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Vasopressin-induced hyponatremia in an adult normotensive trauma patient:A case report

World Journal of Critical Care medicine 2023年第1期12卷 35-40页

作者： maulik K Lathiya Emily Pepperl Daniel schaefer Hussam Al-Sharif Adel Zurob Susan m Cullinan Antonios Charokopos Department of Emergency medicine Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Pulmonary and Critical Care medicine Mayo Clinic Health SystemEau ClaireWI 54703United States

BACKGROUND Arginine vasopressin is a neuropeptide produced in the hypothalamus and released by the posterior pituitary *** addition to maintaining plasma osmolarity,under hypovolemic or hypotensive conditions,it helps maintain plasma volume through renal water reabsorption and increases systemic vascular *** synthetic analogues are widely used in the intensive care unit as a continuous infusion,in addition to hospital floors as an intravenous or intranasal dose.A limited number of cases of hyponatremia in patients with septic or hemorrhagic shock have been reported previously with *** report for the first time a normotensive patient who developed vasopressin-induced *** SUmmARY A 39-year-old man fell off a forklift and sustained an axial load injury to his *** had no history of previous *** was normal except for motor and sensory *** Imagine test showed endplate fracture at C7 and acute traumatic disc at C7 with cortical *** underwent cervical discectomy and fusion,laminectomy,and posterior instrumented *** intensive care unit admission post-surgery,he developed hyponatremia of 121-124 mEq/L post phenylephrine and vasopressin infusion to maintain blood pressure *** was evaluated for syndrome of inappropriate secretion of antidiuretic hormone,hypothyroid,adrenal-induced,or diuretic-induced *** the end of extensive evaluation for the underlying cause of hyponatremia,vasopressin was *** was also put on fluid restriction,given exogenous desmopressin,and a dextrose 5%in water infusion to prevent osmotic demyelination syndrome caused by sodium overcorrection which improved his sodium level to 135 mmol/*** The presentation of vasopressin-induced hyponatremia is uncommon in normotensive patients,and the most difficult aspect of this condition is determining the underlying cause of *** case illustrates that,considering the vast diffe

关键词： Hyponatremia Vasopressin Normotensive Therapy Case report

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Small bowel carcinoid: Location isn’t everything!

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World Journal of Gastrointestinal Surgery 2013年第8期5卷 239-244页

作者： Danielle m Hari Stephanie L Goff heidi J Reich Anna m Leung myung-Shin Sim Ji Hey Lee Edward Wolin Farin Amersi Gastrointestinal Research Program John Wayne Cancer Institute at Saint John’s Health Center Dana-Farber Cancer Institute Division of Surgical Oncology Cedars-Sinai Medical Center Department of Biostatistics John Wayne Cancer Institute at Saint John’s Health Center

AIm: To investigate the prognostic significance of the primary site of disease for small bowel carcinoid(SBC) using a population-based ***: The Surveillance,Epidemiology and End Results(SEER) database was queried for histologically confirmed SBC between the years 1988 and *** survival(OS) and disease-specific survival(DSS) were analyzed using the Kaplan-meier method and compared using Log rank *** rank and multivariate Cox regression analyses were used to identify predictors of survival using age,year of diagnosis,race,gender,tumor histology/size/location,tumor-node-metastasis stage,number of lymph nodes(LNs) examined and percent of LNs with ***: Of the 3763 patients,51.2% were male with a mean age of 62.13 *** follow-up was 50 *** 10-year OS and DSS for duodenal primaries were significantly better when compared to jejunal and ileal primaries(P = 0.02 and multivariate Cox regression analysis,after adjusting for multiple factors,primary site location was not a significant predictor of survival(P = 0.752 for OS and P = 0.966 DSS) while age,number of primaries,number of LNs examined,T-stage and m-stage were independent predictors of ***: This 21-year,population-based study of SBC challenges the concept that location of the primary lesion alone is a significant predictor of survival.

关键词： Small bowel carcinoid Primary tumor location Survival Prognosis National Comprehensive Cancer network guidelines

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Reimagining large river management using the Resist-Accept-Direct(RAD)framework in the Upper mississippi River

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Ecological Processes 2023年第1期12卷 645-664页

作者： Nicole K.Ward Abigail J.Lynch Erik A.Beever Joshua Booker Kristen L.Bouska Holly Embke Jeffrey N.Houser John F.Kocik Joshua Kocik David J.Lawrence mary Grace Lemon Doug Limpinsel madeline R.magee Bryan m.maitland Owen mcKenna Andrew meier John m.morton Jeffrey D.muehlbauer Robert Newman Devon C.Oliver heidi m.Rantala Greg G.Sass Aaron Shultz Laura m.Thompson Jennifer L.Wilkening minnesota Department of Natural Resources Lake CityMN 55041USA U.S.Geological Survey National Climate Adaptation Science CenterRestonVA 22041USA U.S.Geological Survey Northern Rocky Mountain Science CenterBozemanMT 59715USA Department of Ecology Montana State UniversityBozemanMT 59715USA U.S.Fish and Wildlife Service National Wildlife Refuge SystemOak HarborOH 43449USA U.S.Geological Survey Upper Midwest Environmental Sciences CenterLa CrosseWI 54603USA U.S.Geological Survey Midwest Climate Adaptation Science CenterSt.PaulMN 55108USA NOAA NEFSC OronoME 04473USA University of Nebraska-Lincoln LincolnNE 68503USA National Park Service Climate Change Response ProgramFort CollinsCO 80525USA U.S.Fish and Wild-life Service National Wildlife Refuge SystemBloomingtonMN 55437USA Habitat Conservation Division NOAAAlaska RegionAnchorageAK 99513USA Wisconsin Department of Natural Resources MadisonWI 53703USA Aquatic Sciences Center Center for LimnologyUW-MadisonMadisonWI 53706USA U.S.Geological Survey Northern Prairie Wildlife Research Center and Midwest Climate Adaptation Science CenterJamestownND 58401USA U.S.Army Corps of Engineers La CrescentMN 55947USA Alaska Wildlife Alliance AnchorageAK 99520USA U.S.Geological Survey Alaska Cooperative Fish and Wildlife Research UnitUniversity of Alaska FairbanksFairbanksAK 99775USA University of North Dakota Grand ForksND 58202USA minnesota Department of Natural Resources DuluthMN 55804USA Wisconsin Department of Natural Resources Boulder JunctionWI 54512USA Great Lakes Indian Fish and Wildlife Commission(GLIFWC) OdanahWI 54861USA U.S.Geological Survey National Climate Adaptation Science Centerand School of Natural ResourcesUniversity of TennesseeKnoxvilleTN 37996USA U.S.Fish and Wildlife Service National Wildlife Refuge SystemFort CollinsCO 80526USA

Background Large-river decision-makers are charged with maintaining diverse ecosystem services through unprec-edented social-ecological transformations as climate change and other global stressors *** interconnected,dendritic habitats of rivers,which often demarcate jurisdictional boundaries,generate complex management ***,we explore how the Resist–Accept–Direct(RAD)framework may enhance large-river management by promoting coordinated and deliberate responses to social-ecological trajectories of *** RAD frame-work identifies the full decision space of potential management approaches,wherein managers may resist change to maintain historical conditions,accept change toward different conditions,or direct change to a specified future with novel *** the Upper mississippi River System,managers are facing social-ecological transformations from more frequent and extreme high-water *** illustrate how RAD-informed basin-,reach-,and site-scale decisions could:(1)provide cross-spatial scale framing;(2)open the entire decision space of potential management approaches;and(3)enhance coordinated inter-jurisdictional management in response to the trajectory of the Upper mississippi River *** The RAD framework helps identify plausible long-term trajectories in different reaches(or subbasins)of the river and how the associated social-ecological transformations could be managed by altering site-scale *** reach-scale objectives may reprioritize how,where,and when site conditions could be altered to contribute to the basin goal,given the basin’s plausible trajectories of change(e.g.,by coordinating action across sites to alter habitat connectivity,diversity,and redundancy in the river mosaic).Conclusions When faced with long-term systemic transformations(e.g.,>50 years),the RAD framework helps explicitly consider whether or when the basin vision or goals may no longer be achievable,and direct options may open y

关键词： Ecosystem management Transformation Social-ecological system Anthropocene Climate change Basin planning Cross-scale interactions

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Sociology : 7th ed.

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2008年

作者： schaefer Richard T.

来源：畅想之星图书光盘版（南... 评论

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Fit “n” Cool Kids: Effects of Peer-modeling and Goal Setting on Physical Activity

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Open Journal of Preventive medicine 2018年第4期8卷 85-94页

作者： Jessyka N. Larson Timothy A. Brusseau maria m. Newton Stuart J. Fairclough heidi Wengreen James C. Hannon Department of Health Kinesiology & Recreation University of Utah Salt Lake City UT USA Department of Sport & Physical Activity Edge Hill University Ormskirk UK Department of Nutrition Dietetics and Food Sciences Utah State University Logan UT USA College of Education Health and Human Services Kent State University Kent OH USA

Background: Decreasing the risk of overweight and obesity from an early age is imperative and efforts should focus on fostering children’s physical activity (PA). Within school-based interventions, there is insufficient evidence on the effectiveness of the use of character peer-modeling and goal setting to increase physical activity. Therefore, the purpose of this study was to examine the impact of a school-based intervention on PA and enjoyment of PA in grades 3 - 5 elementary school age children at two urban elementary schools. methods: Participants were 95 students of 8 - 10 years old;activity monitors were used to assess physical activity. Daily physical activity and enjoyment was recorded at baseline, intervention, and at a 6-school-week follow-up. Results: PA significantly increased in the intervention school averaging 5549 steps at baseline, 5889 steps during the intervention, and 6515 during follow-up (p Conclusion: The Fit “n” Cool Kids intervention presents the potential of peer-modeling and goal setting for increasing PA at school. Continued interventions in schools may positively influence children’s healthy living patterns.

关键词： Health mVPA Physical Education School Health Youth

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Apolipoprotein B100 is required for hepatitis C infectivity and mipomersen inhibits hepatitis C

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World Journal of Gastroenterology 2016年第45期22卷 9954-9965页

作者： Esperance AK schaefer James meixiong Christina mark Amy Deik Daniel L motola Dahlene Fusco Andrew Yang Cynthia Brisac Shadi Salloum Wenyu Lin Clary B Clish Lee F Peng Raymond T Chung Gastrointestinal Unit Massachusetts General Hospital Bossston MA 02114 United States Department of medicine Harvard Medical School Bossston MA 02114 United States both of the Broad Institute of Harvard and m.I.T. Cambridge MA 02115 United States Temple University Health System Cambridge MA 02142 United States

AIm To characterize the role of apolipoprotein B100(apoB 100) in hepatitis C viral(HCV) infection. mETHODS In this study, we utilize a gene editing tool, transcription activator-like effector nucleases(TALENs), to generate human hepatoma cells with a stable genetic deletion of APOB to assess of apoB in HCV. Using infectious cell culture-competent HCV, viral pseudoparticles, replicon models, and lipidomic analysis we determined the contribution of apoB to each step of the viral lifecycle. We further studied the effect of mipomersen, an FDAapproved antisense inhibitor of apoB 100, on HCV using in vitro cell-culture competent HCV and determined itsimpact on viral infectivity with the TCID50 method. RESULTS We found that apo B100 is indispensable for HCV infection. Using the JFH-1 fully infectious cell-culture competent virus in Huh 7 hepatoma cells with TALENmediated gene deletion of apoB(APOB KO), we found a significant reduction in HCV RNA and protein levels following infection. Pseudoparticle and replicon models demonstrated that apo B did not play a role in HCV entry or replication. However, the virus produced by APOB KO cells had significantly diminished infectivity as measured by the TCID-50 method compared to wildtype virus. Lipidomic analysis demonstrated that these virions have a fundamentally altered lipidome, with complete depletion of cholesterol esters. We further demonstrate that inhibition of apoB using mipomersen, an FDA-approved anti-sense oligonucleotide, results in a potent anti-HCV effect and significantly reduces the infectivity of the virus. CONCLUSION Apo B is required for the generation of fully infectious HCV virions, and inhibition of apo B with mipomersen blocks HCV. Targeting lipid metabolic pathways to impair viral infectivity represents a novel host targeted strategy to inhibit HCV.

关键词： Apolipoprotein Lipid Hepatitis C virus Gene silencing Viral replication

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COVID-19疫情期间成都市地面臭氧污染特征及气象成因分析

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环境科学学报 2021年第10期41卷 4200-4211页

作者：祁宏张小玲康平 Klaus schaefer 向卫国邓中慈卢宁生雷雨成都信息工程大学大气科学学院高原大气与环境四川省重点实验室成都610225 成都平原城市气象与环境四川省野外科学观测研究站成都610225

受COVID-19疫情影响,我国各地采取了一系列封锁管控措施,由此导致大气污染物排放强度降低.本文以成都市为例,分析了2020年上半年的气象条件和大气污染浓度特征,并重点对臭氧浓度变化及同期对比结果进行了细致分析.结果表明:(1)与2019年... 详细信息

受COVID-19疫情影响,我国各地采取了一系列封锁管控措施,由此导致大气污染物排放强度降低.本文以成都市为例,分析了2020年上半年的气象条件和大气污染浓度特征,并重点对臭氧浓度变化及同期对比结果进行了细致分析.结果表明:(1)与2019年同期相比,除O_(3)外的5种污染物(NO_(2)、CO、SO_(2)、Pm_(10)、Pm_(2.5))浓度均降低,降幅分别为13.60%、8.96%、6.30%、4.56%、1.80%,而O_(3)浓度却异常升高,升幅最大值分别出现在2月(35.1%)和5月(36.1%).(2)2020年上半年,O_(3)浓度高值出现时间较2015—2019年提前,气象条件较有利于臭氧的生成.100 hPa和500 hPa位势高度为正距平,气温、日照时数较往年升高,相对湿度和降水量下降,以静小风为主.(3)2020年4月25日—5月6日臭氧污染持续时间长,主要是由于复工复产导致臭氧前体物排放增加,以及稳定的天气形势,使成都长时间处于高温(>30℃)、低湿(40%~60%)、静小风(1.3 m·s^(-1))等不利扩散的气象条件下.气团后向轨迹和污染潜在源区表明研究区受到来自成都偏东一带及川南地区高污染气团短距离输送的影响.

关键词：成都市新冠疫情气象条件后向轨迹潜在源分析

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Nanoimprint Lithography -A Next Generation High Volume Lithography Technique

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半导体技术 2004年第7期29卷 86-91页

作者： R. Pelzer P. Lindner T. Glinsner B.Vratzov C.Gourgon S.Landis P. Kettner C. schaefer EV Group DI Erich Thallner Strasse 1 A-4780 SchaerdingEV Group DI Erich Thallner Strasse 1 A-4780 SchaerdingEV Group DI Erich Thallner Strasse 1 A-4780 SchaerdingAMICA AMO GmbH Huysensweg 25 D-52074 AachenLaboratoire des Technologies de la Microelectronique CNRS 17 R. des MartyrsF- 3805Grenoble Cedex4CEA-LETI 17 R. des Martyrs F- 38054 Grenoble CedexEV Group DI Erich Thallner Strasse 1 A-4780 SchaerdingEV Group DI Erich Thallner Strasse 1 A-4780 Schaerding

Nanoimprint Lithography has been demon-strated to be one of the most promising next genera-tion techniques for large-area structure replicationin the nanometer scale. This fast and low costmethod becomes an increasingly important instru-ment for fabrication of biochemistry,m-fluidic, m-TAS and telecommunication devices, as well as for awide variety of fields in the nm range, like biomedical,nano-fluidics,nano-optical applications, datastorage, *** to the restrictions on wavelength and theenormous development works, linked to high pro-cess and equipment costs on standard lithographysystems, nanoimprint lithography might become areal competitive method in mainstream IC *** are no physical limitations encountered withimprinting techniques for much smaller replicatedstructures, down to the sub-10nm range [1]. Amongseveral Nanoimprint lithography techniques resultsof two promising methods, hot embossing lithogra-phy (HEL) and UV-nanoimprinting (UV-NIL) will bepresented. Both techniques allow rapid prototypingas well as high volume production of fully patternedsubstrates for a wide range of *** paper will present results on HE and UV-NIL, among them full wafer imprints up to 200mmwith high-resolution patterns down to nm range.

关键词：光刻 HEL UV-NIL mCP 光对准

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伺服间隔联轴节可简化工件的装卸输送

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现代制造 2007年第4期 37-38页

作者： Reinhold schaefer

使用带有中间管的具有抗扭刚性的间隔联轴节,可以对在成形压力机上进行工件装卸输送的码放设备的角偏移和轴位移给予补偿。为此使用的Jakob公司的WB型联轴节可以搭接长达5m的轴距,并无间隙地传递500Nm的转矩。轴位移最多可达6mm。

关键词：联轴节输送装卸工件间隔伺服轴位移角偏移

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Genomic consequences of apple improvement

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Horticulture Research 2021年第1期8卷 97-109页

作者： Zoe migicovsky Kyle m.Gardner Christopher Richards C.Thomas Chao heidi R.Schwaninger Gennaro Fazio Gan-Yuan Zhong Sean myles Department of Plant Foodand Environmental SciencesFaculty of AgricultureDalhousie UniversityTruroNSCanada USDA-ARS Plant Germplasm Preservation Research UnitFort CollinsCOUSA USDA-ARS Grape Genetics Research UnitGen evaNYUSA Present address:Agriculture and Agri-Food Canada Fredericton Research and Development CentreFrederictonNBCanada

The apple(malus domestica)is one of the world's most commercially important perennial crops and its improvement has been the focus of human effort for thousands of ***,we genetically characterise over 1000 apple accessions from the United States Department of Agriculture(USDA)germplasm collection using over 30,000 singlenucleotide polymorphisms(SNPs).We con fi rm the close genetic relationship between modern apple cultivars and their primary progenitor species,malus sieversii from Central Asia,and fi nd that cider apples derive more of their ancestry from the European crabapple,malus sylvestris,than do dessert *** determine that most of the USDA collection is a large complex pedigree:over half of the collection is interconnected by a series of fi rst-degree *** addition,15%of the accessions have a fi rst-degree relationship with one of the top 8 cultivars produced in the *** the exception of‘Honeycrisp',the top 8 cultivars are interconnected to each other via pedigree *** cultivars‘Golden Delicious'and‘Red Delicious'were found to have over 60 fi rst-degree relatives,consistent with their repeated use by apple *** detected a signature of intense selection for red skin and provide evidence that breeders also selected for increased fi *** results suggest that Americans are eating apples largely from a single family tree and that the apple's future improvement will bene fi t from increased exploitation of its tremendous natural genetic diversity.

关键词： cultivar crops consequences

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