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Presepsin and Procalcitonin as Potential Biomarkers for Early Diagnosis and Prognosis of Sepsis in Critically Ill Patients

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Open Journal of Medical Microbiology 2021年第3期11卷 267-281页

作者： Reham Sabry hend maghraby maghraby Amany Mohamed Abd Allah Clinical Pathology Department Faculty of Medicine for Girls Al-Azhar University Cairo Egypt Internal Medicine Department Faculty of Medicine for Girls Al-Azhar University Cairo Egypt

Background: Sepsis has a poor prognosis for critically ill patients, even with intensive management. Early diagnosis of sepsis and detection of patients with worsening prognosis are important for immediate intervention to improve the clinical outcome. Objective: To investigate serum presepsin (PS) and procalcitonin (PCT) as early diagnostic and prognostic biomarkers for sepsis in critically ill patients. Methods: 60 critically ill patients with sepsis were subdivided into three groups of sepsis, severe sepsis and septic shock according to Acute Physiology and Chronic Health Evaluation II (APACHEII) and quick Sequential Organ Failure Assessment (qSOFA) scores. Patients were compared with 20 age and sex matched controls. Serum PS and PCT were measured by enzyme linked immunosorbent assay (ELISA). Results: Serum PS and PCT levels were significantly increased in septic patients than controls, and their increase was positively correlated with progression of sepsis severity till reached the highest levels in septic shock. Receiver operating characteristic (ROC) curve for predicting sepsis revealed that PS has the highest area under curve (AUC) (0.967) with 97.5% sensitivity, 85% specificity and cut-off of >635.5

关键词： Sepsis Septic Shock Diagnosis Presepsin Procalcitonin

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Presepsin and Procalcitonin as Potential Biomarkers for Early Diagnosis and Prognosis of Sepsis in Critically Ill Patients

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Open Journal of Medical Microbiology（医学微生物学） 2021年第3期

作者： Reham Sabry hend maghraby maghraby Amany Mohamed Abd Allah

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