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Genetic diversity of food-medicinal Lycium *** China:Insights from chloroplast genome

Chinese Herbal Medicines 2024年第3期16卷 401-411页

作者： Ruyu Yao Bin Wang Michael heinrich Qiuling Wang Peigen Xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikou 570311China Research Group‘Pharmacognosy and Phytotherapy’ UCL School of PharmacyUniversity of LondonLondon WC1N1AXUnited Kingdom Kunming Institute of Botany Chinese Academy of SciencesKunming 650201China

Objective:Goji(fruits of Lycium spp.)is commonly consumed as food and *** increasing market demand for goji has led to its wide cultivation and broad breeding,which might cause loss of genetic *** study aims to uncover the genetic diversity of the cultivated and wild ***:The chloroplast genome(CPG)of 34 accessions of Chinese food-medicinal Lycium spp.,including the popular cultivars and their wild relatives,was re-sequenced and assembled,based on which the genetic diversity was ***:Sequence structural comparison shows that CPG is comparatively conserved within *** analysis indicates that CPG is sufficient for the discrimination of Lycium species;combined with nuclear ribosomal internal transcribed spacer(Nr ITS)sequences,materials with mixed genetic backgrounds can be *** diversity analysis reveals that the modern cultivars are probably with a common maternal parent,while the wild accessions are with higher level of genetic ***:For the first time this study reveals the intraspecies genetic diversity of Lycium *** CPG,highlighting the urgent conservation demand of wild genetic resources of *** study also demonstrates that CPG provides crucial evidence for identification of Lycium species with mixed genetic backgrounds and highlights the importance of the wild relatives in genetic diversity *** CPG-based technology will contribute to the sustainable development of medicinal plants broadly.

关键词： chloroplast genome cultivar food-medicine genetic diversity goji wild relative

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Comparative eye-tracking evaluation of scatterplots and parallel coordinates

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Visual Informatics 2017年第2期1卷 118-131页

作者： Rudolf Netzel jenny Vuong Ulrich Engelke Seán O’Donoghue Daniel Weiskopf julian heinrich Visualization Research Center(VISUS) University of StuttgartStuttgartGermany Commonwealth Scientific and Industrial Research Organisation(CSIRO)(Sydney Hobart)Australia University of Tübingen TübingenGermany

We investigate task performance and reading characteristics for scatterplots(Cartesian coordinates)and parallel *** a controlled eye-tracking study,we asked 24 participants to assess the relative distance of points in multidimensional space,depending on the diagram type(parallel coordinates or a horizontal collection of scatterplots),the number of data dimensions(2,4,6,or 8),and the relative distance between points(15%,20%,or 25%).For a given reference point and two target points,we instructed participants to choose the target point that was closer to the reference point in multidimensional *** present a visual scanning model that describes different strategies to solve this retrieval task for both diagram types,and propose corresponding hypotheses that we test using task completion time,accuracy,and gaze positions as dependent *** results show that scatterplots outperform parallel coordinates significantly in 2 dimensions,however,the task was solved more quickly and more accurately with parallel coordinates in 8 *** eye-tracking data further shows significant differences between Cartesian and parallel coordinates,as well as between different numbers of *** parallel coordinates,there is a clear trend toward shorter fixations and longer saccades with increasing number of *** an area-of-interest(AOI)based approach,we identify different reading strategies for each diagram type:For parallel coordinates,the participants’gaze frequently jumped back and forth between pairs of axes,while axes were rarely focused on when viewing Cartesian *** further found that participants’attention is biased:toward the center of the whole plot for parallel coordinates and skewed to the center/left side for Cartesian *** anticipate that these results may support the design of more effective visualizations for multidimensional data.

关键词： Parallel coordinates Scatterplots Cartesian coordinates Eye tracking Controlled laboratory user study

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Influence of zone formation on stability of continuous fluidized bed layering granulation with external product classification

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Particuology 2015年第6期13卷 1-7页

作者： C. Dreyschultze C. Neugebauer S. Palis A. Buck E. Tsotsas S. heinrich A. Kienle Otto yon Guericke University Universit~tsplatz 2 D-39106 Magdeburg Germany Max Planck Institute for Dynamics of Complex Technical Systems Sandtorstraabe 1 D-39106 Magdeburg Germanyc Hamburg University of Technology Denickestrae 15 D-21073 Hamburg Germany

Continuous fluidized bed layering granulation with external product classification and a sieve-mill cycle can show instability in the form of self-sustained nonlinear oscillations of the particle size distribution. In the present study, the stability and bifurcation analysis of this process is presented. The underlying process models explicitly account for compartmentalization of the fluidized bed into a granulation and a drying zone, which is an important feature of many technical processes. Implications for plant operations are discussed with the help of stability diagrams as a function of zone size, residence time within different zones, the addition of external seeds and particular properties of the sieve-mill cycle.

关键词： Fluidized bed Granulation Population balance Stability Bifurcation

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A novel E153X point mutation in the androgen receptor gene in a patient with complete androgen insensitivity syndrome

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Asian journal of Andrology 1999年第1期1卷 73-77页

作者： Silvia B Copelli Serge Lumbroso Francoise Audran Eliana H Pellizzari juan j heinrich Selva B Cigorraga Charles Sultan Héctor E Chemes Laboratore d'Hormonologie Hopital Lapeyronie et INSER U 439 Pathologie des recepteurs nucleaires.Unite d'Endocrinologie et Gynecologie PediatriquesHopital A.de VillenetiveMontpellier-France CEDIE-CONICET Division de EndocrinologtaHospital de Niflos"Ricardo Gutierrez"Buenos AiresArgentina

Aim:To study a 46,XY newborn patient with a phenotype suggestive of an androgen insensitivity syndrome toconfirn an anomaly in the AR ***:Genomic DNA from leukocytes was isolated in order to analyze SRYgene by PCR and sequencing of the eight exons of AR *** of human Leydig cell mesenchymal precursorsfrom the testis was performed in order to study testosterone production and response to hCG stimulation in ***:Surgical exploration disclosed two testes,no Wolffian structures and important Mullerian *** gene was present in peripheral blood *** of the AR gene evidenced a previously unreported Gto T transversion in exon 1 that changed the normal glutamine 153 codon to a stop *** cell culturesproduced sizable amounts of testosterone and were responsive to hCG ***:This E153X nonsensepoint mutation has not been described previously in cases of AIS,and could lead to the synthesis of a short truncated(153 vs 919 residues)non functional AR probably responsible for the phenotype of complete androgen insensitivitysyndrome(CAIS).

关键词： testicular feminization androgen receptor point mutation Mullerian ducts

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Tetranuclear yttrium and gadolinium 2-acetylcyclopentanoate clusters：Synthesis and their use as spin-coating precursors for metal oxide film formation for field-effect transistor fabrication

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journal of Rare Earths 2018年第10期36卷 1098-1105页

作者： Elaheh Pousaneh Andrea Preuβ Khaybar Assim Tobias Rüffer Marcus Korb jana Tittmann-Otto Sascha Hermann Stefan E.Schulz heinrich Lang Technische Universitat Chemnitz Faculty of Natural Sciences Institute of Chemistry Inorganic Chemistry D-09107 Chemnitz Germany Technische Universitiat Chemnitz Center for Mierotechnologies D-09107 Chemnitz Germany Fraunhofer Institute for Electronic Nano Systems ENAS Technologie-Campus 3 D-09126 Chemnitz Germany

Lanthanide clusters [Ln4（μ3-OH）2（η2-accp）4（（μ-O）-η2-accp）6]（Ln = Y（4）,Gd（5）; accp = 2-acetylcyclopentanoate） are accessible by treatment of [M（NO33·6 H2 O]（M = Y（1）,Gd（2）） with 3 equiv. of Haccp（3） in presence of NaOH. The molecular structures of 4 and 5） in the solid-state are discussed. The thermal behavior of 4 and 5 was studied by TG under Ar and O2, showing multistep decomposition processes. Additionally, DSC studies were carried out under an atmosphere of O2. PXRD measurements of the TG residues confirm the formation of Ln2 ***-coating experiments were carried out with 4 and 5 for Ln2 O3 film deposition on silicon substrates. The layers are smooth, close and are of thicknesses of 18.87±1.13 nm and 25.59 ± 4.55 nm for Ln = Y and Gd, which was evidenced by SEM and EDX studies. Field-effect transistors were successfully fabricated by deposition of carbon nanotubes on top of the Y2 O3 films and formation of palladium contacts by a lift-off procedure. An on/off ratio of more than 4 orders of magnitude is achieved without considerable leakage currents. These results demonstrate the potential use of spin-coated Y2 O3 as a gate dielectric in electronic devices.

关键词： β-Diketonates Yttrium Gadolinium Thermal analysis Spin coating CNT transistor

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Spectral broadening for multi-joule pulse compression in the APOLLON Long Focal Area facility

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High Power Laser Science and Engineering 2022年第2期10卷 7-13页

作者： P.-G.Bleotu j.Wheeler D.Papadopoulos M.Chabanis j.Prudent M.Frotin L.Martin N.Lebas A.Freneaux A.Beluze F.Mathieu P.audebert D.Ursescu j.Fuchs G.Mourou LULI-CNRS CEASorbonne UniversiteEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Faculty of Physics University of Bucharest077125 Bucharest-MagureleRomania Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH) MagureleRO-077125Romania Independent Researcher F-92340 Bourg-La-ReineFrance IZEST Ecole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance

Spectral-broadening of the APOLLON PW-class laser pulses using a thin-film compression technique within the longfocal-area interaction chamber of the APOLLON laser facility is reported,demonstrating the delivery of the full energy pulse to the target interaction *** laser pulse at 7 j passing through large aperture,thin glass wafers is spectrally broadened to a bandwidth that is compatible with a 15-fs pulse,indicating also the possibility to achieve sub-10-fs pulses using 14 *** the post-compressor near the interaction makes for an economical method to produce the shortest pulses by limiting the need for high damage,broadband optics close to the final target rather than throughout the entire laser transport system.

关键词： high energy post-compression nonlinear pulse interaction high-power laser laser diagnostics

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Non-thermal laser driven plasma-blocks for proton boron avalanche fusion as direct drive option

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Matter and Radiation at Extremes 2017年第4期2卷 177-189页

作者： heinrich Hora Shalom Eliezer Noaz Nissim Paraskevas Lalousis Department of Theoretical Physics University of New South WalesSydneyAustralia Soreq Research Center YavneIsrael Institute of Electronic Structure and Laser FORTH HeraklionGreece

Fusion energy from protons reacting with ^(11) B,HB11,is extremely difficult or impossible when using thermal ignition by laser *** changes radically when using picosecond laser pulses with powers above petawatts dominated by nonlinear force driven ultrahigh ac-celeration of plasma blocks for a non-thermal initiation of igniting solid density HB11 *** a cylindrical trapping of the reaction,laser produced ultrahigh magnetic fields above kiloTesla,have to be *** experimentally confirmed highly increased HB11 fusion gains due to avalanche reaction may lead to a scheme of an environmentally clean and economic power reactor.

关键词： Boron laser fusion Plasma-block ignition ultrahigh acceleration Kilotesla field trapping Avalanche reaction Power reactor

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Brief eines Dichters an einen anderen

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德语学习 2012年第5期 19-21页

作者： heinrich von Kleist

Mein teurer Freund! jüngsthin,als ich dich bei der Lektüre meiner Gedichte fand,verbreitetest du dich,mit auβerordentlicher Beredsamkeit,über die Form,und unter beiflligen Rückblicken über die Schule,nach der

关键词：德语学习阅读知识课外阅读学习方法

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First Option for Fusion with CPA-Laser Pulses instead of Thermal Pressures with Dozens of Million Degrees Temperature for Laser-Boron-Fusion

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journal of Energy and Power Engineering 2019年第3期13卷 116-123页

作者： heinrich Hora Gotz j.Kirchhoff Warren R.McKenzie jan Kirchhoff Department of Theoretical Physics University of NSWSydney 2096Australia HB11 Energy Pty.Ltd FreshwaterSydney 2096Australia

To avoid the > 50 million degree temperatures in pressures for fusion,the goal has now been reached that higher pressures from picosecond CPA-laser pulses of more than 10 PW power can ignite nuclear fusion at modest temperatures in a power reactor for generating *** Mourou,who was honoured with the 2018 Physics Nobel Prize,was involved to solve this crucial problem of fusion energy with the reactor design as co-authors(Hora,H.,Korn,G.,Giuffrida,L.,Margarone,D.,Picciotto,A.,Krasa,j.,jungwirth,K.,Ullschmied,j.,Lalousis,P.,Eliezer,S.,Miley,G.H.,Moustaizis,S.,and Mourou,G.,Laser and Particle Beams 33,2015:607)using the CPA Chirped Pulse Amplification.

关键词： Ignition of nuclear fusion clean nuclear power stations ultra-extreme CPA-laser pulses

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DICER-like Proteins and Their Role in Plant-herbivore Interactions in Nicotiana attenuata

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journal of Integrative Plant Biology 2012年第3期54卷 189-206页

作者： Tohir Ahmadovich Bozorov Shree Prakash Pandey Son Truong Dinh Sang-Gyu Kim Maria heinrich Klaus Gase Ian T. Baldwin Department of Molecular Ecology Max Planck Institute for Chemical Ecology 07745 Jena Germany Department of Biological Sciences Indian Institute of Science Education and Research Kolkata Mohanpur CampusPO: BCKV Campus Main Office Mohanpur Nadia West Bengal 741252 India.

DICER-like （DCL） proteins produce small RNAs that silence genes involved in development and defenses against viruses and pathogens. Which DCLs participate in plant-herbivore interactions remains unstudied. We identified and stably silenced four distinct DCL genes by RNAi in Nicotiana attenuata （Torrey ex. Watson）, a model for the study of plant-herbivore interactions. Silencing DCL1 expression was lethal. Manduca sexta larvae performed significantly better on ir-dcl3 and ir-dcl4 plants, but not on ir-dcl2 plants compared to wild type plants. Phytohormones, defense metabolites and microarray analyses revealed that when DCL3 and DCL4 were silenced separately, herbivore resistance traits were regulated in distinctly different ways. Crossing of the lines revealed complex interactions in the patterns of regulation. Single ir-dcl4 and double ir-dcl2 ir-dcl3 plants were impaired in jA accumulation, while jA- Ile was increased in ir-dcl3 plants. Ir-dcl3 and ir-dcl4 plants were impaired in nicotine accumulation; silencing DCL2 in combination with either DCL3 or DCL4 restored nicotine levels to those of WT. Trypsin proteinase inhibitor activity and transcripts were only silenced in ir-dcl3 plants. We conclude that DCL2/3/4 interact in a complex manner to regulate anti-herbivore defenses and that these interactions significantly complicate the already challenging task of understanding smRNA function in the regulation of biotic interactions.

关键词： DICER-like proteins anti-herbivore defense phytohormone signaling Manduca sexta Nicotiana attenuata.

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