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Micro-computed tomography assessment of human femoral trabecular bone for two disease groups(fragility fracture and coxarthrosis):Age and gender related effects on the microstructure

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Journal of Biomedical Science and Engineering 2013年第2期6卷 175-184页

作者： Ana Catarina Vale Manuel F.C.Pereira Antonio Maurício Bruno Vidal Ana Rodrigues Joana Caetano-Lopes Ara Nazarian Joao E.Fonseca helena canhao Maria Fatima Vaz Institute of Materials and Surface Science and Engineering LisbonPortugal Rheumatology Research Unit Instituto de Medicina MolecularFaculdade de Medicina de LisboaLisbonPortugal Center of Petrology and Geochemistry Instituto Superior TécnicoUniversidade Técnica de LisboaLisbonPortugal Rheumatology and Metabolic Bone Diseases Department Hospital de Santa MariaLisbonPortugal Orthopedic Biomechanics Laboratory Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUSA Mechanical Engineering Department Instituto Superior TecnicoUniversidade Tecnica de LisboaLisbonPortugal

The aim of this study was to identify three-dimensional microstructural changes of trabecular bone with age and gender, using micro-computed tomography. Human trabecular bone from two disease groups, osteoporosis and osteoarthritis was analyzed. A prior analysis of the effects of some procedure variables on the micro-CT results was performed. Preliminary micro-CT scans were performed with three voxel resolutions and two acquisition conditions. On the reconstruction step, the image segmentation was performed with three different threshold values. Samples were collected from patients, with coxarthrosis (osteoarthritis) or fragility fracture (osteoporosis). The specimens of the coxarthrosis group include twenty females and fifteen males, while the fragility fracture group was composed by twenty three females and seven males. The mean age of the population was 69 ± 11 (females) and 67 ± 10 years (males), in the coxarthrosis group, while in the fragility fracture group was 81 ± 6 (females) and 78 ± 6 (males) years. The 30 μm voxel size provided lower percentage difference for the microarchitecture parameters. Acquisition conditions with 160 μA and 60 kV permit the evaluation of all the volume’s sample, with low average values of the coefficients of variation of the microstructural parameters. No statistically significant differences were found between the two diseases groups, neither between genders. However, with aging, there is a decrease of bone volume fraction, trabecular number and fractal dimension, and an increase of structural model index and trabecular separation, for both disease groups and genders. The parameters bone specific surface, trabecular thickness and degree of anisotropy have different behaviors with age, depending on the type of disease. While in coxarthrosis patients, trabecular thickness increases with age, in the fragility fracture group, there is a decrease of trabecular thickness with increasing age. Our findings indicate that disease, age and

关键词： Trabecular Bone Micro-Computed Tomography Coxarthrosis Fragility Fracture Age Gender

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