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Single-structure 3-axis Lorentz force magnetometer based on an AlN-on-Si MEMS resonator

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Microsystems & Nanoengineering 2024年第3期10卷 75-86页

作者： Cheng Tu Xu-heng Ou-yang Ying-jie Wu Xiao-sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

This work presents a single-structure 3-axis Lorentz force magnetometer(LFM)based on an AlN-on-Si MEMS *** operation of the proposed LFM relies on the flexible manipulation of applied excitation currents in different directions and frequencies,enabling the effective actuation of two mechanical vibration modes in a single device for magnetic field measurements in three ***,the excited out-of-plane drum-like mode at 277 kHz is used for measuring the x-and y-axis magnetic fields,while the in-plane square-extensional mode at 5.4 MHz is used for measuring the z-axis magnetic *** different configurations of applied excitation currents ensure good crossinterference immunity among the three *** to conventional capacitive LFMs,the proposed piezoelectric LFM utilizes strong electromechanical coupling from the AlN layer,which allows it to operate at ambient pressure with a high *** understand and analyze the measured results,a novel equivalent circuit model for the proposed LFM is also reported in this work,which serves to separate the effect of Lorentz force from the unwanted capacitive *** demonstrated 3-axis LFM exhibits measured magnetic responsivities of 1.74 ppm/mT,1.83 ppm/mT and 6.75 ppm/mT in the x-,y-and z-axes,respectively,which are comparable to their capacitive counterparts.

关键词： resonator Lorentz structure

Identifying Three New AGNs among Fermi Unidentified Gigaelectronvolt Sources

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Research in Astronomy and Astrophysics 2024年第7期24卷 257-267页

作者： Shun-Hao Ji Zhong-Xiang Wang Qiang-Meng Huang Ruo-heng yang Department of Astronomy School of Physics and AstronomyYunnan UniversityKunming 650091China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

We report our identification of three gigaelectronvoltγ-ray sources,4FGL J0502.6+0036,4FGL J1055.9+6507,and 4FGL J1708.2+5519,as Active Galactic Nuclei(AGNs).They are listed in the latest Fermi-Large Area Telescope source catalog as unidentified *** find that the sources all showedγ-ray flux variations in recent *** different survey catalogs,we are able to find a radio source within the error circle of each source's *** analysis of optical sources in the fields allows us to determine the optical counterparts,which showed similar variation patterns to those seen inγ-*** optical counterparts have reported redshifts of 0.6,1.5,and 2.3,respectively,estimated from photometric *** addition,we also obtain an X-ray spectrum of 4FGL J0502.6+0036 and a flux upper limit on the X-ray emission of 4FGL J1055.9+6507 by analyzing the archival *** broadband spectral energy distributions of the three sources from radio toγ-rays are *** mainly theγ-ray properties of the three sources with those of different sub-classes of AGNs,we tentatively identify them as *** optical spectroscopy is highly warranted for obtaining their spectral features and thus verifying the identification.

关键词： gamma-rays galaxies-(galaxies)BL Lacertae objects general-(galaxies)quasars general

The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1424-1448页

作者： heng yang Xiangqi Fan Xiangbing Mao Bing Yu Jun He Hui Yan Jianping Wang Institute of Animal Nutrition Sichuan Agricultural UniversityKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationKey Laboratory of Animal Disease-Resistant Nutrition and Feed of China Ministry of Agriculture and Rural AffairsKey Laboratory of Animal Disease-Resistant Nutrition of Sichuan ProvinceNo.211Gongpinghuimin RoadWenjiang DistrictChengduSichuan Province 611130People’s Republic of China

Rotavirus is one of the pathogenic causes that induce diarrhea in young animals, especially piglets, worldwide. However, nowadays, there is no specific drug available to treat the disease, and the related vaccines have no obvious efficiency in some countries. Via analyzing the pathogenesis of rotavirus, it inducing diarrhea is mainly due to disturb enteric nervous system, destroy gut mucosal integrity, induce intracellular electrolyte imbalance, and impair gut microbiota and immunity. Many studies have already proved that prebiotics and probiotics can mitigate the damage and diarrhea induced by rotavirus infection in hosts. Based on these, the current review summarizes and discusses the effects and mechanisms of prebiotics and probiotics on rotavirus-induced diarrhea in piglets. This information will highlight the basis for the swine production utilization of prebiotics and probiotics in the prevention or treatment of rotavirus infection in the future.

关键词： Diarrhea Piglet Prebiotics Probiotics Rotavirus

Conservation genomic investigation of an endangered conifer,Thuja sutchuenensis,reveals low genetic diversity but also low genetic load

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Plant Diversity 2024年第1期46卷 78-90页

作者： Tongzhou Tao Richard IMilne Jialiang Li heng yang Shiyang Wang Sihan Chen Kangshan Mao Key Laboratory for Bio-Resource and Eco-Environment of Ministry of Education&Sichuan Zoige Alpine Wetland Ecosystem National Observation and Research Station College of Life ScienceSichuan UniversityChengduChina Institute of Molecular Plant Science School of Biological ScienceUniversity of EdinburghEdinburgh EH93BFUK College of Science Tibet UniversityLhasa 850000Xizang Autonomous RegionPR China

Endangered species generally have small populations with low genetic diversity and a high genetic *** sutchuenensis is an endangered conifer endemic to southwestern *** was once considered extinct in the wild,but in 1999 was ***,little is known about its genetic *** collected 67 individuals from five wild,isolated *** populations,and used 636,151 SNPs to analyze the level of genetic diversity and genetic load in *** to delineate the conservation units of ***,based on whole transcriptome sequencing data,as well as target capture sequencing *** found that populations of *** could be divided into three *** groups had low levels genetic diversity and were moderately genetically *** findings also indicate that *** suffered two severe bottlenecks around the Last Glaciation Period and Last Glacial *** Thuja species,*** presented the lowest genetic load and hence might have purged deleterious mutations efficiently through purifying ***,distribution of fitness effects analysis indicated a high extinction risk for *** lines of evidence identified three management units for *** *** possesses a low genetic load,low genetic diversity,suboptimal fitness,and anthropogenic pressures all present an extinction risk for this rare *** might also hold true for many endangered plant species in the mountains all over the world.

关键词： Sichuan Arborvitae Genetic load Deleterious mutations Demographic history Conservation genomics

Research on Distributed Coordination Control Method for Microgrid System Based on Finite-time Event-triggered Consensus Algorithm

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Chinese Journal of Electrical Engineering 2024年第2期10卷 103-115页

作者： Lizhen Wu heng yang Jianping Wei Wendong Jiang College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhou 730050China National Active Distribution Network Technology Research Center Beijing Jiaotong UniversityBeijing 100044China

Microgrids are networked control systems with multiple distributed generators(DGs).Microgrids are associated with many problems,such as communication delays,high sampling rates,and frequent controller updates,which make it challenging to realize coordination control among the ***,finite-time consensus algorithms and event-triggered control methods are combined to propose a distributed coordination control method for microgrid *** DG in the microgrid system serves as an agent node in the control network,and a distributed secondary controller is designed using finite-time consensus algorithm,such that the frequency and voltage restoration control has a faster convergence time and better anti-interference *** event-triggered function was designed based on the state information of the *** controller exchanges the state information at the trigger *** stability is analyzed using the Lyapunov stability theory,and it is verified that the controller cannot exhibit the Zeno phenomenon in the event-triggered process.A simulation platform was developed in Matlab/Simulink to verify that the proposed control method can effectively reduce the frequency of controller updates during communication delays and the burden on the communication network.

关键词： Microgrid event-triggered control distributed secondary control finite-time consensus algorithm coordination control

Spatiotemporal transformable nano-assembly for on-demand drug delivery to enhance anti-tumor immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 103-118页

作者： Chenglin Liang Ge Zhang Linlin Guo Xinyi Ding heng yang Hongling Zhang Zhenzhong Zhang Lin Hou School of Pharmaceutical Sciences Key Laboratory of Targeting Therapy and Diagnosis for Critical DiseasesZhengzhou UniversityZhengzhou 450001China

Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy,but fibrotic matrix severely blocks senescence inducers penetration and immune cells ***,we designed a cancer-associated fibroblasts(CAFs)triggered structure-transformable nano-assembly(HSD-P@V),which can directionally deliver valsartan(Val,CAFs regulator)and doxorubicin(DOX,senescence inducer)to the specific *** detail,DOX is conjugated with hyaluronic acid(HA)via diselenide bonds(Se-Se)to form HSD micelles,while CAFs-sensitive peptide is grafted onto the HSD to form a hydrophilic polymer,which is coated on Val nanocrystals(VNs)surface for improving the stability and achieving responsive *** arriving at tumor microenvironment and touching CAFs,HSD-P@V disintegrates into VNs and HSD micelles due to sensitive peptide *** can degrade the extracellularmatrix,leading to the enhanced penetration of *** targets tumor cells,releases DOX to induce senescence,and recruits effector immune ***,senescent cells are cleared by the recruited immune cells to finish the integrated anti-tumor *** vitro and in vivo results show that the nanoassembly remarkably inhibits tumor growth as well as lungmetastasis,and extends tumorbearing mice *** work provides a promising paradigm of programmed delivering multi-site nanomedicine for cancer immunotherapy.

关键词： Cells senescence Tumor stroma Structure transformable Programmed delivery Anti-tumor immunotherapy

Across two phylogeographic breaks: Quaternary evolutionary history of a mountain aspen (Populus rotundifolia) in the hengduan Mountains

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Plant Diversity 2024年第3期46卷 321-332页

作者： Jieshi Tang Xiaoyan Fan Richard I.Milne heng yang Wenjing Tao Xinran Zhang Mengyun Guo Jialiang Li Kangshan Mao Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life SciencesState Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610065PR China Institute of Molecular Plant Sciences University of EdinburghEdinburgh EH93JHUK School of Ecology and Environment Tibet UniversityLhasa 850000PR China

Biogeographical barriers to gene flow are central to plant *** East Asia,plant distribution is greatly influenced by two phylogeographic breaks,the Mekong-Salween Divide and Tanaka-Kaiyong Line,however,few studies have investigated how these barriers affect the genetic diversity of species that are distributed across *** we used 14 microsatellite loci and four chloroplast DNA fragments to examine genetic diversity and distribution patterns of 49 populations of Populus rotundifolia,a species that spans both the Mekong-Salween Divide and the Tanaka-Kaiyong Line in southwestern *** and migration hypotheses were tested using coalescent-based *** historical gene flow was observed between the western and eastern groups of ***,but substantial flow occurred across both the Mekong-Salween Divide and Tanaka-Kaiyong Line,manifesting in clear admixture and high genetic diversity in the central ***-borne pollen and seeds may have facilitated the dispersal of *** following prevalent northwest winds in the *** also found that the hengduan Mountains,where multiple genetic barriers were detected,acted on the whole as a barrier between the western and eastern groups of *** niche modeling suggested that *** has undergone range expansion since the last glacial maximum,and demographic reconstruction indicated an earlier population expansion around 600 *** phylogeographic pattern of *** reflects the interplay of biological traits,wind patterns,barriers,niche differentiation,and Quaternary climate *** study emphasizes the need for multiple lines of evidence in understanding the Quaternary evolution of plants in topographically complex areas.

关键词： Chloroplast DNA Microsatellite Phylogeographic break Populus rotundifolia Quaternary history Wind direction

Lewis acid-doped transition metal dichalcogenides for ultraviolet–visible photodetectors

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Chinese Physics B 2024年第9期33卷 628-635页

作者： heng yang Mingjun Ma Yongfeng Pei Yufan Kang Jialu Yan Dong He Changzhong Jiang Wenqing Li Xiangheng Xiao School of Physics and Technology Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of EducationWuhan UniversityWuhan 430072China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430072China

Ultraviolet photodetectors(UV PDs)are widely used in civilian,scientific,and military fields due to their high sensitivity and low false alarm *** present a temperature-dependent Lewis acid p-type doping method for transition metal dichalcogenides(TMDs),which can effectively be used to extend the optical response *** p-type doping based on surface charge transfer involves the chemical adsorption of the Lewis acid SnCl_(4)as a light absorption layer on the surface of WS_(2),significantly enhancing its UV photodetection *** 365 nm laser irradiation,WS_(2)PDs exhibit response speed of 24 ms/20 ms,responsivity of 660 mA/W,detectivity of 3.3×10^(11)Jones,and external quantum efficiency of 226%.Moreover,we successfully apply this doping method to other TMDs materials(such as MoS_(2),MoSe_(2),and WSe_(2))and fabricate WS_(2) lateral p–n heterojunction PDs.

关键词： two-dimensional (2D) materials p-type doping transition metal dichalcogenides photodetectors

Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency

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Journal of Integrative Medicine 2024年第1期22卷 72-82页

作者： Jing-shun Meng Yun He heng-bin yang Li-ping Zhou Si-yuan Wang Xi-lin Feng Omar Yahya Al-shargi Xiao-min Yu Li-qing Zhu Chang-quan Ling Shanghai University of Traditional Chinese Medicine Shanghai 201203China Oncology Department of Traditional Chinese Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China Faculty of Traditional Chinese Medicine Naval Medical UniversityShanghai 200043China State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology(Ministry of Education) School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Yantai Fuheng Biological Technology Co. Ltd.YantaiShandong Province 264006China. Department of Clinical Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

Objective Melittin and its derivatives have been characterized to establish effective gene delivery *** capability of facilitating endosomal release enhances the nanoparticles-based gene ***,little investigation has been conducted to explore its potential application in the context of viral *** Various melittin-derived peptides were inserted into the loop VIII of the capsid proteins of recombinant adeno-associated virus *** vectors carrying either gfp or fluc genes were subjected to qPCR assays and transduction assays of HEK293T cells to investigate the efficiency of vector production and gene *** addition,the ability of a specific p5RHH-rAAV vector to deliver genes was examined through in vitro transduction of different cultured cells and in vivo tail vein administration to C57BL/6 ***,the intricate details of the vector-mediated transduction mechanisms were revealed by specific pharmacological inhibitors of every stage of the rAAV2 intracellular life *** A total of 76 melittin-related peptides were compiled from existing *** them,cMA2,Melt13,p5RHH and aAR3 were found to significantly enhance the gene delivery efficiency of rAAV2 *** p5RHH-rAAV2 vectors efficiently transduced not only rAAV-potent cell lines but also cell lines previously considered resistant to ***,bafilomycin A1,a vacuolar endosome acidification inhibitor,completely inhibited the transgene expression mediated by the p5RHH-rAAV2 *** importantly,p5RHH-rAAV8 vectors also demonstrated increased hepatic transduction in vivo in C57BL/6 *** The incorporation of melittin analogues into the rAAV capsids results in a significant improvement in rAAV-mediated transgene *** further modifications remain an area of interest,our studies have substantially broadened the pharmacological prospects of melittin in the context of viral vector-mediated gene delivery.

关键词： Melittin Recombinant adeno-associated virus Capsid engineering Transduction efficiency