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CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

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Coupling metal oxide nanoparticle catalysts for water oxidation to molecular light absorbers

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Journal of Energy Chemistry 2017年第2期26卷 241-249页

作者： heinz Frei Molecular Biophysics and Integrated Bioimaging Division Lawrence Berkeley National LaboratoryUniversity of CaliforniaBerkeleyCA 94720USA

Water oxidation, as a mandatory reaction of solar fuels conversion systems, requires the use of light absorbers with electronic properties that are well matched with those of the multi-electron catalyst in order to achieve high efficiency. Molecular light absorbers offer flexibility in fine tuning of orbital energetics,and metal oxide nanoparticles have emerged as robust oxygen evolving catalysts. Hence, these material choices offer a promising approach for the development of photocatalytic systems for water ***, efficient charge transfer coupling of molecular light absorbers and metal oxide nanoparticle catalysts has proven a challenge. Recent new approaches toward the efficient coupling of these components based on synthetic design improvements combined with direct spectroscopic observation and kinetic evaluation of charge transfer processes are discussed.

关键词： Water oxidation catalysts Metal oxides Molecular light absorbers Artificial photosynthesis Charge transfer Electronic coupling

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Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro Mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo Mario Reis Alvares-da-Silva Roberta C Marchiori Cleber Rosito Pinto Kruel Marcio Fernandes Chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with HCC being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with HCC awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To compare the outcomes of TACE and TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TACE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each HCC nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

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Quasiresiduals in Semigroups with Natural Partial Order

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Algebra Colloquium 2017年第3期24卷 361-380页

作者： heinz Mitsch Fakul t für Mathematik Universit t Wien Oskax Morgenstern Platz 1 A-1090 Wien Austria

A semigroup （S, .） is called right （left） quasiresiduated if for any a, b in S there exists x in S such that ax≤s b （xa≤s b） with respect to the natural partial order ≤s of S. This concept has its origin in the theory of residuated semigroups, but can also be seen as a generalization of the right （left） simplicity of semigroups. It is first studied for totally-, resp., trivially-ordered semigroups, and then for semigroups with idempotents. In particular, the cases when （S≤s） is directed downwards and when S contains a zero （with respect to a more restrictive definition） are dealt with. Throughout, examples are given; in total, 30 classes of （often well-known） semigroups of this kind are specified.

关键词： semigroup natural partial order quasiresidual

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Premotor Diagnosis of Parkinson's Disease

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Neuroscience Bulletin 2017年第5期33卷 526-534页

作者： heinz Reichmann Department of Neurology Dresden University of Technology Fetscherstraβe 74 01307 Dresden Germany

Typical Parkinsonian symptoms consist of bradykinesia plus rigidity and/or resting tremor. Some time later postural instability occurs. Pre-motor symptoms such as hyposmia, constipation, REM sleep behavior disorder and depression may antecede these motor symp- toms for years. It would be ideal, if we had a biomarker which would allow to predict who with one or two of these pre-motor symptoms will develop the movement disorder Parkinson＇s disease （PD）. Thus, it is interesting to learn that biopsies of the submandibular gland or colon biopsies may be a means to predict PD, if there is a high amour of abnormally folded alpha-synuclein and phosphorylated alpha-synuclein. This would be of relevance if we would have available means to stop the propagation of abnormal alpha-synuclein which is otherwise one of the reasons of this spreading disease PD.

关键词： Parkinson's disease Gut-brain-axis Premotorsymptoms Hyposmia. Constipation REM sleep behavior disorder

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Resolvent Estimates and Quantification of Nonlinear Stability

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Acta Mathematica Sinica,English Series 2000年第1期16卷 1-20页

作者： heinz-Otto Kreiss Jens Lorenz Department of Mathematics UCLALos AngelesCA 90095USA Department of Mathematics and Statistics UNMAlbuquerqueNM 87131USA

The aim of this paper is to clarify the role played by resolvent estimates for nonlinear *** will give examples showing that a large resolvent may lead to a small domain of nonlinear *** other examples the resolvent is large,but the domain of nonlinear stability is completely *** case prevails depends on the details of the problem. We will also show that the size of the resolvent depends in an essential way on the norms that are used.

关键词： Resolvent estimates Nonlinear stability Pseudospectrum Convection-dominated flow

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Improvement of the Corrosion Resistance of High Alloyed Austenitic Cr-Ni-Mo Stainless Steels by Solution Nitriding

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材料热处理学报 2004年第5期25卷 316-321页

作者： Christine Eckstein heinz- Joachim Spies Jochen Albrecht Dept. of Materials Eng. Technische Universitat Bergakademie Freiberg 09599 Freiberg/GermanyDept. of Materials Eng. Technische Universitat Bergakademie Freiberg 09599 Freiberg/GermanyInstitut Fresenius GmbH Solid State Analytic Zur Wetterwarte 10Haus 107 01109 Dresden Germany

Characteristic features of austenitic steel grades combine a good corrosion resistance with a low hardness, wear resistance and scratch resistance. An interesting possibility for improving the wear behaviour of these steels without loss of their corrosion resistance lies in enriching the near surface region with nitrogen. The process of a solution nitriding allows the rise of the solution of nitrogen in the solid phase. On this state nitrogen increases the corrosion resistance and the tribilogical load-bearing capacity. The aim of the study was, to investigate the improvement of the pitting corrosion behaviour by solution nitriding. A special topic was to observe the effect of nitrogen by different molybdenum content. So austenitic stainless steels (18% Cr, 12% Ni, Mo gradation between 0.06 to 3.6%) had been solution nitrided. The samples could be prepared with various surface content of nitrogen from 0.04 to 0.45% with a step-by-step grinding. The susceptibility against pitting corrosion of these samples had been tested by determination of the stable pitting potential in 0.5M and 1M NaCl at 25°C. For the investigated steel composition and the used corrosion system there is no influence of molybdenum on the effectiveness of nitrogen. The influence of nitrogen to all of the determined parameters can be described well by PRE = Cr + 3,3 * Mo + 25 *N. XPS analysis of the sample surfaces support the results of the pitting corrosion *** surface investigations with an acid elektolyte (0,1M HC1 + 0,4M NaCl) were performed. In this case the passivation effective nitrogen content increases markedly with rising molybdenum concentration of the steel. Obviously an interaction of Mo and N is connected with a strongly acid electrolyte.

关键词：耐蚀性奥氏体不锈钢 Cr-Ni-Mo 渗氮 PRE 稳定点蚀电位

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Effect of deformation temperature on precipitation, microstructural evolution, mechanical and corrosion behavior of 6082 Al alloy

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Transactions of Nonferrous Metals Society of China 2017年第3期27卷 475-492页

作者： NikhilKUMAR R.JAYAGANTHAN heinz-GünterBROKMEIER department of metallurgical and materials engineering¢re of nanotechnology indian institute of technology roorkeeRoorkee 247667India department of engineering design indian institute of technology madrasChennai 600036India institute of materials science and engineering clausthal university of technologyagricolastrasse 6d-38678 clausthal-zellerfeldgermany&helmholtz zentrum geesthachtMax Planck Straße 1D-21502 GeesthachtGermany

The influence of cryorolling(CR),room temperature rolling(RTR)and post annealing on precipitation,microstructuralevolution(recovery,recrystallisation and grain growth),mechanical and corrosion behavior,was investigated in the present *** precipitation kinetics and microstructural morphology of CR,RTR,and post annealed samples were investigated by differentialscanning calorimetry(DSC),transmission electron microscopy(TEM),and electron back scattered diffraction(EBSD)to elucidatethe observed mechanical *** annealing at200°C,UTS and hardness of CR samples(345MPa and HV127)wereimproved as compared to RTR samples(320MPa and HV115).The increase in hardness and UTS of CR samples after annealing at200°C was due to precipitation ofβ''from Al matrix,which imparted higher Zener drag effect as compared to RTR *** in corrosion and pitting potentials was observed for CR samples(?1.321V and?700mV)as compared to RTRsamples(?1.335V and?710mV).In CR samples,heavy dislocation density and dissolution of Mg4Al3Si4-precipitates in the Almatrix have improved corrosion resistance of the alloy through formation of protective passive layer and suppression of galvanic cell,respectively.

关键词： aluminum alloy cryorolling mechanical property corrosion potential precipitation

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Dynamic compressive strength and failure mechanisms of microwave damaged sandstone subjected to intermediate loading rate

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Transactions of Nonferrous Metals Society of China 2022年第11期32卷 3714-3730页

作者： Pin WANG Tu-bing YIN Xi-bing LI heinz KONIETZKY School of Resources and Safety Engineering Central South UniversityChangsha 410083China Geotechnical Institute TU Bergakademie FreibergFreiberg09596Germany

To investigate the influence of microwave heating on the dynamic behavior and failure mechanisms of rock,dynamic compression tests were conducted on microwave-irradiated sandstone specimens using a modified split Hopkinson pressure bar(SHPB)*** results show that microwave radiation can effectively weaken the compressive strength of *** specimens show three different failure modes under impact load:tensile failure,tensile−shear composite failure and compressive−shear *** dynamic Poisson’s ratio,calculated using the measured P-and S-wave velocities,is introduced to describe the deformation characteristics of *** the increase in microwave power and heating time,the Poisson’s ratio declines first and then increases slightly,and the turning point occurs at 244.6℃.Moreover,the microstructural characteristics reveal that microwave radiation produces dehydration,pore expansion,and cracking of the *** damage mechanisms caused by microwave radiation are discussed based on thermal stress and steam pressure inside the rock,which provides a reasonable explanation for the experimental results.

关键词： sandstone microwave radiation thermal cracking dynamic compressive strength failure patterns split Hopkinson pressure bar

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Effects of elevated pO_3 on carbon cycle between above andbelowground organs of trees

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Journal of Environmental Sciences 2006年第5期18卷 932-936页

作者： LIU Xi-ping Rennenberg heinz Matyssek Rainer College of Life Sciences Northwest Sci-Tech University of Agriculture and Forestry Yangling 712100 China Institute of Forest Botany and Tree Physiology University Freiburg D-79110 Freiburg Germany Department of Ecopogy/Ecophysiology of Plants Technical University Munich D-85354 Freising Germany

Translocation of carbohydrate from leaves to roots via phloem and reallocation from roots to leaves via xylem regulate the allocation of carbon （C） between above and belowground organs of trees. To quantitatively analyze effects of elevated ozone concentrations pO3 on the internal cycle of C, juvenile beech and spruce were grown in phytotrons and exposed to ambient and elevated pO3 （i.e. twice-ambient O3 levels, restricted to 〈 150 ppb） for two growing seasons. The translocation of C in the phloem and xylem was quantitatively studied by investigating the phloem/xylem-loading of sugars, the differentiation of stem conductive tissue and the hourly water flow through the stem. Results in the present study shown, elevated pO3 significantly decreased C translocation from shoot to roots in beech by reducing both sugar concentration in the phloem and conductive phloem area. Elevated pO3 also significantly decreased C reallocation from the roots to the shoot in beech by reducing both of sugar concentration in the xylem and transpiration rate. The adverse effects of elevated pO3 on C translocation in the phloem and xylem, however, were small in spruce. Contrasting to beech, spruce is less sensitive to elevated pO3, regarding to phloem differentiation and sugar concentrations in the phloem and xylem.

关键词： beech carbon cycle elevated pO3 phloem spruce xylem

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