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a.prospective ca.cer chemo-immunothera.y a.proa.h media.ed by synergistic CD326 ta.geted porous silicon na.ovectors

Na.o Resea.ch 2015年第5期8卷 1505-1521页

作者： Moha.ma.-a.i Sha.ba.i Neha.Shrestha.Ermei Ma.ila.Fra.cisca.a.a.jo a.exa.dra.Correia.Toma. Ra.os Bruno Sa.mento Ja.no Sa.onen Jouni Hirvonen helder a. santos Division of Pha.ma.eutica. Chemistry a.d Technology Faculty of Pharmacy University ofHelsinki FI-00014 Helsinki Finland La.ora.ory of Industria. Physics Departmen t of Physics and Astronomy University of Turku FI-20014 Turku Finland INEB - Instituto de Engenha.ia.Biomedica NewTherapies Group Universidade do Porto Rua do Campo Alegre 823 4150-180 Porto Portuga ICBa. - Instituto Ciencia. Biomedica. a.el Sa.a.a. University of Porto Rua de Jorge Viterbo Ferreira 4050-313 Porto Portugal Fa.ulty of Pha.ma.y University of Coimbra 3000-548 Coimbra Portugal IINFa.TS - Instituto de Investiga.a. e Forma.a. a.a.ca.a.em Ciencia. e Tecnologia. da.Sa.de Instituto Superior de Ciencias da Saude-Norte Department of Pharmaceutical Sciences CESPU Rua Central de Gandra 4585-116 Gandra Portugal

Combina.ion thera.y via.na.opa.ticula.e systems ha. a.rea.y been proposed a. a.synergistic a.proa.h for ca.cer trea.ment. Herein, undecylenic a.id modified therma.ly hydroca.bonized porous silicon na.opa.ticles （UnTHCPSi NPs） loa.ed with sora.enib a.d surfa.e-biofunctiona.ized with a.ti-CD326 a.tibody （a.） were developed for ca.cer chemo-immunothera.y in MCF-7 a.d MDa.MB-231 brea.t ca.cer cells. The cytocompa.ibility study showed no significa.t toxicity for the ba.e a.d a.tibody-conjuga.ed UnTHCPSi （Un-a.） NPs a. concentra.ions lower tha. 200 μg·mL^-1. Compa.ed to the ba.e UnTHCPSi, Un-a. NPs loa.ed with sora.enib reduced the prema.ure drug relea.e in pla.ma. increa.ing the proba.ility of proper drug ta.geting. In a.dition, high cellula. intera.tion a.d subsequent interna.iza.ion of the Un-a. NPs into the cells expressing CD326 a.tigen demonstra.ed the possibility of improving a.tigen-media.ed endocytosis via.CD326 ta.geting. While a. in vitro a.titumor study revea.ed a.higher inhibitory effect of the sora.enib-loa.ed Un-a. NPs compa.ed to the drug-loa.ed UnTHCPSi NPs in the CD326 positive MCF-7 cells, there wa. no difference in the a.ti-prolifera.ion impa.t of both the a.ovementioned NPs in the CD326 nega.ive MDa.MB-231 cells, suggesting CD326 a. a. a.propria.e receptor for a.-media.ed drug delivery. It wa. a.so shown tha. the a.ti-CD326 a. ca. a.t a. a. immunothera.eutic a.ent by inducing a.tibody dependent cellula. cytotoxicity a.d enha.cing the intera.tion of effector immune a.d ca.cer cells for subsequent pha.ocytosis a.d cytokine secretion. Hence, the developed na.ovectors ca. be a.plied for simulta.eous tumor-selective drug ta.geting a.d immunothera.y.

关键词： CD326 a.tibody porous silicon na.opa.tides chemo-immunothera.y brea.t ca.cer drug ta.geting

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The effect of drying of Piper hispidinervium bydifferent methods a.d its influence on the yield ofessentia. oil a.d sa.role

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Informa.ion Processing in a.riculture 2023年第1期10卷 28-39页

作者： helder Kiyoshi Miya.a.a.a.berda. Silva.santos Systema.ic Investiga.ion in Biotechnology a.d Molecula. Biodiversity La.ora.ory Federal University of Para´Bele´m 66075-110PABrazil

The Piper hispidinervium lea.es a.d thin stems were dried under la.ora.ory a.d field *** drying wa. performed using a.sha.e dryer opera.ing with a.d without forced convection a.d a. oven dryer opera.ing a. 30 a.d 40*** experiments were conducted using sola. dryers with three different covers,i.e.,tra.spa.ent,bla.k pla.tic,a.d pa.m stra. *** essentia. oil extra.tion wa. performed by stea. distilla.ion,a.d the sa.role content wa. a.a.yzed by ga. *** ma.hema.ica. models(Pa.e,loga.ithmic,Henderson a.d Pa.is,fra.tiona.,a.d diffusion)were fitted with the experimenta. da.a.a.d compa.ed ba.ed on the coefficient of determina.ion(R2),root mea. squa.e error(RMSE)a.d *** suggest tha. the best model wa. the loga.ithmic model(R2>0.99,RMSEa.d v2a.role content increa.ed up to 95%of the extra.ted oil;however,when the drying time wa. prolonged,both the oil yield a.d sa.role content of the extra.ted oil decrea.ed.

关键词： Modeling Drying kinetics Essentia. oil extra.tion Sa.role extra.tion Pipera.ea.

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Na.opa.ticles-ba.ed photothera.y systems for ca.cer trea.ment: Current sta.us a.d clinica. potentia.

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Bioa.tive Ma.eria.s 2023年第5期23卷 471-507页

作者： Jia.hen Li Shiqi Wa.g Fla.ia.Fonta.a.Christos Ta.einos Moha.ma.-a.i Sha.ba.i Huijie Ha. helder a.santos Depa.tment of Biomedica. Engineering W.J.Kolff Institute for Biomedical Engineering and Materials ScienceUniversity Medical Center GroningenUniversity of GroningenAnt.Deusinglaan 1Groningen9713 AVthe Netherlands W.J.Kolff Institute for Biomedica. Engineering a.d Ma.eria.s Science University Medical Center GroningenUniversity of GroningenUniversity of GroningenAntonius Deusinglaan 19713 AVGroningenthe Netherlands Drug Resea.ch Progra. Division of Pha.ma.eutica. Chemistry a.d Technology Faculty of PharmacyUniversity of HelsinkiHelsinkiFI-00014Finland

Rema.ka.le progress in photothera.y ha. been ma.e in recent deca.es,due to its non-inva.iveness a.d insta.t thera.eutic *** a.dition,with the ra.id development of na.oscience a.d na.otechnology,photothera.y systems ba.ed on na.opa.ticles or na.ocomposites a.so evolved a. a. emerging hotspot in na.omedicine resea.ch,especia.ly in *** this review,first we briefly introduce the history of photothera.y,a.d the mecha.isms of photothera.y in ca.cer ***,we summa.ize the representa.ive development over the pa.t three to five yea.s in na.opa.ticle-ba.ed photothera.y a.d highlight the design of the innova.ive na.opa.ticles ***,we discuss the fea.ibility a.d the potentia. of the na.opa.ticle-ba.ed photothera.y systems in clinica. a.tica.cer thera.eutic a.plica.ions,a.ming to predict future resea.ch directions in this *** review is a.tutoria. work,a.ming a. providing useful insights to resea.chers in the field of na.otechnology,na.oscience a.d ca.cer.

关键词： Photothera.y Ca.cer Na.opa.ticles Thera.eutic effect Clinica. potentia.

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Neona.a. Fc receptor-ta.geted lignin-enca.sula.ed porous silicon na.opa.ticles for enha.ced cellula. intera.tions a.d insulin permea.ion a.ross the intestina. epithelium

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Bioa.tive Ma.eria.s 2022年第3期7卷 299-315页

作者： Joa. P.Ma.tins Pa.rícia.Figueiredo Shiqi Wa.g Erika.Espo Elena.Celi Bea.riz Ma.tins Ma.ia.na.Kemell Ka.ina.Moslova.Ermei Ma.il Ja.no Sa.onen Ma.ri a.Kostia.nen Christia. Celia.Vincenzo Cerullo Ta.a.i Viita.a.Bruno Sa.mento Jouni Hirvonen helder a.santos Drug Resea.ch Progra. Division of Pharmaceutical Chemistry and TechnologyFaculty of PharmacyUniversity of HelsinkiFI-00014HelsinkiFinland Depa.tment of Pha.ma.y University of Chieti-Pescara“G d’Annunzio”I-66100ChietiItaly Drug Resea.ch Progra. Division of Pharmaceutical BiosciencesFaculty of PharmacyUniversity of HelsinkiFI-00014HelsinkiFinland Depa.tment of Chemistry University of HelsinkiFI-00014HelsinkiFinland Depa.tment of Physics a.d a.tronomy University of TurkuFI-20014TurkuFinland Biohybrid Ma.eria.s Department of Bioproducts and BiosystemsAalto UniversityFI-00076AaltoFinland i3S-Instituto de Investiga.a. e Inova.a. em Sa.de University of Porto4200-135PortoPortugal INEB-Instituto de Engenha.ia.Biomedica University of Porto4200-135PortoPortugal CESPU-Instituto de Investiga.a. e Forma.a. a.a.ça.a.em Ciencia. e Tecnologia. da.Sa.de 4585-116GandraPortugal Helsinki Institute of Life Science(HiLIFE) University of HelsinkiFI-00014HelsinkiFinland

Ora. insulin delivery could cha.ge the life of millions of dia.etic pa.ients a. a. effective,sa.e,ea.y-to-use,a.d a.forda.le a.terna.ive to insulin injections,known by a. inherently thwa.ted pa.ient ***,we designed a.multista.e na.opa.ticle(NP)system ca.a.le of circumventing the biologica. ba.riers tha. lea. to poor drug a.sorption a.d bioa.a.la.ility a.ter ora. *** na.osystem consists of a. insulin-loa.ed porous silicon NP enca.sula.ed into a.pH-responsive lignin ma.rix,a.d surfa.e-functiona.ized with the Fc fra.ment of immunoglobulin G,which a.ts a. a.ta.geting liga.d for the neona.a. Fc receptor(FcRn).The developed NPs presented sma.l size(211±1 nm)a.d na.row size *** NPs rema.ned inta.t in stoma.h a.d intestina. pH conditions,relea.ing the drug exclusively a. pH 7.4,which mimics blood *** formula.ion showed to be highly cytocompa.ible,a.d surfa.e pla.mon resona.ce studies demonstra.ed tha. FcRn-ta.geted NPs present higher ca.a.ity to intera.t a.d being interna.ized by the Ca.o-2 cells,which express FcRn,a. demonstra.ed by Western ***,in vitro permea.ility studies showed tha. Fc-functiona.ized NPs induced a. increa.e in the a.ount of insulin tha. permea.ed a.ross a.Ca.o-2/HT29-MTX co-culture model,showing a.pa.ent permea.ility coefficients(Pa.p)of 2.37×10􀀀6 cm/s,over the 1.66×10􀀀6 cm/s observed for their non-functiona.ized ***,these results demonstra.e the potentia. of these NPs for ora. delivery of a.ti-dia.etic drugs.

关键词： Na.opa.ticles Porous silicon Lignin FcRn Insulin Ora. drug delivery

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The full length <i>PtSRP</i>(<i>Pisolithus tinctorius</i>symbiosis rela.ed protein) funga. mRNa.encodes a.potentia. ma.ker of ectomycorrhiza.forma.ion

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a.erica. Journa. of Molecula. Biology 2012年第3期2卷 258-264页

作者： helder Elísio E. Vieira.Cláudia.E. P. Lima.Ca.los E. Ca.za.a.a.Silva.Ba.tolomeu a.ioli-santos Ela.ne Ma.osso Depa.ta.ento de Micologia Universidade Federal de Pernambuco Recife Brazil La.ora.ório de Imunologia.Celula. e Molecula. Centro de Pesquisas René Rachou Belo Horizonte Brazil

The Pisolithus tinctorius symbiosis rela.ed protein expressed sequence ta. (EST PtSRP) wa. previously identified in the first hours of the intera.tion between the fungus Pisolithus tinctorius a.d sweet chestnut Ca.ta.ea.sa.iva. a.d pa.tia.ly cha.a.terized a. a.funga. ma.ker gene of ectomycorrhiza. symbiosis forma.ion. We used the 5’ ra.id a.plifica.ion of cDNa.ends (Ra.E) to obta.n the PtSRP mRNa.5’ region, a.d together with our previously reported 3’ mRNa.region, the full mRNa.sequence wa. a.sembled by use of bioinforma.ics tools a.d deposited to GenBa.k (a.cession: GU733439). The full-length mRNa.sequence (636 bp) revea.ed the loca.ions of the 5’ a.d 3’ untra.sla.ed regions (UTRs) a.d conta.ned the Koza. sequence (ccc a.g a.G a. in the 5’ UTR. The in silico tra.sla.ed PtSRP open rea.ing fra.e (ORF) codes for a.127 a.ino a.id protein a.d conta.ned four puta.ive post-tra.sla.iona. modifica.ion sites (two N-glycosyla.ion a.d two phosphoryla.ion). The protein seconda.y structure is postula.ed to be composed of one N-termina. hydrophobic tra.smembra.e a.pha.helix a.d a. lea.t six hydrophilic beta.stra.ds sprea. a.ross the protein. Sub-cellula. loca.iza.ion prediction suggests tha. the protein is involved in cellula. secretory pa.hwa., supported by the presence of a.clea.a.e site motif close to the membra.e a.chor. The da.a.presented herein indica.e the role of PtSRP a. a.funga. membra.e secreted protein involved in ea.ly sta.es of ectomycorrhiza. forma.ion, with a.plica.ion a. a.possible ma.ker for na.cent ectomy-corrhiza.funga. development.

关键词： Ectomycorrhiza Symbiosis Rela.ed Genes/Proteins Ra.E EST

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彩云之南,雨林天堂——西双版纳万达文华度假酒店

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城市环境设计 2016年第5期 226-229页

作者：李颖悟 helder santos 陈江陈英男陈鹤 Oa.欧安地建筑设计事务所

西双版纳,古代傣语为"勐巴拉娜西",是"理想而神奇的乐土"之意。西双版纳万达文华度假酒店坐落于中国云南省最南端,西双版纳景洪市嘎栋区东北方向,群山密林的优美风景中,建筑融于自然,也成为了风景的一部分。建筑师充分发掘了西双版纳热... 详细信息

西双版纳,古代傣语为"勐巴拉娜西",是"理想而神奇的乐土"之意。西双版纳万达文华度假酒店坐落于中国云南省最南端,西双版纳景洪市嘎栋区东北方向,群山密林的优美风景中,建筑融于自然,也成为了风景的一部分。建筑师充分发掘了西双版纳热带自然环境和少数民族风情文化的独特资源,融入傣族建筑的整体风格,让建筑在内外空间上的关照与交流延伸至精神的层面,呈现出了从属于自然环境的气质,提供了一个隐于自然风景、私密幽静的度假乐土。

关键词：度假酒店达文文华酒店西双版纳云南雨林彩云之南天堂

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花水湾名人度假酒店

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中国建筑装饰装修 2011年第2期 80-85页

作者：李颖悟何樾温凡松 helder santos Irwin 董谦魏岢苏欣彭敏杰吕婧婧美国Oa.建筑设计事务所成都市建筑设计院

精选理由借问酒家何处有,牧童遥指杏花村＂大自然的魅力结合古人诗词意境,轻柔的出现在空间里。一切人工设计都是遵照自然的感觉,力求与环境融为一体,故建筑室内外装饰均以＂花、水＂为主题进行设计,尽显山海中的＂花与水＂之感。

关键词：度假酒店名人水人工设计室内外装饰大自然酒家空间

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