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Standards of liver cirrhosis care in Central Australia

World Journal of hepatology 2022年第3期14卷 559-569页

作者： Sreecanth S Raja Robert G Batey Suzanne Edwards hein h aung Department of Gastroenterology Alice Springs HospitalAlice Springs 0870Northern TerritoryAustralia Department of Medicine Alice Springs HospitalAlice Springs 0870Northern TerritoryAustralia Department of Statistician School of Public HealthUniversity of AdelaideAdelaide 5000South AustraliaAustralia

BACKGROUND Liver cirrhosis and hepatocellular carcinoma(hCC)are highly prevalent in Australia’s Northern *** factors include high levels of alcohol consumption,viral hepatitis and metabolic *** Aboriginal residents form a significant proportion of the Central Australian population and present a challenge to traditional models of liver *** surveillance and variceal screening are core components of liver cirrhosis *** To assess participation in hCC and variceal surveillance programmes in a Central Australian liver cirrhosis patient *** Retrospective cohort study of patients with liver cirrhosis presenting to Alice Springs hospital,Australia between January 1,2012 and December 31,*** data,disease severity,attendance at hepatology clinics,participation in variceal and/or hCC surveillance programmes was *** analyses were conducted to assess factors associated with two independent outcomes:Participation in hCC and variceal *** Of 193 patients were identified.82 patients(42.4%)were female.154 patients(80%)identified as *** Model for End-stage Liver Disease Score at diagnosis was *** was the most common cause of *** patients were younger than non-Aboriginal patients(48.4 years vs 59.9 years,Phere were similar rates of excess alcohol intake(72.6%vs 66.7%,P=0.468)and obesity(34.5%vs 38.4%,P=0.573 across non-Aboriginal and Aboriginal cohorts.20.1%of patients took part in hCC surveillance and 42.1%of patients completed variceal *** patients were less likely to engage with either hCC surveillance(OR:0.38,95%CI:0.16-0.9,P=0.025)or undergo variceal screening(OR:0.31,95%CI:0.14-0.65,P=0.002).CONCLUSION hCC or variceal surveillance programmes had less uptake amongst Aboriginal *** emphasis needs to be placed on eliminating cultural obstacles to accessing hepatology services.

关键词： Viral hepatitis Cirrhosis hepatocellular carcinoma Alcoholic liver disease Central australia

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Characterization of Electrical Tree Degradation of Epoxy Resin under Thermal and Temperature Stresses by Photoelastic Effect

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Chinese Journal of Electrical Engineering 2024年第1期10卷 12-20页

作者： hein htet aung Yuhuai Wang Jin Li Ying Zhang Tatsuo Takada School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China Department of Power Generation and Transformation Engineering Baoding Technical College of Electric PowerBaoding 071051China Measurement and Electric Machine Control Laboratory Tokyo City UniversityTokyo 158-8557Japan

Epoxy resin is widely used in the support,insulation,and packaging components of electrical equipment owing to their excellent insulation,thermal,and mechanical ***,epoxy-resin insulation often suffers from thermal and mechanical stresses under extreme environmental conditions and a compact design,which can induce electrical tree degradation and insulation failure in electrical *** this study,the photoelastic method is employed to investigate the thermal-mechanical coupling stress dependence of the electrical treeing behavior of epoxy *** electrical tree growth morphology and stress distribution were observed using the photoelastic *** correlation between the tree length and overall accumulated damage with an increase in mechanical stress is *** results show that compressive stress retards the growth of electrical trees along the electric field,while tensile stress has accelerating *** proves that the presence of thermal stress can induce more severe accumulated damage.

关键词： Epoxy resin electrical tree degradation thermal stress mechanical stress photoelastic effects

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Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

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World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich hao-Tian Wu Jing-Xuan he Yin-Qi Zhao Max T aung hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas h Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASh),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the hTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASh,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASh,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

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Differential Roles of Arabidopsis Dynamin-Related Proteins DRP3A,DRP3B,and DRP5B in Organelle Division

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Journal of Integrative Plant Biology 2012年第11期54卷 921-931页

作者： Kyaw aung MSU-DOE Plant Research Laboratory and Plant Biology Department Michigan State UniversityEast LansingMI 48824USA

Dynaminrelated proteins （DRPs） are key components of the organelle division machineries, functioning as molecular scissors during the fission process. In Arabidopsis, DRP3A and DRP3B are shared by peroxisomal and mitochondrial division, whereas the structurallydistinct DRP5B （ARC5） protein is involved in the division of chloroplasts and peroxisomes. here, we further investigated the roles of DRP3A, DRP3B, and DRP5B in organelle division and plant development. Despite DRP5B＇s lack of stable association with mitochondria, drp5B mutants show defects in mitochondrial division.

关键词： Arabidopsis dynamin-related protein mitochondria.

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Chemical Constituents from the Whole Plant of Cuscuta reflexa

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Natural Products and Bioprospecting 2020年第5期10卷 337-344页

作者： Tin Thu Thu aung Meng-Yuan Xia Pyae Phyo hein Rong Tang Dong-Dong Zhang Jun Yang Xue-Fei Yang Dong-Bao hu Yue-hu Wang Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China School of Chemical Biology and Environment Yuxi Normal UniversityYuxi 653100People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

Two new 2h-pyran-2-one glucosides,cuscutarosides A(1)and B(2),and one new steroidal glucoside,7β-methoxy-β-sitosterol 3-O-β-glucopyranoside(3),together with 12 known compounds(4-15)were isolated from the whole plant of Cuscuta reflexa(Convolvulaceae)collected from *** chemical structures of these new compounds were elucidated based on extensive spectroscopic *** antiobesity activity of these isolates was evaluated using porcine pancreatic lipase(PPL),and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin,platelet-activating factor(PAF),arachidonate(AA),or collagen.7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside(3)showed weak PPL inhibitory *** A(1),its acetylated derivative(1a),and scrophenoside B(8)showed weak inhibitory activity against rabbit platelet aggregation induced by *** 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA.

关键词： Cuscuta reflexa Porcine pancreatic lipase Platelet aggregation 2h-pyran-2-one glucosides Steroidal glucosides

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Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species

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Zoological Research 2020年第6期41卷 656-669页

作者： Christian Roos Kristofer Mhelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin aung Ko Lin aung Lin Khin Mar Yi Paing Soe Zin Mar hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AhChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael hofreiter Dietmar Zinner Frank Momberg Primate Genetics Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Gene Bank of Primates German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Chances for Nature(CfN) Goettingen 37073Germany Australian Museum Research Institute Australian MuseumSydneyNew South Wales 2010Australia Natural history Museum London SW7 BDUK Wildlife Conservation Society(WCS)-Myanmar Program Yangon 11041Myanmar Fauna&Flora International(FFI)-Myanmar Programme Yangon 11201Myanmar Popa Mountain Park Nature and Wildlife Conservation DivisionForest DepartmentPopa 05242Myanmar World Wide Fund for Nature(WWF)-Myanmar Yangon 11191Myanmar Department of Zoology Jagannath UniversityDhaka 1100Bangladesh Primate Research and Conservation Division AaranyakGuwahatiAssam 781028India Department of Anthropology Emory UniversityAtlantaGA 30322USA Department of Anthropology Yale UniversityNew HavenCT 06511USA Department of Mammalogy American Museum of Natural HistoryNew YorkNY 10024USA Naturalis Biodiversity Center Leiden 2333 CRThe Netherlands Lee Kong Chian Natural history Museum National University of SingaporeSingapore 117377Singapore Department of Environmental Science and Policy George Mason UniversityFairfaxVA 22030USA Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China Cuc Phuong Commune Nho Quan DistrictNinh Binh ProvinceVietnam School of Life Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510275China Center for Biodiversity Conservation and Endangered Species Ho-Chi-Minh CityVietnam Institute for Biochemistry and Biology University of PotsdamPotsdam 14476Germany Cognitive Ethology Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Leibniz Science Campus Primate Cognition Goettingen 37077Germany De

Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian *** several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly ***’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and ***,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of ***,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two *** analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the *** group branched first,followed by the *** group,and the *** and *** groups most *** four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within ***,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two *** the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the *** subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three ***,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of *** but the entire Trachypithecus genus as well.

关键词： Colobinae Integrative zoology Mitochondrial genome Museum specimens New species

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Challenges in early phase of implementing the 1-3-7 surveillance and response approach in malaria elimination setting:A field study from Myanmar

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Infectious Diseases of Poverty 2020年第1期9卷 100-100页

作者： Poe Poe aung Zaw Win Thein Zar Ni Min hein Kyaw Thet aung Nwe Oo Mon Nay Yi Yi Linn aung Thi Khin Thet Wai Thae Maung Maung Duke Global health Institute Myanmar Program YangonMyanmar 不详

Background:The National Plan for Malaria Elimination(NPME)in Myanmar(2016–2030)aims to eliminate indigenous Plasmodium falciparum malaria in six states/regions of low endemicity by 2020 and countrywide by *** achieve this goal,in 2016 the National Malaria Control Program(NMCP)implemented the“1-3-7”surveillance and response *** study aims to identify the barriers to successful implementation of the NPME which emerged during the early phase of the“1-3-7”approach ***:A mixed-methods study was conducted with basic health staff(BhS)and Vector Born Disease Control Program(VBDC)staff between 2017 and 2018 in six townships of six states/regions targeted for sub-national elimination by 2020.A self-administered questionnaire,designed to assess the knowledge required to implement the“1-3-7”approach,was completed by 544 *** analysis was performed for quantitative findings and thematic analysis was conducted for qualitative findings using *** ***:Although 83%of participants reported performing the key activities in the“1-3-7”surveillance and response approach,less than half could report performing those activities within 3 days and 7 days(40 and 43%,respectively).Low proportion of BhS correctly identified six categories of malaria cases and three types of foci(22 and 26%,respectively).In contrast,nearly 80%of respondents correctly named three types of case detection *** cited challenges included‘low community knowledge on health’(43%),‘inadequate supplies’(22%),and‘transportation difficulty’(21%).Qualitative data identified poor knowledge of key surveillance activities,delays in reporting,and differences in reporting systems as the primary *** dominant perceived barrier to success was inability to control the influx of migrant workers into target jurisdictions especially in hard-to-reach *** with township medical officers and the NMCP team leaders further highlighted the necessity o

关键词： Malaria elimination 1-3-7 approach Surveillance and response Basic health staff Mixed methods Myanmar

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Insights into facet-dependent reactivity of CuO–CeO2 nanocubes and nanorods as catalysts for CO oxidation reaction

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Chinese Journal of Catalysis 2020年第6期41卷 1017-1027页

作者： Yu aung May Wei-Wei Wang han Yan Shuai Wei Chun-Jiang Jia Key Laboratory of Colloid and Interface Chemistry Ministry of EducationKey Laboratory of Special Aggregated MaterialsSchool of Chemistry and Chemical EngineeringShandong UniversityJinan 250100ShandongChina

Copper–ceria(Cu O–CeO2) catalysts have been known to be very effective for the oxidation of CO, and their chemical behavior has been extensively studied during the last decades. however, the effect of different CeO2 crystal surfaces on the catalytic activity of Cu O–CeO2 for the oxidation of CO is still unclear and should be further elucidated. In this study, we deposited 1 wt% Cu on mostly {100}-exposed CeO2 nanocubes(1 Cu Ce NC) and mostly {110}-exposed CeO2 nanorods(1 Cu Ce NR), respectively. Both 1 Cu Ce NC and 1 Cu Ce NR have been used as catalysts for the oxidation of CO and achieved 100% and 50% CO conversion at 130 ℃, respectively. The differences in the catalytic activity of 1 Cu Ce NC and 1 Cu Ce NR were analyzed using temperature-programmed reduction of h2 and temperature-programmed desorption of CO techniques. The results confirmed the excellent reducibility of the 1 Cu Ce NC catalyst, which was attributed to the weak interactions between Cu and the CeO2 support. Moreover, in situ diffuse reflectance infrared Fourier-transform spectroscopy studies indicated that the {100} planes of 1 Cu Ce NC facilitated the generation of active Cu(I) sites, which resulted in the formation of highly reactive Cu(I)-CO species during the oxidation of CO. Both the excellent redox properties and effective CO adsorption capacity of the 1 Cu Ce NC catalyst increased its catalytic reactivity.

关键词： Copper–ceria catalyst Crystal facets CO oxidation Redox property Active site

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苯酚和苯胺类化合物对光泽精化学发光的增强和抑制作用

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光谱学与光谱分析 2007年第10期27卷 1945-1950页

作者：石明娟 aung Myint 董永平崔华中国科学技术大学化学系安徽合肥230026

研究了苯酚和苯胺类化合物在不同ph下对光泽精-h2O2-Co2+体系化学发光(Chemiluminescence,CL)的影响。在NahCO3-Na2CO3缓冲体系中,具有吸电子基团或两个-Oh处于间位的化合物在中间的ph(即ph9.9)呈现增强作用,其他的化合物呈现抑制作用;... 详细信息

研究了苯酚和苯胺类化合物在不同ph下对光泽精-h2O2-Co2+体系化学发光(Chemiluminescence,CL)的影响。在NahCO3-Na2CO3缓冲体系中,具有吸电子基团或两个-Oh处于间位的化合物在中间的ph(即ph9.9)呈现增强作用,其他的化合物呈现抑制作用;在NaOh体系中,所有的化合物都呈现抑制作用。化合物对光泽精CL增强和抑制作用与化合物的结构、介质、以及介质的ph有关。通过研究光泽精CL反应混合物的荧光光谱以及光泽精体系的CL光谱等,提出了其增强和抑制作用的可能机理。苯酚和苯胺类化合物与光泽精竞争消耗溶液中的h2O2/hO2-,导致了化合物对光泽精CL的抑制作用;同时,苯酚和苯胺类化合物可以作为亲核试剂与光泽精反应形成一种加成物,这种加成物与光泽精相互作用生成光泽精自由基,然后与溶解氧反应产生CL,从而增强光泽精的CL。这两种作用相互竞争,导致了不同的条件下,化合物对光泽精CL增强和抑制作用的出现。

关键词：光泽精苯酚苯胺化学发光 ph

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Seasonal changes on two different spatial scales： response of aquatic invertebrates to water body and microhabitat

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Insect Science 2005年第4期12卷 263-280页

作者： WILCO C.E.P. VERBERK hein h. VAN KLEEF MARTIJN DIJKMAN PAUL VAN hOEK PETER SPIERENBURG hANS ESSELINK Bargerveen Foundation Radboud University Nijmegen Department of Environmental Studies Institute for Wetland and Water Research Radboud University Nijmegen Department of Animal Ecology and Ecophysiology Radboud University NijmegenNijmegen the Netherlands

Knowledge about the spatial and temporal scales of both habitat use and the functional significance of different adaptations is essential for an understanding of the population dynamics of invertebrate assemblages. This fundamental knowledge is not only interesting from an academic point of view, but is sorely lacking and needed in the field of restoration ecology. Many species are threatened due to degradation. Knowing what environmental conditions are needed dtLring the life cycle of these species is important in the design of restoration measures which aim to lift existing bottlenecks for threatened species. To assess the relative importance of water type and microhabitat in structuring the invertebrate assemblage during different seasons, invertebrates were sampled in three water bodies differing in trophic level and acidity. Different parts within a water body （microhabitats） were sampled separately and each water body was sampled in all four seasons. Results show that water body is an important factor structuring the invertebrate assemblage early in the season, whereas microhabitat became more important later in the season. Structural complexity of microhabitats was related to the type of locomotion employed by invertebrates. Seasonal differences could be related to population dynamics （reproduction, mortality）. Moreover, fluctuations in resource availability were expected to differ between the water bodies, with highest fluctuations in the eutrophic water body and with fluctuations becoming less predictable later in the season. This was confirmed by the data： species synchronization to pulses in food availability was strongest in the eutrophic water body. Moreover, synchronization was strongest in summer, while in autumn waters were invaded by dispersive species. Based on these results a synthesis is presented on the functioning of the different waters during the different seasons.

关键词： dispersal fluctuations in resource availability food substrate synchronization

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