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Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2210-2227页

作者： qing Zhao Junjie Feng Fubin Liu Qianxin Liang Manlin Xie Jiaming Dong Yanfang Zou Jiali ye Guilong Liu Yue Cao Zhaodi Guo Hongzhi Qiao Lei Zheng Kewei Zhao Guangzhou Key Laboratory of Chinese Medicine Research on Prevention and Treatment of Osteoporosis the Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378China Guangdong Engineering Research Center of Chinese Herbal-derived Vesicles Guangzhou University of Chinese MedicineGuangzhou 510006China Department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai 519000China Department of Blood Transfusion Guangdong Heyou International HospitalFoshan 528306China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Although various anti-osteoporosis drugs are available,the limitations of these therapies,including drug resistance and collateral responses,require the development of novel anti-osteoporosis *** Drynariae displays a promising anti-osteoporosis effect,while the effective component and mechanism remain ***,we revealed the therapeutic potential of Rhizoma Drynariae-derived nanovesicles(RDNVs)for postmenopausal osteoporosis and demonstrated that RDNVs potentiated osteogenic differentiation of human bone marrow mesenchymal stem cells(hBMSCs)by targeting estrogen receptor-alpha(ERα).RDNVs,a natural product isolated from fresh Rhizoma Drynariae root juice by differential ultracentrifugation,exhibited potent bone tissue-targeting activity and anti-osteoporosis efficacy in an ovariectomized mouse ***,effectively internalized by hBMSCs,enhanced proliferation and ERαexpression levels of hBMSC,and promoted osteogenic differentiation and bone ***,via the ERαsignaling pathway,RDNVs facilitated mRNA and protein expression of bone morphogenetic protein 2 and runt-related transcription factor 2 in hBMSCs,which are involved in regulating osteogenic *** analysis revealed that naringin,existing in RDNVs,was the active component targeting ERαin the osteogenic *** together,our study identified that naringin in RDNVs displays exciting bone tissue-targeting activity to reverse osteoporosis by promoting hBMSCs proliferation and osteogenic differentiation through estrogen-like effects.

关键词： Rhizoma Drynariae-derived nanovesicles Bone marrow mesenchymal stem cells Bone targeting Osteogenic differentiation ERαsignaling Naringin Bone morphogenetic protein 2 Runt-related transcription factor 2

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Effects of loneliness and isolation on cardiovascular diseases:a two sample Mendelian Randomization Study

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Journal of Geriatric Cardiology 2024年第3期21卷 340-348页

作者： Jia-Yin CAI Xin WANG Cong-Yi Zheng Xue CAO Zhen HU Run-qing GU Yi-Xin TIAN ye TIAN Lan SHAO Lin-Feng ZHANG Zeng-Wu WANG Division of Prevention and Community Health National Center for Cardiovascular DiseaseNational Clinical Research Center of Cardiovascular DiseaseState Key Laboratory of Cardiovascular DiseaseFuwai HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijingChina

BACKGROUND Loneliness and isolation are associated with multiple cardiovascular diseases(CVDs),but there is a lack of research on whether they were causally *** conducted a Mendelian Randomization(MR)study to explore causal relationships between loneliness and isolation and multiple *** Single nucleotide polymorphisms associated with loneliness and isolation were identified from a genome-wide association study(GWAS)of 455,364 individuals of European ancestry in the IEU GWAS *** data for 15 CVDs were also obtained from the IEU GWAS *** used three MR methods including inverse variance weighting,MR-Egger,and weighted median estimation to assess the causal effect of exposure on ***'s Q test and MR-Egger intercept test were used to evaluate the heterogeneity and *** MR analysis showed that loneliness and isolation were significantly associated with essential hypertension(OR=1.07,95%CI:1.03-1.12),atherosclerotic heart disease(OR=1.04;95%CI:1.02-1.06),myocardial infarction(OR=1.02;95%CI:1-1.04)and angina(OR=1.04;95%CI=1.02-1.06).No heterogeneity and pleiotropy effects were found in this *** Causal relationship of loneliness and isolation with CVDs were found in this study.

关键词： diseases cardiovascular angina

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脓毒症动物模型研究现状及思考

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中华预防医学杂志 2024年第2期58卷 171-176页

作者：叶青尚世强浙江大学医学院附属儿童医院实验检验中心杭州310052

感染性疾病是导致儿童死亡的首要原因,脓毒症则是一种全球性导致儿童死亡的重要感染性危重疾病,病死率高,严重威胁儿童的健康。早期诊断已成为治疗严重脓毒症的关键。脓毒症动物模型的建立有助于更好地诊断脓毒症,从而采取干预措施,改... 详细信息

感染性疾病是导致儿童死亡的首要原因,脓毒症则是一种全球性导致儿童死亡的重要感染性危重疾病,病死率高,严重威胁儿童的健康。早期诊断已成为治疗严重脓毒症的关键。脓毒症动物模型的建立有助于更好地诊断脓毒症,从而采取干预措施,改善脓毒症患者的预后。本文就现有脓毒症动物模型的种类及优缺点等进行综述,并提出脓毒症动物模型的优化建议,为实验模型的选择和优化提供参考依据,以促进其“逆向转化”到临床的能力。

关键词：脓毒症动物模型临床转化

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A new deformable cable for rock support in high stress tunnel: Steel pipe shrinkable energy-absorbing cable

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International Journal of Mining Science and Technology 2024年第08期 1083-1093页

作者： Xuezhen Wu Mingzhu Zhao qing ye Yujing Jiang Tao Deng Hanfang Zheng Gang Wang Zhenchang Guan College of Civil Engineering Fuzhou University School of Engineering Nagasaki University Key Laboratory of Underground Engineering Fujian University of Technology

High stress in surrounding rock will lead to serious problems, e.g., rock burst in hard rock and large deformation in soft rock. The applied support system under high in-situ stress conditions should be able to carry high load and also accommodate large deformation without experiencing severe damage. In this paper, a specially designed energy-absorbing component for rock bolt and cable that can solve the above problems was proposed. The energy-absorbing component can provide support resistance by plastic deformation of the metal including constraint annulus and compression pipe. For practical engineering,two forms were proposed. One was installed in the surrounding rock by reaming, and the other was installed directly outside the surrounding rock. During the dilation of the surrounding rock, the relative displacement of constraint annulus and compression pipe occurs, resulting in deformation *** resistance is transmitted to the rock bolt or cable, providing support resistance. The lab test and numerical simulation showed that the energy-absorbing component can perfectly achieve the large deformation effect, the deformation amount is as high as 694 mm, and the bearing capacity is stable at367 k N. The field application tests were carried out in the mining roadway of Xinjulong coal mine, and the results showed that the new type of cable can ensure itself not to break under the condition of large deformation of the surrounding rock. The energy-absorbing component has the superiorities of performing large constant resistance and controllable deformation to effectively control the unpredictable disasters such as large deformation in soft rock and rock burst in hard rock encountered in deep strata.

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CCDC181 is required for sperm flagellum biogenesis and male fertility in mice

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Zoological Research 2024年第5期45卷 1061-1072页

作者： Xiang-Jun Zhang Xiao-Ning Hou Jian-Teng Zhou Bao-Lu Shi Jing-Wei ye Meng-Lei Yang Xiao-Hua Jiang Bo Xu Li-Min Wu qing-Hua Shi Division of Reproduction and Genetics First Affiliated Hospital of University of Science and Technology of China(USTC)Hefei National Laboratory for Physical Sciences at MicroscaleSchool of Basic Medical SciencesDivision of Life Sciences and MedicineBiomedical Sciences and Health Laboratory of Anhui ProvinceInstitute of Health and MedicineHefei Comprehensive National Science CenterUniversity of Science and Technology of ChinaHefeiAnhui 230001China

The structural integrity of the sperm flagellum is essential for proper sperm *** defects can result in male infertility,yet the precise mechanisms underlying this relationship are not fully ***181,a coiled-coil domain-containing protein,is known to localize on sperm flagella and at the basal regions of motile *** this knowledge,the specific functions of CCDC181 in flagellum biogenesis remain *** this study,Ccdc181 knockout mice were *** absence of CCDC181 led to defective sperm head shaping and flagellum ***,the Ccdc181 knockout mice exhibited extremely low sperm counts,grossly aberrant sperm morphologies,markedly diminished sperm motility,and typical multiple morphological abnormalities of the flagella(MMAF).Additionally,an interaction between CCDC181 and the MMAF-related protein LRRC46 was identified,with CCDC181 regulating the localization of LRRC46 within sperm *** findings suggest that CCDC181 plays a crucial role in both manchette formation and sperm flagellum biogenesis.

关键词： Male infertility CCDC181 MMAF Spermiogenesis Flagellum biogenesis

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Enhancing Generic Reaction Yield Prediction through Reaction Condition-Based Contrastive Learning

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Research 2024年第3期 685-702页

作者： Xiaodan Yin Chang-Yu Hsieh Xiaorui Wang Zhenxing Wu qing ye Honglei Bao Yafeng Deng Hongming Chen Pei Luo Huanxiang Liu Tingjun Hou Xiaojun Yao Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao 999078China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China. Faculty of Applied Sciences Macao Polytechnic UniversityMacao 999078China. CarbonSilicon AI Technology Co.Ltd HangzhouZhejiang 310018China Center of Chemistry and Chemical Biology Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510530China.

Deep learning(DL)-driven efficient synthesis planning may profoundly transform the paradigm for designing novel pharmaceuticals and ***,the progress of many DL-assisted synthesis planning(DASP)algorithms has suffered from the lack of reliable automated pathway evaluation *** a critical metric for evaluating chemical reactions,accurate prediction of reaction yields helps improve the practicality of DASP algorithms in the real-world ***,accurately predicting yields of interesting reactions still faces numerous challenges,mainly including the absence of high-quality generic reaction yield datasets and robust generic yield *** compensate for the limitations of high-throughput yield datasets,we curated a generic reaction yield dataset containing 12 reaction categories and rich reaction condition ***,by utilizing 2 pretraining tasks based on chemical reaction masked language modeling and contrastive learning,we proposed a powerful bidirectional encoder representations from transformers(BERT)-based reaction yield predictor named *** achieved comparable or even superior performance to the best previous models on 4 benchmark datasets and established state-of-the-art performance on the newly curated *** found that reaction-condition-based contrastive learning enhances the model’s sensitivity to reaction conditions,and Egret is capable of capturing subtle differences between reactions involving identical reactants and products but different reaction ***,we proposed a new scoring function that incorporated Egret into the evaluation of multistep synthesis *** results showed that yield-incorporated scoring facilitated the prioritization of literature-supported high-yield reaction pathways for target *** addition,through meta-learning strategy,we further improved the reliability of the model’s prediction for reaction types with limited data and lower data *** r

关键词： synthesis generic holds

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Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2024年第10期30卷 1431-1449页

作者： Zheng-Yang Li Yu-qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Department of Gastroenterology Jinshan Hospital of Fudan UniversityShanghai 201508China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Gastroenterology Dalian Friendship HospitalDalian 116001Liaoning ProvinceChina Department of Pathology Jinshan Hospital of Fudan UniversityShanghai 201508China

BACKGROUND Serotonin receptor 2B(5-HT2B receptor)plays a critical role in many chronic pain *** possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diarrhea(IBS-D)was investigated in the present *** To investigate the possible involvement of 5-HT2B receptor in the altered gut sensation in rat model and patients with *** Rectosigmoid biopsies were collected from 18 patients with IBS-D and 10 patients with irritable bowel syndrome with constipation who fulfilled the Rome IV criteria and 15 healthy *** expression level of the 5-HT2B receptor in colon tissue was measured using an enzyme-linked immunosorbent assay and correlated with abdominal pain *** IBS-D rat model was induced by intracolonic instillation of acetic acid and wrap *** in visceral sensitivity and 5-HT2B receptor and transient receptor potential vanilloid type 1(TRPV1)expression were examined following 5-HT2B receptor antagonist *** in visceral sensitivity after administration of the TRPV1 antago-INTRODUCTION Irritable bowel syndrome(IBS)is a chronic functional bowel disorder characterized by recurrent abdominal pain with altered bowel habits that affects approximately 15%of the population worldwide[1].IBS significantly impacts the quality of life of *** the pathogenesis of IBS is not completely understood,the role of abnormal visceral sensitivity in IBS has recently emerged[2,3].5-Hydroxytryptamine(5-HT)is known to play a key role in the physiological states of the gastrointestinal *** 5-HT levels in IBS with diarrhea(IBS-D)patients were greater than those in healthy controls[4],suggesting a possible role of 5-HT in the pathogenesis of *** serotonin receptor 2(5-HT2 receptor)family comprises three subtypes:5-HT2A,5-HT2B,and *** 5-HT2 receptors exhibit 46%-50%overall sequence identity,and all of these receptors preferentially bind to Gq/

关键词： Diarrhea-predominant irritable bowel syndrome Serotonin receptor 2B Transient receptor potential vanilloid type-1 Visceral hypersensitivity Abdominal pain

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探索新时期中国传统村落保护与利用之路:理论创新与实践路径——写在专辑刊发之后的话

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自然资源学报 2024年第8期39卷 2008-2010页

作者：程叶青海南师范大学地理与环境科学学院海口571158

系统探索中国传统村落保护与利用的理论认知、政策机制、实践经验和实现路径,对于推动中国乡村振兴与中国式现代化具有重要的理论和现实意义。为更好地服务于国家战略需求,推进中国传统村落保护利用与乡村振兴研究的纵深结合,受《自然... 详细信息

系统探索中国传统村落保护与利用的理论认知、政策机制、实践经验和实现路径,对于推动中国乡村振兴与中国式现代化具有重要的理论和现实意义。为更好地服务于国家战略需求,推进中国传统村落保护利用与乡村振兴研究的纵深结合,受《自然资源学报》编辑部委托,在中国自然资源学会和国家社会科学基金重大项目、国家自然科学基金项目的支持下,海南师范大学程叶青教授、安徽建筑大学陈晓华教授、西南林业大学唐雪琼教授和华南师范大学陶伟教授共同策划组织了“新时期传统村落保护与利用”专辑。专辑的组稿得到了国内地理学、经济学、管理学、社会学和城乡规划学等相关学科专家的积极响应与参与。经专家评审,本专辑精选15篇论文,包括专家访谈、景观基因与景观修复、有机更新与活态化、多功能性与价值实现、旅游发展与地方营造5个栏目。

关键词：国家社会科学基金海南师范大学华南师范大学传统村落保护国家战略需求乡村振兴中国式现代化景观基因

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Fragility crossover mediated by covalent-like electronic interactions in metallic liquids

Materials Futures

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Materials Futures 2024年第2期3卷 117-130页

作者： Hui-Ru Zhang Liang Gao Yu-Hao ye Jia-Xin Zhang Tao Zhang qing-Zhou Bu Qun Yang Zeng-Wei Zhu Shuai Wei Hai-Bin Yu Wuhan National High Magnetic Field Center and School of Physics Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Department of Chemistry Aarhus University8000 AarhusDenmark iMAT Centre for Integrated Materials Research Aarhus University8000 AarhusDenmark

Fragility is one of the central concepts in glass and liquid sciences,as it characterizes the extent of deviation of viscosity from Arrhenius behavior and is linked to a range of glass ***,the intervention of crystallization often prevents the assessment of fragility in poor glass-formers,such as supercooled metallic *** experimental data on their compositional dependence are scarce,let alone fundamentally *** this work,we use fast scanning calorimetry to overcome this obstacle and systematically study the fragility in a ternary La–Ni–Al system,over previously inaccessible composition *** observe fragility dropped in a small range with the Al alloying,indicating an alloying-induced fragility *** use x-ray photoelectron spectroscopy,resistance measurements,electronic structure calculations,and DFT-based deep-learning atomic simulations to investigate the cause of this fragility *** results show that the fragility crossover can be fundamentally ascribed to the electronic covalency associated with the unique Al–Al *** findings provide insight into the origin of fragility in metallic liquids from an electronic structure perspective and pave a new way for the design of metallic glasses.

关键词： metallic glass fragility fast scanning calorimetry density functional theory deep learning potential

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Emerging interactively stretchable electronics with optical and electrical dual-signal feedbacks based on structural color materials

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Nano Research 2024年第3期17卷 1837-1855页

作者： Jialin Wang Kai Zhao Changqing ye Yanlin Song School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190China

The booming development of wearable devices has aroused increasing interests in flexible and stretchable *** mechanosensory functionality,these devices are highly desirable on account of their wide range of applications in electronic skin,personal healthcare,human–machine interfaces and ***,they are mostly limited by single electrical signal feedback,restricting their diverse applications in visualized mechanical *** by the mechanochromism of structural color materials,interactively stretchable electronics with optical and electrical dual-signal feedbacks are recently emerged as novel sensory platforms,by combining both of their sensing mechanisms and ***,recent studies on interactively stretchable electronics based on structural color materials are *** a brief introduction of their basic components(i.e.,stretchable electronics and mechanochromic structural color materials),two types of interactively stretchable electronics with respect to the nanostructures of mechanochromic materials are outlined,focusing primarily on their design considerations and fabrication ***,the main challenges and future perspectives of these emerging devices are discussed.

关键词： stretchable electronics structural color materials interactive sensing mechanochromism dual-signal feedbacks

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