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Intrauterine insemination with donor sperm:only the number of motile spermatozoa inseminated influences both pregnancy and live-birth rates

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Asian Journal of Andrology 2022年第3期24卷 287-293页

作者： Marie Cardey-Lefort Berengere Ducrocq Audrey Uk helen behal Anne-Laure Barbotin Geoffroy Robin Reproductive Biology Institute Lille University HospitalLille F-59037France Lille University Lille University HospitalULR 2694-METRICSLille F-59000France Endocrine Gynecology and Reproductive Medicine Unit Lille University HospitalLille F-59037France

Intrauterine insemination with donor sperm(IUI-D)is an assisted reproductive technology(ART)offered to couples with definitive male infertility or risk of genetic disease ***,we sought to evaluate our practice in IUI-D and identify factors that influenced the success *** performed a retrospective,single-center study of all IUI-D procedures performed at Lille University Medical Center(Lille,France)between January 1,2007,and December 31,*** and multivariate analyses with a mixed logistic model were used to identify factors associated with clinical pregnancies and live *** included 322 couples and 1179 IUI-D *** clinical pregnancy rate was 23.5%,and the live birth rate was 18.9%per *** a multivariate analysis,the women’s age was negatively associated with the live birth *** number of motile spermatozoa inseminated was the only factor associated with both clinical pregnancies and live births,with a chosen threshold of 0.75 *** clinical pregnancy and live birth rates were,respectively,17.3%and 13.0%below the number of motile spermatozoa inseminated threshold and 25.9%and 21.0%at or above the threshold(all P=0.005).The number of motile spermatozoa inseminated was the only factor that significantly influenced both pregnancies and live-birth rates after ***,below a threshold of 0.75 million motile spermatozoa inseminated,those rates were significantly *** of this number of motile spermatozoa inseminated threshold may help centers to allocate donations more effectively while maintaining reasonable waiting times for patients.

关键词： intrauterine insemination male infertility number of motile spermatozoa inseminated sperm donor

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