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Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membranedecorated nanoparticles

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3218-3231页

作者： Wen Zhang Yihui Zhai Ying Cai Xiang Gong Yunxuan jiang Rong Rong Chao Zheng Binyu Zhu helen He Zhu Hao Wang Yaping Li Pengcheng Zhang China State Institute of Pharmaceutical Industry Shanghai 201203China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Biomedical Engineering&State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech UniversityShanghai 201210China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China Yantai Institute of Materia Medica Shandong 264000China State Key Laboratory of Oncogenes and Related Genes Renji-Med-X Stem Cell Research CenterDepartment of UrologyRen Ji HospitalSchool of Medicine and School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200127China University of Chinese Academy of Sciences Beijing 100049China

Current cytotoxic T lymphocyte(CTL)activating immunotherapy requires a major histocompatibility complex I(MHC-I)-mediated presentation of tumor-associated antigens,which malfunctions in around half of patients with triple-negative breast cancer(TNBC).Here,we create a LCL161-loaded macrophage membrane decorated nanoparticle(LMN)for immunotherapy of MHC-I-deficient *** on the macrophage membrane helps LMNs recognize CD47-expressing cancer cells for targeted delivery of LCL161,which induces the release of high mobility group protein 1 and proinflammatory cytokines from cancer *** released cytokines and high mobility group protein 1 activate antitumor immunity by increasing the intratumoral density of the phagocytic macrophage subtype by 15 times and elevating the intratumoral concentration of CTL lymphotoxin by 4.6 *** also block CD47-mediated phagocytosis *** inhibit the growth of MHC-I-deficient TNBC tumors,as well as those resistant to combined therapy of anti-PDL1 antibody and albumin-bound paclitaxel,and prolong the survival of animals,during which process CTLs also play important *** macrophage membrane-decorated nanoparticle presents a generalizable platform for increasing macrophagemediated antitumor immunity for effective immunotherapy of MHC-I-deficient cancers.

关键词： MHC-I deficiency Macrophage CD47 Immunotherapy Triple-negative breast cancer Phagocytosis Immune checkpoint Innate immunity

基于深度神经网络模拟复杂多孔介质中两相驱替过程

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石油勘探与开发 2024年第5期51卷 1126-1140页

作者： ASADOLAHPOUR Seyed Reza jiang Zeyun LEWIS helen 闵超赫瑞瓦特大学能源、地球科学、基础设施与社会学院地球能源工程研究所爱丁堡EH144AS英国西南石油大学理学院成都610500 油气藏地质及开发工程全国重点实验室西南石油大学成都610500

为了预测复杂孔隙结构中毛管压力主导下两相流排驱过程中的流体分布,从仿真多孔介质和岩石CT图像中抽取子样本,并采用孔隙形态模拟器(PMS)生成流体分布,以创建多样化的数据集,将距离图及像素大小、界面张力、接触角、压力作为输入参数,... 详细信息

为了预测复杂孔隙结构中毛管压力主导下两相流排驱过程中的流体分布,从仿真多孔介质和岩石CT图像中抽取子样本,并采用孔隙形态模拟器(PMS)生成流体分布,以创建多样化的数据集,将距离图及像素大小、界面张力、接触角、压力作为输入参数,通过改造、训练、评估卷积神经网络(CNN)、递归神经网络(RNN)和视觉转换器(ViT),优选用于预测流体分布的模型。模拟分析表明,常用的卷积和递归神经网络在捕捉流体连通性方面存在不足。基于ViT构建了一个高维视觉转换器(HD-ViT),该转换器先忽略孔隙的空间位置仅根据其大小进行排驱,再在后处理步骤中追加流体连通要求,这种方法允许在任何坐标方向预设出入口,并使用不同尺寸和不同分辨率的图像进行渗流状态推断。通过在砂岩和碳酸盐岩大图像上验证,并与微流控驱替测试的实验结果比较,证实了HD-ViT模型的有效性、精确性和速度优势,且在捕捉孔隙尺度三维流动方面存在较大的潜力。

关键词：两相驱替流体分布深度神经网络视觉转换器孔隙形态模拟器大数据集

Glycerol phosphate shuttle enzyme GPD2 drives glucose oxidation to regulate macrophage inflammatory responses

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Glycerol phosphate shuttle enzyme GPD2 drives glucose oxidat...

Microwave-assisted catalyst-free hydrolysis of fibrous cellulose for deriving sugars and biochemicals

第三届中国生物物理学会代谢生物学分会学术研讨会

作者： P.Kent Langston Aya Nambu Jonathan Jung Munehiko Shibata H.Ibrahim Aksoylar Jiahui Lei Peining Xu Mary T.Doan helen jiang Michael R.MacArthur Xia Gao Yong Kong Edward T.Chouchani Jason W.Locasale Nathaniel W.Synder Tiffany Horng Department of Genetics & Complex Diseases Harvard T.H.Chan School of Public Health School of Medicine University of Glasgow A.J.Drexel Autism Institute Drexel University Department of Pharmacology & Cancer Biology Duke University School of Medicine Depart of Immunobiology Yale University School of Medicine Department of Cell Biology Harvard Medical School School of Life Sciences and Technology ShanghaiTech University

＜正＞Macrophages are activated during microbial infection to coordinate inflammatory responses and host *** we show that in macrophages activated by bacterial lipopolysaccharide （LPS）,mitochondrial glycerol 3-phosphate dehydrogenase （GPD2） regulates glucose oxidation to drive inflammatory ***2,a component of the glycerol 3-phosphate shuttle （GPS）,boosts glucose oxidation to fuel Acetyl-CoA production,histone acetylation and inflammatory gene

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Frontiers of Chemical Science and Engineering 2019年第4期13卷 718-726页

作者： Songshan jiang helen Daly Huan Xiang Ying Yan Huiping Zhang Christopher Hardacre Xiaolei Fan School of Chemical Engineering and Analytical Science The University of ManchesterManchester M139PLUK School of Chemistry and Chemical Engineering Chongqing University of Science and TechnologyChongqing 401331China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China

Microwave(MW)assisted catalyst-free hydrolysis of fibrous cellulose(FC,cellulolysis)at 200℃promoted a cellulose conversion o f ca.37.2%and quantitative production o f valuable C5/C6 sugars(e.g.,glucose)and the according platform biochemicals(e.g.,5-hydroxymethylfurfliral),corresponding to an overall selectivity o f 96.5%.Conversely,conventional hydrothermal cellulolysis under similar conditions was not effective,even after 24 h,carbonising the *** on the systematic study of MW-assisted cellulolysis,the specific interaction between water molecules and macroscopic FC under the MW irradiation was proposed,accounting for the interpretation o f the experimental *** kinetic energy o f water molecules under the MW irradiation facilitated the C-C(in the non-hindered surface-CH2OH groups)and C-O-C bond breaking(inside the cellulose cavities)in FC,producing primary cellulolysis products of xylose,glucose and cellobiose.

关键词： microwave fibrous cellulose hydrolysis sugars mechanism

Unc-51-like kinase(ULK)complex-independent autophagy induced by hypoxia

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Protein & Cell 2019年第5期10卷 376-381页

作者： Yan Feng helen H.Kang Pui-Mun Wong Minghui Gao Ping Wang Xuejun jiang Shanghai Tenth People's Hospital of Tongji University School of MedicineTongji UniversityShanghai 200072China Cell Biology Program Memorial Sloan-Kettering Cancer CenterNew YorkNY 10065USA Immunology and Microbial Pathogenesis Program Weill Cornell Graduate School of Medical SciencesNew YorkNY 10065USA Human Genetics and Embryology Laboratory Agency for ScienceTechnology and ResearchInstitute of Medical BiologySingapore 138632Singapore HIT Center for Life Sciences The School of Life Sciences and TechnologyHarbin Institute of TechnologyHarbin 150001China

Dear Editor,Macroautophagy(referred to as autophagy herein)is an evolutionarily con served,lysosomal degradatio n process by which cells rid themselves of aggregated proteins and damaged organelles(He and Klionsky,2009).This process involves a finely orchestrated molecular pathway comprising a plethora of ATG proteins essential for autophagosome *** mammalian Unc-51-like kinase(ULK)complex plays an essential role to initiate canonical autophagy pathway by relaying upstream nutrient and stress signals to downstream autophagy machinery(Mizushima,2010;Wong et al.,2013).

关键词： Unc-51-like kinase ULK hypoxia

Sol-Gel Template Synthesis and Photoluminescence Properties of (Pb_(0.5)Sr_(0.5))TiO_(3) Nanotube Arrays

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Chinese Physics Letters 2011年第7期28卷 278-281页

作者： jiang Yan-Ping WANG Yu CHAN Lai Wa helen TANG Xin-Gui ZHOU Yi-Chun Key Laboratory of Low-Dimensional Materials and Application Technology Xiangtan UniversityXiangtan 411105 Department of Applied Physics and Materials Research Centre Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina School of Physics&Optoelectric Engineering and Guangzhou Higher Education Mega CenterGuangdong University of TechnologyGuangzhou 510006

Lead strontium titanate(Pb_(0.5)Sr_(0.5))TiO_(3)(PST)nanotube arrays are prepared by a sol-gel and spin-coating process using an anodic aluminium oxide *** structure and morphology of the as-prepared sample are characterized by x-ray diffraction,scanning electron microscopy and transmission electron *** results show that the as-prepared PST sample possesses a perovskite structure with a relatively uniform diameter of about 200 ***(PL)spectrum of the sample shows emission bands centered at about 2.87 eV at room temperature,which consists of three intense emission sub-bands at 3.02,2.87 and 2.76 eV,*** energy corresponding to the central PL peak is lower than the band-gap energy(3.2 eV)of PST bulk materials,which may originate from the size effect of the PST nanotube *** multi-peaks in the PL spectrum may be attributed to the radiative recombination of trapped electrons and holes in tail and gap states induced by local defect and oxygen *** Raman scattering spectrum of the PST nanotube arrays,which are obviously broadened in comparison with the bulk materials,show that their phonon modes are in agreement with those allowed in the tetragonal phase.

关键词： template perovskite bands

Composite materials for primary aircraft structures:from development phase to high volume production rate

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民用飞机设计与研究 2020年第1期 125-128页

作者： LI helen FIORE Lucien jiang Zhen Hexcel Composites-Shanghai 20210 China Hexcel Composites-Dayneux 01120 France

From 1980’s decade,the introduction of carbon composite materials in structural applications has been consistently increased in the successive generations of civil aircraft from Single Aisle to Middle-long Range to achieve a culminant point with more than 50%in structure weight in recent commercial civil *** evolution,done through successive iterations,has been possible by combining in the same time the improvement of intrinsic composite material performances and its transformation into prepreg production technologies together with the development of new manufacturing process for material lay-up automation at composite shop-floor manufacturer of aircraft composite *** challenges are still coming to continuously develop materials and technologies in order to pursue the production more cost-effective composite *** to higher aircraft production rate for single aisle,new challenges may force material and aircraft designers and producers to furthermore drive new products and processes introduction and new ways of transformation within in next decade of composite aircraft *** propose to illustrate these trends using past and recent developments and our return of experience from Hexcel on Civil Aircraft programs.

关键词： composite materials structural applications prepreg technology automatic lay-up processes high production volume rate

Breakthrough cancer medicine and its impact on novel drug development in China: report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting

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Chinese Journal of Cancer 2014年第12期33卷 620-624页

作者： Feng Roger Luo Jian Ding helen X. Chen Hao Liu Man-Cheong Fung Maria Koehler Jean Pierre Armand Lei jiang Xiao Xu Ge Zhang Li Xu Pascal Qian Li Yan The US Chinese Anti-Cancer Association MartinezCA 94553 USA Department of Oncology Janssen Research & Development LLC RaritanNJ 08869 USA Shanghai Institute of Materia Medica Chinese Academy of Sciences Cancer Therapy Evaluation Program National Cancer Institute Novartis Pharmaceuticals (China) Oncology Pfizer Oncology New YorkNY 10017 USA Institut Gustave Roussy Cancer Campus Grand Paris ACEA Biosciences Inc. jiangsu Hengrui Medicine Co. Ltd. Beijing Cancer Hospital and Institute Peking University School of Oncology

The US Chinese Anti-Cancer Association(USCACA)teamed up with Chinese Society of Clinical Oncology(CSCO)to host a joint session at the17th CSCO Annual Meeting on September 20th,2014in Xiamen,*** a focus on breakthrough cancer medicines,the session featured innovative approaches to evaluate breakthrough agents and established a platform to interactively share successful experiences from case studies of 6 novel agents from both the United States and *** goal of the session is to inspire scientific and practical considerations for clinical trial design and strategy to expedite cancer drug development in China.A panel discussion further provided in-depth advice on advancing both early and full development of novel cancer medicines in China.

关键词：抗癌药物中国临床美国学会肿瘤协会新药

新西兰医院-社区-家庭老年健康管理见闻与启示

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护理学杂志 2020年第11期35卷 98-100页

作者：马国珍姜鹏君薛晶金娅芳 Song Jenny Lin helen 华中科技大学协和深圳医院日间手术管理中心广东深圳518052 华中科技大学协和深圳医院肛肠外科广东深圳518052 华中科技大学协和深圳医院介入科广东深圳518052 华中科技大学同济医学院附属协和医院心内科 Waikato Regional in New Zealand Waikato Institute of Technology Centre for Health and Social Practice Waikato Regional in New Zealand Waikato Regional Diabetes Service

介绍新西兰怀卡托省医院-社区-家庭老年健康管理相关情况。多学科团队通过服务对象的健康管理系统对医院术后患者进行早日康复,恢复其回归社会的能力;针对居家有康复需求的居民,政府把相应的服务人员与物品转移至家庭进行高效康复;为了... 详细信息

介绍新西兰怀卡托省医院-社区-家庭老年健康管理相关情况。多学科团队通过服务对象的健康管理系统对医院术后患者进行早日康复,恢复其回归社会的能力;针对居家有康复需求的居民,政府把相应的服务人员与物品转移至家庭进行高效康复;为了维持及促进居民的健康,社区诊所成立相应的多学科服务团队,科学、规范地管理服务对象的健康。可参照其完善我国老年健康管理体系,以满足社区老年人健康护理服务需求。

关键词：新西兰老年人健康老龄化医院社区家庭联动管理健康管理