检索结果-南通市图书馆

A Preliminary Report of Predisposing Factors and Predominant Microbiological Diagnosis of Corneal Ulcers Seen at the Federal Teaching Hospital Abakaliki, Nigeria

引用

Open Journal of Ophthalmology 2019年第2期9卷 94-104页

作者： Chimdia e. Ogbonnaya Favoured Walter-Ugwuocha edak ezeanosike Chinyelu N. ezisi Boniface N. Ukwah helen A. Ginger-eke Department of Ophthalmology Ebonyi State University Abakaliki Nigeria Department of Medical Laboratories Zankli Hospital Abuja Nigeria Department of Medical Laboratory Sciences (Medical Microbiology Unit) Faculty of Health Science and Technology Ebonyi State University Abakaliki Nigeria

Background: Microbial keratitis often results in poor visual outcome despite treatment. A revision of treatment protocol based on local evidence may be required in order to obtain better treatment outcome. Objectives: To determine the predisposing factors and predominant microbiological diagnosis of corneal ulcers seen at the Federal Teaching Hospital Abakaliki (FeTHA), ebonyi State, Nigeria. Materials and Methods: This is a preliminary report of an on-going longitudinal descriptive study of all consenting corneal ulcer patients managed at the FeTHA eye clinic over a 4-month period. Information obtained were socio-demographic data, presenting complaints, duration of symptoms prior to presentation, history of preceding trauma, medications used before presentation, presenting and final visual acuity and microbiological diagnosis. Results: A diagnosis of corneal ulcer was made in 8 out of the 852 outpatients seen over the study period giving a hospital prevalence rate of 0.59%. Five patients (62.50%) were males, five (62.50%) were farmers and 4 patients (50%) were above 60 years of age. The microbial diagnoses were bacterial keratitis 37.5% (Staphylococcus aureus), fungal keratitis 25% (Fusarium spp. and aspergillus) and acanthamoeba (25%). None of the patients ever used contact lenses. There was a history of eye trauma in 50% of the patients. All the eyes presented blind after a period of failed attempts to treat by self or quacks. Mean duration before presentation was two weeks. Treatment improved the visual acuity in 37.5% of patients. Conclusion: Bacteria, fungi and acanthamoeba organisms were the microbiological isolates from the scrapings of corneal ulcer patients seen in the eye clinic of FeTHA;with bacterial organisms being the most common. Farming activities, preceding eye trauma, delayed presentation, self-medication and use of traditional eye medications (TeM) were common findings among the patients. A future larger study is recommended to confirm the findin

关键词： Microbial Keratitis Microbial Diagnosis Corneal Ulcer Predisposing Factors Abakaliki

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The RCSB PDB structural genomics portal

The RCSB PDB structural genomics portal

引用

The 4th ISGO International Conference on Structural Genomics

作者： Andrei Kouranov Joanna de la Cruz John Westbrook Philip e.Bourne helen M.Berman Department of Chemistry & Chemical Biology Rutgers The State University of New JerseyPiscatawayNJ 08854-8087 USA San Diego Supercomputer Center & Skaggs School of Pharmacy and Pharmaceutical Sciences/The Burham Instititute University of California San Diego La JollaCA 92093-0537 USA

The RCSB PDB provides many services for the worldwide structural genomics efforts. These range from providing target tracking resources to data deposition tools that extract information from the steps involved in high throughput structure determination (Yang et al., 2004). Online tools, summary reports, and target information are available from the portal at http://*** (Kouranov et al., 2006).

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

劳依德·布朗:划燃火柴伸向油桶(英文)

引用

外国文学研究 2007年第4期29卷 7-22页

作者：玛丽.海伦.华盛顿美国马里兰州立大学

劳依德·布朗在1951年发表了小说《铁城》,其亲共产主义和亲黑人的政治观注定了它在20世纪50年代冷战时期被谴责和被压制的命运。如果说在麦卡锡主义时期对这部政治上极左的小说的拒绝还可以理解,那么它仍被排除在当前的非洲裔美国文学... 详细信息

劳依德·布朗在1951年发表了小说《铁城》,其亲共产主义和亲黑人的政治观注定了它在20世纪50年代冷战时期被谴责和被压制的命运。如果说在麦卡锡主义时期对这部政治上极左的小说的拒绝还可以理解,那么它仍被排除在当前的非洲裔美国文学及其批评史之外这一事实却令人费解——除非它仍处于一种没有被意识到的反共气氛之中。本文认为,正是由于布朗在50年代与共产主义的密切联系,他不仅可以自由地拒绝加在黑人作家身上的知识束缚和美学束缚,特别是要求他们放弃黑人人物和黑人主题以赢得白人主流文学认同的压力;而且能够接触并利用那些与由政治色彩较淡的作家们所发起的文学形式实验相关的左翼文学和文化产品。正是由于这样的影响,《铁城》富有想象地将黑人民间传统、现代主义实验以及激进观点融合起来。本文同时认为,尽管布朗的作品,包括"黑人作家该走哪条路?"(1951)和他在左翼期刊上发表的批评文章,旨在挑战理查德·赖特、拉尔夫·艾利森、切斯特·海姆斯、J·桑德斯·雷丁等同时代作家的保守立场,而在当今布朗仍被排除在经典之外也暴露了当代非洲裔美国文学批评实践中的保守立场。

关键词：非洲裔美国文学20世纪50年代冷战现代主义共产主义

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

关于经验基础问题及其他质疑的回应

引用

哲学分析 2019年第1期10卷 49-52,196-197页

作者：海伦.朗基诺王不凡美国斯坦福大学哲学系东华大学马克思主义学院

批判的语境经验主义在经验内容上关注构成证据相关性的基础,它通过共同体的批评性互动来建构一种动态而可靠的语境及其规范。朗基诺指出理性和社会二分是对知识概念的误解导致的,而批判的语境经验主义规范来自科学自身的形象。与认知科... 详细信息

批判的语境经验主义在经验内容上关注构成证据相关性的基础,它通过共同体的批评性互动来建构一种动态而可靠的语境及其规范。朗基诺指出理性和社会二分是对知识概念的误解导致的,而批判的语境经验主义规范来自科学自身的形象。与认知科学中的生成主义进路比较看,批判的语境经验主义主要思考科学探究的过程,它关乎作为公共知识的科学。批判的语境经验主义和实践实在论都拒绝上帝之眼的可能,但在形而上学和规范性问题上两者依然存在差别。

关键词：批判的语境经验主义规范互动

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

encapsulation of phenolic compounds through the complex coacervation technique for the enrichment of diet chewable candies

引用

Food Bioscience 2023年第1期51卷 325-334页

作者： Lisiane Pintanela Vergara helen Cristina dos Santos Hackbart Cristina Jansen Alves Gabriela Niemeyer Reissig Bruna Santos Wachholz Caroline Dellinghausen Borges Josiane Freitas Chim Rui Carlos Zambiazi Department of Agroindustrial Science and Technology Federal University of PelotasPelotasRSBrazil Federal Institute of Rio Grande do Sul Campus CAVGPelotasRSBrazil Laboratory of Plant Cognition and electrophysiology Department of BotanyInstitute of BiologyFederal University of PelotasPelotasRSBrazil Center of Chemical Pharmaceutical and Food SciencesFederal University of PelotasPelotasRSBrazil

The aim of this study was to encapsulate blackberry juice through complex coacervation,using carrageenan,tragacanth,and xanthan associated with pea protein as wall materials,in addition to characterizing the particles and evaluating the profile of release in vitro after its application in diet chewable candies with blended pulp of blackberry,butia and red *** following analyses were performed:phenolic compounds,turbidimetry,encapsulation efficiency,antioxidant activity,morphology(SeM),functional groups(FTIR),thermal behavior(DSC),and in vitro *** complex coacervation between pea protein/carrageenan,pea protein/tragacanth,and pea protein/xanthan particles occurred at pH 3.09,4.61,and 3.45 respectively,in a ratio of 1:2(w/w).Higher values of encapsulation efficiency and antioxidant activity were observed for pea protein/carrageenan and pea protein/*** and FTIR analyses confirmed the *** application of pea protein/tragacanth particles in the production of candies proved to be efficient for providing the highest percentages of phenolic compound release in the intestinal phase.

关键词： Pea protein Carrageenan gum Tragacanth gum Xanthan gum In vitro digestion Blackberry juice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An excess of prostanoid eP3 receptors decreases hetero-oligomerization with thromboxane A2 receptors

An excess of prostanoid EP3 receptors decreases hetero-oligo...

引用

第十五届国际药理学大会

作者： Chow Kevin Cheng Christopher Wise helen Department of Pharmacology The Chinese University of Hong Kong. Department of Biochemistry The Chinese University of Hong Kong. Department of Pharmacology The Chinese University of Hong Kong.

＜正＞The prostaglandin e2receptor subtype eP3and thromboxane A2（TP）receptors mediate synergistic vasoconstrictor responses.N-terminally-tagged human TP（HA-hTPalpha）and human eP3（2myc-heP3-I）receptors were prepared with Renilla lucifera se（Rluc）or Green Fluorescence Protein（GFP2）at the C-termini in order to assess oligomerization by the generation of a Bioluminescence Resonance energy Transfer（BReT）*** values were0.37+/-0.06and0.16+/-0.00and BReT50values w ere1.54+/-0.61and0.9 +/-0.21in living HeK293cells transfected with hTP or heP3receptors，reˉspectively（mean+/-SeM，n=3）.The heP3-Rluc receptors were also able to oligomerize with hTP-GFP2receptors，producing BReTmax and BReT50values of0. 09+/-0.02and1.20+/-0.33，***ˉever，when the heP3-GFP2cDNA was in excess of hTP-Rluc cDNA，Bret2signals *** conclusion，hTP and heP3receptors constitutively form hoˉmooligomers，but the formation of hetero-oligomers b etween these prostanoid receptors is attenuated when heP3receptors are in excess of hTP receptors.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

TRPC3 plays a role in the neural differentiation of mouse embryonic stem cells and cell survival

TRPC3 plays a role in the neural differentiation of mouse em...

引用

第十一届全国钙信号和细胞功能研讨会

作者： helen Baixia Hao Sarah e.Webb Marc Moreau Catherine Leclerc Jianbo Yue Andrew L. Miller Division of Life Science and State Key Laboratory of Molecular Neuroscience HKUST Centre de Biologie du Développement UMR-CNRS 5547 and GDR2688 Université Toulouse III Department of Biomedical Sciences City University of Hong Kong

The neural differentiation of embryonic stem cells(eSCs) is a dynamic and complex process, which has been shown to be regulated by several different signaling pathways. Ca2+is a highly versatile intra-and intercellular second messenger, has been reported to be involved in several of these regulatory pathways. Thus, by inference we hypothesized that Ca2+ may play an important role in regulating neural differentiation of eSCs. The goal of our research was, therefore, to investigate the role of canonical transient receptor potential channel subtype 3(TRPC3), a cation channel that is permeable to both Ca2+ and Na+, in the regulation of the neural differentiation of mouse eSCs(m eSCs). We demonstrate that TRPC3 is expressed in m eSCs and that it contributes to store-operated Ca2+ entry(SOCe) in these cells following treatment with thapsigargin. We also show that the level of TRPC3 expression gradually increases as m eSCs differentiate into cells of the neural lineage. sh RNA knockdown of TRPC3 suppressed its expression by 0% and led to a reduction in the expression of the neural differentiation markers: nestin, sox1 and tuj1. Furthermore, treatment of m eSCs with the TRPC3 inhibitor, pyr3, also inhibited the expression of these neural differentiation markers and reduced the amount of SOCe. Interestingly, TRPC3 knockout with CRISPR/Cas9, or inhibition with pyr3 also resulted in dramatic cell death during the early stages of m eSC-derived neural differentiation. Taken together, TRPC3 appears to positively regulate the neural differentiation of m eSCs and it is also appears to be required for cell survival during this process. We are now studying how the suppression of TRPC3 affects the cellular and molecular mechanisms involved in the inhibition of neural differentiation and cell survival.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

CD4⁺ T-Cell Count, Serum Zinc, Copper and Selenium Levels in HIV Sero-Positive Subjects on ART and ART Naïve Subjects in Port Harcourt, Nigeria

引用

Journal of Biosciences and Medicines 2022年第5期10卷 105-116页

作者： Donatus Onukwufor Onwuli helen Waribo-Anthony Okwuchi eberechukwu Anyalebechi Chioma Ugochukwu River State University Nkpolu Oroworukwo Port Harcourt Nigeria Rivers State University Teaching Hospital Port Harcourt Nigeria

Background: HIV infection results in depletion of immunocompetent cells such as CD4+ T-cells. Trace elements such as Copper, Zinc and selenium are known to be involved in immune function. In recent times, HIV-positive patients are treated with antiretroviral therapy (ART), with significant progress. This study was aimed at evaluating CD4+ T-cells levels, serum Copper, Zinc and Selenium levels in HIV seropositive subjects on ART and ART naive subjects (HIV positive subjects that have not started ART treatment) in Rivers State, Nigeria. Methods: 150 subjects aged 20 to 79 years were recruited after informed consent. 70 subjects were HIV-positive on ART, 30 subjects were HIV-positive ART naïve subjects, while 50 subjects were apparently healthy subjects. Ten (10) milliliters of blood was collected using a standard venipuncture technique from each subject for the analysis of CD4 T-cells using BD fluorescent activated cell sorter (FACSC count), serum Copper and Zinc were analyzed colorimetrically using semi auto-analyzer WP 21e, while selenium was analyzed using atomic absorption spectrophotometer eLICO, SL173. Data generated were analyzed using Graph-Pad Prism version 8.0.2 and p Result: This study revealed a significant reduction in mean zinc, selenium and CD4+ T-cell level respectively (p = 0.0006;0.0001;0.0001) in HIV-Positive subjects on ART and ART naive. There was also a significant increase in mean serum copper level in the HIV-positive subject as compared to control subjects (p = 0.0001). ART treatment improved the CD4+ T cell count and serum levels of selenium and zinc;however, ART did not correct the imbalance. Furthermore, female subjects on ART have a significantly higher CD4+ T-cell count than the males (p Conclusion: Selenium and Zinc deficiency are associated with HIV disease despite the role of ART hence micronutrient supplementation is advised for HIV-positive subjects on ART.

关键词： Anti Retroviral Therapy (ART) Human Immunodeficiency Virus (HIV) Trace elements CD4 T-Cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

对附加规范的批评性回应

引用

哲学分析 2019年第2期10卷 37-39,196页

作者：海伦·朗基诺[美] 王不凡(译) 斯坦福大学哲学系东华大学马克思主义学院

认知责任的公平性和社会地位的多样性是扩展批评的语境经验主义规范的两种努力。但在朗基诺看来,学术权威的平等性同时适用于共识者和异议者,多样性并非来源于规范,而是来自起初致力于批评互动的认识论观点。多样性和共享标准之间的张... 详细信息

认知责任的公平性和社会地位的多样性是扩展批评的语境经验主义规范的两种努力。但在朗基诺看来,学术权威的平等性同时适用于共识者和异议者,多样性并非来源于规范,而是来自起初致力于批评互动的认识论观点。多样性和共享标准之间的张力不需要更多的附加规范来缓和。共同体必须扩大自身的包容性,才能使批评的话语有效。此外,科学实践中的意会内容在经受住了批评性的审查之后才会转化为知识。

关键词：批评的语境经验主义规范多样性共享标准

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Octopamine enhances learning

引用

National Science Review 2024年第6期11卷 82-83页

作者： Yvette e.Fisher Department of Molecular and Cell Biology and helen Wills Neuroscience Institute University of California

Across the animal kingdom, diverse monoamines actuate and modulate neural circuit function. However, measuring the rapid dynamics of these neuromodulators at cellular resolution has historically presented significant ... 详细信息

关键词： learning enhances octopamine

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：