检索结果-南通市图书馆

Pathologic and Relative Pathogenetic Research of Varicocele

在线全文

cnki会议

学校读者我要写书评

暂无评论

Pathologic and Relative Pathogenetic Research of Varicocele

第十六届全国泌尿外科学术会议

作者： LIU Yingqingl,MA Chengminl*,ZHANG Xiushan2,YAN Junning2,HU Zhixu3 Ma ke1,CHEN Hongbing1,ZHANG Chao1,LIU Cheng1, 1.DePartment of Urology,2.DePartment of Pathology, Third Affiliated HosPital of Anhui Medical University,hefei 230061,China 3.DePartment of Urology,HosPital of Anhui CorPs of Chinese Armed Police Forces,hefei 230041, China 230032

Objective:To investigate Pathologic changes and relative Pathogenesis of varicocele。Methods:Pathologic and immunohistochemical aPPearance were observed in 30 cases of varicocele and 8 cases of normal men,s internal s...

关键词：

市民社会与政治国家的对立——潘恩《常识》中的市民社会思想解读

在线全文

cnki会议

学校读者我要写书评

暂无评论

沈阳教育学院学报 2002年第4期4卷 11-13页

作者：王兆良安徽医科大学社会科学部安徽合肥230032

潘恩是18世纪杰出的政治思想家、激进的资产阶级民主主义革命家和理论家。他的《常识》及其关于市民社会对抗国家的思想在西方政治思想史上产生了重要的影响。

关键词：市民社会政治国家《常识》政治思想托马斯·潘恩

在线全文

学校读者我要写书评

暂无评论

完善医学生道德教育的渠道和内容

中国医学伦理学 2003年第4期16卷 60-61,F003页

作者：武惠庭安徽医科大学社科部安徽合肥230032

重视和加强医学生的道德教育 ,既是贯彻落实《公民道德建设实施纲要》 ,提高全民族思想道德素质 ,全面建设小康社会的迫切需要 ,也是适应时代需要 ,培养合格的医科大学生所面临的重要任务。反思现有医学生的道德教育 ,笔者以为 ,无论在... 详细信息

重视和加强医学生的道德教育 ,既是贯彻落实《公民道德建设实施纲要》 ,提高全民族思想道德素质 ,全面建设小康社会的迫切需要 ,也是适应时代需要 ,培养合格的医科大学生所面临的重要任务。反思现有医学生的道德教育 ,笔者以为 ,无论在教育渠道 ,还是在教育内容和方法上都有待进一步完善 ,否则难以达到理想的道德教育目的。

关键词：医学生道德教育公共道德家庭美德大学生道德职业道德科学道德

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways

在线全文

学校读者我要写书评

暂无评论

Melatonin modulates TLR4-mediated inflammatory genes through...

中华预防医学会自由基预防医学专业委员会2012年夏季学术交流会

作者： XIA Mi-zhen,LIANG Ying-Li,WANG Hua,CHEN Xi,HUANG Yin-yin, ZHANG Zhi-hui,CHEN Yuan-hua,ZHANG Chen,ZHAO Mei,XU De-xiang Department of Toxicology,Anhui Medical University,hefei 230032

Increasing evidence demonstrates that melatonin has an anti-inflammatory ***,the molecular mechanisms remain *** the present study,we investigated the effect of melatonin on toll-like receptor 4(TLR4)-mediated molecule myeloid differentiation factor 88(MyD88)- and TRIF-dependent signaling pathways in lipopolysaccharide(LPS)-stimulated RAW264.7 ***264.7 cells were incubated with LPS(2.0μg/ml)in the absence or presence of melatonin(10,100,1000μM).As expected, melatonin inhibited TLR4-mediated tumor necrosis factor alpha(TNF-α),interleukin(IL)-1(3, IL-6,IL-8 and IL-10 in LPS-stimulated RAW264.7 *** addition,melatonin significantly attenuated LPS-induced upregulation of cyclooxygenase(COX)-2 and inducible nitric oxide synthase(iNOS)in RAW264.7 *** analysis showed that melatonin inhibited the expression of MyD88 in LPS-stimulated RAW264.7 *** it had no effect on TLR4-mediated phosphorylation of c-Jun N-terminal kinase(JNK),p38 and extracellular regulated protein kinase(ERK),melatonin significantly attenuated the activation of nuclear factor kappa B(NF-kB)in LPS-stimulated RAW264.7 *** addition,melatonin inhibited TLR4-mediated Akt phosphorylation in LPS-stimulated RAW264.7 ***, melatonin significantly attenuated the elevation of interferon(IFN)-regulated factor-3(IRF3), which was involved in TLR4-mediated TRIF-dependent signaling pathway,in LPS-stimulated RAW264.7 ***,melatonin significantly alleviated LPS-induced IFN-βin *** conclusion,melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways.

关键词： Melatonin lipopolysaccharide toll-like receptor inflammation molecule myeloid differentiation factor 88 Akt nuclear factor kappa B

Effect of triterpene acids of eriobotrya japonica（Thunb.）lindl.1eaf on TNF-α、TGF-β1 expression in alveolar macrophage of pulmonary fibrosis rats

在线全文

cnki会议

学校读者我要写书评

暂无评论

Effect of triterpene acids of eriobotrya japonica（Thunb.）l...

国际药理学术研讨会暨第三届两岸三地药理学学术会议

作者： Ya-Ru Yang,Yan Huang,Dan Xie,Juan Liu,Jun Li, College of Pharmacy,Anhui Medical University,hefei,An Hui,China Anhui Key Laboratory For Activity Research Of Nature Medicine,hefei,An Hui,China No.81 Meishan Road,Department of Pharmacy,Anhui Medical University hefei,Anhui 230032, People’s Republic of China

＜正＞Ami:To investigate the therapeutic effects and some mechanism of triterpene acids of loquat（TAL） on Bleomycin A5-induced pulmonary fibrosis ***:The model of pulmonary fibrosis was

关键词： TAL blecomycin-A5 hydrochloride alveolar macrophages

Effects of extract from Paeonia lactiflora and Astragalus membranaceus on hepatic fibrosis and its possible mechanism

在线全文

cnki会议

学校读者我要写书评

暂无评论

Effects of extract from Paeonia lactiflora and Astragalus me...

中国药理学会第十次全国学术会议

作者： SUN Wu-yi,WEI Wei~*,LIU Hao,LI Xiang,WANG Ling (Institute of Clinical Pharmacology,Anhui Medical University,the Key Laboratory of Antiinflammatory and Immunopharmacology,Ministry of Education,P.R,hefei 230032,China)

AIM:SQDG is standardized extract of the Chinese herb prescription composed of Paeonia lactiflora and Astragalus *** was mainly composed of paeoniflorin and astragaloside IV *** present study was designed to investigate the effects of SQDG on porcine serum-induced liver fibrosis rats in vivo according to the changes of histopathological examination,serum transaminase activities,serum fibrotic markers and lipid peroxidation. Furthermore,the roles of G protein coupled signal pathway and mitogen-activated protein kinase(MAPK) pathways

关键词：

骨保护素基因修饰的Cos-7细胞系的培养与鉴定

在线全文

cnki会议

学校读者我要写书评

暂无评论

实用口腔医学杂志 2005年第3期21卷 322-326页

作者：梅陵宣曹寅吴迪赵春晖安徽医科大学口腔医学院 230032

目的:构建pSecTag opg真核分泌表达穿梭载体,培养经opg基因修饰的Cos 7细胞系并检测其表达能力,为基因工程技术治疗牙周病提供物质基础。方法:提取293细胞的总mRNA,设计和合成特异性引物,进行逆转录-聚合酶链反应(RT PCR),扩增出具有抑... 详细信息

目的:构建pSecTag opg真核分泌表达穿梭载体,培养经opg基因修饰的Cos 7细胞系并检测其表达能力,为基因工程技术治疗牙周病提供物质基础。方法:提取293细胞的总mRNA,设计和合成特异性引物,进行逆转录-聚合酶链反应(RT PCR),扩增出具有抑制破骨细胞功能的opg基因cDNA,并将其重组到载体中测序;用脂质体法将目的基因转染至Cos 7细胞,应用免疫组织化学和Westernblot方法证实转染的细胞表达OPG。结果:重组质粒pSecTag2 /B opg经PCR、HindIII单酶酶切及EcoRI和BamHI双酶酶切,电泳显示均能切下与预期大小相符的片段,经测序证实此基因与GenBank中[gi: 33878056]提供的序列完全一致;经免疫组织化学和Westernblot方法检测,在转染opg基因的Cos 7细胞中有OPG表达。结论:成功构建了pSecTag2 /B opg分泌表达穿梭载体,并培养出高分泌表达OPG的Cos 7细胞系。

关键词：骨保护素基因克隆载体细胞表达

Cadmium-induced teratogenicity:association with reactive oxygen species(ROS) - mediated endoplasmic reticulum stress in placenta

在线全文

学校读者我要写书评

暂无评论

Cadmium-induced teratogenicity:association with reactive oxy...

中华预防医学会自由基预防医学专业委员会2012年夏季学术交流会

作者： WANG Zhen,WANG Hua,XU Zhong-mei,Jl Yan-li,CHEN Yuan-hua, ZHANG Zhi-hui,ZHANG Cheng,MENG Xiu-hong,ZHAO Mei,XU De-xiang Department of Toxicology,Anhui Medical University,hefei,230032

The placenta is essential for sustaining the growth of the *** increased endoplasmic reticulum(ER)stress has been associated with the impaired placental and fetal ***(Cd)is a potent teratogen that caused fetal malformation and growth *** present study investigated the effects of maternal Cd exposure on placental and fetal *** pregnant mice were intraperitoneally injected with CdCl(4.5 mg/kg)on gestational day *** expected,maternal Cd exposure during early limb development significantly increased the incidences of forelimb ectrodactyly in *** obvious impairment in the labyrinth,a highly developed tissue of blood vessels,was observed in placenta of mice treated with *** addition,maternal Cd exposure markedly repressed cell proliferation and increased apoptosis in *** experiment showed that maternal Cd exposure significantly upregulated the expression of GRP78,an ER ***,maternal Cd exposure induced the phosphorylation of placental eIF2α, a downstream molecule of PERK *** addition,maternal Cd exposure significantly increased the level of placental CHOP,another target of PERK signaling,indicating that the unfolded protein response(UPR)signaling was activated in placenta of mice treated with ***,alpha-phenyl-N-t-butylnitrone,a free radical spin-trapping agent, significantly alleviated Cd-induced placental ER stress and *** together,these results suggest that reactive oxygen species(ROS)-mediated ER stress might be involved in Cd-induced impairment on placental and fetal *** may be used as pharmacological agents to protect against Cd-induced fetal malformation and growth restriction.

关键词： Cadmium teratogenicity endoplasmic reticulum stress placenta unfolded protein response

75mGy　X线全身照射与低剂量环磷酰胺合用对荷瘤小鼠肺肿瘤转移的治疗作用

在线全文

cnki会议

学校读者我要写书评

暂无评论

实用肿瘤杂志 1996年第3期11卷 127-129页

作者：金敖兴黄帼汪思应魏道严张宝霆安徽医科大学核医学教研室安徽医科大学肿瘤研究室安微医科大学病理生理教研室

经低水平Ｘ线照射后，荷瘤小鼠肺肿瘤转移结节明显减少；与低剂量环磷酰胺（ＣＴＸ）合用，也可使荷瘤小鼠的肺转移结节减少。对荷瘤小鼠体内免疫功能的研究表明，小鼠脾脏细胞ＮＫ活性、白细胞介素Ⅱ（ＩＬ－２）诱导的ＬＡＫ活性ＬＴ... 详细信息

经低水平Ｘ线照射后，荷瘤小鼠肺肿瘤转移结节明显减少；与低剂量环磷酰胺（ＣＴＸ）合用，也可使荷瘤小鼠的肺转移结节减少。对荷瘤小鼠体内免疫功能的研究表明，小鼠脾脏细胞ＮＫ活性、白细胞介素Ⅱ（ＩＬ－２）诱导的ＬＡＫ活性ＬＴＲ及时ＩＬ－２的反应性均显著增强，当与低剂量ＣＴＸ合用时上述抗肿瘤免疫功能也提高，提示低剂量照射能通过有效地激活体内抗肿瘤免疫功能而具有显著的抗肿瘤转移效果，从而为探讨小剂量照射临床应用可能性提供可靠的实验依据。

关键词：肺肿瘤肿瘤转移 X线照射环磷酰胺