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Evaluation of Angiopoietin-2 Serum Level as a Marker of Cardiovascular Risk in Children with Chronic Kidney Disease

Open Journal of Nephrology 2015年第4期5卷 105-116页

作者： Manal Abdel-Salam Asmaa Abd EL Wakeel Soheir Ibrahim Tagreed Abdel-Rahman hend ezzat Randa Sabour Department of Pediatrics Faculty of Medicine Al-Azhar University Cairo Egypt Department of Cardiology Faculty of Medicine Al-Azhar University Cairo Egypt Department of Clinical Pathology Faculty of Medicine Al-Azhar University Cairo Egypt Department of Radiology Faculty of Medicine Al-Azhar University Cairo Egypt

Background: Cardiovascular complications are a major clinical problem in uremic patients accounting for 44% of all deaths in this population. Angiopoietin cytokines are involved with controlling micro vascular permeability, vasodilatation and vasoconstriction by signaling smooth muscle cells surrounding vessels. Aim: To assess Angiopoietin-2 serum level as an early marker of cardiovascular risks in children with chronic kidney disease on regular hemodialysis and correlate with intimal medial thickness and echo data in those children. Patients and methods: The study included 40 children with CKD on regular hemodialysis (HD), and they were selected from the hemodialysis unit of Al-Zahraa Hospital, Al-Azhar University, during the period from December 2014 to April 2015. Another group of 40 apparently healthy children, matches age and sex with patients group as a controls. Angiopoietin-2 serum level, Doppler ultrasound (U/S) to assess: intima-media thickness (IMT) and the peak systolic velocity (PSV) of the main arteries including the (aorta, carotid and femoral) arteries, conventional echo and tissue Doppler imaging (TDI) of mitral and tricuspid annular velocities are obtained for both groups. Results: Children on regular HD have significantly higher (Angiopoietin-2) serum level compared to their controls, and it is (161.35 ± 38.30 ng/ml) and (9.25 ± 12.64 ng/ml) respectively (p, 0.000) and increases in the aorta, carotid and femoral (IMT) with significant increase in their mean systolic velocities in patients group compared to the controls. Significant increase in tricuspid valve late diastolic velocity (TVA vel m/s) and (E/e’ ratio) obtained by (TDI), its abnormalities threshold is detected in patients group than controls, with significant increase right ventricular systolic pulmonary pressure in patients compared to the controls. Conclusions: Higher prevalence of right ventricular dysfunction is detected by conventional and TDI echo in children on hemodialysis. Angi

关键词： Chronic Kidney Disease Angiopoietin-2 Intima-Medial Thickness

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Impact of lifestyle interventions on pathogenesis of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第20期30卷 2633-2637页

作者： Wafaa Mohamed ezzat Department of Internal Medicine Medical Research and Clinical Studies InstituteNational Research CenterGiza 12311Egypt

This editorial builds on the article titled“Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease”by Zeng et *** carried out a critical examination of nonalcoholic fatty liver disease(NAFLD)pathogenesis and how lifestyle interventions could facilitate disease resolution,particularly highlighting that non-alcoholic steatohepatitis(NASH)is a severe form of *** discussion details that weight loss is a pivotal factor in disease outcomes:A 3%-5%reduction is enough for resolution in 50%of non-obese individuals,while a 7%-10%reduction achieves similar benefits in obese individuals,as demonstrated by magnetic resonance ***,the editorial underscores that such lifestyle changes are instrumental not only in resolving NAFLD but also in reversing hepatic steatosis and *** insights,derived from the research,emphasize the critical role of personalized lifestyle modifications in halting the progression of NAFLD to NASH and even reversing fibrosis,thus offering a template for effective patient management.

关键词： Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Diet Physical activity Life style

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Portal vein tumor thrombosis in hepatocellular carcinoma patients: Is it the end?

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Liver Research 2024年第3期8卷 141-151页

作者： Walaa Abdelhamed hend Shousha Mohamed El-Kassas Endemic Medicine Department Sohag UniversitySohagEgypt Endemic Medicine Department Faculty of MedicineCairo UniversityCairoEgypt Endemic Medicine Department Faculty of MedicineHelwan UniversityCairoEgypt Liver Disease Research Center College of MedicineKing Saud UniversityRiyadhSaudi Arabia

Hepatocellular carcinoma(HCC)is the sixth most prevalent form of cancer globally and the third leading cause of cancer-related *** incidence of portal vein tumor thrombosis(PVTT)in HCC patients is 21%at one year and 46%at three *** presence of PVTT has consistently been associated with a poor prognosis for HCC patients over the past ***,HCC prognosis is influenced not only by the presence of PVTT but also by the degree or extent of ***,there is a lack of global consensus or established protocols regarding the optimal management of HCC with associated *** Barcelona Clinic for Liver Cancer classifies HCC patients with PVTT as stage C,indicating an advanced stage,and limiting treatment recommendations for these patients to systemic *** recent years,there has been an increase in the availability of therapeutic options for HCC patients with *** modalities include systemic therapy,transarterial chemoembolization,surgical resection,stereotactic body radiotherapy,transarterial radioembolization,and liver *** ideal therapy for each patient necessitates a multidisciplinary *** review article presents the latest updates in managing HCC patients with PVTT.

关键词： Hepatocellular carcinoma(HCC) Portal vein tumor thrombosis(PVTT) Staging Systemic therapies Locoregional treatment Immunotherapy

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Smart Healthcare Activity Recognition Using Statistical Regression and Intelligent Learning

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Computers, Materials & Continua 2024年第1期78卷 1189-1205页

作者： K.Akilandeswari Nithya Rekha Sivakumar hend Khalid Alkahtani Shakila Basheer Sara Abdelwahab Ghorashi Department of Computer Sciences Government Arts College(Autonomous)Salem636007India Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Information Systems College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11671Saudi Arabia

In this present time,Human Activity Recognition(HAR)has been of considerable aid in the case of health monitoring and *** exploitation of machine learning with an intelligent agent in the area of health informatics gathered using HAR augments the decision-making quality and *** many research works conducted on Smart Healthcare Monitoring,there remain a certain number of pitfalls such as time,overhead,and falsification involved during ***,this paper proposes a Statistical Partial Regression and Support Vector Intelligent Agent Learning(SPR-SVIAL)for Smart Healthcare *** first,the Statistical Partial Regression Feature Extraction model is used for data preprocessing along with the dimensionality-reduced features extraction ***,the input dataset the continuous beat-to-beat heart data,triaxial accelerometer data,and psychological characteristics were acquired from IoT wearable *** attain highly accurate Smart Healthcare Monitoring with less time,Partial Least Square helps extract the dimensionality-reduced *** that,with these resulting features,SVIAL is proposed for Smart Healthcare Monitoring with the help of Machine Learning and Intelligent Agents to minimize both analysis falsification and *** evaluation is carried out for factors such as time,overhead,and false positive rate accuracy concerning several *** quantitatively analyzed results indicate the better performance of our proposed SPR-SVIAL method when compared with two state-of-the-art methods.

关键词： Internet of Things smart health care monitoring human activity recognition intelligent agent learning statistical partial regression support vector

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Surface activation of viscose textiles via air,argon,and oxygen dielectric barrier discharge plasma:influence of peak voltage

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Plasma Science and Technology 2024年第7期26卷 134-147页

作者： Shrouk ELASHRY Usama M.RASHED Mostafa A.WAHBA hend M.AHMED Nabil M.ELSIRAGY Plasma Laboratory Physics DepartmentFaculty of scienceTanta UniversityTanta 31527Egypt Physics Department Faculty of Science(Male)Al-Azhar UniversityCairo 11651Egypt Textile Research Industrial Division National Research CentreDokkiGiza 12622Egypt

This paper discusses the use of atmospheric pressure dielectric barrier discharge(DBD)plasma treatment to enhance the surface qualities of viscose *** study explores the effects of different plasma gases,discharge voltages,and exposure times on the treated *** findings emphasize the importance of optimizing the plasma's peak voltage to achieve the desired surface treatment *** document also presents data on colour strength,wettability,colour fastness,and tensile strength of the treated fabrics,as well as scanning electron microscopy(SEM)analysis of surface morphology and chemical analysis using fouriertransition infrared spectroscopy(FTIR)and energy dispersive X-ray(EDX).The results show that treatment at a peak voltage of 11.83 k V is more efficient,except for the tensile strength which is enhanced at a peak voltage of 8.92 k *** oxygen plasma treatment significantly improves the colour strength,which exhibits an increase from 11 to *** intensified colour was attributed to the significant influence of electrostatic interactions between the charged hydroxyl groups of the oxygen plasma treated viscose textiles and the dye molecules,which enhance the *** oxygen DBD plasma exhibits a higher ability to enhance the properties of textiles when compared to air and argon *** study presents a sustainable,economical,secure,and ecologically friendly approach to explore new fabrics for specific uses.

关键词： Lissajous diagrams printability wettability tensile strength SEM EDX FTIR

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Particle Swarm Optimization-Based Hyperparameters Tuning of Machine Learning Models for Big COVID-19 Data Analysis

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Journal of Computer and Communications 2024年第3期12卷 160-183页

作者： hend S. Salem Mohamed A. Mead Ghada S. El-Taweel Department of Computer Sciences Suez Canal University Ismailia Egypt

Analyzing big data, especially medical data, helps to provide good health care to patients and face the risks of death. The COVID-19 pandemic has had a significant impact on public health worldwide, emphasizing the need for effective risk prediction models. Machine learning (ML) techniques have shown promise in analyzing complex data patterns and predicting disease outcomes. The accuracy of these techniques is greatly affected by changing their parameters. Hyperparameter optimization plays a crucial role in improving model performance. In this work, the Particle Swarm Optimization (PSO) algorithm was used to effectively search the hyperparameter space and improve the predictive power of the machine learning models by identifying the optimal hyperparameters that can provide the highest accuracy. A dataset with a variety of clinical and epidemiological characteristics linked to COVID-19 cases was used in this study. Various machine learning models, including Random Forests, Decision Trees, Support Vector Machines, and Neural Networks, were utilized to capture the complex relationships present in the data. To evaluate the predictive performance of the models, the accuracy metric was employed. The experimental findings showed that the suggested method of estimating COVID-19 risk is effective. When compared to baseline models, the optimized machine learning models performed better and produced better results.

关键词： Big COVID-19 Data Machine Learning Hyperparameter Optimization Particle Swarm Optimization Computational Intelligence

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恶嗪N-稠合咪唑-2-硫酮合成的机理研究:添加剂和溶剂的作用（英文）

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分子科学学报 2024年第3期40卷 256-266页

作者： MOHAMED hend 袁海艳张景萍东北师范大学化学学院

采用密度泛函理论计算了在无催化剂协助、水协助、三氟乙酸（TFA）协助条件下，2,2-二羟基-1-苯乙酮（1）,（2-氨基苯）甲醇（2）和KSCN（3）合成3-苯基-2,5-二氢-1-氢-苯并[d]咪唑并[5,1-b][1,3]恶嗪-1-硫酮的反应机理。计算结果表明，... 详细信息

采用密度泛函理论计算了在无催化剂协助、水协助、三氟乙酸（TFA）协助条件下，2,2-二羟基-1-苯乙酮（1）,（2-氨基苯）甲醇（2）和KSCN（3）合成3-苯基-2,5-二氢-1-氢-苯并[d]咪唑并[5,1-b][1,3]恶嗪-1-硫酮的反应机理。计算结果表明，TFA、水和底物2可以改变和促进该反应。基于底物不同的反应顺序共探究了3种机理M1（1+2然后与3反应）、M2（1+3然后与2反应）和M3（2+3然后与1反应）,并发现底物2的亲核性强于底物3。计算表明TFA-水共同协助机理M1的路径最优，决速步是[3+2]环加成过程。TFA和水分子在整个反应中起着至关重要的作用，通过N—H…O,O—H…O及C—H…O相互作用来稳定过渡态和中间体的结构。它们还作为氢键（HBs）给体和受体，通过改变乙二醛-水合物和KSCN的反应形式来提高底物的反应活性。底物2作为HBs受体促进了烯醇-酮互变异构和质子转移过程。进一步发现该反应可以用水替换CH3CN,为合成绿色恶嗪杂环类化合物提供了新的方案。

关键词：密度泛函理论反应机理添加剂和溶剂多组分反应

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Fractional thermoelasticity applications for porous asphaltic materials

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Petroleum Science 2016年第3期13卷 550-560页

作者： Magdy ezzat Shereen ezzat Department of Mathematics Faculty of Science and Letters in Al Bukayriyyah Al-Qassim University Faculty of Education Alexandria University

A new mathematical model of poro-thermoelasticity has been constructed in the context of a new consideration of heat conduction with fractional ***-dimensional application for a poroelastic half-space saturated with fluid is *** surface of the halfspace is assumed to be traction-free,permeable,and subjected to *** Laplace transform technique is used to solve the *** inversion of the Laplace transform will be obtained numerically and the numerical values of the temperature,stresses,strains,and displacements will be illustrated graphically for the solid and the liquid.

关键词： Generalized thermo-poroelasticity Asphaltic material Thermal shock Fractional calculus Numerical results

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A critical review of microbially induced carbonate precipitation for soil stabilization:The global experiences and future prospective

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Pedosphere 2023年第5期33卷 717-730页

作者： Safaa M.ezzat Microbiology Department Central Laboratory for Environmental Quality Monitoring(CLEQM)National Water Research Center(NWRC)El-Kanater 13621/6Egypt

Microbially induced carbonate precipitation(MICP)is a new technology having the potential to induce soil stabilization and provide a green and sustainable comprehensive solution to some geotechnical engineering problems in the *** present article is dedicated to present a critical review of this technology and discuss its mechanisms of action and the key factors influencing its *** global experiences and national participation from Egypt are demonstrated,in addition to attempts for real life *** review provides an insight into the practical steps taken to mitigate some of the current limitations of MICP application and the identified gaps in analogous *** was concluded that integrating MICP with existing technologies would favor both engineering needs and market *** addition,providing effective solutions to MICP limitations would highlight this technology as an eco-friendly and cost-effective option to several engineering ***,recommendations focused on encouraging global collaboration for knowledge transfer about this technology among different countries,as well as positive financial support from industrial entities to aid in the progress of scientific research and achieving large-scale applications in the near future,are provided.

关键词： biocementation calcite geotechnical engineering urease activity ureolytic bacteria

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Practical approach to linear endoscopic ultrasound examination of the gallbladder

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World Journal of Radiology 2024年第6期16卷 184-195页

作者： Hussein Hassan Okasha Eyad Gadour Hassan Atalla Omar AbdAllah AbdEl-Hameed Reem ezzat Ahmed Elsayed Alzamzamy Elsayed Ghoneem Rasha Ahmad Matar Zeinab Hassan Bogdan Miutescu Ayman Qawasmi Katarzyna M Pawlak Ahmed Elmeligui Department of Internal Medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt Department of Gastroenterology and Hepatology King Abdulaziz Hospital-National GuardAhsa 31982Saudi Arabia Department of Medicine School of MedicineZamzam University CollegeKhartoum 11113Sudan Department of Internal Medicine Hepatology and Gastroenterology UnitFaculty of MedicineMansoura UniversityMansoura 35516Egypt Department of Internal Medicine Faculty of MedicineAssiut UniversityAssiut 71511Egypt Department of Gastroenterology and Heptology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11728Egypt Department of Gastroenterology and Advance Endoscopy Sultant Qaboos Comprehensive Cancer Care and Research CentreMuscat 0961Oman Department of Internal Medicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom Department of Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional Research Centre in Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 30041Romania Department of Gastroenterology Al-Makassed Islamic Charitable Society HospitalCairo 11124Egypt Division of Gastroenterology St.Michael’s HospitalUniversity of TorontoToronto M5B 1W8Canada Department of Gastroenterology Southend University HospitalEssex SS26XTUnited Kingdom

The gallbladder(GB)is a susceptible organ,prone to various pathologies that can be identified using different imaging *** ultrasound(TUS)is typically the initial diagnostic method due to its numerous well-established ***,in cases of uncertainty or when a definitive diagnosis cannot be established,computed tomography(CT)or magnetic resonance imaging may be employed to provide more detailed ***,CT scans may sometimes offer inadequate spatial resolution,which can limit the differentiation of GB lesions,particularly when smaller yet clinically relevant abnormalities are ***,endoscopic ultrasound(EUS)provides higher frequency compared to TUS,superior spatial resolution,and the option for contrast-enhanced harmonic imaging,enabling a more comprehensive ***,EUS can serve as a supplementary tool when conventional imaging methods are *** review will describe the standard EUS examination of the GB,focusing on its endosonographic characteristics in various GB path-ologies.

关键词： Endoscopic ultrasound Linear endoscopic ultrasound Gallbladder anatomy Gallbladder pathologies Therapeutic endoscopic ultrasound

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