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HBeAg negative serological status and low viral replication levels characterize chronic hepatitis B virus-infected women at reproductive age in Greece: A one-year prospective single center study

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World Journal of Gastroenterology 2005年第31期11卷 4879-4882页

作者： Ioannis S. elefsiniotis Irene Glynou Ioanna Magaziotou Konstantinos D. Pantazis Nikolaos V. Fotos Hero Brokalaki helen Kada George Saroglou Department of Internal Medicine Department of Microbiology Department of Neonatology

AIM： To evaluate the seroprevalence of hepatitis B surface antigen （HBsAg） in 13 581 women at reproductive age and the hepatitis B e antigen （HBeAg）/anti-HBe status as well as serum hepatitis B virus （HBV）-DNA levels in a subgroup of HBsAg（＋） pregnant women at labor in Greece. MeTHODS： Serological markers were detected using enzyme immunoassays. Serum HBV-DNA was determined by a sensitive quantitative PCR assay. Statistical analysis of data was based on parametric methodology. ReSULTS： Overall, 1.156% of women were HBsAg（＋） and the majority of them （71.3%） were Albanian. The prevalence of HBsAg was 5.1% in Albanian women, 4.2% in Asian women and 1.14% in women from eastern european countries. The prevalence of HBsAg in African （0.36%） and Greek women （0.29%） was very low. Only 4.45% of HBsAg （＋） women were also HBeAg（＋） whereas the vast majority of them were HBeAg（-）/anti-HBe（＋）. Undetectable levels of viremia （〈200 copies/mL） were observed in 32.26% of pregnant women at labor and 29.03% exhibited extremely low levels of viral replication （〈400 copies/mL）. Only two pregnant women exhibited extremely high serum HBV- DNA levels （〉10 000 000 copies/mL）, whereas 32.26% exhibited HBV-DNA levels between 1 500 and 40 000 copies/mL. CONCLUSION： The overall prevalence of HBsAg is relatively low among women at reproductive age in Greece but is higher enough among specific populations. The HBeAg（-）/anti-HBe（＋） serological status and the extremely low or even undetectable viral replicative status in the majority/of HBsAg（＋） women of our study population, suggestthat only a small proportion of HBsAg（＋） women in Greece exhibit a high risk for vertical transmission of the infection.

关键词： Hepatitis B Reproductive age Verticaltransmission HBeAg HBV-DNA

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Magnetoelectric and converse magnetoelectric responses in TbxDy1-xFe2-y alloy & Pb(Mg1/3Nb2/3)1-xTixO3 crystal laminated composites

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Science Bulletin 2008年第14期 2130-2135页

作者： OR Siu Wing CHAN helen L W Department of Applied Physics The Hong Kong Polytechnic University

Measured results of magnetoelectric (Me) and converse magnetoelectric (CMe) effects of TbxDy1-xFe2-y/ Pb(Mg1/3Nb2/3)(1-x)TixO3/TbxDy1-xFe2-y (TD/PMNT/TD) and PMNT/TD/PMNT laminated composites are pre- sented. Me effect was determined by measuring laminate voltage output under a Helmholtz-gener- ated AC field biased by a DC field (0―1 kOe) (1 Oe = 79.58 A/m). The CMe effect was measured by re- cording the voltage induced in a solenoid encompassing the Me sample while exposed to a DC bias field and PMNT layer driven by a 10 V AC source. The Me and CMe responses in the two laminated structure are linear. The highest values of Me coefficients in TD/PMNT/TD and PMNT/TD/PMNT com- posites are 384 mV/Oe and 158 mV/Oe, respectively, while the highest values of CMe coefficients in the two composites are 118 mG/V and 162 mG/V (1 G=10-4 T), respectively.

关键词： magnetoelectric effect converse magnetoelectric effect piezoelectricity magnetostriction TbxDy1-xFe2-y alloy Pb(Mg1/3Nb2/3)(1-x)TixO3 crystal

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Potential Range expansion of the Invasive Red Shiner, <i>Cyprinella lutrensis</i>(Teleostei: Cyprinidae), under Future Climatic Change

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Open Journal of ecology 2014年第9期4卷 554-564页

作者： helen M. Poulos Barry Chernoff College of the environment Wesleyan University Middletown USA Departments of Biology and earth and environmental Studies Wesleyan University Middletown USA

We built climate envelope models under contemporary and future climates to explore potential range shifts of the invasive Red Shiner-Cyprinella lutrensis. Our objective was to estimate aquatic habitat vulnerability to Red Shiner invasion in North America under future climatic change. We used presence records from within the species’ native and invaded distributions, a suite of bioclimatic predictor variables from three climate models (CCCma, CSIRO, and HadCM3), and maximum entropy modeling to generate potential distribution maps for the year 2080. Our model predicted major range expansion by Red Shiner under both low and high carbon emissions scenarios. The models exceeded average area under the receiver operator characteristic curve values of 0.92, indicating good overall model performance. The model predictions fell largely outside of areas of climatic extrapolation (i.e. regions predicted into environments different from training the region) indicating good model performance. The results from this study highlight the large potential range expansion across North America of Red Shiner under future warmer climates.

关键词： Invasive Fishes Maxent Climate envelope Model Climate Change Biological Invasions Cyprinella Lutrensis

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关于减重,团队干预可能比一对一干预更有效

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英国医学杂志中文版 2022年第3期25卷 172-173页

作者： helen Saul Deniz Gursul 徐静(译) NIHR Centre for engagement and Dissemination TwickenhamUK 中华心血管病杂志编辑部

研究Abbott S,Smith e,Tighe B,Lycett *** versus one-to-one multi-component lifestyle interventions for weight management:a systematic review and meta-analysis of randomised controlled trials.J Hum Nutr Diet 2021;34:485-93.研究背景在英国,约1/4的人患有肥胖症。肥胖会增加某些疾病的患病风险,如糖尿病、心脏病、卒中及一些癌症。肥胖缩短预期寿命、影响患者生存质量,并且显著增加英国国家健康体系(NHS)和社会的经济负担。

关键词：患病风险肥胖症预期寿命

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Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic e. coli

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Journal of Animal Science and Biotechnology 2019年第4期10卷 969-980页

作者： Kwangwook Kim Yijie He Xia Xiong Amy ehrlich Xunde Li helen Raybould edward R.Atwill elizabeth A.Maga Jens JΦrgensen Yanhong Liu Department of Animal Science University of CaliforniaDavisCA 95616USA School of Veterinary Medicine University of CaliforniaDavisCA 95616USA Chr.Hansen A/S HoersholmDenmark

Background: There is growing evidence to support the beneficial effects of supplementing direct-fed microbials(DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investigate dietary supplementation of Bacillus subtilis(DSM 25841) on growth performance, diarrhea, gut permeability and immunity of weaned pigs experimentally infected with a pathogenic F-18 escherichia coli(e. coli).Results: The F18 e. coli infection reduced(P erformance and intestinal villi height, whereas increased(P ea and transcellular and paracellular permeability in the jejunum compared with non-challenged control. Supplementation of Bacillus subtilis linearly enhanced average daily gain of e. coli infected pigs from d 0 to 5 post-inoculation(PI)(P ementation of high dose of Bacillus subtilis reduced(P ellular and paracellular permeability on d 5 and d11 PI compared with the e. coli infected pigs fed with control diet. e. coli infection up-regulated(P e m RNA expression of SLC5 A10(soluble carrier family 5 member 10) and MUC2(mucin 2) on d 5 PI, but down-regulated(P expression of SLC5 A10, MUC2, and CLDN1 on d 11 PI in jejunal mucosa when pigs were fed with the control diet. Supplementation of Bacillus subtilis linearly up-regulated(P e m RNA expression of CFTR and ZO1 on d 5 PI and SLC5 A10 and MUC2 on d 11 PI in jejunal mucosa of e. coli infected pigs. In addition, e. coli infection increased(P e m RNA expression of several immune genes(IL1 A, IL1 B, and IL7 on d 5 PI, and IL1 B, IL6, IL7, and TNF on d 11 PI) in the ileal mucosa of weaned pigs. Inclusion of Bacillus subtilis to control diet linearly down-regulated gene expression of IL1 A on d 5 PI(P = 0.07) and IL6 on d 11 PI(P eal mucosa of e. coli infected ***: Supplementation of Bacillus subtilis(DSM 25841) enhanced growth r

关键词： Bacillus subtilis Growth rate Gut barrier function Intestinal inflammation Pathogenic escherichia coli Weaned pigs

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A flexible protruding microelectrode array for neural interfacing in bioelectronic medicine

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Microsystems & Nanoengineering 2022年第6期8卷 165-179页

作者： helen Steins Michael Mierzejewski Lisa Brauns Angelika Stumpf Alina Kohler Gerhard Heusel Andrea Corna Thoralf Herrmann Peter D.Jones Günther Zeck Rene von Metzen Thomas Stieglitz NMI Natural and Medical Sciences Institute at the University of Tübingen ReutlingenGermany Laboratory for Biomedical Microtechnology Department of Microsystems EngineeringUniversity of FreiburgFreiburgGermany Institute of Biomedical electronics TU WienViennaAustria Bernstein Center Freiburg University of FreiburgFreiburgGermany BrainLinks-BrainTools University of FreiburgFreiburgGermany

Recording neural signals from delicate autonomic nerves is a challenging task that requires the development of a lowinvasive neural interface with highly selective,micrometer-sized *** paper reports on the development of a three-dimensional(3D)protruding thin-film microelectrode array(MeA),which is intended to be used for recording low-amplitude neural signals from pelvic nervous structures by penetrating the nerves transversely to reduce the distance to the *** gold pillars(O 20 or 50μm,~60μm height)were fabricated on a micromachined polyimide substrate in an electroplating *** sidewalls were insulated with parylene C,and their tips were optionally modified by wet etching and/or the application of a titanium nitride(TiN)*** microelectrodes modified by these combined techniques exhibited low impedances(~7 kΩ at 1 kHz for ∅ 50μm microelectrode with the exposed surface area of~5000μm^(2))and low intrinsic noise *** functionalities were evaluated in an ex vivo pilot study with mouse retinae,in which spontaneous neuronal spikes were recorded with amplitudes of up to 66μ*** novel process strategy for fabricating flexible,3D neural interfaces with low-impedance microelectrodes has the potential to selectively record neural signals from not only delicate structures such as retinal cells but also autonomic nerves with improved signal quality to study neural circuits and develop stimulation strategies in bioelectronic medicine,e.g.,for the control of vital digestive functions.

关键词： neural microelectrode electronic

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AN ACCURATe SOLUTION OF THe LINeAR THeORY OF THe WIND-DRIVeN OCeAN CIRCULATION-I. THe GeNeRALIZeD SOLUTION

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Journal of Hydrodynamics 2003年第6期15卷 96-105页

作者： Zhang Qing-hua, Qu Yuan-yuan, Xia Chang-shuiKey Laboratory of Marine Science and Numerical Modeling, State Oceanic Administration, First Institute of Oceanography, Qingdao 266061, China, e-mail: qu-helen @ *** Key Laboratory of Marine Science and Numerical Modeling State Oceanic Administration First Institute of Oceanography Qingdao 266061 China

To model the wind-driven ocean circulation of the isobath rectangular basin,the linear vorticity equation with the meridional friction terra was used compared to the Munk'stheory on the ocean circulation. The generalized solution of the vorlicity equation was thus workedout in the sense of Fourier averaging by using the corrected Fourier expansion. The method to obtainthe undetermined coefficients was presented using the viscous boundary conditions.

关键词： wind-driven ocean circulation meridional friction corrected fourierexpansion

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基于多边形边界约简的启发式在线时间序列表示算法

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计算机工程 2004年第4期30卷 25-27,75页

作者：翁颖钧朱仲英 helen Yu 上海交通大学自动化系上海200030 Department of e.e.e.University of Strathclyde GlasgowU.K

提出了一种新颖的可在线计算的时间序列启发式算法。算法具有多边形约简算法相同的优良的近似质量，并可在固定数据缓冲区空间内在线运算。用启发式搜索方法自动获取最佳分段数。在随机时间序列上仿真试验证明算法有很高的逼近质量和较... 详细信息

提出了一种新颖的可在线计算的时间序列启发式算法。算法具有多边形约简算法相同的优良的近似质量，并可在固定数据缓冲区空间内在线运算。用启发式搜索方法自动获取最佳分段数。在随机时间序列上仿真试验证明算法有很高的逼近质量和较低的计算复杂性。

关键词：时间序列多边形边界约简数据挖掘启发式搜索

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人参皂甙对CD_(34)^+造血干/祖细胞的增殖和分化作用

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中国中西医结合杂志 2000年第9期20卷 673-676页

作者：金锦梅 Tao helen 高瑞兰 BH Chong 浙江中医学院附属医院杭州310006 澳大利亚威尔士王子医院

目的 :探索人参皂甙 (GS)对CD34 +造血干 /祖细胞的刺激增殖和诱导分化作用。方法 :采用免疫磁珠法 (MACS)分离纯化脐血CD34 +细胞 ,在造血细胞半固体和液体培养体系中加入不同浓度的GS ,检测对CD34 +造血干 /祖细胞增殖 ,形成祖细胞集... 详细信息

目的 :探索人参皂甙 (GS)对CD34 +造血干 /祖细胞的刺激增殖和诱导分化作用。方法 :采用免疫磁珠法 (MACS)分离纯化脐血CD34 +细胞 ,在造血细胞半固体和液体培养体系中加入不同浓度的GS ,检测对CD34 +造血干 /祖细胞增殖 ,形成祖细胞集落的提高率 ,并用流式细胞仪检测液体培养后细胞表面标记的变化。结果 :GS( 5～ 50 μg/ml)能提高BFU e、CFU e、CFU GM、CFU GeMM集落产率 ( % ) ,分别为87 6± 2 6、63 3± 2 8、58 0± 3 1和 96 3± 5 5(均P <0 0 1)。GS 2 5μg/ml是液体培养刺激CD34 +细胞体外增殖的最佳浓度。GS诱导细胞 14天后 ,细胞表面表达CD33+细胞随GS的浓度升高而增加 ,在GS 50 μg/ml时以CD15+细胞数最高 ,CD71+细胞和G A+细胞数仅在 2 5μg/ml时高于未加GS的对照组。结论 :GS不但能促进CD34 +造血干 /祖细胞的增殖 ,并且能诱导定向分化 ,具有类生长因子和协同生长因子的作用。

关键词：人参皂甙 CD34^+细胞增殖分化造血干细胞

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第一性

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2001年

作者：海伦·费希尔（helen e.Fisher）王家湘译

本书包括：网式思维、组织中的妇女、妇女的词汇、看透别人的心思、妇女如何领导、明天属于妇女、性文明、合作的社会等内容。

ISBN: (纸本)720505169X

本书包括：网式思维、组织中的妇女、妇女的词汇、看透别人的心思、妇女如何领导、明天属于妇女、性文明、合作的社会等内容。

关键词：哲学、宗教心理学

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