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High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome as potential targets for evaluating the therapeutic effects and mechanism of geniposide

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Frontiers of Medicine 2020年第5期14卷 651-663页

作者： heng Fang Aihua Zhang Xiaohang Zhou Jingbo yu Qi song Xijun Wang National Chinmedomics Research Center Sino-America Chinmedomics Technology Collaboration CenterNational TCM Key Laboratory of Serum PharmacochemistryLaboratory of MetabolomicsDepartment of Pharmaceutical AnalysisHeilongjiang University of Chinese MedicineHarbin 150040China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyAvenida Wai LongTaipaMacao 519020China

High-throughput metabolomics can clarify the underlying molecular mechanism of diseases via the qualitative and quantitative analysis of *** study used the established Yang Huang syndrome(YHS)mouse model to evaluate the efficacy of geniposide(GEN).Urine metabolic data were quantified by ultraperformance liquid chromatography-tandem mass *** non-target screening of the massive biological information dataset was performed,and a total of 33 metabolites,including tyramine glucuronide,aurine,and L-cysteine,were identified relating to *** differential metabolites directly participated in the disturbance of phase I reaction and hydrophilic transformation of ***,they were completely reversed by ***,as the auxiliary technical means,we also focused on the molecular prediction and docking results in network pharmacological and integrated analysis *** used integrated analysis to communicate the multiple results of metabolomics and network *** study is the first to report that GEN indirectly regulates the metabolite“tyramine glucuronide”through its direct effect on the target heme oxygenase 1 in ***,heme oxygenase-1,a prediction of network pharmacology,was the confirmed metabolic enzyme of phase I reaction in *** study indicated that the combination of high-throughput metabolomics and network pharmacology is a robust combination for deciphering the pathogenesis of the traditional Chinese medicine(TCM)syndrome.

关键词： metabolomics liquid chromatography-mass spectrometry metabolites metabolic pathways

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欧洲抗风湿病联盟与欧洲儿科风湿病学会“Still病诊断与管理推荐, 包括全身型幼年特发性关节炎和成人Still病”解读

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中华儿科杂志 2025年第1期63卷 39-42页

作者：于仲勋宋红梅中国医学科学院北京协和医学院北京协和医院儿科北京

2024年9月Annals of the Rheumatic Diseases在线发表了"Still病的诊断与管理推荐", 囊括了Still病的定义、诊断、治疗、并发症管理等方面。本文对该推荐进行解读, 以促进临床医生对Still病的认识更新。

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电子管高频功率放大器的新算法

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长春工业大学学报 2004年第3期25卷 33-35页

作者：闫智义王立臣陈戈珩宋宇长春工业大学计算机科学与工程学院吉林长春130012

介绍了卡茨曼给出的计算电子管功放级的一种新算法,指出卡氏法的局限性,提出有用的改进意见,建立了利用通用曲线进行计算的方法。按此方法可对欠压、临界、弱过压状态的电子管功率放大器进行计算,精度与图解法(十三点法)相近。新法物理... 详细信息

介绍了卡茨曼给出的计算电子管功放级的一种新算法,指出卡氏法的局限性,提出有用的改进意见,建立了利用通用曲线进行计算的方法。按此方法可对欠压、临界、弱过压状态的电子管功率放大器进行计算,精度与图解法(十三点法)相近。新法物理意义明确,计算简便,适于现场使用。

关键词：电子管功放电子管功率放大器现场使用新算法过压状态图解法高频功率临界物理意义

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Anomalies of Doped-LiNbO_(3) Crystal in Photorefractive Phase Conjugation with Relation to Structural Phase Transformation

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Chinese Physics Letters 1996年第2期13卷 137-140页

作者： LIU Jin-song LIANG Chang-hong AN yu-ying LI Ming-hua XU yu-heng WU Zhong-kang Department of Applied Physics Xidian UniversityXi'an 710071 Department of Chemistry Harbin Institute of TechnologyHarbin 150001 Department of Physics Nankai University Tianjin 300071

We investigate the photorefractive phase conjugation in a Ce:Fe:LiNbO_(3) crystal asa function of temperature(293-393 K)and find the phase conjugate reflectivity in-creases sharply in the vicinity of 55,70 and 110℃.The anomalous phenomenon ispossibly concerned with the structural phase transformation of a crystal,which in-duces an extra internal electric ficld to influence the phase *** value ofthe field is estimated at the order of 10^(5)V/m,in agreement with the published data.

关键词： transformation Transformation phase

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Visible-light-driven thio-carboxylation of alkynes with CO_(2):facile synthesis of thiochromones

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Science China Chemistry 2023年第5期66卷 1457-1466页

作者： Meng Miao Lei Zhu Hong Zhao Lei song Si-Shun Yan Li-Li Liao Jian-heng Ye yu Lan Da-Gang yu Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China College of Pharmacy Third Military Medical UniversityChongqing 400038China School of Chemistry and Chemical Engineering Chongqing Key Laboratory of Theoretical and Computational ChemistryChongqing UniversityChongqing 400030China College of Chemistry and Institute of Green Catalysis Zhengzhou UniversityZhengzhou 450001China

Difunctionalizing carboxylation of alkynes with CO_(2)is a sustainable and important strategy to generate valuable acrylate derivatives from both readily available starting *** protocols,however,always suffer from the use of excess metallic reagents and transition metal ***,we report the first thio-carboxylation of alkynes with thiophenols and CO_(2),which is a visible-light-driven and transition metal-free *** contrast to previous carboxylations of alkynes via two-electron activation of CO_(2),mechanistic and computational investigations suggest that the single-electron activation of CO_(2)is involved in the thio-carboxylation,rendering uniqueβ-*** following cyclizing acylation affords important thiochromones ***,the one-pot method features mild reaction conditions(room temperature,1 atmosphere of CO_(2)),high chemo-and regio-selectivity,easy scalability and facile derivatization of products to bioactive compounds.

关键词： carbon dioxide visible light carboxylation thiochromones

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Amino acid assisted aqueous synthesis of highly stable CsPbBr_(3)nanocrystals for cell imaging

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Nano Research 2025年第1期18卷 675-683页

作者： Xue Li Yanan Guo Guoying Tan Qingyi Liu Nan song yu Tang State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China

Lead halide perovskite nanocrystals(NCs)exhibit excellent optoelectronic performance and have drawn great interests in the fields of biological imaging and ***,the poor stability of CsPbX_(3)(X=Cl,Br,I)in water is still a challenge to hinder their practical *** this work,a facile strategy has been developed for aqueous synthesis of CsPbX_(3) nanocrystals,in which L-glutamic acid(LGlu)has been used to replace oleic acid in the synthetic *** from the synergic effects of L-Glu and oleylamine(OAm),CsPbBr_(3)nanocrystals(L-Glu/OAm-CsPbBr_(3)NCs)with high water stability have been directly prepared under a mild condition at room temperature in water,facilitated by the process of crystal phase transformation from Cs_(4)PbBr_(6) to CsPbBr_(3).L-Glu/OAm-CsPbBr_(3)NCs exhibit a high quantum yield of 85%and a narrow full width at half maximum of 16 nm,demonstrating their efficient luminescence in ***,L-Glu on the surface have contributed greatly to an acidic environment and passivation of surface defects,improving the water stability and dispersibility of CsPbBr_(3)***,L-Glu/OAm-CsPbBr_(3)NCs exhibit great biocompatibility due to the presence of L-Glu,resulting in their good performance for HeLa cell ***,we propose a facile and effective method to prepare CsPbBr_(3)nanocrystals with excellent water stability by using L-Glu and OAm as cooperated ligands and expand their application in cell imaging.

关键词： aqueous synthesis cell imaging lead halide perovskite nanocrystals L-glutamic acid phase transformation

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei song Zheng-Zhi Wu Qian-Qian Jiang Shao-yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Robust Iterated Sigma Point FastSLAM Algorithm for Mobile Robot Simultaneous Localization and Mapping

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Chinese Journal of Mechanical Engineering 2011年第4期24卷 693-700页

作者： song yu song Yongduan LI Qingling Center for Intelligent System and Renewable Energy Beijing Jiaotong University Beijing 100044 China State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin 150080 China Institute of Automation Chinese Academy of Sciences Beijing 100190 China

Simultaneous localization and mapping （SLAM） is a key technology for mobile robots operating under unknown environment. While FastSLAM algorithm is a popular solution to the SLAM problem, it suffers from two major drawbacks： one is particle set degeneracy due to lack of observation information in proposal distribution design of the particle filter; the other is errors accumulation caused by linearization of the nonlinear robot motion model and the nonlinear environment observation model. For the purpose of overcoming the above problems, a new iterated sigma point FastSLAM （ISP-FastSLAM） algorithm is proposed. The main contribution of the algorithm lies in the utilization of iterated sigma point Kalman filter （ISPKF）, which minimizes statistical linearization error through Gaussian-Newton iteration, to design an optimal proposal distribution of the particle filter and to estimate the environment landmarks. On the basis of Rao-Blackwellized particle filter, the proposed ISP-FastSLAM algorithm is comprised by two main parts： in the first part, an iterated sigma point particle filter （ISPPF） to localize the robot is proposed, in which the proposal distribution is accurately estimated by the ISPKF; in the second part, a set of ISPKFs is used to estimate the environment landmarks. The simulation test of the proposed ISP-FastSLAM algorithm compared with FastSLAM2.0 algorithm and Unscented FastSLAM algorithm is carried out, and the performances of the three algorithms are compared. The simulation and comparing results show that the proposed ISP-FastSLAM outperforms other two algorithms both in accuracy and in robustness. The proposed algorithm provides reference for the optimization research of FastSLAM algorithm.

关键词： mobile robot simultaneous localization and mapping (SLAM) particle filter Kalman filter unscented transformation

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Analysis of Genetic Diversity of Processing Apple Varieties

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Agricultural Sciences in China 2006年第10期5卷 745-750页

作者： song Ye ZHAI heng YAO yu-xin LI Ming DU yuan-peng College of Horticultural Science and Engineering Shandong Agricultural University Taian 271018 P.R.China

Genetic diversity of 18 processing apple varieties and two fresh varieties were evaluated using 12 simple sequence repeats （SSR） primer pairs previously identified in Malus domestica Borkh. A total of 87 alleles in 10 loci were detected using 10 polymorphic SSR markers selected within the range of 5-14 alleles per locus. All the 20 varieties could be distinguished using two primer pairs and they were divided into four groups using cluster analysis. The genetic similarity （GS） of groups analyzed using cluster analysis varied from 0.14 to 0.83. High acid variety Avrolles separated from other varieties with GS less than 0.42. The second group contained Longfeng and Dolgo from Northeast of China, the inherited genes of Chinese crab apple. The five cider varieties with high tannin contents, namely, Dabinette, Frequin rouge, Kermerrien, ***, and *** were clustered into the third group. The fourth group was mainly composed of 12 juice and fresh varieties. Principal coordinate analysis （PCO） also divided all the varieties into four groups. Juice and fresh apple varieties, Longfeng and Dolgo were clustered together, respectively, using both the analyses. Both the analyses showed there was much difference between cider and juice varieties, cider and fresh varieties, as well as Chinese crab apple and western European crab apple, whereas juice varieties and fresh varieties had a similar genetic background. The genetic diversity and differentiation could be sufficiently reflected by combining the two analytical methods.

关键词： processing apple varieties genetic diversity simple sequence repeats cluster analysis principal coordinate analysis

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Sandwich structured ultra-strong-heat-shielding aerogel/copper composite insulation board for safe lithium-ion batteries modules

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Journal of Energy Chemistry 2023年第1期76卷 438-447,I0011页

作者： heng yu Xiaowei Mu yulu Zhu Can Liao Longfei Han Jingwen Wang Wei Cai Yongchun Kan Lei song yuan Hu State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230027AnhuiChina Department of Chemical Engineering University of Massachusetts Amherst01003MAUSA

The fire hazard of lithium-ion batteries(LIBs)modules is extremely serious due to their high ***,once a battery catches fire,it can easily result in a fire of the entire LIBs *** this work,a sandwich structure composite thermal insulation(STI)board(copper//silica dioxide aerogel//copper)with the advantages of low thermal conductivity(0.031 W m-1K-1),low surface radiation emissivity(0.1)and good thermal convection inhibition effect has been *** thermal runaway(TR)occurrence time of adjacent LIBs increases from 1384 s to more than 6 h+due to the protection of STI *** TR propagation occurs within LIBs modules with protect of a STI board when a battery catches *** ultra-strong-heat-shielding mechanism of STI board has been *** TR propagation of LIBs modules has been insulated effectively by STI board through reducing the heat transfer of convection,conduction and *** air flow rate between the heater and LIBs and radiant heat absorbed by LIBs decrease by 63.5%and 35.1%with protection of STI board,respectively.A high temperature difference inside the STI board is also *** work provides direction for the designing of safe thermal insulation board for LIBs modules.

关键词： Insulation board Ultra-strong-heat-shielding Lithium-ion battery modules Thermal runaway propagation Mechanism

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