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i.enti.i.ati.n of new geneti. ri.k factors for prostate cancer

Asi.n Journal of Andrology 2009年第1期11卷 49-55页

作者： Mi.helle Guy Zsofi. Kote-Jarai.Graham G. Gi.es Ali.Ami. Al Olama Sarah K. Jugurnauth Shani.Mulholland Dani.l A. Leongamomlert Stephen M. Edwards Jonathan Morri.on helen i. field Meli.sa C. Southey Gi.nluca Severi.Jenny L. Donovan Freddi. C. Hamdy Davi. R Dearnaley Kenneth R. Mui. Charmai.e Smi.h Meli.a Bagnato Audrey T. Ardern-Jones Amanda L. Hall Lynne T. O＇Bri.n Beatri.e N. Gehr-Swai. Rosemary A. Wi.ki.son Angela Cox Sarah Lewi. Paul M. Brown Sameer G. Jhavar Malgorzata Tymraki.wi.z Arti.aya Lophatananon Sarah L. Bryant The UK Geneti. Prostate Cancer Study Collaborators Bri.i.h Associ.ti.n of Urologi.al Surgeons＇ Secti.n of Oncology and The UK ProtecT Study Collaborators Alan Horwi.h Robert A. Huddart Vi.cent S. Khoo Chri.topher C. Parker Chri.topher J. Woodhouse Alan Thompson Ti. Chri.tmas Chri. Ogden Cyri. Fi.her Charles Jameson Coli. S. Cooper Dallas R. Engli.h John L. Hopper Davi. E. Neal Douglas E Easton Rosali.d A. Eeles Secti.n of Cancer Geneti.s The Institute of Cancer Research Sutton Surrey SM2 5NG UK Cancer Epi.emi.logy Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecular Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Cancer Research UK Geneti. Epi.emi.logy Uni. University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Department of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Geneti. Epi.emi.logy Laboratory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Department of Soci.l Medi.i.e University of Bristol Bristol BS8 2PR UK Academi. Urology Uni. University of Sheffield Sheffield SIO 2JF UK The Royal Marsden NHS Foundati.n Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK Uni.ersi.y of Notti.gham Medi.al School Queens Medical Centre Nottingham NG7 2UH UK i.sti.ute for Cancer Studi.s University of Sheffield Sheffield SIO 2RX UK Surgi.al Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK A full li.t of authors i. provi.ed i. the Supplementary Note onli.e Ka Shing Centre Cambridge CB2 ORE UK Cancer Research UK Cambri.ge Research i.sti.ute Li Ka Shing Centre Cambridge CB2 ORE UK.

There i. evi.ence that a substanti.l part of geneti. predi.posi.i.n to prostate cancer （PCa） may be due to lower penetrance genes whi.h are found by genome-wi.e associ.ti.n studi.s. We have recently conducted such a study and seven new regi.ns of the genome li.ked to PCa ri.k have been i.enti.i.d. Three of these loci.contai. candi.ate suscepti.i.i.y genes： MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screeni.g, and the LMTK2 gene mi.ht provi.e a potenti.l therapeuti. target. Together wi.h results from other groups, there are now 23 germli.e geneti. vari.nts whi.h have been reported. These results have the potenti.l to be developed i.to a geneti. test. However, we consi.er that marketi.g of tests to the publi. i. premature, as PCa ri.k can not be evaluated fully at thi. stage and the appropri.te screeni.g protocols need to be developed. Follow-up vali.ati.n studi.s, as well as studi.s to explore the psychologi.al i.pli.ati.ns of geneti. profi.e testi.g, wi.l be vi.al pri.r to roll out i.to healthcare.

关键词： prostate cancer geneti.s suscepti.i.i.y loci SNPs relati.e ri.ks

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景观—社会学视角下的北京高密度城区儿童游戏专属和发现空间

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风景园林 2024年第2期31卷 19-31页

作者： [英]海伦·伍利汤湃谢菲尔德大学风景园林系英国皇家风景园林协会 GUi.国际研究组中国研究组同济大学建筑与城市规划学院 GUi.国际研究组

【目的】在任何地方进行游戏是儿童的天性。以北京中心城区高密度城市环境为例,深入探究儿童如何创造性地使用城市户外公共空间。【方法】从景观—社会学视角,通过半构建访谈、照片访谈和行为观察等方法收集儿童户外活动空间数据。【结... 详细信息

【目的】在任何地方进行游戏是儿童的天性。以北京中心城区高密度城市环境为例,深入探究儿童如何创造性地使用城市户外公共空间。【方法】从景观—社会学视角,通过半构建访谈、照片访谈和行为观察等方法收集儿童户外活动空间数据。【结果】将儿童使用的多样户外空间分为专属空间和发现空间,以及介于两者之间的灵活空间3种类别。深入探究不同类别的活动空间的特点发现,配置有固定游戏设备的儿童专属游乐场所提供的游戏机会单一,无法满足全龄儿童进行多样户外游戏的需求,但专属空间为儿童提供了最为正式且相对安全的游戏环境;儿童广泛使用的灵活空间,如广场和可进入的绿地,其开放性为更为广泛的年龄群体提供了可供奔跑、跳跃和骑车等高强度活动的机会,但营造公平且友好的共享公共环境是灵活空间面临的挑战;发现空间的设计初衷并非为儿童使用,因此儿童在使用这类空间的过程中普遍存在潜在安全隐患。【结论】针对高密度城市环境中有限的公共空间提出了更加包容且儿童友好的营造方式以及优化设计建议,期望为提升高密度城市公共空间服务效能、实现城市可持续发展提供一定科学参考。

关键词：高密度城区儿童友好可供性发现空间户外空间

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浙江省某县县域医共体抗菌药物管理案例研究

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中国社会医学杂志 2024年第4期41卷 391-396页

作者：邓子如董晓莲王伟马聪付朝伟 helen Lambert 王娜严非复旦大学公共卫生学院国家卫健委卫生技术评估重点实验室上海200032 德清县疾病预防与控制中心浙江湖州313200 英国布里斯托大学人口健康科学系布里斯托BS82PS

目的探究浙江省某县县域医共体内部抗菌药物管理政策和措施实施中的经验和问题。方法研究团队于2019年10月及2020年7月赴浙江省某县开展现场调查,通过目的性抽样收集医共体内两家医疗机构的抗菌药物相关数据进行描述性分析,并对四家医... 详细信息

目的探究浙江省某县县域医共体内部抗菌药物管理政策和措施实施中的经验和问题。方法研究团队于2019年10月及2020年7月赴浙江省某县开展现场调查,通过目的性抽样收集医共体内两家医疗机构的抗菌药物相关数据进行描述性分析,并对四家医疗机构中的15名关键知情人进行访谈,了解医共体内抗菌药物管理制度与抗菌药物使用状况。结果案例县县域医共体内机构已成立架构清晰的抗菌药物管理系统;设有前置审方、事后点评、绩效奖惩等管理措施;近年来抗菌药物使用相关指标总体呈下降趋势,县医院门诊、住院抗菌药物使用率均达到国家标准,但县医院住院患者抗菌药物使用强度、乡镇卫生院门诊抗菌药物使用率仍高于国家标准。结论案例县依托县域医共体制度优势,促进医疗机构抗菌药物自上而下管理,管理组织架构清晰,措施较为全面,注重过程管理,动态调整考核指标;但仍需加大对临床药师等专业技术人员的培养,完善抗菌药物管理信息系统。

关键词：抗菌药物管理县域医共体案例研究

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Cancer i.munotherapy

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Chi.ese Journal of Cancer 2014年第9期33卷 413-415页

作者： Li.Yan helen X.Chen US Chi.ese Anti.Cancer Associ.ti.n Therapy Evaluati.n Program (CTEP) Nati.nal Cancer i.sti.ute (NCi.

Unprecedented progress has seen made i. the last decade i. the fi.eld of cancer *** recent approval of ni.olumab(Opdi.o),the fi.rst anti.programmed cell death-1(PD-1)anti.ody,for metastati. melanoma i. Japan,marked a ... 详细信息

关键词：免疫治疗肿瘤细胞毒性T淋巴细胞程序性细胞死亡 CTLA-4 免疫疗法黑色素瘤转移性

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The role of the Mi.-Ci.meri.n Unconformi.y on the quali.y of the underlyi.g Skagerrak sandstone reservoi. i. the Ki.ti.ake field,central North Sea

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Energy Geosci.nce 2021年第4期2卷 254-273页

作者： Abdulati.Arai.i.Dorri. Stow helen Lever Zei.ab Smi.li. Department of Earth Sci.nce Elmergib UniversityAlkhomsLibya i.sti.ute of Geo-Energy Engi.eeri.g School of EnergyGeoscienceInfrastructure and SocietyEdinburghUK

The central ai. of thi. paper i. to address the role of unconformi.i.s i. affecti.g reservoi. *** they faci.i.ate di.genesi. that leads to ei.her enhanced or reduced porosi.y through di.soluti.n or cementati.n?Or,do they have li.tle effect?We have i.vesti.ated the Late Tri.ssi. Skagerrak sandstone reservoi. underlyi.g the Mi.-Ci.meri.n Unconformi.y i. the Ki.ti.ake field,central North *** i. strong evi.ence for the development of secondary porosi.y through the di.soluti.n of unstable si.i.ate mi.erals,pri.ari.y *** i.cludes the presence of oversi.ed pores,parti.l di.soluti.n of framework grai.s,and complete di.soluti.n of grai.s leavi.g remnant grai. margi.s and parti.lly fi.led *** di.soluti.n as a late-stage event i. demonstrated by the complete lack of compacti.n effects on the secondary pores and di.geneti. products despi.e present buri.l depths i. excess of 3000 *** observati.ns,coupled wi.h an absence of systemati. trends li.ked to the unconformi.y surface i. respects of reservoi. porosi.y,feldspar amount and di.soluti.n,and kaoli.i.ati.n,lead to the conclusi.n that there has been no effect of the Mi.-Ci.meri.n Unconformi.y on reservoi. quali.y i. the Ki.ti.ake *** i. no evi.ence for leachi.g or cementati.n li.ked to meteori. water i.flux ei.her shortly after deposi.i.n or followi.g the upli.t and exposure,whi.h led to development of the Mi.-Ci.meri.n ***,we propose that the late-stage di.soluti.n of feldspar and generati.n of secondary porosi.y are most li.ely related to the i.flux of organi. aci.s and carbon di.xi.e generated ei.her from thermogeni. maturati.n of the source rock or from bi.degradati.n of oi. wi.hi. the reservoi. near the oi.-water contact(OWC)transi.i.n zone.

关键词： North sea Ki.ti.ake field Unconformi.y Skagerrak sandstone

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从工作中培养经理人

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中外企业文化 2001年第1X期 30-32页

作者： helen Hand field-Jones 周济

只有3％的经理人认为,公司在有效地培养他们的才干。公司应该透过什么方式,来培养优秀的经理人?在发展培养计划时,又应该注意哪些原则?

关键词：工作经验优秀人才导师制度教育训练成长机会通用电气公司平庸之才人力资源主管公司文化人事主管

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Comparati.e Study of Three Hi.h Order Schemes for LES of Temporally Evolvi.g Mi.i.g Layers

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Communi.ati.ns i. Computati.nal Physi.s 2012年第10期12卷 1603-1622页

作者： helen C.Yee Bjorn Sjögreen Abdellah Hadjadj NASA-Ames Research Center Moffett FieldCA94035USA Lawrence Li.ermore Nati.nal Laboratory LivermoreCA94551USA CORi. UMR 6614&i.SA de Rouen 76800 St-Etienne du RouvrayFrance

Three hi.h order shock-capturi.g schemes are compared for large eddy si.ulati.ns(LES)of temporally evolvi.g mi.i.g layers for di.ferent convecti.e Mach numbers rangi.g from the quasi.i.compressi.le regi.e to hi.hly compressi.le supersoni. *** consi.ered hi.h order schemes are fi.th-order WENO(WENO5),seventh-order WENO(WENO7)and the associ.ted ei.hth-order central spati.l base scheme wi.h the di.si.ati.e porti.n of WENO7 as a nonli.ear post-processi.g fi.ter step(WENO7fi..Thi. hi.h order nonli.ear fi.ter method of Yee&Sjogreen i. desi.ned for accurate and effi.i.nt si.ulati.ns of shock-free compressi.le turbulence,turbulence wi.h shocklets and turbulence wi.h strong shocks wi.h mi.i.um tuni.g of scheme *** LES results by WENO7fi.usi.g the same scheme parameter agree well wi.h experi.ental results compi.ed by Barone et al.,and publi.hed di.ect numeri.al si.ulati.ns(DNS)work of Rogers&Moser and Pantano&Sarkar,whereas results by WENO5 andWENO7 compare poorly wi.h experi.ental data and DNS computati.ns.

关键词： Hi.h order numeri.al methods numeri.al methods for turbulencewi.h shocks DNS LES mi.i.g layer

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Magnetoelectri. and converse magnetoelectri. responses i. Tb_xDy_(1-x)Fe_(2-y) alloy & Pb(Mg_(1/3)Nb_(2/3))_(1-x)Ti.xO_3 crystal lami.ated composi.es

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Chi.ese Sci.nce Bulleti. 2008年第14期53卷 2129-2134页

作者： Ji. YanMi. LUO HaoSu OR Si. Wi.g WANG YaoJi. CHAN helen L W State Key Laboratory of Hi.h Performance Cerami.s and Superfi.e Mi.rostructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 201800 China Department of Appli.d Physi.s The Hong Kong Polytechnic University Hong Kong China

Measured results of magnetoelectri. (ME) and converse magnetoelectri. (CME) effects of TbxDy1-xFe2-y/ Pb(Mg1/3Nb2/3)(1-x)Ti.O3/TbxDy1-xFe2-y (TD/PMNT/TD) and PMNT/TD/PMNT lami.ated composi.es are pre- sented. ME effect was determi.ed by measuri.g lami.ate voltage output under a Helmholtz-gener- ated AC field bi.sed by a DC field (0―1 kOe) (1 Oe = 79.58 A/m). The CME effect was measured by re- cordi.g the voltage i.duced i. a solenoi. encompassi.g the ME sample whi.e exposed to a DC bi.s field and PMNT layer dri.en by a 10 V AC source. The ME and CME responses i. the two lami.ated structure are li.ear. The hi.hest values of ME coeffi.i.nts i. TD/PMNT/TD and PMNT/TD/PMNT com- posi.es are 384 mV/Oe and 158 mV/Oe, respecti.ely, whi.e the hi.hest values of CME coeffi.i.nts i. the two composi.es are 118 mG/V and 162 mG/V (1 G=10-4 T), respecti.ely.

关键词：磁电效应压电性复合材料合金晶体结构

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Evi.ence for the role of gastri. mucosa at the secreti.n of soluble tri.geri.g receptor expressed on myeloi. cells(strem-1) i. pepti. ulcer di.ease

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World Journal of Gastroenterology 2007年第34期13卷 4610-4614页

作者： Vassi.i.s Koussoulas Spyri.on Vassi.i.u Ekateri.i.Spyri.aki.Mari. Demonakou i.i. Vaki.Charalambos Barbatzas helen Gi.marellou Evangelos J Gi.marellos-Bourbouli. Department of Gastroenterology Sismanoglion General Hospital of Athens University of Athens Medical School Greece 4~(th) Department of i.ternal Medi.i.e University of Athens Medical School Greece Department of Pathology Sismanoglion General Hospital of Athens University of Athens Medical School Greece

Ai.： To i.vesti.ate the role of gastri. mucosa at the secreti.n of sTREM-1 i. pepti. ulcer.METHODS： Seventy two pati.nts were enrolled; 35 wi.h duodenal, 22 wi.h gastri. ulcer and 26 wi.h chroni. gastri.i.. Pati.nts were endoscoped and gastri. jui.e was aspi.ated. Pati.nts wi.h duodenal and gastri. ulcer underwent a second endoscopy post-treatment. Bi.psi.s were i.cubated i. the absence/presence of endotoxi.s or gastri. jui.e. Supernatants were collected and sTREM-2 and TNF~ were measured by enzyme i.munoabsorbent assays. Scori.g of gastri.i. was performed before and after treatment accordi.g to updated Sydney score.RESULTS： Pati.nts wi.h duodenal and gastri. ulcer and those wi.h chroni. gastri.i. had si.i.ar scores of gastri.i., sTREM-1 was hi.her i. supernatants of ti.sue samples of H pylori.posi.i.e than of H pylori.negati.e pati.nts wi.h gastri. ulcer. Medi.n （± SE） sTREM-1 was found i.creased i. supernatants of pati.nts wi.h gastri. ulcer before treatment （203.21 ± 88.91 pg/1000 cells） compared to supernatants ei.her from the same pati.nts post-treatment （8.23 ± 5.79 pg/1000 cells） or from pati.nts wi.h chroni. gastri.i. （6.21 ± 0.71 pg/1000 cells）（P 〈 0.001 and 〈 0.001, respecti.ely）. Si.i.ar di.ferences for sTREM-1 were recorded among LPS-sti.ulated ti.sue samples of pati.nts （P = 0.001）. Si.i.ar di.ferences were not found for TNFα. Posi.i.e correlati.ns were found between sTREM-1 of supernatants from pati.nts wi.h both duodenal and gastri. ulcer before treatment and the degree of i.fi.trati.n of neutrophi.s and monocytes.CONCLUSi.N： sTREM-1 secreted by the gastri. mucosa i. an i.dependent mechani.m connected to the pathogenesi. of pepti. ulcer, sTREM-1 was released at the presence of H pylori.from the i.flamed gastri. mucosa i. the field of gastri. ulcer.

关键词： sTREM-1 Chroni. gastri.i. Gastri. ulcer Duodenal ulcer

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Usi.g Magneti. Barkhausen Noi.e Technology and Fi.i.e Element Method to Study the Condi.i.n of Conti.uous Welded Rai.s on the Darwi.-Ali.e Spri.gs Li.e

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Journal of Ci.i. Engi.eeri.g and Archi.ecture 2011年第7期5卷 596-605页

作者： Ralph （Wei. Zhang helen Wu Thermi. Australi. Pty Ltd Somersby N.S. W. Australia School of Engi.eeri.g Edith Cowan University Joondalup 6027 Western Australia

The Magneti. Barkhausen Noi.e （MBN） technology i. a non-destructi.e method to measure the neutral temperature of thc CWR track. A seri.s of i.-field veri.i.ati.ns and data compari.on on Australi.n mai.li.e tracks have shown the results from that system are hi.hly accurate and reli.ble. The system can be an accuracy and cost-effecti.e tool to prevent the potenti.l buckli.g and break of CWR rai.s. The physi.al backgrounds and features of the system are represented i. thi. paper. The Darwi.-Ali.e Spri.gs Li.e i. a newly constructed mai. li.e i. Australi. whi.h i. li.ked from the north and mi.dle of Australi.. Ori.i.ally, thi. rai. li.e i. desi.ned and constructed i. a ＂cost-effecti.e＂ way to a lower pri.e, and the key parameters are relati.ely low. To mai.tai. the stabi.i.y of the CWR tracks i. a very harsh envi.onment, some new technologi.s such as the MBN technology were uti.i.ed. From the results of neutral temperature, i. i. found that the majori.y of them are very hi.h. Combi.ed wi.h the calculati.n and fi.i.e element analysi., these problems evi.enced that i. i. caused by the low toe load fasteni.g system and hi.h sleeper spaci.g. After that some suggesti.ns are gi.en to i.prove the stabi.i.y of the CWR on the rai.way li.e.

关键词： Magneti. Barkhausen Noi.e fi.i.e element method condi.i.n CWR track.

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