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AT1 receptor downregulation:A mechanism for improving glucose homeostasis

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World journal of Diabetes 2023年第3期14卷 170-178页

作者： Diana L Lopez Oscar E Casillas Hiram j jaramillo Tatiana Romero-Garcia j.Gustavo Vazquez-jimenez Department of Internal Medicine General Hospital of MexicaliMexicali 21000Baja CaliforniaMexico Faculty of Medicine Autonomous University of Baja CaliforniaMexicali 21000Baja CaliforniaMexico Faculty of Sports Autonomous University of Baja CaliforniaMexicali 21289Baja CaliforniaMexico

There is a pathophysiological correlation between arterial hypertension and diabetes mellitus, established since the pre-diabetic state in the entity known as insulin resistance. It is known that high concentrations of angiotensin-Ⅱ enable chronic activation of the AT1 receptor, promoting sustained vasoconstriction and the consequent development of high blood pressure. Furthermore, the chronic activation of the AT1 receptor has been associated with the development of insulin resistance. From a molecular outlook, the AT1 receptor signaling pathway can activate the jNK kinase. Once activated, this kinase can block the insulin signaling pathway, favoring the resistance to this hormone. In accordance with the previously mentioned mechanisms, the negative regulation of the AT1receptor could have beneficial effects in treating metabolic syndrome and type 2diabetes mellitus. This review explains the clinical correlation of the metabolic response that diabetic patients present when receiving negatively regulatory drugs of the AT1 receptor.

关键词： Type 2 diabetes mellitus High blood pressure Insulin receptor Insulin signaling pathway AT1 receptor Angiotensin II signaling pathway

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基于优化算法的串联体系可靠度分析(英文)

计算力学学报 2004年第6期21卷 665-670页

作者：李刚 Meyer j 大连理工大学工业装备结构分析国家重点实验室辽宁大连116024 科罗拉多州立大学化学工程系

结构体系的失效概率数学上可以表示为结构体系失效域上联合概率密度函数的积分,一般情况下很难直接积分求解。近几十年来,结构体系可靠度分析一直是可靠度领域的一个研究热点,人们提出许多方法,如:Monte-Carlo法、重要性抽样法与界限法... 详细信息

结构体系的失效概率数学上可以表示为结构体系失效域上联合概率密度函数的积分,一般情况下很难直接积分求解。近几十年来,结构体系可靠度分析一直是可靠度领域的一个研究热点,人们提出许多方法,如:Monte-Carlo法、重要性抽样法与界限法和概率网络估算技术等,这些算法在求解精度、计算效率、收敛性和易使用性等方面是不同的。本文采用优化算法(改进的可行方向法、序列线性规划和序列二次规划法)进行串联体系可靠度分析,并且与其他算法(HL-RF法、Monte-Carlo法和重要性抽样法)的结果以及一些精确解进行了比较。结果表明,相对于其他算法,基于优化算法的可靠度分析适用性广,在收敛性和健实性等方面具有明显的优势。

关键词：体系可靠度一次二阶矩法优化算法 Monte—Carlo法重要性抽样法

Between the Foreground and the Background Lies the Middle Ground:Painting a Harmonious Early Childhood Curriculum Landscape

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ECNU Review of Education 2022年第2期5卷 328-337页

作者： jennifer j.Chen Kean University

Highlights This commentary centers on one of the insightful articles in this Special Issue:"Curriculum Hybridization and Cultural Glocalization:A Scoping Review of International Research on Early Childhood Curriculum in China and Singapore,"authored by Yang and Li(2022).The commented article provides insights and directions regarding early childhood curriculum policy and practice in China and *** with Yang and Li's(2022)findings,this commentary further paints a new threecomponent framework(the foreground,the background,and the middle ground)for understanding and harmonizing the global-local dissonance in the early childhood curriculum *** both hindsight and foresight,this commentary also provides insights for policy and practice to advance a harmonious early childhood curriculum landscape in China and Singapore as well as in other societies confronted with similar predicaments.

关键词： China curriculum policy and practice early childhood curriculum global culture local culture Singapore

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湍流搅拌槽中的液滴尺寸分布

石油化工 1998年第2期27卷 122-127页

作者：陈中 Prass,j 武汉化工学院化学工程系

基于群体平衡（ＰｏｐｕｌａｔｉｏｎＢａｌａｎｃｅ）概念，从液滴的湍流破碎机理出发，建立了一个描述搅拌槽液液分散体系中的液滴尺寸分布的数学模型。模型参数根据试验结果由Ｍａｒｑｕａｒｄｔ方法确定。通过引入相对分配函数，提... 详细信息

基于群体平衡（ＰｏｐｕｌａｔｉｏｎＢａｌａｎｃｅ）概念，从液滴的湍流破碎机理出发，建立了一个描述搅拌槽液液分散体系中的液滴尺寸分布的数学模型。模型参数根据试验结果由Ｍａｒｑｕａｒｄｔ方法确定。通过引入相对分配函数，提高了模型精度，并适用于体积分布密度具有双峰的乳液分散体系。

关键词：液滴尺寸分布液滴破碎群体平衡

THE INVESTIGATION ON THE RHEOLOGICAL BEHAVIOR OF SEMI-SOLID ALUMINUM ALLOY DURING DIE CASTING

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Acta Metallurgica Sinica(English Letters) 2002年第6期15卷 511-516页

作者： X.j. Yang and j.Liu School of Mechanic & Electronic Engineering, Nanchang University, jiangxi 330029, China School of Mechanic & Electronic Engineering, Shanghai University, Shanghai 200072, China Sch. of Mech. and Electron. Eng. Nanchang Univ. Nanchang 330029 China Sch. of Mech. and Electron. Eng. Shanghai Univ. Shanghai 200072 China

Under the condition of die casting and reheating temperature of 570-580 degC, the rheological behavior of semi-solid aluminum alloy (A356) is pseudoplasticity at the shearrate of 2X10^-1X10^4s^(-1), and also shows dil... 详细信息

关键词： shear rate apparent viscosity viscosity model thixocasting

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蓝宝石火花塞(英文)

人工晶体学报 2003年第3期32卷 257-262页

作者： j. Linhart 进步技术公司

在如何提高火花塞的工作质量方面有多种方法 ,但是其中最重要的一个问题还没有得到解决 ,那就是火花塞工作的热学模型问题。理想的火花塞应该能在点火的瞬间被立刻加热 ,并且在接下来的电脉冲过程中迅速冷却 ,由此在热量的存储与散发之... 详细信息

在如何提高火花塞的工作质量方面有多种方法 ,但是其中最重要的一个问题还没有得到解决 ,那就是火花塞工作的热学模型问题。理想的火花塞应该能在点火的瞬间被立刻加热 ,并且在接下来的电脉冲过程中迅速冷却 ,由此在热量的存储与散发之间取得平衡 ,以避免自点火。本文力图展示一种具有自动调节源于点火区域热流能力的火花塞 ,其技术的关键是顶部绝缘体材料 ,它是由蓝宝石单晶制作 ,而非传统的氧化铝陶瓷。

关键词：蓝宝石火花塞自动调节热流热学模型

The Characterization of Sputtered Zr-Ge-N Thin Films as Diffusion Barriers Between Copper and Silicon

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稀有金属材料与工程 2012年第S1期41卷 120-123页

作者： Yang, j. j. Liu, B. Liao, X. D. jiao, G. H. Xu, K. W. Sichuan Univ Inst Nucl Sci & Technol Minist Educ Key Lab Radiat Phys & Technol Chengdu 610064 Peoples R China CAS Xian Inst Opt & Precis Mech State Key Lab Transient Opt & Photon Xian 710049 Peoples R China Xi An jiao Tong Univ State Key Lab Mech Behav Mat Xian 710049 Peoples R China

The main purpose of the present micro-structural analysis by transmission electron microscopy(TEM)and X-ray diffraction(XRD)was to investigate whether amorphous Zr-Ge-N films are a potential candidate as a diffusion barrier for Cu wiring used in Si *** Zr-Ge-N films were prepared by a radio frequency(RF)reactive magnetron sputter-deposition technique using N2 and Ar mixed gas,and the film structure was found to be sensitive to the gas flow ratio of N2 *** during *** Zr-Ge-N films were obtained when the N2/(Ar+N2)ratio was smaller than 0.2 and amorphous-like Zr-Ge-N films were obtained when the ratio was larger than *** barrier test was performed by annealing the Cu/Zr-Ge-N/Si film stack under Ar *** deposited Zr-Ge-N(C)films remained amorphous even after high temperature *** Cu diffusion profile in the film was assessed by the Auger electron spectroscopy(AES).The results indicate that Cu diffusion was minimal in amorphous Zr-Ge-N(C)films even at high annealing temperatures of 800℃.

关键词： Zr-Ge-N films diffusion barrier micro-structural thermal stability

Incidence and consequences of varicella in children treated for cancer in Guatemala

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世界儿科杂志:英文版 2016年第3期12卷 320-326页

作者： Amy E.Caruso Brown Edwin j.Asturias Mario Melgar Federico A.Antillon-Klussmann Pamela Mettler Myron j.Levin Center for Bioethics and Humanities and Department of Pediatrics SUNY Upstate Medical University Center for Global Health and Department of Epidemiology Colorado School of Public HealthAuroraColoradoUSA National Unit of Pediatric Oncology Guatemala CityGuatemala Department of Biostatistics and Informatics Colorado Biostatistics ConsortiumColorado School of Public HealthAuroraColoradoUSA Section of Pediatric Infectious Diseases Department of PediatricsUniversity of Colorado Denver Anschutz Medical CampusAuroraColoradoUSA

Background:Varicella-zoster virus infection is associated with significant morbidity and mortality in immune-compromised children,despite treatment with antiviral *** varicella vaccine programs have significantly decreased this risk in many highincome countries,but in most low-income and middleincome countries,the burden of varicella in children treated for malignancy is poorly defi ***:We retrospectively reviewed records of children at the National Unit of Pediatric Oncology(UNOP)in Guatemala diagnosed with varicella between january 2009 and March 2013 in order to calculate incidence of varicella and evaluate morbidity,mortality,treatment interruption,and ***:Fifty-nine cases of varicella were *** was 23.4 cases per 1000 person-years(p-y).66.1%of cases occurred in children with leukemia(median age 5.2 years;interquantile range 3.4-7 years)and 41.0%of these occurred during maintenance *** of exposure was identified for 14/59(23.7%)*** were hospitalized(71.2%)and given intravenous acyclovir(64.4%).Eight(13.6%)children required critical care,and two(3.4%)died from disseminated varicella with multiorgan *** was delayed or omitted due to varicella in 50%.No signifi cant differences in outcomes based on nutritional and immunologic status were *** minimum average cost of treatment per episode was 598.75 ***:Varicella is a significant problem in children treated for cancer in Guatemala,where effective post-exposure prophylaxis is *** the absence of universal varicella vaccination,strategies to improve recognition of exposure and the future use of novel inactivated vaccines currently under investigation in clinical trials could mitigate this burden.

关键词： cancer developing countries immunocompromised host oncology varicella

Giant Magneto-impedance Effect in Composite Wires with Different Core Layer

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Nano-Micro Letters 2013年第2期5卷 140-144页

作者： R.L.Wang X.Li X.H.Kong Y.X.Guo j.Z.Ruan Z.j.Zhao Department of Physics Engineering Research Center for Nanophotonics & Advanced Instrument Ministry of Education East China Normal University Experimental Teaching Center of Physics Shanghai Ocean University

Composite structure materials were potential sensing elements for magnetic sensors due to Giant magnetoimpedance(GMI) effect. Two kinds of composite wires with different magnetic/non-magnetic structures were fabricated by using electroless deposition methods and the magnetoimpedance properties were investigated. The maximum GMI ratio of 114% was acquired at 60 MHz in the composite wires with a ferromagnetic core, whereas, 116% of maximum GMI ratio was found in the composite wires with a conductive core at low frequency of 600 k Hz. These results exhibit that the GMI ratio reaches the maximum when magnetoresistance ratio ?R/R and magnetoinductance ratio ?X/X make the comparative contributions to the total magnetoimpedance(MI). The obvious GMI effect obtained in the composite wires with conductive core frequency may provide a candidate for applications in magnetic sensors, especially at low frequencies.

关键词： Composite wires Electroless deposition Giant Magnetoimpedance effect Resistivity