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The physiological polyphosphate as a healing biomaterial for chronic wounds:crucial roles of its antibacterial and unique metabolic energy supplying properties

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Journal of Materials Science & Technology 2023年第4期135卷 170-185页

作者： Werner E.G.Müller Hadrian Schepler Meik Neufurth Shunfeng Wang Veronica Ferrucci Massimo Zollo Rongwei Tan heinz c.schröder Xiaohong Wang ERc Advanced Investigator Grant Research Group at the Institute for Physiological chemistry University Medical Center of the Johannes Gutenberg UniversityDuesbergweg 6Mainz D-55128Germany Department of dermatology University Clinic MainzLangenbeckstr.1Mainz D-55131Germany Dipartimento di Medicina Molecolare e Biotecnologie Mediche Universitàdegli Studi di Napoli Federico IIVia Sergio Pansini 5Naples 80131Italy ceinge Biotecnologie Avanzate Francesco Salvatore Via G.Salvatore 486Naples 80145Italy Shenzhen Lando Biomaterials co. Ltd.Shenzhen 518107China

Insufficient metabolic energy,in the form of adenosine triphosphate(ATP),and bacterial infections are among the main causes for the development of chronic *** we showed that the physi-ological inorganic polymer polyphosphate(polyP)massively accelerates wound healing both in animals(diabetic mice)and,when incorporated into mats,in patients with chronic ***,we focused on a hydrogel-based gel formulation,supplemented with both soluble sodium polyP(Na-polyP)and amor-phous calcium polyP nanoparticles(ca-polyP-NP).Exposure of human epidermal keratinocytes to the gel caused a significant increase in extracellular ATP level,an effect that was even enhanced when Na-polyP was combined with ***,it is shown that the added polyP in the gel is converted into a coacervate,leading to encapsulation and killing of *** data on human chronic wounds showed that the administration of hydrogel leads to the complete closure of these *** analysis of biopsies showed an increased granulation of the wounds and an enhanced microvessel *** results indicate that the polyP hydrogel,due to its properties to entrap bacteria and generate metabolic energy,is a very promising formulation for a new therapy for chronic wounds.

关键词： Inorganic polyphosphate Nanoparticles Hydrogel coacervate Human chronic wounds Antibacterial activity Metabolic energy

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生物无机化学范式的转变:硅质海绵动物中二氧化硅的酶促缩聚反应(英文)

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化学进展 2013年第4期25卷 435-445页

作者：王晓红甘露 heinz c.schrder Werner E.G.Müller 国家地质实验测试中心中国地质科学院北京100037 德国美因茨约翰尼斯-古腾堡大学医学中心生理化学所美因茨55128

硅蛋白的发现导致了生物无机化学范式的转变,因为它是第一个可以催化无机单体合成无机聚合物分子的酶。分子生物学,生物化学和细胞生物学数据证实,两种硅质海绵动物,包括寻常海绵和六放海绵,它们的骨针都是由硅蛋白/酶催化合成的。这种... 详细信息

硅蛋白的发现导致了生物无机化学范式的转变,因为它是第一个可以催化无机单体合成无机聚合物分子的酶。分子生物学,生物化学和细胞生物学数据证实,两种硅质海绵动物,包括寻常海绵和六放海绵,它们的骨针都是由硅蛋白/酶催化合成的。这种酶不仅存在于硅质海绵骨针内部,而且也存在于硅质海绵骨针表面。在硅质海绵骨针生长过程中,它催化生物二氧化硅的合成而构建硅薄层,一层层的硅薄层逐步沉积从而形成硅质海绵骨针。寻常海绵动物Suberites domuncula体外实验获得的硅蛋白活性数据(催化生物二氧化硅的形成)反映了体内骨针生长所需的生物二氧化硅量。本文最后总结了在寻常海绵动物骨针生长和成熟过程中出现的生物熔合现象,即内部的硅薄层"烧结"在一起形成致密的硅棒。强壮的和坚硬的生物二氧化硅骨架的形成需要经历一个硬化过程,这个过程由海绵动物排水通道表面的细胞膜控制,排除生物二氧化硅缩聚反应过程中释放出的水分而使材料固化。

关键词：范式转变生物无机化学海绵动物硅蛋白生物硅结构层次

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Influence of cO_(2)/HcO_(3)^(-) on Microbial communities in Two Karst caves with High cO_(2)

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Journal of Earth Science 2023年第1期34卷 145-155页

作者： Jiyu chen Qiang Li Qiufang He heinz c.schroder Zujun Lu Daoxian Yuan Key Laboratory of Karst Dynamics MNR&GZARInstitute of Karst GeologyChinese Academy of Geological SciencesGuilin541004China International Research center on Karst under the Auspices of UNEScO Guilin541004China college of Life Science Guangxi Normal UniversityGuilin541006China Laboratory of Ecology of Rare and Endangered Species and Environmental Protection Ministry of EducationGuilin541004China School of Geographical Sciences Southwest UniversityChongqing400715China Institute for Physiological chemistry University Medical Center of Johannes Gutenberg UniversityMainz55128Germany

There is limited knowledge about microbial communities and their ecological functions in karst caves with high cO_(2)***,we studied the microbial community compositions and functions in Shuiming cave( "SMc",cO_(2)concentration 3 303 ppm) and Xueyu cave( "XYc",cO_(2)concentration 8 753 ppm) using Illumina MiSeq high-throughput sequencing in combination with BIOLOG *** results showed that Proteobacteria,Actinobacteria and Bacteroidetes were dominant phyla in these two caves,and Thaumarchaeota was the most abundant in the rock wall samples of *** microbial diversity in the water samples decreased with increasing HcO_(3)^(-)concentration,and it was higher in XYc than that in *** microbial community structures in the sediment and rock wall samples were quite different between the two *** concentrations of cO_(2)can reduce the microbial diversity on the rock walls in karst caves,probably through changing microbial preference for different types of carbon sources and decreasing the microbial utilization rate of carbon *** results expanded our understanding of microbial community and its response to environments in karst caves with high cO_(2).

关键词： karst cave cO_(2) microbial community composition microbiology function carbon source utilization

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硅质海绵骨针矿化机制及仿生应用研究进展

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地球学报 2011年第2期32卷 129-141页

作者：王晓红汪顺锋甘露 Ute Schloβacher 周峰 Klaus P.Jochum Matthias Wiens heinz c.schrder Werner E.G.Müller 中国地质科学院国家地质实验测试中心北京100037 德国美因茨大学医学中心德国美因茨55128 德国马-普化学所德国美因茨55020

硅质海绵动物是地球上最简单、最古老的多细胞动物,它经几百万年的自然进化成就了适应自然和接近完美的技术蓝图,为人类利用纳米生物技术仿生合成生物无机矿物材料提供了一种崭新的节能和"环境友好"技术,在光纤、微电子和生物医学材料... 详细信息

硅质海绵动物是地球上最简单、最古老的多细胞动物,它经几百万年的自然进化成就了适应自然和接近完美的技术蓝图,为人类利用纳米生物技术仿生合成生物无机矿物材料提供了一种崭新的节能和"环境友好"技术,在光纤、微电子和生物医学材料等领域具有广阔的仿生应用前景。生长在深海1000m以下水深的单根海绵动物的根须骨针长达3m,是世界上最长的生物硅,也是生物硅化机制和仿生应用研究不多见的载体。本文系统总结了我们在单根海绵动物根须骨针结构、组成、机械性能、光物理性能、生化特性和分子生物学基础、矿化机制和生物医学领域仿生应用等方面的研究成果。

关键词：海绵动物六放海绵动物根须骨针生物硅硅蛋白生物硅化

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深海六放海绵大骨针的结构与特性(英文)

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动物学报 2007年第3期53卷 557-569页

作者：王晓红李锦和乔莉 heinz c.schr der carsten EcKERT Klaus KROPF 王毅民冯庆玲 Werner E. G. MLLER 国家地质实验测试中心中国科学院海洋所清华大学材料系 Institutfr Physiologische chemie Abteilung Angewandte Molekularbiologie Universitat Duesbergweg 6 D-55099 Mainz Germany

在海绵动物(多孔动物)中,六放海绵和寻常海绵为硅质骨骼。生活在深海(1000m)中的六放海绵是最古老的海绵动物,其中间单根海绵和春氏单根海绵有长达3m的骨针,是地球上最长的生物硅结构。利用电子显微技术观测,这些直径达8mm的巨大根须骨... 详细信息

在海绵动物(多孔动物)中,六放海绵和寻常海绵为硅质骨骼。生活在深海(1000m)中的六放海绵是最古老的海绵动物,其中间单根海绵和春氏单根海绵有长达3m的骨针,是地球上最长的生物硅结构。利用电子显微技术观测,这些直径达8mm的巨大根须骨针具有同心层状结构,其横截面显示明显的构造分界:中间为含有轴丝的轴管,外围是一50 -150μm厚的轴筒,最外面为层状区(300 -500层,每层厚度3 -5μm)。生物化学研究显示其主要的蛋白质为35kD大分子,另外,还检测到23 -24kD多肽,可能是硅蛋白相关蛋白。依据现有的红血球凝聚活性,从骨针提取物中也检测到了凝集素。由电子探针获得其化学成分主要为Si , K和Na。此外,骨针的光传输实验表明,该巨大根须骨针用作光纤可传输600nm至1 400nm范围的光,而滤掉小于600nm的光(类似高通滤波器)和大于1 400nm的红外光(类似低通滤波器)。另外,从六放海绵的空囊泡沫海绵中分离出一个基因并确证了其推导的编码蛋白序列,该蛋白编码一个光裂合酶相关蛋白,蛋白相似性比较结果显示属于光裂合酶相关蛋白中多细胞动物隐色素一类。基于以上数据给出了六放海绵硅质骨针形成的示意图。另外,由单根海绵骨针可作为波导传输光/电和/或化学信号,推断在海绵动物中有类似神经系统的网络系统。

关键词：海绵中间单根海绵春氏单根海绵骨针生物硅形成光导硅蛋白相关蛋白纳米生物技术

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cD4^(+)T cells produce IFN-I to license cDc1s for induction of cytotoxic T-cell activity in human tumors

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cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël c.de Groot Marij J.P.Welters Tom de Wit Ellen schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos charlotte L.Zuur Noel F.c.c.de Miranda heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

cD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDc1s)to induce cD8^(+)cytotoxic T lymphocyte(cTL)anticancer responses,as proven in mouse *** recently identified cDc1s with a transcriptomic imprint of cD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDc1 licensing by cD4^(+)T cells in *** cD4^(+)T cells produce IFNβvia the STING pathway,which promotes MHc-I antigen(cross-)presentation by cDc1s and thereby improves their ability to induce cTL anticancer *** cooperation with cD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDc1s required for cTL response ***-I-producing cD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to cTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDcs and tumor-reactive cD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing cD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： cD4^(+)T-cell help cDc1 licensing IFN-I signaling cD40 costimulation (cross-)presentation cTL priming Tumor control

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Flashing light in sponges through their siliceous fiber network:A new strategy of “neuronal transmission” in animals

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Science Bulletin 2012年第25期 3301-3312页

作者： schrder heinz c MüLLER Werner E G ERc Advanced Grant Research Group at the Institute for Physiological chemistry University Medical Center of the Johannes Gutenberg UniversityMainz D-55099Germany

Sponges(phylum Porifera) represent a successful animal taxon that evolved prior to the Ediacaran-cambrian boundary(542 million years ago).They have developed an almost complete array of cell-and tissue-based interaction systems necessary for the establishment of a functional,multicellular ***,a network of neurons,one cell/tissue-communication system is missing in *** fact is puzzling and enigmatic,because these animals possess receptors known to be involved in the nervous system in evolutionary younger animal *** an example,the metabotropic glutamate/GABA-like receptor has been identified and cloned by ***,we have identified a novel light transmission/light responsive system in sponges that is based on their skeletal elements,the siliceous glass fibers,termed *** classes of sponges,the Hexactinellida and the Demospongiae,possess a siliceous skeleton that is composed of *** the large spicules from hexactinellid sponges(>5 cm) revealed that these spicules are effective light-collecting optical *** we can report that the demosponge,Suberites domuncula,has a biosensor system consisting of the(organic) light producing luciferase and the(inorganic) light transducing silica *** light transmission features of these smaller spicules(200 μm) has been demonstrated and the ability of the sponge tissue to generate light had been *** for a luciferase gene in *** was *** the next step,we searched for a protein potentially involved in light *** a protein was identified,cloned and recombinantly expressed from *** protein sequence displays two domains characteristic of a cryptochrome,the N-terminal photolyase-related region and the c-terminal FAD-binding *** experimental data indicate that sponges may employ a network of luciferase-like proteins,a spicular system and a cryptochrome as the light source,optical waveguide and photosensor,***

关键词： sponges Suberites domuncula "nervous"-like signal system light transmission siliceous spicules luciferase cryptochrome

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海绵动物的演化意义及其生物硅的仿生应用

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科学通报 2007年第12期52卷 1372-1381页

作者： Werner E G Müller 王晓红曾令森 heinz c.schrder Institute of Physiological chemistry University of Mainz Duesbergweg 6D-55099 MainzGermany 国家地质实验测试中心中国地质科学院中国地质科学院地质研究所

海绵动物是地球上最古老、最简单的动物,但对它在生物进化中的定位却经历了一个漫长而复杂的认识过程.作为“活化石”,海绵动物为生物演化研究提供了最好的证据;而对海绵动物研究更令人入胜的是近年来人们发现硅质海绵动物骨针的独特结... 详细信息

海绵动物是地球上最古老、最简单的动物,但对它在生物进化中的定位却经历了一个漫长而复杂的认识过程.作为“活化石”,海绵动物为生物演化研究提供了最好的证据;而对海绵动物研究更令人入胜的是近年来人们发现硅质海绵动物骨针的独特结构和良好光纤特性,从而开辟了利用纳米生物技术进行仿生合成的广泛研究领域.综述了海绵动物的发现及新的分子生物学进化证据,骨针硅蛋白催化合成生物硅的研究进展及仿生合成在纳米生物技术和医学领域的潜在应用.

关键词：海绵动物生物演化海绵动物骨针生物硅仿生合成

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Extremely severe hypochloremic metabolic alkalosis after ileorectal anastomosis in a patient with chronic intestinal pseudo-obstruction

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Gastroenterology Report 2023年第1期11卷 563-565页

作者： Peter heinz-Erian Andreas RJanecke Thomas Muller Peter Rehder Elisabeth Bruder Thomas Menter heinz Zoller Markus Pirklbauer Michael Rieger Department of Pediatric and Adolescent Medicine Medical University of InnsbruckInnsbruckTyrolAustria Department of Urology Medical University of InnsbruckInnsbruckTyrolAustria Institute of Pathology University Hospital BaselBaselBaselSwitzerland Department of Internal Medicine I Medical University of InnsbruckInnsbruckTyrolAustria Department of Internal Medicine IV Medical University of InnsbruckInnsbruckTyrolAustria Department of Radiology District Hospital HallHallTyrolAustria

Introduction chronic intestinal pseudo-obstruction(cIPO),defined as chronic constipation without mechanical obstruction of the gastrointestinal tract[1,2],often presents with a truly chameleon-like symptomatology including irregular defecation,abdominal pain and distension,nausea,vomiting,and sometimes fluid/electrolyte *** diarrhea was found in17%of cIPO cases,its nature,however,has not been precisely *** deviations of electrolyte and acid–base status,to the best of our knowledge,have not been reported.

关键词： obstruction diarrhea chronic

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Design of molecule-based magnetic conductors

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Nano Research 2014年第12期7卷 1832-1842页

作者： Naureen Akhtar Graeme R. Blake Roberto Felici heinz Amenitsch Thomas T. M. Palstra Petra Rudolf Zernike Institute for Advanced Materials University of Groningen Nijenborgh 4 NL-9747AG Groningen The Netherlands ESRF BP 220 F-38043 Grenoble Cedex 9 France Institute of Inorganic chemistry Graz University of Technology Stremayerg. 9/IV A-8010 Graz Austria

Enabling the use of rationally designed thin films in technological devices is a recognized goal in materials science. However, constructing such thin films using highly ordered supramolecular architectures with well-controlled size and growth direction has remained an elusive target. Here, we introduce a layer-by- layer protocol to grow hybrid thin films of molecule-based magnetic conductors comprising arachidic acid and donor bis（ethylenedioxy）tetrathiafulvalene （BEDO-TTF） as the organic component and cu/Gd complexes as the inorganic component. The construction of layered hybrid thin films was achieved at ambient conditions by employing the Langmuir-Blodgett method, which provides good control over film thickness and packing of molecules in the monolayer. As demonstrated by X-ray diffraction, these films are crystalline with distinct organic and inorganic sublattices, where the BEDO-TTF molecular layer is interfaced with the inorganic layer. Due to the flexibility of the Langmuir-Blodgett deposition technique, this result indicates a route toward the preparation of well-ordered films with various functionalities, determined by the choice of the inorganic compound that is combined with the π-unit of BEDO-TFF. Moreover, the ability to deposit films on a variety of substrates establishes the potential for lower-cost device fabrication on inexpensive substrates.

关键词： molecule-based materials self-assembly ordered heterostructures multifunctionality ultra-thin films

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