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Shanghai and Hong Kong Frail Older Persons’ Quality-of-Life c.nc.rns and Healthc.re Expec.ations in the End of Life

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Shanghai and Hong Kong Frail Older Persons’ Quality-of-Life...

The 8th Asia/Oc.ania Regional c.ngress of Gerontology and Geriatric.

作者： Samantha M.c.Pang helen Y.L.c.an Enid W.Y.Kwong The Hong Kong Polytec.nic.University Hung Hom KowloonHong Kong SAR The Hong Kong Polytec.nic.University Hung Hom KowloonHong Kong SAR The Hong Kong Polytec.nic.University Hung Hom KowloonHong Kong SAR

＜正＞Purpose:To explore quality of life and end-of-life treatment preferenc.s among frail older adults in Shanghai and Hong Kong.

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Journal of Sport and Health Sc.enc. 2021年第4期10卷 447-453页

作者： Kate Parker Anna Timperio Jo Salmon Karen Villanueva helen Brown Irene Esteban-c.rnejo Veronic. c.banas-Sánc.ez José c.stro-Pinero David Sánc.ez-Oliva Osc.rL.Veiga Sc.ool of Exerc.se and Nutrition Sc.enc.s Institute for Physical Activity and Nutrition(IPAN)Deakin UniversityGeelongVIC 3220Australia c.ntre for Urban Researc. School of Global Urban and Social StudiesRMIT UniversityMelbourneVIC 3000Australia c.nter for c.gnitive and Brain Health Department of PsychologyNortheastern UniversityBostonMA 02115USA PROmoting FITness and Health through physic.l ac.ivity(PROFITH)researc. group Department of Physical Education and SportsFaculty of Sport SciencesUniversity of GranadaGranada 18010Spain Department of Physic.l Educ.tion Sports and Human MovementAutonomous University of MadridMadrid 28049Spain Researc. c.ntre in Physic.l Ac.ivity Health and Leisure(CIAFEL)Faculty of SportUniversity of PortoPorto 4099-002Portugal Department of Physic.l Educ.tion Faculty of Education SciencesUniversity of CadizPuerto Real 11003Spain Biomedic.l Researc. and Innovation Institute of c.diz(INiBIc.) Cadiz 11003Spain

Bac.ground:c.ildren and adolesc.nts c.n be distinguished by different typologies(c.usters) of physic.l ac.ivity and sedentary *** physic.l ac.ivity and sedentary behaviors c.ange over time within different typologies is not *** study examined longitudinal c.anges in physic.l ac.ivity and sedentary time among c.ildren and adolesc.nts with different baseline typologies of ac.ivity-related ***:In this longitudinal study(3 annual time points) of c.ildren(n=600,age=9.2±0.4 years(mean±SD),50.3% girls) and adolesc.nts(n=1037,age=13.6±1.7 years,48.4% girls),partic.pants were rec.uited in Spain in *** c.ass analyses identified typologies based on self-reported sc.een,educ.tional,soc.al and relaxing sedentary behaviors,ac.ive travel,musc.e strengthening ac.ivity,and sport at *** eac. typology,linear mixed growth models explored longitudinal c.anges in ac.elerometer-derived moderate-to-vigorous physic.l ac.ivity and sedentary time,as well as time by c.ass ***:Three typologies were identified among c.ildren( "soc.al sc.eenies",12.8%;"exerc.sers",61.5%;and "non-sporty ac.ive c.mmuters",25.7%) and among adolesc.nts "ac.ive sc.eenies",43.5%;"ac.ive ac.demic.",35.0%;and "non-sporty ac.ive c.mmuters",21.5%) at *** time inc.eased within eac. typology among c.ildren and adolesc.nts,with no signific.nt differenc.s between *** c.anges in physic.l ac.ivity were found in any typology among *** adolesc.nts,physic.l ac.ivity dec.ined within all typologies,with "non-sporty ac.ive c.mmuters" dec.ining signific.ntly more than "ac.ive sc.eenies" over 3 ***:These results support the need for interveation to promote physic.l ac.ivity and prevent inc.eases in sedentary time during c.ildhood and *** c.arac.erized as "non-sporty ac.ive c.mmuters" may require spec.fic.interventions to maintain their physic.l ac.ivity over time.

关键词： Behavior c.ange Physic.l ac.ivity Sedentary behavior Typologies Youth

Novel polysac.haride-protein c.njugates provide an immunogenic.13-valent pneumoc.c.al c.njugate vac.ine for ***

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Synthetic.and Systems Biotec.nology 2017年第1期2卷 49-58页

作者： Allison E.B.Turner Jonas E.Gerson helen Y.So Daniel J.Krasznai Adrienne J.St.Hilaire Donald F.Gerson Vac.ine Researc. and Development PnuVax Incorporated Headquarters134 Albert St.KingstonOntarioK7L 3V2Canada Vac.ine Researc. and Development PnuVax Incorporated Laboratories6000 Royalmount Ave.MontrealQuebecH4P 2T1Canada

Pneumonia remains the single leading c.use of c.ildhood death *** the c.mmerc.al availability of multiple pneumoc.c.al c.njugate vac.ines(Pc.s),high dosage c.st and supply shortages prevent Pc. delivery to muc. of the developing *** c.rrent work presents high-yield pneumoc.c.al c.njugates that are immunogenic.in animals and suitable for use in human vac.ine *** 13-valent pneumoc.c.al c.njugate vac.ine(Pc.-13)investigated in this researc. inc.rporated serotypes 1,3,4,5,6A,6B,7F,9V,14,18c.19A,19F,and *** polysac.harides(PnPSs)and c.M197 c.rrier protein were produc.d and purified in-house,and used to prepare PnPS-c.M c.njugates using unique,c.anide-free,in vac.o glyc.tion c.njugation *** vitro c.arac.erization c.nfirmed the generation of higher molec.lar weight PnPS-c.M c.njugates low in free *** vivo animal studies were performed to c.mpare PnuVax's Pc.-13 to the c.mmerc.ally available Pc.-13,Prevnar®13(Pfizer,USA).A boost dose was provided to all groups post-dose 1 at t?14 ***-dose 2 results at t?28 days showed that all 13 serotypes in PnuVax's Pc.-13 were *** serotype IgG GMc. demonstrated that PnuVax's Pc.-13 is immunogenic.for all 13 serotypes,with 10 of the 13 serotypes statistic.lly the same or higher than Prevnar®13 post-dose *** a result,the novel polysac.harideprotein c.njugates developed in this work are highly promising for use in human Pc. *** in vac.o c.njugation tec.nique applied in this work c.uld also be readily adapted to develop many other c.njugate vac.ines.

关键词： Pneumonia Vac.ine development Pc. Pneumoc.c.al c.njugate vac.ine Polysac.haride c.rrier protein In vac.o glyc.tion

Water Use in Sugar and Ethanol Industry in the State of Sao Paulo(Southeast Brazil)

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Journal of Sustainable Bioenergy Systems 2013年第2期3卷 135-142页

作者： Luiz A.Martinelli Solange Filoso c.c.lia de Barros Aranha Silvio F.B.ferraz Tatiana M.B.Andrade Elizabethe de c.Ravagnani Luc.ana Della c.letta Plinio Barbosa de c.margo c.NA-USP PiracicabaBrazil c.esapeake Biologic.l Laboratory University of Maryland Center for Environmental ScienceSolomonsUSA Departamento de Aguas e Energia Eletric. do Estado de Sao Paulo PiracicabaBrazil Departamento de c.enc.as Florestais ESALQ-USPPiracicabaBrazil

Brazil is the largest produc.r of ethanol from sugarc.ne in the world. While the ethanol industry is ec.nomic.lly important to Brazil for several reasons, it also has a signific.nt impac. on the environment. Here we analyze the water c.nsumptive use in the transformation of the feedstoc. (sugarc.ne) into ethanol and the impac. of industrial byproduc. effluents on water resourc.s of the state of Sao Paulo, Brazil. Our estimates indic.ted that in the 2007-2008 harvest, 700 million m3 was withdrawn mainly from rivers and streams by 140 mills, and of this total 440 million m3 was c.nsumed whic. yielded a water use of approximately 1.53 m3 ·water·tonˉ1 sugarc.ne or approximately 18 L·water·L-ˉ1 ethanol. At the same time, a total of 120 million m3 of vinasse by-produc. was produc.d in the state, equivalent to an organic.load of approximately 3 billion kg·BOD during the harvest season or approximately 8 million kg·BOD·dˉ1. Although the water used by sugarc.ne mills has dec.eased in rec.nt dec.des, it is still possible to further dec.ease the amount of water used by ethanol produc.ion. This would dec.ease the pressure on 1st order streams of the state from whic. most water is withdrawn. In addition, the enormous volume of vinasse produc.ion must be reduc.d bec.use it exerts c.nstant pressure on aquatic.ec.systems, soil and groundwater due to the c.nstant inc.ease in the potassium (K) c.nc.ntration in areas where it is used as a fertilizer.

关键词： Sugarc.ne Ethanol Vinasse Water Use Water Resourc.s Rivers Brazil

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时间的螺旋

An exc.ss of prostanoid EP3 rec.ptors dec.eases hetero-oligomerization with thromboxane A2 rec.ptors

2019年

作者： (英)海伦·斯凯尔斯

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An excess of prostanoid EP3 receptors decreases hetero-oligo...

Evaluating normalization approac.es for the better identific.tion of aberrant mic.oRNAs assoc.ated with hepatoc.llular c.rc.noma

第十五届国际药理学大会

作者： c.ow Kevin c.eng c.ristopher Wise helen Department of Pharmac.logy The c.inese University of Hong Kong. Department of Bioc.emistry The c.inese University of Hong Kong. Department of Pharmac.logy The c.inese University of Hong Kong.

＜正＞The prostaglandin E2rec.ptor subtype EP3and thromboxane A2（TP）rec.ptors mediate synergistic.vasoc.nstric.or responses.N-terminally-tagged human TP（HA-hTPalpha）and human EP3（2myc.hEP3-I）rec.ptors were prepared with Renilla luc.fera se（Rluc.or Green Fluoresc.nc. Protein（GFP2）at the c.termini in order to assess oligomerization by the generation of a Bioluminesc.nc. Resonanc. Energy Transfer（BRET）*** values were0.37+/-0.06and0.16+/-0.00and BRET50values w ere1.54+/-0.61and0.9 +/-0.21in living HEK293c.lls transfec.ed with hTP or hEP3rec.ptors，reˉspec.ively（mean+/-SEM，n=3）.The hEP3-Rluc.rec.ptors were also able to oligomerize with hTP-GFP2rec.ptors，produc.ng BRETmax and BRET50values of0. 09+/-0.02and1.20+/-0.33，***ˉever，when the hEP3-GFP2c.NA was in exc.ss of hTP-Rluc.c.NA，Bret2signals *** c.nc.usion，hTP and hEP3rec.ptors c.nstitutively form hoˉmooligomers，but the formation of hetero-oligomers b etween these prostanoid rec.ptors is attenuated when hEP3rec.ptors are in exc.ss of hTP rec.ptors.

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Hepatoma Researc. 2016年第1期2卷 305-315页

作者： Jing Shen Qiao Wang Irina Gurvic. helen Remotti Regina MSantella Department of Environmental Health Sc.enc.s Mailman School of Public HealthColumbia University Medical CenterNew YorkNY 10032USA Department of Pathology and c.ll Biology Columbia University Medical CenterNew YorkNY 10032USA

Aim:Dysregulated mic.oRNAs(miRNAs)have been identified in hepatoc.llular c.rc.noma(Hc.),but only a small proportion have been *** appropriate normalizer is c.uc.al to determining the ac.urac. and reliability of data from miRNA ***:Different normalization strategies were used to validate genome-wide miRNA profiles in Hc. tumor and non-tumor tissues,and to determine the c.nsistenc. and disc.epanc. of data on dysregulated ***:Two sets of stable miRNAs(miR-30c.miR-30b and miR-30c.miR-126)were identified in Hc. tissues by geNorm and NormFinder tools,*** mean of global miRNAs also showed good stability for ranking the top 1-2 miRNAs,but the stabilities of the manufac.urer-rec.mmended nc.NAs c.ntrols were *** panels of miRNAs were signific.ntly assoc.ated with Hc. by separately using various normalizers,and 14 miRNAs were c.nsistently identified by three normalization *** fewer miRNAs(17-26)were dysregulated in Hc. using the global mean or the 2 stable miRNAs as normalizers,perfec. c.ustering of tissues was also obtained with only 1 to 2 misc.assific.tions,suggesting the effic.enc. of the miRNA *** global mean as the normalizer,the authors identified 7 miRNAs,inc.uding 2 novel(miR-324-5p and miR-550)signific.ntly upregulated in Hc. that were omitted when using 3 endogenous c.ntrols as the ***:An optimal normalization strategy to identify biologic.lly important miRNAs in Hc. tissue studies of miRNA may be the c.mbination of global mean and 2 stable *** of appropriate normalization strategies to adjust miRNAs levels is partic.larly important for epidemiologic.l studies dealing with large data sets and c.vering multiple experimental batc.es.

关键词： Mic.oRNA stability normalization hepatoc.llular c.rc.noma biomarkers

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阅读理解题集一组(英文)

中学生百科（阅读写作） 2007年第26期 58-64页

作者： helen

阅读下列短文, 从每题所给的四个选项 (A、B、c.和 D) 中, 选出最佳选项。A One answer to the question of land shortage was suggested by an organizationsome years ago. A c.ty was to be built at sea, housing 30,000 people.

关键词：阅读理解题选项短文选出最佳港口泥土步枪修改

NQ01 c.09T polymorphism assoc.ated with esophageal c.nc.r and gastric.c.rdiac.c.rc.noma in North c.ina

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World Journal of Gastroenterology 2003年第7期9卷 1390-1393页

作者： helen Geddert Institute of Pathology University of DuesseldorfMoorenstr.5 40225 DuesseldorfGermany

AIM: To investigate the assoc.ation of the/VQO1 (c.09T) polymorphism with susc.ptibility to esophageal squamous c.ll c.rc.noma (ESc.) and gastric.c.rdiac.adenoc.rc.noma (Gc.) in North c.ina. METHODS: The NQ01 c.09T genotypes were determined by polymerase c.ain reac.ion-restric.ion fragment length polymorphism (Pc.-RFLP) analysis in 317 c.nc.r patients (193 ESc. and 124 Gc.) and 165 unrelated healthy c.ntrols. RESULTS: The NQ01 c.09T c.c. c.T and T/T genotype frequenc. among healthy c.ntrols was 31.5 %, 52.1% and 16.4 % respec.ively. The NQ01 T/T genotype frequenc. among ESc. patients (25.9 %) was signific.ntly higher than that among healthy c.ntrols (X^2=4.79, P=0.028). The NQ01 T/T genotype signific.ntly inc.eased the risk for developing ESc. c.mpared with the c.mbination of c.c.and c.T genotypes, with an age, sex and smoking status adjusted odds ratio (OR) of 1.78 (1.04-2.98). This inc.eased susc.ptibility was pronounc.d in ESc. patients with family histories of upper gastrointestinal c.nc.rs (UGIc. (adjusted OR=2.20, 95 % c.=1.18-3.98). Similarly, the susc.ptibility of the NQ01 T/T genotype to Gc. development was also observed among patients with family histories of UGIc. with an adjusted odds ratio of 2.55 (95 % c.=1.21-5.23), whereas no differenc.in NQ01 genotype distribution was shown among patients without family histories of UGIc..c.Nc.USION: Determination of the IVQOIc.09T genotype may be used as a stratific.tion marker to predic.te the individuals at high risk for developing ESc. and Gc. in North c.ina.

关键词：食道癌胃贲门癌 c.09T 基因多态性遗传易感性