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Recent advances and future challenges in the use of nanoparticles for the dispersal of infectious biofilms

Journal of Materials Science & Technology 2021年第25期84卷 208-218页

作者： Shuang Tian henny c.van der mei Yijin Ren Henk J.Busscher Linqi Shi State Key Laboratory of Medicinal chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of EducationInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China University of Groningen and University Medical center Groningen Department of Biomedical EngineeringAntonius Deusinglaan 19713 AVGroningenthe Netherlands University of Groningen and University Medical center Groningen Department of OrthodonticsHanzeplein 19700 RBGroningenthe Netherlands

Increasing occurrence of intrinsically antimicrobial-resistant,human pathogens and the protective biofilm-mode in which they grow,dictates a need for the alternative control of infectious *** bacteria utilize dispersal mechanisms to detach parts of a biofilm as part of the biofilm life-cycle during times of nutrient scarcity or *** here identify recent advances and future challenges in the development of dispersants as a new infection-control ***(DNase)and other extracellular enzymes can disrupt the extracellular matrix of a biofilm to cause ***,a variety of small molecules,reactive oxygen species,nitric oxide releasing compounds,peptides and molecules regulating signaling pathways in biofilms have been described as *** their own,dispersants do not inhibit bacterial growth or kill bacterial *** natural,as well as artificial dispersants,are unstable and hydrophobic which necessitate their encapsulation in smart nanocarriers,like p H-responsive micelles,liposomes or *** on their composition,nanoparticles can also possess intrinsic dispersant *** dispersed from an infectious biofilm end up in the blood circulation where they are cleared by host immune ***,this sudden increase in bacterial concentration can also cause *** antibiotic loading of nanoparticles with dispersant properties or combined administration of dispersants and antibiotics can counter this ***,biofilm remaining after dispersant administration appears more susceptible to existing *** part of the natural biofilm life-cycle,no signs of"dispersant-resistance"have been *** are therewith promising for the control of infectious biofilms.

关键词： Dispersant Enzymes EPS eDNA Antibiotic resistance Dispersal mechanism Nanoparticles

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Possibilities and impossibilities of magnetic nanoparticle use in the control of infectious biofilms

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Journal of Materials Science & Technology 2021年第10期69卷 69-78页

作者： Kecheng Quan Zexin Zhang Yijin Ren Henk J.Busscher henny c.van der mei Brandon W.Peterson college of chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China University of Groningen and University Medical center Groningen Department of Biomedical Engineering9713 AVGroningenthe Netherlands University of Groningen and University Medical center Groningen Department of OrthodonticsHanzeplein 19713 GZGroningenthe Netherlands

Targeting of chemotherapeutics towards a tumor site by magnetic nanocarriers is considered promising in *** nanoparticles are also considered for use in infection-control as a new means to prevent antimicrobial resistance from becoming the number one cause of death by the year *** this end,magnetic nanoparticles can either be loaded with an antimicrobial for use as a delivery vehicle or modified to acquire intrinsic antimicrobial *** nanoparticles can also be used for the local generation of heat to kill infectious *** appealing for tumor-and infectioncontrol,injection in the blood circulation may yield reticuloendothelial uptake and physical obstruction in organs that yield reduced targeting *** can be prevented with suitable surface ***,precise techniques to direct magnetic nanoparticles towards a target site are *** problem of precise targeting is aggravated in infection-control due to the micrometer-size of infectious biofilms,as opposed to targeting of nanoparticles towards centimeter-sized *** review aims to identify possibilities and impossibilities of magnetic targeting of nanoparticles for *** first review targeting techniques and the spatial resolution they can achieve as well as surface-chemical modifications of magnetic nanoparticles to enhance their targeting efficiency and antimicrobial *** is concluded that targeting problems encountered in tumor-control using magnetic nanoparticles,are neglected in most studies on their potential application in *** biofilm targeting by smart,self-adaptive and pH-responsive,antimicrobial nanocarriers for instance,seems easier to achieve than magnetic *** leads to the conclusion that magnetic targeting of nanoparticles for the control of micrometer-sized infectious biofilms may be less promising than initially ***,using propulsion rather than pr

关键词： Magnetic nanoparticles Magnetic targeting Biofilm Infection Antimicrobials

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In-biofilm generation of nitric oxide using a magnetically-targetable cascade-reaction container for eradication of infectious biofilms

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Bioactive Materials 2022年第8期7卷 321-334页

作者： Guang Yang Da-Yuan Wang Yong Liu Fan Huang Shuang Tian Yijin Ren Jianfeng Liu Yingli An henny c.van der mei Henk J.Busscher Linqi Shi State Key Laboratory of Medicinal chemical Biology Key Laboratory of Functional Polymer MaterialsMinistry of EducationInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071PR China University of Groningen and University Medical center Groningen Department of Biomedical EngineeringAntonius Deusinglaan 19713AVGroningenthe Netherlands University of Groningen and University Medical center Groningen Department of OrthodonticsHanzeplein 19700RBGroningenthe Netherlands Key Laboratory of Radiopharmacokinetics for Innovative Drugs Chinese Academy of Medical Sciencesand Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300192PR China

cascade-reaction chemistry can generate reactive-oxygen-species that can be used for the eradication of infectious ***,suitable and sufficient oxygen sources are not always available near an infection site,while the reactive-oxygen-species generated are ***,we developed a magnetic cascade-reaction container composed of mesoporous Fe_(3)O_(4)@SiO_(2) nanoparticles containing glucose-oxidase and L-arginine for generation of ***-oxidase was conjugated with APTES facilitating coupling to Fe_(3)O_(4)@SiO_(2) nanoparticles and generation of H_(2)O_(2) from glucose.L-arginine was loaded into the nanoparticles to generate NO from the H_(2)O_(2) *** an externally-applied magnetic field,cascade-reaction containers could be homogeneously distributed across the depth of an infectious ***-reaction containers with coupled glucose-oxidase were effective in killing planktonic,Gram-positive and Gram-negative *** efficacy of the L-arginine based second cascade-reaction was only observed when H_(2)O_(2) as well as NO were generated *** vivo accumulation of cascade-reaction containers inside abdominal Staphylococcus aureus biofilms upon magnetic targeting was observed real-time in living mice through an implanted,intra-vital ***,vancomycin-resistant,abdominal *** biofilms could be eradicated consuming solely endogenous glucose,without any glucose ***,a new,non-antibiotic-based infection-control strategy has been provided,constituting a welcome addendum to the shrinking clinical armamentarium to control antibiotic-resistant bacterial infections.

关键词： Magnetic nanoparticles Bacterial infection Glucose Reactive-oxygen-species Intra-vital window

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Bacterial outer membrane vesicles for targeted treatment of bacterial infections

Bacterial outer membrane vesicles for targeted treatment of ...

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ASTF2023（第五届）抗菌科学与技术论坛

作者： henny c.van der mei Rui Shi Ziliang Dong chongqing Ma Renfei Wu Rui Lv Sidi Liu Yijin Ren Zhuang Liu Jian Liu Henk J.Busscher University of Groningen University Medical Center Groningen Soochow University

Bacterial infections play an important role in human *** bacterial infections of internal organs are characterized by a rapid onset and severe consequences,making them a significant threat to human *** drug accumulation at the site of infection and inadequate intracellular delivery pose important obstacles,impeding the efficacy of infection *** treatment strategies to enhance the therapeutic effect of current antibiotics need to be ***-derived biological nanocarriers such as outer-membrane vesicles(OMVs) are promising nanocarriers for drug-delivery,but low harvesting yield constitute an *** we used PEGylated magnetic iron-oxide nanoparticles(MNPs) to increase their uptake by Escherichia coli,which increased their OMVs *** OMVs could be magnetically harvested at 60-fold higher yields than achieved by *** OMVs containing MNPs accumulated throughout the whole biofilm in an applied magnetic field in contrast to OMVs without MNPs which only accumulated on the outside of the ***,magnetic OMVs bear potential for use as a drug carrier with the advantage that they can be magnetically targeted to an infection *** of magnetic OMV use in an animal model is only useful if animals enter a study in an equally sick conditions as humans when they decide to go to a *** infection that proceeds extremely fast to a life-threatening conditions for which the use of magnetic OMVs could be useful is *** addition,meningitis is extremely difficult to treat due to the fact that antimicrobials need to cross the blood-brain ***,the potential of magnetic OMVs as a nanocarrier was demonstrated in a murine meningitis model,showing positive results.

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Rational Design of cost-Effective Metal-Doped ZrO_(2)for Oxygen Evolution Reaction

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Nano-Micro Letters 2024年第9期16卷 385-396页

作者： Yuefeng Zhang Tianyi Wang Liang mei Ruijie Yang Weiwei Guo Hao Li Zhiyuan Zeng Department of Materials Science and Engineering and State Key Laboratory of Marine PollutionCity University of Hong Kong83 Tat Chee AvenueKowloon 999077Hong KongPeople’s Republic of China Advanced Institute for Materials Research(WPI‑AIMR) Tohoku UniversitySendai 980‑8577Japan Shenzhen Research Institute City University of Hong KongShenzhen 518057People’s Republic of China Shanxi Supercomputing center Lvliang 033000ShanxiPeople’s Republic of China

The design of cost-effective electrocatalysts is an open challenging for oxygen evolution reaction(OER)due to the“stable-oractive”*** dioxide(ZrO_(2)),a versatile and low-cost material that can be stable under OER operating conditions,exhibits inherently poor OER activity from experimental ***,we doped a series of metal elements to regulate the ZrO_(2)catalytic activity in OER via spin-polarized density functional theory calculations with van der Waals *** modeling as a function of the OER activity descriptor(G_(O*)-G_(HO*))displays that 16 metal dopants enable to enhance OER activities over a thermodynamically stable ZrO_(2)surface,among which Fe and Rh(in the form of single-atom dopant)reach the volcano peak(*** optimal activity of OER under the potential of interest),indicating excellent OER *** energy diagram calculations,density of states,and ab initio molecular dynamics simulations further showed that Fe and Rh are the effective dopants for ZrO_(2),leading to low OER overpotential,high conductivity,and good *** cost-effectiveness,single-atom Fe doped ZrO_(2)emerged as the most promising catalyst for *** finding offers a valuable perspective and reference for experimental researchers to design cost-effective catalysts for the industrial-scale OER production.

关键词： Oxygen evolution reaction Metal oxide Electrocatalysis Surface Pourbaix analysis Doping

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Evaluation of compatibilizers for Improving compatibility between Waste Vegetable Oil and Aged Asphalt

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1278-1286页

作者： WANG Yanghui DING Yongjie LI Danli cAO Zhilong SUN Guoqiang mei Zijun Department of Road and Urban Railway Engineering Beijing University of TechnologyBeijing 100124China School of civil Engineering Chongqing Jiaotong UniversityChongqing 400074China Shanghai Municipal Engineering Design Instit Shanghai 230031China

Modifying agents 2,2-Bis(4-glycidyloxyphenyl)propane(2BPE)and dibutyl phthalate(DBP)were selected to enhance the *** using molecular simulation software(Materials Studio,MS),nine systems were constructed,including molecular models of aged asphalt and WVO monomers with 2BPE and/or *** solubility parameters,Flory-Huggins parameters,and interaction energies of these systems were calculated to determine the impact of 2BPE and DBP on the compatibility of WVO and aged *** showed that the addition of 2BPE and DBP reduced the difference in the solubility parameters between WVO and aged asphalt,thus improving the compatibility between WVO and aged ***,using a combination of 2BPE and DBP in both aged asphalt and rejuvenator was found to be more effective than using either 2BPE or DBP ***,it was determined that evaluating the compatibility of WVO and aged asphalt using van der Waals potential and non-bonding energy as evaluation indicators was more accurate than using electrostatic potential energy.

关键词： road engineering aged asphalt compatibility molecular dynamics solubility parameter Flory-Huggins parameter

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Osteoblast integration of dental implant materials after challenge by sub-gingival pathogens: a co-culture study in vitro

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International Journal of Oral Science 2015年第4期7卷 250-258页

作者： Bingran Zhao henny c.van der mei Minie Rustema-Abbing Henk J Busscher Yijin Ren Department of Orthodontics University of Groningen and University Medical Center Groningen Department of Biomedical Engineering University of Groningen and University Medical Center Groningen

Sub-gingival anaerobic pathogens can colonize an implant surface to compromise osseointegration of dental implants once the soft tissue seal around the neck of an implant is broken. In vitro evaluations of implant materials are usually done in monoculture studies involving either tissue integration or bacterial colonization. co-culture models, in which tissue cells and bacteria battle simultaneously for estate on an implant surface, have been demonstrated to provide a better in vitro mimic of the clinical situation. Here we aim to compare the surface coverage by U2OS osteoblasts cells prior to and after challenge by two anaerobic sub-gingival pathogens in a co-culture model on differently modified titanium （Ti）, titanium-zirconium （TiZr） alloys and zirconia surfaces. Monoculture studies with either U2OS osteoblasts or bacteria were also carried out and indicated significant differences in biofilm formation between the implant materials, but interactions with U2OS osteoblasts were favourable on all materials. Adhering U2OS osteoblasts cells, however, were significantly more displaced from differently modified Ti surfaces by challenging sub-gingival pathogens than from TiZr alloys and zirconia variants. combined with previous work employing a co-culture model consisting of human gingival fibroblasts and supra-gingival oral bacteria, results point to a different material selection to stimulate the formation of a soft tissue seal as compared to preservation of osseointegration under the unsterile conditions of the oral cavity.

关键词： biofilm co-culture dental implant osteoblasts sub-gingival pathogens titanium-zirconium alloy

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In vivo biofilm formation on stainless steel bonded retainers during different oral health-care regimens

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International Journal of Oral Science 2015年第1期7卷 42-48页

作者： Marije A Jongsma henny c.van der mei Jelly Atema-Smit Henk J Busscher Yijin Ren Department of Orthodontics University of Groningen and University Medical Centre Department of Biomedical Engineering University of Groningen and University Medical Centre

Retention wires permanently bonded to the anterior teeth are used after orthodontic treatment to prevent the teeth from relapsing to pre-treatment positions. A disadvantage of bonded retainers is biofilm accumulation on the wires, which produces a higher incidence of gingival recession, increased pocket depth and bleeding on probing. This study compares in vivo biofilm formation on single-strand and multi-strand retention wires with different oral health-care regimens. Two-centimetre wires were placed in brackets that were bonded to the buccal side of the first molars and second premolars in the upper arches of 22 volunteers. Volunteers used a selected toothpaste with or without the additional use of a mouthrinse containing essential oils. Brushing was performed manually. Regimens were maintained for 1 week, after which the wires were removed and the oral biofilm was collected to quantify the number of organisms and their viability, determine the microbial composition and visualize the bacteria by electron microscopy. A 6-week washout period was employed between regimens. Biofilm formation was reduced on single-strand wires compared with multi-strand wires; bacteria were observed to adhere between the strands. The use of antibacterial toothpastes marginally reduced the amount of biofilm on both wire types, but significantly reduced the viability of the biofilm organisms. Additional use of the mouthrinse did not result in significant changes in biofilm amount or viability. However, major shifts in biofilm composition were induced by combining a stannous fluoride- or triclosan-containing toothpaste with the mouthrinse. These shifts can be tentatively attributed to small changes in bacterial cell surface hydrophobicity after the adsorption of the toothpaste components, which stimulate bacterial adhesion to the hydrophobic oil, as illustrated for a Streptococcus mutans strain.

关键词： antimicrobials biofilm bonded retention wires mouthrinse orthodontics

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OVOL1 inhibits breast cancer cell invasion by enhancing the degradation of TGF-β type I receptor

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1842-1859页

作者： chuannan Fan Qian Wang Gerard van der Zon Jiang Ren cedrick Agaser Roderick c.Slieker Prasanna Vasudevan Iyengar Hailiang mei Peter ten Dijke Department of cell and chemical Biology Leiden University Medical CenterLeiden 2300 RCThe Netherlands Oncode Institute Leiden University Medical CenterLeiden 2300 RCThe Netherlands Department of Biomedical Data Sciences Sequencing Analysis Support CoreLeiden University Medical CenterLeiden 2300 RCThe Netherlands Department of Epidemiology and Data Science Amsterdam Public Health InstituteAmsterdam Cardiovascular Sciences InstituteAmsterdam UMClocation VUmcAmsterdam 1081 HVThe Netherlands

Ovo-like transcriptional repressor 1(OVOL1)is a key mediator of epithelial lineage determination and mesenchymal–epithelial transition(MET).The cytokines transforming growth factor-β(TGF-β)and bone morphogenetic proteins(BMP)control the epithelial–mesenchymal plasticity(EMP)of cancer cells,but whether this occurs through interplay with OVOL1 is not ***,we show that OVOL1 is inversely correlated with the epithelial–mesenchymal transition(EMT)signature,and is an indicator of a favorable prognosis for breast cancer ***1 suppresses EMT.

关键词： invasion breast cancer

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Optimizing Growth conditions for Digoxin Production in Digitalis lanata Ehrh

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World Journal of Traditional chinese Medicine 2016年第2期2卷 24-35页

作者： Herman A.van Wietmarschen Hansj?rg Hagels Ron Peters Jolanda Heistek Jan van der Greef mei Wang TNO Netherlands Organization for Applied Scientific Research Microbiology & Systems Biology Sino-Dutch centre for Preventive and Personalized Medicine Boehringer Ingelheim Pharma Gmb H & co.KG Business center Klazienaveen Jolanda: Heistek Result Groenloper SU Bio Medicine

Objective: Digoxin is a therapeutic cardenolide widely used to treat various heart conditions such as atrial flutter, atrial fibrillation and heart failure in both Western as well as chinese medicine. Digoxin is extracted from cultivated Digitalis lanata Ehrh. plants, known as Mao Hua Yang Di Huang in chinese medicine. This manuscript presents two studies that were conducted to optimize the cultivation conditions for digoxin production in the TcM Mao Hua Yan Di Huang in a greenhouse under GAP ***: Two experiments were designed in which 4 growth conditions were compared. Levels of digoxin, gitoxin, digitoxin, α-acetyldigoxin, β-acetyl-digoxin were measured using HPLc-UV and compared between the ***: Normal soil, no cO_2 enrichment combined with a cold shock was found to be the optimal condition for producing digoxin in the first experiment. Gitoxin content was significantly lower in plants grown in this condition. Mechanical stress as well as the time of harvesting showed no statistically significant differences in the production of cardenolides. In the second experiment the optimal condition was found to be a combination of cold nights, sun screen, fertilizer use and no milled ***: This study shows that digoxin production can be increased by controlling the growth conditions of D. lanata Ehrh. The effect of cold was important in both experiments for improving digoxin production. cultivating chinese herbal medicines in optimized greenhouse conditions might be an economically attractive alternative to regular open air cultivation.

关键词： Digitalis lanata Ehrh mao hua yang di huang cardenolides content optimisation TcM

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