检索结果-南通市图书馆

Insights on Blood Cytokines Production under Different <i>In Vitro</i>Mycobacterial Antigens in Tuberculosis Intestinal Parasites Co Infected Patients

引用

Advances in Microbiology 2018年第3期8卷 161-174页

作者： Renan Jeremias da Silva Fernanda C. Q. Mello Janaína A. Leung Antonio Henrique Almeida de Moraes Neto Leila de Souza Fonseca helio ribeiro de siqueira Health Care Victor Vala and CSEGSF Team Maria Helena Féres Saad Laboratory of Cellular Microbiology Oswaldo Cruz Institute (IOC) Fiocruz Rio de Janeiro Brazil Federal University of Rio de Janeiro Clementino Fraga Filho Hospital Rio de Janeiro RJ Brazil Laboratory of Innovations in Therapies Teaching and Bioproducts Oswaldo Cruz Institute (IOC) Fiocruz Rio de Janeiro Brazil Rio de Janeiro State University Pedro Ernesto Hospital Rio de Janeiro Brazil Victor Vala Family Clinic and Health Care-School Germano Silval Farias (CSEGSF) ENSP/Fiocruz Rio de Janeiro Brazil

Background: The concomitant presence of intestinal parasite infections (IP) and tuberculosis (TB) has relevance. M. tuberculosis immune response is associated with type 1 T helper cell (Th1) while IP is associated with type Th2 cell. However, there are several contradictory reports on cytokine production under coinfection and this could be in association to the mycobacterial antigens used in the studies. Aim: To get insight into the effects of different M. tuberculosis-specific antigens (ESAT-6/CFP-10 and 38 kDa/CFP-10) in generating of appropriate cytokines on peripheral blood mononuclear cells of IPTB co infected patients. Method: ELISA assessed IFN-γ and other 16 cytokines production and plasm IgE. In 18 months, we documented demographic, economic, clinical characteristics and IP frequency in individuals from Brazil. Results: An overall 10/35 (28.5%) were IPTB co infected and 40/76 (52.6%;p = 0.024) asymptomatic intestinal parasite infected community controls (IPCC). Endo-limax nana (40%) and Entamoeba coli (22%), were the most nonpathogenic protozoan identified and Entamoeba histolytica, Giardia intestinalis, Ascaris lumbricoides and Strongyloides stercoralis were the pathogenic species (40%). IgE was higher in IPCC (p = 0.036). Cytokine profiles were significantly biased toward a Th2 type IL-5 (p = 0.001) and IL-13 (p = 0.033), pro-inflammatory GM-CSF (p = 0.019) and borderline lower IL-1β in IPTB, all associated with ESAT-6/CFP-10, while IL-7 was borderline lower, but 38 kDa/CFP-10 associated;as well as IL-8 higher (p dent IPTB coinfection did not exert a significant inhibitory effect in IFN-γ production in response to either of the two antigens, but the partial discrepancy in Th1/Th2 response, is associated with the antigen priming cells.

关键词： Mycobacterium tuberculosis Intestinal Parasites Mycobacterial Antigens IgE Cytokines

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multidimensional Projections for Visual Analysis of Social Networks

引用

Journal of Computer Science & Technology 2012年第4期27卷 791-810页

作者： Rafael Messias Martins Gabriel Faria Andery Henry Heberle Fernando Vieira Paulovich Alneu de Andrade Lopes helio Pedrini Rosane Minghim Institute of Mathematics and Computer Science University of Sao PauloSao Carlos 13566-590Brazil CPM Braxis Capgemini Sao Paulo 04543-900Brazil Institute of Computing University of CampinasCampinas-SP 13083-852Brazil

Visual analysis of social networks is usually based on graph drawing algorithms and tools. However, social networks are a special kind of graph in the sense that interpretation of displayed relationships is heavily dependent on context. Context, in its turn, is given by attributes associated with graph elements, such as individual nodes, edges, and groups of edges, as well as by the nature of the connections between individuals. In most systems, attributes of individuals and communities are not taken into consideration during graph layout, except to derive weights for force-based placement strategies. This paper proposes a set of novel tools for displaying and exploring social networks based on attribute and connectivity mappings. These properties are employed to layout nodes on the plane via multidimensional projection techniques. For the attribute mapping, we show that node proximity in the layout corresponds to similarity in atgribute, leading to easiness in locating similar groups of nodes. The projection based on connectivity yields an initial placement that forgoes force-based or graph analysis algorithm, reaching a meaningful layout in one pass. When a force algorithm is then applied to this initial mapping, the final layout presents better properties than conventional force-based approaches. Numerical evaluations show a number of advantages of pre-mapping points via projections. User evaluation demonstrates that these tools promote ease of manipulation as well as fast identification of concepts and associations which cannot be easily expressed by conventional graph visualization alone. In order to allow better space usage for complex networks, a graph mapping on the surface of a sphere is also implemented.

关键词： social network visual exploration multidimensional visualization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts

引用

Journal of Animal Science and Biotechnology 2012年第1期3卷 25-31页

作者： Helena Emilia CCC Manso helio C Manso Filho Luiz E de Carvalho Marianne Kutschenko Eduardo T Nogueira Malcolm Watford department of Animal Sciences Rural Federal University of PernambucoRecifePE52171-900Brazil departament of Animal Sciences Federal University of CearáFortalezaCE60020-181Brazil Ajinomoto do Brazil S oPauloSP04015-001Brazil department of Nutritional Sciences Rutgers UniversityNew BrunswickNJ08901USA.

Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine. A number of recent studies have indicated that lactation is accompanied by a mild catabolic state in which skeletal muscle proteins are degraded to provide amino acids that are used to synthesize additional glutamine. In this study we tested the hypothesis that supplemental L-glutamine or the commercially available glutamine supplement Aminogut （2.5% by weight mixed into daily feed） provided to gilts from 30 days prior to parturition until 21 days post-parturition would prevent a decrease in skeletal muscle glutamine while increasing the glutamine content of the milk. Muscle glutamine content decreased （P 〈 0.05） in control animals during lactation but this was prevented by supplementation with either L-glutamine or Aminogut. In this study, neither lactation nor supplementation had any effect on plasma glutamine or glutamate content. Free glutamine, and the total glutamine plus glutamate concentrations in milk from the control and the Aminogut group rose （P 〈 0.05） during the first 7 days of lactation, with milk concentrations in the L-glutamine supplemented group showing a similar trend （P = 0.053）. Milk glutamate remained constant between day 7 and 21 of lactation in the control and L-glutamine supplemented groups, but by day 21 of lactation the free glutamine, glutamate, and glutamine plus glutamate concentrations in milk from Aminogut-treated gilts were higher than those of control gilts. Thus dietary glutamine supplementation can alleviate the fall in intramuscular glutamine content during lactation in gilts, and may alleviate some of the catabolic effects of lactation. Furthermore, the increased milk glutamine content in the supplemented gilts may provide optimum nutrition for piglet development.

关键词： glutamate glutamine lactation milk pig skeletal muscle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical Research of the Viscoelastic Behavior of Shale Gas Rock and Its Influence on Fracturing

Numerical Research of the Viscoelastic Behavior of Shale Gas...

引用

作者： helio Mahesso（海力）中国石油大学(北京)

学位级别：硕士

Over the past decade,the combination of horizontal drilling and hydraulic fracturing has allowed access to large volumes of shale gas that were previously uneconomical to *** productivity of shale reservoir is highly dependent on the design of hydraulic fracturing *** order to successfully design the treatment,a good understanding of the shale mechanical properties is *** thesis purposes that proppant embedment can be divided into two mechanisms,elastic deformation and creep *** proppant particle has a negligible size in comparison with propped fracture ***,in this thesis,we consider that the load distributed over a part of the boundary of a semiinfinite solid may describe the *** developed a new model to perform a numerical parametric sensitivity analysis of proppant embedment into the shale reservoir rock by combining simplified physical process with elastic *** also develop an analytical model to estimate proppant embedment depth for a given conditions,making clear which factor is more important in embedding and improving understanding of the *** to the results of analysis in this thesis,in shale formation,creep deformation of shale gas reservoir rock and proppant embedment are obvious during long term production stage and it may leads to the fracture ***,there will not be a fracture which sustain fracture width ***,in soft formation like shale,propped fracture may heal due to *** means re-frac is required after a period of production if the operators wants to maintain the production *** mechanisms described in this thesis provide a new understanding about *** provides us a tool to determine how much the degree will be.

关键词：

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Automatic detection and evaluation of sugarcane planting rows in aerial images

引用

Information Processing in Agriculture 2023年第3期10卷 400-415页

作者： Bruno Moraes Rocha Afonso Ueslei da Fonseca helio Pedrini Fabrızzio Soares Instituto de Informa´tica Universidade Federal de Goia´sGoiaˆnia 74690-900GOBrazil Institute of Computing University of CampinasCampinas 13083-852SPBrazil

Sugarcane planting is an important and growing activity in ***,several techniques have been developed over the years to maximize crop productivity and profit,amongst them,processing of sugarcane field *** this sense,this research aims to identify and analyze crop rows and measure their gaps from aerial images of sugarcane *** this,a small Remotely Piloted Aircraft captured the images,generating orthomosaics of the areas for ***,each orthomosaic is classified with the K-Nearest Neighbor algorithm to segment regions of *** row orientation is estimated using the RGB gradient *** operations and computational geometry models are then used to detect and map rows and gaps along the planting row *** evaluate the results,crop rows are mapped and compared to manually taken *** technique obtained an error smaller than 2%when compared to gap length in crop rows from an orthomosaic with the area of 8.05 ha(ha).The proposed approach can map the positioning of the automatically generated row segments appropriately onto manually created ***,our method also achieved similar results when confronted with a manual technique for differing growth stages(40 and 80 days after harvest)of the sugarcane *** proposed method presents a great potential to be adopted in sugarcane planting monitoring。

关键词： Sugarcane Planting Rows Aerial Images Remotely Piloted Aircraft

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimizing Nitrogen Use Efficiency for No-Till Corn Production by Improving Root Growth and Capturing NO_(3)-N in Subsoil

引用

Pedosphere 2016年第4期26卷 474-485页

作者： Eduardo F. CAIRES Renato ZARDO FILHO Gabriel BARTH helio A. W. JORIS department of Soil Science and Agricultural Engineering State University of Ponta Grossa Ponta Grossa 84030-900 Green Circle Growers 51051 US FIighway 20 Oberlin OH 44074 ABC Foundation Research and Agricultural development Castro 84165-700

Subsoil acidity restricts root growth and reduces crop yields in many parts of the world. More than half of the fertilizer nitrogen(N) applied in crop production is currently lost to the environment. This study aimed to investigate the effect of gypsum application on the efficiency of N fertilizer in no-till corn(Zea mays L.) production in southern Brazil. A field experiment examined the effects of surface-applied gypsum(0, 5, 10, and 15 Mg ha^(-1)) and top-dressed ammonium nitrate(NH_4NO_3)(60, 120, and 180 kg N ha^(-1)) on corn root length, N uptake, and grain yield. A greenhouse experiment was conducted using undisturbed soil columns collected from the field experiment site to evaluate NO_3-N leaching, N uptake, and root length with surface-applied gypsum(0 and 10 Mg ha^(-1)) and top-dressed NH_4NO_3(0 and 180 kg N ha^(-1)). Amelioration of subsoil acidity due to gypsum application increased corn root growth,N uptake, grain yield, and N use efficiency. Applying gypsum to the soil surface increased corn grain yield by 19%–38% and partial factor productivity of N(PFPN) by 27%–38%, depending on the N application rate. Results of the undisturbed soil column greenhouse experiment showed that improvement of N use efficiency by gypsum application was due to the higher N uptake from NO_3-N in the subsoil as a result of increased corn root length. Our results suggest that ameliorating subsoil acidity with gypsum in a no-till corn system could increase N use efficiency, improve grain yield, and reduce environmental risks due to NO_3-N leaching.

关键词： ammonium nitrate grain yield N uptake nitrate leaching partial factor productivity of nitrogen soil acidity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

development of an ADC radiation tolerance characterization system for the upgrade of the ATLAS LAr calorimeter

引用

Chinese Physics C 2017年第2期41卷 151-158页

作者：刘洪斌陈虎成陈凯 James Kierstead Francesco Lanni helio Takai 金革 State Key Laboratory of Particle detection and Electronics University of Science and Technology of China Hefei 230026 China department of Modern Physics University of Science and Technology of China Hefei 230026 China Brookhaven National Laboratory Upton NY 11973 U.S.A.

ATLAS LAr calorimeter will undergo its Phase-I upgrade during the long shutdown（LS2） in 2018, and a new LAr Trigger Digitizer Board（LTDB） will be designed and installed. Several commercial-off-the-shelf（COTS）multi-channel high-speed ADCs have been selected as possible backups of the radiation tolerant ADC ASICs for the LTDB. To evaluate the radiation tolerance of these backup commercial ADCs, we developed an ADC radiation tolerance characterization system, which includes the ADC boards, data acquisition（DAQ） board, signal generator,external power supplies and a host computer. The ADC board is custom designed for different ADCs, with ADC drivers and clock distribution circuits integrated on board. The Xilinx ZC706 FPGA development board is used as a DAQ board. The data from the ADC are routed to the FPGA through the FMC（FPGA Mezzanine Card）connector, de-serialized and monitored by the FPGA, and then transmitted to the host computer through the Gigabit Ethernet. A software program has been developed with Python, and all the commands are sent to the DAQ board through Gigabit Ethernet by this program. Two ADC boards have been designed for the ADC, ADS52J90 from Texas Instruments and AD9249 from Analog devices respectively. TID tests for both ADCs have been performed at BNL, and an SEE test for the ADS52J90 has been performed at Massachusetts General Hospital（MGH）. Test results have been analyzed and presented. The test results demonstrate that this test system is very versatile, and works well for the radiation tolerance characterization of commercial multi-channel high-speed ADCs for the upgrade of the ATLAS LAr calorimeter. It is applicable to other collider physics experiments where radiation tolerance is required as well.

关键词： radiation tolerance characterization high-speed multi-channel ADC total ionization dose single event effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mathematical modelling for Zoonotic Visceral Leishmaniasis dynamics:A new analysis considering updated parameters and notified human Brazilian data

引用

Infectious Disease Modelling 2017年第2期2卷 143-160页

作者： helio Junji Shimozako Jianhong Wu Eduardo Massad Faculty of Medicine University of S~ao Paulo and LIM 01-HCFMUSPAvenida Dr.Arnaldo 45501246-903Sao PauloSPBrazil Centre for Disease Modelling York Institute for Health ResearchYork University4700Keele StreetTorontoONM3J 1P3Canada London School of Hygiene and Tropical Medicine University of LondonUK

Brazil is one of the highest endemic countries for Zoonotic Visceral Leishmaniasis:according to the Brazilian Ministry of Health,the annual number of new human cases and deaths due to this disease has been increasing for the last 20 *** addition,regarding the Americas,the specific relationship between canine and human for Visceral Leishmaniasis dynamics is still not well *** this work we propose a new model for Zoonotic Visceral Leishmaniasis,based on the models previously published by Burattini et al.(1998)and Ribas et al.(2013).Herein,we modeled the disease dynamics using a modified set of differential equations from those two authors,considering the same assumptions(inclusion of human,dog and sandfly populations,all constants over time).From this set of equations we were able to calculate the basic reproduction number R 0 and to analyze the stability and sensitivity of the system to the parameters *** main result,when the stability of the system is reached,the normalized reporting human cases rate is estimated in 9.12E-08/*** estimation is very close to the 2015 report from Araçatuba city,5.69E-08/*** also observed from stability and sensitivity analysis that the activity of sandfly population is critical to introduction and maintenance of Zoonotic Visceral Leishmaniasis in the *** addition,the importance of dog as source of infection concentrates on latent dog,since it does not show clinical symptoms and signs and,therefore,has a great contribution to disease *** conclusion,considering the presently ethical issues regarding to elimination of positive dog in Brazil and the highly sensitivity of disease dynamics on sandfly population,we recommend that the sandfly population control should be prioritized.

关键词： Zoonotic Visceral Leishmaniasis Disease dynamics Mathematical modelling Epidemiology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison of Two Protocols of Agar Gel Immunodiffusion(AGID)Used to Diagnose of Equine Infectious Anemia(EIA)

引用

Open Journal of Veterinary Medicine 2015年第7期5卷 169-174页

作者： Maria do Rosario Oliveira da Cunha Beltrao Cid Aristoteles de siqueira Alencar Adriana Soares Leite Leonardo Tavares Freitas Julianne Cortizo Gonzalez Vania Lucia de Assis Santana helio Cordeiro Manso-Filho department of Veterinary Medicine Federal Rural University of PernambucoRecifeBrazil National Animal and Plant Laboratory Ministry of AgricultureLivestock and Food SupplyRecifeBrazil

The aim of the present study was to compare two protocols of Agar Gel Immunodiffusion (AGID) that can be used to diagnose Equine Infectious Anemia (EIA). Different volumes of reagents and support for agar gel were used, as recommended by the Ministry of Agriculture, Livestock and Food Supply (MAPA) and the World Organization for Animal Health (OIE). Equidae sera samples (n = 1000) were tested using a national commercial kit and different volumes (i.e. 25 μL—MAPA and 50 μL—OIE) of reagents and standard sera. Antigen was used as recommended by MAPA. The results were assessed by two operators, 48 hours after beginning the test. At the end of the experiment, a Kappa index of 1 was obtained by the operators, for the interpretation of the results and for the different volumes of reagents used. Similar results of agreement (Kappa index = 1) were obtained when using slides or Petri dishes as support for the agar gel. In both cases, an almost perfect agreement was achieved, suggesting that the use of different supports does not affect the results. These findings indicate that both protocols (MAPA and OIE) can be used to diagnose EIA.

关键词： Horses Equids EIA Diagnosis AGID Serology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical Assessment of the Use of Propinox Hydrochloride and Scopolamine Hydrochloride in the Treatment of Abdominal Colic: A Retrospective, Comparative Study

引用

International Journal of Clinical Medicine 2016年第7期7卷 474-480页

作者： helio Rzetelna Carlos Frederico Porto Alegre Rosa Mario Kirzner Lucas Pereira Jorge de Medeiros Camila Melo Marcia Gonçalves ribeiro Lisa Oliveira José Galvão Alves Mauro Geller Gastroenterology department Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil Clinical Medicine department Centro Universitário Volta Redonda (UNIFOA) Volta Redonda Brazil Clinical Medicine and Gastroenterology department Universidade Estácio de Sá (UNESA) Rio de Janeiro Brazil Clinical Medicine department Escola de Medicina Souza Marques Rio de Janeiro Brazil 5Inflammatory Bowel Diseases Outpatient Unit-18 ª enfermaria da Santa Casa da Misericórdia do Rio de Janeiro Rio de Janeiro Brazil Federaç&atildeo Brasileira de Gastroenterologia S&atildeo Paulo Brazil Grupo de Estudos de Doenças Inflamatórias Intestinais Rio de Janeiro Brazil UNESA Rio de Janeiro Brazil Gastroenterology Post-Graduation Program-PUC-Rio Rio de Janeiro Brazil Neurology Post-Graduation Program Universidade Federal do Estado do Rio de Janeiro (UERJ) Rio de Janeiro Brazil Pharmacology department—UFRJ Rio de Janeiro Brazil Medical Genetics Service IPPMG-Universidade Federal Rio de Janeiro Rio de Janeiro Brazil Immunology department Teresópolis Medical School (UNIFESO) Teresópolis Brazil Clinical Immunology Instituto de Pós-Gradua&ccedil&atildeo Médica Carlos Chagas (IPGMCC) Rio de Janeiro Brazil

Objectives: The purpose of this study was to evaluate and compare the use of propinox hydrochloride and scopolamine hydrochloride in patients presenting abdominal colic (abdominal pain), in terms of treatment efficacy and tolerability. Material & Methods: This was an analytical, retrospective, comparative study based on hospital records of outpatients treated at Serviço de Clínica Médica do Hospital das Clínicas Costantino Otaviano (HCTCO) and at Santa Casa de Misericórdia do Rio de Janeiro, from 1988-1998. Subjects were divided into two groups: patients from Group 1 were treated with propinox hydrochloride, while patients from Group 2 were treated with scopolamine hydrochloride. Statistical analysis was performed using GraphPad Prism version 5.0. For comparison of categorical variables, we used the chi-squared or Fisher’s test, while continuous variables were analyzed using ANOVA or the Student’s T test. Results: A total of 1042 subjects were included, of which 525 were allocated to Group 1 and 517 to Group 2. Mean treatment duration was 9.166 days (±4.208) in Group 1 and 8.795 days (±5.052) in Group 2, with no statistically significant difference in treatment duration between the two groups (p = 0.198). All subjects in Group 1 were treated with propinox 10 mg (2 coated tablets, three times per day) while all subjects in Group 2 were treated with scopolamine hydrochloride 10 mg (2 coated tablets, three times per day). There were no statistically significant between-group differences in weight, BMI, heart rate, and respiratory rate at pre- and post-treatment;with the exception of higher post-treatment systolic blood pressure in Group 1, blood pressure measures also remained homogenous. Adverse events were reported among both treatment groups with no significant between-group difference in incidence (p = 0566). At pretreatment, pain intensity was more severe in Group 1 (p = 0.0257), while at post-treatment, there was no statistically significant difference betw

关键词： Abdominal Colic Propinox Hydrochloride Scopolamine Hydrochloride

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：