2)emissions from motor vehicles have been increasing in large urban centers,thus contributing to air *** general objective of this study is to analyze simulations of CO2 emissions among students who use public transport in the city of Passo Fundo,in the state of Rio Grande do Sul,***,this study was developed in three stages:(1)verification of the time used by higher education students at Faculdade meridional(ImeD)in relation to urban mobility;(2)understanding of the transport mode used by these students,taking into account the one which appears with the highest incidence;(3)simulating CO2 emissions from the modes of transport used by students after the application of the environmental Impact Simulator(eIS)used by the National Public Transport Association(ANTP,in Portuguese)for the modeling of transport indexes aimed at analyzing CO2 *** considering the total of 3,079 students who assigned to a sample of 66 questionnaires,a reduction of CO2 emissions of 4,527.04 kg during a year in relation to the use of public transport was found.

关键词： Public transport urban mobility environmental impacts environmental analysis pollution reduction

2-aminoethyl Dihydrogen Phosphate as a modulator of Proliferative and Apoptotic effects in Breast Cancer Cell Lines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmacy and Pharmacology 2021年第3期9卷 83-97页

作者： manuela Garcia Laveli da Silva Laertty Garcia de Sousa Cabral monique Gonçalves Alves Thais deOliveira Conceição henrique Hesse Rosa Andrea Nogueira Laiso Daniel da Conceição Rabelo Durvanei Augusto maria Development and Innovation Laboratory Butantan InstituteSao PauloSP 05503-900Brazil Faculty of medicine University of São PauloSao PauloSP 01246-000Brazil

Background: Breast cancer is a type of cancer that affects more women throughout the world, in developing anddeveloped countries. 2-AeH2P is a phospholipid analog of cellular membrane, which makes it different from existing molecules fortheir absorption, stability and display anti-inflammatory, anti-proliferative and pro-apoptotic properties. methods: mCF-7 humanbreast adenocarcinoma cells were treated with 2-AeH2P. The viability and adhesion cells were evaluated by mTT assay. Cell cyclephases, apoptosis, markers and mitochondrial potential were assessed by flow cytometry. morphological ultrastructural analyzeswere performed by laser confocal microscopy. Results: mCF-7 Tumor cells acquired round shapes, lost cytoplasmic expansions,formed clusters in suspension and decreased significantly viability. There were changes in the morphology, membrane fragmentationand loss of cytoplasmic projection. The obtained concentrations for IC50% were 37.2;25.8;1.8 mm for periods of 24, 48 and 72 h,respectively. Changes in the distribution of cell population phases of the cell cycle showed an increase in fragmented DNA and anincrease in the G2/m phase. The expression β-gal showed proliferative reduction induced by 2-AeH2P. Laser confocal microscopyshowed changes in the mitochondrial membrane and alteration in distribution. Proliferative index of mCF-7 tumor cells treated with2-AeH2P decreased significantly when compared to fibroblast normal cells. The compound 2-AeH2P is a phospholipid withantiproliferative potential and apoptosis modulator.

关键词： Human Breast Adenocarcinoma mCF-7 2-AeH2P Antitumor Apoptosis Cell cycle Senescence