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Short-term effect of physical activity on sleep health:A population-based study using accelerometry

Journal of Sport and Health Science 2022年第5期11卷 630-638页

作者： Andrea Wendt Inácio Crochemore M.da Silva helen goncalves Ana Menezes Fernando Barros Fernando C.Wehrmeister Post-graduate Program in Epidemiology Federal University of PelotasPelotas 96020-220Brazil

Background:Regular physical activity(PA) is an important behavior in improving sleep ***,the short-term effects of PA on sleep are still *** study aimed to verify the effect of different intensities of PA practiced in different periods of the day on the subsequent sleep night in a population-based cohort of young ***::Prospective analyses were conducted for PA performed during the day and its effect on the following sleep night using data from the22-year follow-up of the 1993 Pelotas Birth Cohort in Brazil(mean age of participants-22.6 years).Wrist-worn accelerometry was usedto measure both PA and sleep *** intensity,we analyzed the sleep effect of light PA(LPA),moderate PA,and vigorous PA,stratified by *** variables were sleep time window(STW;the difference between sleep onset and sleep end),total sleep time(TST;the sum of minutes classified as sleep in STW),and sleep percent(SP;SP=(TST/STW);expressed in percentage).We performed generalized estimating equations using Stata ***::The means of STW,TST,and SP were 443.6 min/day,371.1 min/day,and 84%,*** spent in moderate PA and vigorous PA in the morning and afternoon was not associated with sleep *** men,10 min/day of morning LPA increased TST by2.56 min/*** women,10 min/day of morning LPA increased SP by 0.15 percentage *** LPA also increased SP by 0.09 percentage points for *** PA seems to have an inverse effect on sleep variables for any intensity and both ***::The effect of PA on sleep health is intrinsically related to the period of the day in which it is *** effect magnitude is different between *** better sleep health,it is preferable that PA be performed during the day.

关键词： Accelerometer Exercise Physical activity Population-based study Sleep health

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Immune checkpoint inhibitors in clinical trials

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Chinese Journal of Cancer 2014年第9期33卷 434-444页

作者： Elad Sharon Howard Streicher Priscila goncalves helen X.Chen Cancer Therapy Evaluation Program Division of Cancer Treatment and DiagnosisNational Cancer Institute Medical Oncology Service Center for Cancer ResearchNational Cancer Institute

Immunology-based therapy is rapidly developing into an effective treatment option for a surprising range of cancers. We have learned over the last decade that powerful immunologic effector cells may be blocked by inhibitory regulatory pathways controlled by specific molecules often called "immune checkpoints." These checkpoints serve to control or turn off the immune response when it is no longer needed to prevent tissue injury and autoimmunity. Cancer cells have learned or evolved to use these mechanisms to evade immune control and elimination. The development of a new therapeutic class of drugs that inhibit these inhibitory pathways has recently emerged as a potent strategy in oncology. Three sets of agents have emerged in clinical trials exploiting this strategy. These agents are antibodybased therapies targeting cytotoxic T-lymphocyte antigen 4(CTLA4), programmed cell death 1(PD-1), and programmed cell death ligand 1(PD-L1). These inhibitors of immune inhibition have demonstrated extensive activity as single agents and in combinations. Clinical responses have been seen in melanoma, renal cell carcinoma, non-small cell lung cancer, and several other tumor types. Despite the autoimmune or inflammatory immune-mediated adverse effects which have been seen, the responses and overall survival benefits exhibited thus far warrant further clinical development.

关键词：临床试验免疫学检查站癌症程序性细胞死亡细胞毒性T淋巴细胞自身免疫性免疫控制

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