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Single-crystalline hole-transporting layers for efficient and stable organic light-emitting devices

light(Science & Applications) 2024年第7期13卷 1341-1353页

作者： Gao-Da Ye Ran Ding Su-heng li Lei Ni Shu-Ting Dai Nian-Ke Chen Yue-Feng liu Runda Guo Lei Wang Xian-Bin li Bin Xu Jing Feng State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin Street130012 ChangchunChina. State Key Laboratory of Supermolecular Structures and Materials The Institute of Theoretical ChemistryJilin University2699 Qianjin Street130012 ChangchunChina. Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology430074 WuhanChina

Efficient charge-carrier injection and transport in organic light-emitting devices(OLEDs)are essential to simultaneously achieving their high efficiency and long-term ***,the charge-transporting layers(CTLs)deposited by various vapor or solution processes are usually in amorphous forms,and their low charge-carrier mobilities,defectinduced high trap densities and inhomogeneous thickness with rough surface morphologies have been obstacles towards high-performance ***,organic single-crystalline(SC)films were employed as the hole-transporting layers(HTLs)instead of the conventional amorphous films to fabricate highly efficient and stable *** highmobility and ultrasmooth morphology of the SC-HTLs facilitate superior interfacial characteristics of both HTL/electrode and HTL/emissive layer interfaces,resulting in a high Haacke’s figure of merit(FoM)of the ultrathin top electrode and low series-resistance joule-heat loss ratio of the ***,the thick and compact SC-HTL can function as a barrier layer against moisture and oxygen *** a result,the SC-OLEDs show much improved efficiency and stability compared to the OLEDs based on amorphous or polycrystalline HTLs,suggesting a new strategy to developing advanced OLEDs with high efficiency and high stability.

关键词： crystalline amorphous charge

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Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome

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World Journal of Diabetes 2024年第4期15卷 724-734页

作者： Gu-Lao Zhang Yuan liu Yan-Feng liu Xian-Tao Huang Yu Tao Zhen-Huan Chen heng-li Lai Department of Cardiology Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330000Jiangxi ProvinceChina

BACKGROUND Diabetic cardiomyopathy(DCM),which is a complication of diabetes,poses a great threat to public *** studies have confirmed the role of NLRP3(NOD-like receptor protein 3)activation in DCM development through the inflammatory *** is an oral hypoglycemic dipeptidyl peptidase-IV inhibitor used to treat *** has recently been reported to have anti-inflammatory and protective effects on myocardial *** To examine the therapeutic effects of teneligliptin on DCM in diabetic *** Streptozotocin was administered to induce diabetes in mice,followed by treatment with 30 mg/kg *** Marked increases in cardiomyocyte area and cardiac hypertrophy indicator heart weight/tibia length reductions in fractional shortening,ejection fraction,and heart rate;increases in creatine kinase-MB(CK-MB),aspartate transaminase(AST),and lactate dehydrogenase(LDH)levels;and upregulated NADPH oxidase 4 were observed in diabetic mice,all of which were significantly reversed by ***,NLRP3 inflammasome activation and increased release of interleukin-1βin diabetic mice were inhibited by *** mouse cardiomyocytes were treated with high glucose(30 mmol/L)with or without teneligliptin(2.5 or 5μM)for 24 ***3 inflammasome *** in CKMB,AST,and LDH levels in glucose-stimulated cardiomyocytes were markedly inhibited by teneligliptin,and AMP(p-adenosine 5‘-monophosphate)-p-AMPK(activated protein kinase)levels were ***,the beneficial effects of teneligliptin on hyperglycaemia-induced cardiomyocytes were abolished by the AMPK signaling inhibitor compound *** Overall,teneligliptin mitigated DCM by mitigating activation of the NLRP3 inflammasome.

关键词： Diabetic cardiomyopathy Teneligliptin NLRP3 AMPK Interleukin-1β

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Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions

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Chinese Journal of Integrative Medicine 2024年第6期30卷 565-576页

作者： KE Jun-yu SONG Jin-bin li Long HE Zhen-fan HUANG Zhuo-jian liU Zheng-lin CHEN Gui-rong WANG Hai-yan WEN Su-ru ZHOU heng-li MA Hui-lin DU Qun WU Yong-qiang li Yan-wu CHEN Xin-lin School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou510006China Department of Surgery II Gaozhou Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineGaozhou525200China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou510405China The First Clinical Medical College of Guangzhou University of Traditional Chinese Medicine Guangzhou510405China

Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these macrophages, it can result in an M1/M2 macrophage activation imbalance, subsequently leading to a loss of control over intestinal inflammation. This shift transforms normal inflammatory responses into pathological damage within the intestines. In patients with ulcerative colitis-associated colorectal cancer (UC-CRC), disorders related to intestinal inflammation are closely correlated with an imbalance in the polarization of intestinal M1/M2 macrophages. Therefore, reinstating the equilibrium in M1/M2 macrophage polarization could potentially serve as an effective approach to the prevention and treatment of UC-CRC. This paper aims to scrutinize the clinical evidence regarding Chinese medicine (CM) in the treatment of UC-CRC, the pivotal role of macrophage polarization in UC-CRC pathogenesis, and the potential mechanisms through which CM regulates macrophage polarization to address UC-CRC. Our objective is to offer fresh perspectives for clinical application, fundamental research, and pharmaceutical advancement in UC-CRC.

关键词： macrophage ulcerative colitis colon cancer Chinese medicine

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Malignant myopericytoma originating from the colon: A case report

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1918-1925页

作者： heng-li Zhang Min Zhang Jing-Qiang Guo Fang-Nan Wu Jin-De Zhu Chao-Yong Tu Xin-liang Lv Kun Zhang Department of General Surgery The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Pathology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Myopericytoma is a benign tumor that typically occurs within subcutaneous tissue and most often involves the distal extremities,followed by the proximal extremities,neck,thoracic vertebrae and oral *** resection is often *** myopericytoma is extremely rare and has a poor ***,we report for the first time a case of malignant myopericytoma originating from the *** SUMMARY A 69-year-old male was admitted to our hospital with right upper quadrant pain for five *** suggested a liver mass with hemorrhage.A malignant hepatic tumor was the initial *** resection was performed after a complete preoperative work *** postoperative pathology suggested that the mass was a malignant myoblastoma unrelated to the *** months after the first surgery,an enhanced computed tomography(CT)scan revealed a recurrence of the *** diagnosis of malignant myopericytoma derived from the colon was confirmed on histopathological examination of the specimen from the second *** patient did not return to the hospital regularly for *** first postoperative abdominal CT examination six months after the second surgery demonstrated multiple liver *** time between the diagnosis of the tumor to death was approximately one *** Malignant myopericytoma is a rare *** diagnosis may be *** to a lack of treatment options,prognosis is poor.

关键词： Malignant myopericytoma liver tumor Colonic neoplasms Abdominal pain

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Ovarian-adnexal reporting and data system ultrasound evaluation and pathological characteristics of ovarian collision tumor

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World Journal of Clinical Cases 2024年第22期12卷 4932-4939页

作者： Chan Yin Yong Wang Zhi-Hui Fei li-Hong Sun Wei-Ai Zhou heng li Department of Ultrasound Hunan University of Arts and Sciences Affiliated Changde Maternal and Child Health HospitalChangde 415000Hunan ProvinceChina Department of Ultrasound People's Hospital of Shimen CountyChangde 415300Hunan ProvinceChina Department of Ultrasound Medicine The Maternal and Child Health Hospital of ChangdeChangde 415000Hunan ProvinceChina Department of Psychology The Maternal and Child Health Hospital of ChangdeChangde 415000Hunan ProvinceChina Department of Gynaecology Hunan University of Arts and Sciences Affiliated Changde Maternal and Child Health HospitalChangde 415000Hunan ProvinceChina Department of Ultrasound The First People's Hospital of ChangdeChangde 415000Hunan ProvinceChina

BACKGROUND Collision tumor are neoplasms,including two histologically distinct tumors that coexist in the same mass without histological *** incidence of collision tumor is low and is rare *** To investigate ultrasound images and application of ovarian-adnexal reporting and data system(O-RADS)to evaluate the risk and pathological characteristics of ovarian collision *** This study retrospectively analyzed 17 cases of ovarian collision tumor diagnosed pathologically from January 2020 to December *** clinical features,ultrasound images and histopathological features were collected and *** O-RADS score was used for *** O-RADS score was determined by two senior doctors in the gynecological ultrasound *** with O-RADS score of 1-3 were classified as benign tumors,and lesions with O-RADS score of 4 or 5 were classified as malignant *** There were 17 collision tumors detected in 16 of 6274 patients who underwent gynecological *** average age of 17 women with ovarian collision tumor was 36.7 years(range 20-68 years),in whom,one occurred bilaterally and the rest occurred *** average tumor diameter was 10 cm,of which three were 2-5 cm,11 were 5-10 cm,and three were>10 ***(29.4%)tumors with O-RADS score 3 were endometriotic cysts with fibroma/serous cystadenoma,and unilocular or multilocular cysts contained a small number of parenchymal ***(64.7%)tumors had an O-RADS score of 4,including two in category 4A,six in category 4B,and three in category 4C;all of which were multilocular cystic tumors with solid components or multiple papillary ***(5.9%)tumor had an O-RADS score of *** case was a solid mass,and a small amount of pelvic effusion was detected under *** pathology was high-grade serous cystic cancer combined with cystic mature *** were nine(52.9%)tumors with elevated serum carbohydrate antigen(CA)125 and two(11.8%)with

关键词： Ovarian collision tumor Ovarian-adnexal reporting and data system Epithelial tumor Serous cystadenoma Ultrasound images

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胎儿炎症反应综合征和早产儿肺疾病

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中华实用儿科临床杂志 2024年第9期39卷 718-720页

作者：刘丹丹李恒冯梦婷徐巍吉林大学第一医院新生儿科长春

胎儿炎症反应综合征(FIRS)是一种以全身炎症反应和胎儿血浆白细胞介素-6水平升高为特征的疾病, 常导致早产及全身多系统损伤, 造成新生儿发病率、死亡率升高。累及肺部可导致新生儿呼吸窘迫综合征和支气管肺发育不良。现就其发病机制及... 详细信息

胎儿炎症反应综合征(FIRS)是一种以全身炎症反应和胎儿血浆白细胞介素-6水平升高为特征的疾病, 常导致早产及全身多系统损伤, 造成新生儿发病率、死亡率升高。累及肺部可导致新生儿呼吸窘迫综合征和支气管肺发育不良。现就其发病机制及对肺部疾病的影响进行综述, 以期引起临床医师的关注, 并为探究有效的预防和治疗措施提供方向。

关键词：胎儿炎症反应综合征婴儿, 早产呼吸窘迫综合征支气管肺发育不良

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高超声速飞行器流场电磁场松耦合数值模拟

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力学学报 2024年第6期56卷 1678-1687页

作者：李恒王斌叶柳青李凯金科西安电子科技大学空间科学与技术学院西安710126 西安电子科技大学广州研究院广州510555 西安电子科技大学应用力学中心西安710126 极端环境下装备效能教育部重点实验室西安710126

在高超声速再入式飞行器通信黑障问题众多解决方案中,电磁调控方法是最具可行性的方法之一.一个细致可靠的电磁调控方案不仅需要准确考虑外加电磁场对导电流体作用,还需要考虑因流体高速运动产生的感生电磁场对导电流体的作用.对于高超... 详细信息

在高超声速再入式飞行器通信黑障问题众多解决方案中,电磁调控方法是最具可行性的方法之一.一个细致可靠的电磁调控方案不仅需要准确考虑外加电磁场对导电流体作用,还需要考虑因流体高速运动产生的感生电磁场对导电流体的作用.对于高超声速飞行器典型飞行状态,全磁流体力学方法因数值刚性问题很难直接用于流场和电磁场耦合模拟,而低磁雷诺数近似方法无法考虑感生磁场对导电流体作用.针对磁流体力学两种经典方法应用于高超声速飞行器电磁调控方案设计时存在的困难和不足,文章在数值求解流动控制方程N-S方程和电磁控制方程双曲Maxwell方程的基础上,将两者结合起来松耦合迭代求解,建立适用于高超声速飞行器流场和电磁耦合的数值模拟方法.通过磁流体激波反射和二维超声速磁流体喷管两个典型算例,对文章的数值方法进行验证.基于数值方法对外加偶极子磁场作用下某高超声速飞行器典型飞行状态下流场电磁耦合问题进行了研究,数值模拟结果表明,磁雷诺数为0.7557时,不考虑感生磁场对流体运动影响时激波脱体距离相对于考虑感生磁场作用时大11.11%,此误差已不容忽视,对于该飞行状态,应完整考虑流场和磁场相互作用而不是仅考虑外加磁场对流场运动影响.

关键词：磁流体动力学 N-S方程 Maxwell方程数值模拟感生磁场松耦合

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Spatially resolved transcriptomic profiling of placental development in dairy cow

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Zoological Research 2024年第3期45卷 586-600页

作者： Guang-Hui Tan Shi-Jie liu Ming-Le Dou De-Feng Zhao Ao Zhang heng-Kuan li Fu-Nong Luo Tao Shi Hao-Ping Wang Jing-Yuan Lei Yong Zhang Yu Jiang Yi Zheng Fei Wang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Animal Biotechnology of the Ministry of Agriculture Northwest A&F UniversityYanglingShaanxi 712100China College of Information Engineering Northwest A&F UniversityYanglingShaanxi 712100China

The placenta plays a crucial role in successful mammalian *** animals possess a semi-invasive placenta characterized by a highly vascularized structure formed by maternal endometrial caruncles and fetal placental cotyledons,essential for full-term fetal *** cow placenta harbors at least two trophoblast cell populations:uninucleate(UNC)and binucleate(BNC)***,the limited capacity to elucidate the transcriptomic dynamics of the placental natural environment has resulted in a poor understanding of both the molecular and cellular interactions between trophoblast cells and niches,and the molecular mechanisms governing trophoblast differentiation and *** fill this knowledge gap,we employed Stereo-seq to map spatial gene expression patterns at near single-cell resolution in the cow placenta at 90 and 130 days of gestation,attaining high-resolution,spatially resolved gene expression *** on clustering and cell marker gene expression analyses,key transcription factors,including YBX1 and NPAS2,were shown to regulate the heterogeneity of trophoblast cell *** communication and trajectory analysis provided a framework for understanding cell-cell interactions and the differentiation of trophoblasts into BNCs in the placental *** analysis of cell trajectories identified a set of genes involved in regulation of trophoblast ***,spatial modules and co-variant genes that help shape specific tissue structures were ***,these findings provide foundational insights into important biological pathways critical to the placental development and function in cows.

关键词： Spatial transcriptomics Dairy cow Placenta Gestation

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金融空间关联网络的平衡发展效应——基于网络节点中心性视角

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财经科学 2024年第1期 33-46页

作者：李恒殷志高河南大学经济学院

基于城市网络视角探讨金融发展对经济增长和经济差距的影响,对完善金融有效支持实体经济体制机制、推动区域经济平衡发展具有重要参考价值。本文使用2011—2020年中国284个地级以上城市数据,实证检验金融空间关联网络的平衡发展效应。... 详细信息

基于城市网络视角探讨金融发展对经济增长和经济差距的影响,对完善金融有效支持实体经济体制机制、推动区域经济平衡发展具有重要参考价值。本文使用2011—2020年中国284个地级以上城市数据,实证检验金融空间关联网络的平衡发展效应。研究表明,金融网络中心性能够促进城市经济增长、缩小城市经济差距,有利于推动经济平衡发展。地理区位和城市群类型差异会诱致金融网络中心性的平衡发展效应产生异质性,具体表现为对东部地区和核心城市群地区的影响更为明显。在宏观层面,金融网络中心性能够通过增强城市经济韧性和市场潜能缩小城市经济差距,而企业进入和企业成长则是金融网络中心性推动城市经济平衡发展的重要微观基础。进一步分析发现,金融网络中心性会缩小城市内部差距和南北地区差距,但并不利于城乡之间的经济平衡发展。

关键词：金融空间关联网络节点中心性城市经济差距区域平衡发展

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手术物品清点环节护理中断事件的危险因素分析

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中华护理教育 2024年第5期21卷 574-579页

作者：郭栋付秀荣李恒山西医科大学护理学院太原市030000

目的调查与分析手术物品清点环节护理中断事件的现状及危险因素,为提出针对性的防范措施提供参考。方法通过便利抽样法,选取2022年6月—10月山西省某三级甲等综合医院的手术进行观察,采用自行编制的手术物品清点环节护理中断事件调查表... 详细信息

目的调查与分析手术物品清点环节护理中断事件的现状及危险因素,为提出针对性的防范措施提供参考。方法通过便利抽样法,选取2022年6月—10月山西省某三级甲等综合医院的手术进行观察,采用自行编制的手术物品清点环节护理中断事件调查表进行数据收集,分析手术物品清点环节护理中断事件的危险因素。结果最终观察了385台手术,其中244台(63.4%)的手术物品清点环节发生护理中断事件。Logistic回归分析显示,外科医生数量、手术时间、多外科联合手术、急诊手术、巡回护士工作年限和器械护士学历是手术物品清点环节发生护理中断事件的危险因素。结论手术物品清点环节受到多种危险因素的影响,早期识别并评估这些因素有助于早期干预护理中断事件,保证患者安全。

关键词：手术室护理安全管理物品清点护理中断危险因素

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