Fibrosis resulting from pathological repair secondary to recurrent or persistent tissue damage often leads to organ failure and *** fibrosis is a crucial but easily neglected pathological feature in hepatobiliary dis...
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Fibrosis resulting from pathological repair secondary to recurrent or persistent tissue damage often leads to organ failure and *** fibrosis is a crucial but easily neglected pathological feature in hepatobiliary disorders,which may promote the development and progression of benign and malignant biliary diseases through pathological healing mechanisms secondary to biliary tract *** the etiology and pathogenesis of biliary fibrosis is beneficial to the prevention and treatment of biliary *** this review,we emphasized the importance of biliary fibrosis in cholangiopathies and summarized the clinical manifestations,epidemiology,and aberrant cellular composition involving the biliary ductules,cholangiocytes,immune system,fibroblasts,and the micro*** also focused on pivotal signaling pathways and offered insights into ongoing clinical trials and proposing a strategic approach for managing biliary fibrosis-related *** review will offer a comprehensive perspective on biliary fibrosis and provide an important reference for future mechanism research and innovative therapy to prevent or reverse fibrosis.
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