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Phenotypic Characterization Murine Sarcoma TG-180 Immunophenotypical Characterization Murine Sarcoma TG-180

Open Journal of Pathology 2015年第2期5卷 59-64页

作者： Thais M.T.Bernardes Hugo E.O.Beserra Stephane C.O.R.Vexenat helio langoni Noeme S.Rocha Department of Clinical Veterinary Medicine Laboratory of Investigative and Comparative PathologySchool of Veterinary Medicine and Animal ScienceSao Paulo State UniversityBotucatuBrazil Department of Veterinary Hygiene and Public Health School of Veterinary Medicine and Animal ScienceSao Paulo State UniversityBotucatuBrazil

The sarcoma is the generic nomenclature for neoplasm of mesodermal cells, which express in man and animals. Silent growth requires early diagnosis technique for identifying their proteins. The experimental model in vivo murine sarcoma 180-TG (TG-180), is widely used in research to provide the stimuli of infectious and neoplastic antigens. In this case, the technique of immunohisto-chemistry helps identify the expressions of tumor cell variants. The objective of the research was to characterize immunoexpression murine sarcoma TG 180, by immunohistochemistry, antibodies AE1/AE3, vimentin, CD3, CD 45, CD79α and S100A4. For this, murine sarcoma TG-180, was implanted subcutaneously in 20 mice “Swiss”, male, 30 days old, 28 g for 10 days. Samples were taken and subjected to immunohistochemistry, via use of HistoMouse-MA™? kit. There was specifically labeled S100A4 and vimentin antibodies, indicative of poorly differentiated neoplasms fibroblasts. In fact, the model is established by identifying the origin of the cell, once identified, chemotherapeutic tests can also be performed. Neoplasia like these, when installed in man and animals, depending on the degree of aggressiveness requires treatment protocol varied between surgery and chemotherapy or combination of treatments.

关键词： Immunohistochemistry Neoplasia Mice Tumor Origin

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