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Glutathione-S-transferase (GSTM1,GSTT1) and the risk of gastrointestinal cancer in a Korean population

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World Journal of Gastroenterology 2009年第45期15卷 5716-5721页

作者： Jin-Mei Piao Min-Ho Shin sun-Seog Kweon hee Nam Kim Jin-Su Choi Woo-Kyun Bae Hyun-Jeong Shim Hyeong-Rok Kim Young-Kyu par. Yoo-Duk Choi Soo-Hyun Kim Depar.ment of Preventive Medicine Chonnam National University Medical School Gwangju 501-746 South Korea Jeonnam Regional Cancer Center Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Genome Research Center for Hematopoietic Diseases Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Depar.ment of Hematology-Oncology Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Depar.ment of Surgery Chonnam National University Hwasun Hospital Hwasun Jeollanam-do 519-809 South Korea Depar.ment of Pathology Chonnam National University Medical School Gwangju 501-746 South Korea Depar.ment of Laboratory Medicine Chormam National University Medical School Gwangju 501-746 South Korea

AIM： To evaluate the association of glutathione S-trans-ferase mu （GSTM1） and glutathione S-transferase theta （GSTT1） null genotypes with the risk of gastric cancer （GC） and colorectal cancer （CRC） in a South Korean population. METHODS： We conducted a population-based, large- scale case-control study including 2213 GCs, 1829 CRCs, and 1699 controls. Null and non-null genotypes of GSTM1 and GSI-F1 were determined using realtime PCR. RESULTS： The null genotypes of GSTM1 and GSTT1 were not significantly associated with elevated risk of gastric （OR = 1.070, 95% CI = 0.935-1.224; OR = 1.101, 95% CI = 0.963-1.259, respectively） or colorectal cancer （OR = 1.065, 95% CI = 0.923-1.228; OR = 1.041, 95% CI = 0.903-1.200, respectively）. The frequency of the combined null GST genotype was not different between the two cancer groups and controls. Moreover, smoking, drinking, and age did not modify the association between these genotypes and the risk of gastric or colorectal cancer. CONCLUSION： GSTM1 and GSCI-1 null genotypes were not associated with increased risk of GC or CRC in Koreans.

关键词： Glutathione S-transferase mu Glutathione S-transferase theta Gastric cancer Colorectal cancer South Korean population

Treatment of Dyeing Wastewater by Using Positive Pulsed Corona Discharge to Water Surface

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Plasma Science and Technology 2007年第1期9卷 71-75页

作者： Young sun MOK HyunTaeAHN JoengTaiKIM Depar.ment of Chemical Engineering Cheju National UniversityJeju 690-756South Korea Depar.ment of Architectural Engineering Kyung Hee UniversityYongin-si446-701South Korea

This study investigated the treatment of textile-dyeing wastewater by using an electrical discharge technique （positive pulsed corona discharge）. The high-voltage electrode was placed above the surface Of the wastewater while the ground electrode was submerged in the wastewater. The electrical discharge starting at the tip of the high voltage electrode propagated toward the surface of the wastewater, producing various oxidative radicals and ozone. Oxygen was used as the working gas instead of air to prevent nitrogen oxides from forming. The simulated wastewater was made up with amaranth, which is a kind of azo dye. The results obtained showed that the chromaticity of the wastewater was almost completely removed within an hour. The ultraviolet/visible spectra of the wastewater treated by the electrical discharge revealed that the total hydrocarbon level also decreased significantly.

关键词： positive pulsed corona discharge textile-dyeing wastewater chromaticity

Output-feedback based par.ial integrated missile guidance and control law design

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Journal of Systems Engineering and Electronics 2016年第6期27卷 1238-1248页

作者： Xuejiao sun Rui Zhou Delong Hou School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Beijing Institute of Electronic System Engineering Beijing 100854China

An output-feedback based par.ial integrated guidance and control (IGC) law for missile interceptor is proposed with the smooth finite time convergence property. Firstly, a novel outputfeedback based smooth sliding mode control is proposed for a class of nonlinear systems in the presence of immeasurable state and disturbance. The finite time convergence property of this control scheme is proved based on the Lyapunov stability and homogeneous principle. Then, the proposed control method is applied to the design of par.ial IGC law. A kind of scaling methods is also developed to reach the rapid convergence of the system. An important dominance of this control scheme is the smooth characteristic, which may result in chattering free convergence. The simulation results indicate the high precision and smooth elevator deflection of the proposed output feedback base par.ial IGC law. © 2016 Beijing Institute of Aerospace Information.

关键词： Control system synthesis Control theory Electronic guidance systems Guided missiles Missiles Sliding mode control

Acute mediastinitis arising from pancreatic mediastinal fistula in recurrent pancreatitis

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World Journal of Gastroenterology 2014年第40期20卷 14997-15000页

作者： In Soo Choe Yong Seok Kim Tae hee Lee sun Moon Kim Kyung Ho Song Hoon Sup Koo Jung Ho par. Jin Sil Pyo Ji Yeong Kim In Seok Choi Division of Gastroenterology and Hepatology Department of Internal Medicine Konyang University College of Medicine Daejeon 302-718 South Korea Depar.ment of General Surgery Konyang University College of Medicine Daejeon 302-718 South Korea

Acute mediastinitis is a fatal disease that usually originates from esophageal perforation and surgical *** cases of descending necrotizing mediastinitis can occur following oral cavity and pharynx infection or can be a complication of *** most common thoracic complications of pancreatic disease are reactive pleural effusion and pneumonia,while rare complications include thoracic conditions,such as pancreaticopleural fistula with massive pleural effusion or hemothorax and extension of pseudocyst into the *** have been no reports of acute mediastinitis originating from pancreatitis in South *** this report,we present the case of a 50-year-old female suffering from acute mediastinitis with pleural effusion arising from recurrent pancreatitis that improved after surgical intervention.

关键词： Mediastinitis Complication Fistula Recurrent Pancreatitis

大林姬鼠两亚种线粒体DNA细胞色素b基因和控制区的序列多样性(英文)

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兽类学报 2010年第3期30卷 256-263页

作者： Hung sun Koh Kyung hee Jang 王金星 Bae Keun Lee Nam Jung par. Depar.ment of Biology Chungbuk National Universitycheongju361763 山东大学生命科学学院济南250100

为了研究大林姬鼠两亚种(韩国的指名亚种及中国东北和内蒙古地区的东北亚种)线粒体DNA的变异程度并确定朝鲜亚种的分类地位,我们分别将来自韩国和中国东北长白山地区的两亚种的线粒体DNA的细胞色素b基因和控制区进行了测序分析。我们将... 详细信息

为了研究大林姬鼠两亚种(韩国的指名亚种及中国东北和内蒙古地区的东北亚种)线粒体DNA的变异程度并确定朝鲜亚种的分类地位,我们分别将来自韩国和中国东北长白山地区的两亚种的线粒体DNA的细胞色素b基因和控制区进行了测序分析。我们将测序所得到细胞色素b基因序列与来自基因库的大林姬鼠5个亚种的相应的单倍型进行了分析,结果显示大林姬鼠可分为4个类群[类群1:韩国大林姬鼠指名亚种;类群2:中国长白山和内蒙古地区的东北亚种、俄罗斯外加贝尔的majuculus亚种;类群3:中国长春的东北亚种、俄罗斯Primorye(俄罗斯远东地区)rufulus亚种、俄罗斯库页岛(俄罗斯远东地区)和日本北海道地区的giliacus亚种;类群4:中国黑龙江海林地区的东北亚种]。线粒体的控制区序列分析显示韩国指名亚种也不同于中国东北地区的东北亚种。本研究的类群1,2和3与Serizawaetal.(2002)的研究的K、S和R的分支相对应。这表明韩国指名亚种(类群1和分支K)的线粒体DNA与其他类群不同。另外,我们还发现在细胞色素b基因构建的系统树中,东北亚种可以与类群2(分支S)及类群3(分支R的不同亚种聚合在一起。我们认为线粒体DNA的母性遗传与两个相邻亚种的个体之间的种内杂交造成了基于细胞色素b序列对东北亚种的聚类分析结果与基于形态学特征的分类结果的不一致。因此,我们提出对这些显示出核苷酸序列多样性的东北亚种不能只用细胞色素b的数据进行亚种分类,还应该结合形态学和核DNA特征进行进一步分析。最后,我们还发现韩国的指名亚种的细胞色素b序列在平均距离16.93%的基础上不同于来自基因库的***。Jones and Johnson(1965)指出了韩国的大林姬鼠在形态上的区别,所以我们认为韩国的大林姬鼠指名亚种***是一种具有形态和遗传特异性的地方亚种。

关键词： DNA系统学细胞色素b基因控制区大林姬鼠

Two-step generation of induced pluripotent stem cells from mouse fibroblasts using Id3 and Oct4

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分子细胞生物学报:英文版 2012年第1期4卷 59-62页

作者： Jai-hee Moon June Seok Heo Suhyun Kwon Jihyun Kim Jihye Hwang Phil Jun Kang Aeree Kim Hyun Ok Kim Kwang Youn Whang Byung sun Yoon Seungkwon You Laboratory of Cell Function Regulation College of Life Sciences and BiotechnologyKorea UniversitySeoulRepublic of Korea Cell Therapy Center College of MedicineYonsei UniversitySeoulRepublic of Korea Depar.ment of Pathology College of MedicineKorea University Guro HospitalSeoulRepublic of Korea Division of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoulRepublic of Korea

Dear Editor,Somatic cells can be reprogrammed into pluripotent stem cells,called induced pluripotent stem cells(iPSCs),by defined transcription factors(Takahashi et al.,2006).The reprogramming of somatic cells may be a continuous stochastic process in which nearly all somatic donor cells have the ability to give rise to iPSCs with continuous passaging and the expression of defined factors(Hanna et al.,2009).However,the reprogramming process can be divided into discrete stages,including the generation of dedifferentiated pre-pluripotent cells followed by authentic pluripotent cells(Silva et al.,2009).

关键词： pluripotent programming

Sojucktang induces apoptosis via loss of mitochondrial membrane potential and caspase-3 activation in KLE human endometrial cancer cells

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Chinese Science Bulletin 2009年第23期54卷 4387-4392页

作者： OH Yeon-Suk KWON hee-Young JEONG Soo-Jin par. Ki-Young KIM sun-Young LEE Hyo-Jung LEE Hyo-Jeong LEE Eun-Ok AHN Kwang Seok KIM sung-Hoon Cancer Preventive Material Development Research Center Oriental Medical CollegeKyunghee University College of Medicine Kyunghee University

Sojucktang (SJT) has long been used for the treatment of endometrial diseases in Korea. However, the mechanisms responsible for the SJT-induced apoptosis in endometrial cancer cells remain unclear. In the present study, SJT was demonstrated to show cytotoxic effect and induce apoptotic cell death via mitochondrial regulation in KLE endometrial cancer cells. Linderae Radix, Glycyrrhizae Radix, Zedoariae Rhizoma, Trogopterorum Faeces and Agelicae Gigantis Radix were found to be the potent constituent herbs of SJT to significantly decrease the viability of KLE cells by a tetra zolium salt (XTT) assay. Apoptotic bodies were observed in SJT-treated KLE cells by 4′-6-diamidino-2-phenylindole (DAPI) and TdT-mediated-dUTP nick-end labeling (TUNEL) assay. SJT also increased sub-G1 DNA contents of the cell cycle undergoing apoptosis in a dose-dependent manner. Furthermore, it was observed that SJT activated caspase-3 and cleaved poly (ADP-ribose) polymerase (par.), and decreased mitochondrial membrane potential in a dose-dependent manner. Taken together, this study shows that SJT exerts anti-tumor activity against KLE endometrial cancer cells via mitochondrial dependent apoptosis induction.

关键词：线粒体膜电位 caspase 子宫内膜癌细胞凋亡活化癌细胞诱导细胞毒作用

Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis

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Molecular Plant 2023年第12期16卷 1867-1870页

作者： Hong Gil Lee Seo Young Jang Eun Yee Jie Seung hee Choi Ok-sun par. Soon Hyung Bae Hyun-Soon Kim Suk Weon Kim Geum-Sook Hwang Pil Joon Seo Depar.ment of Chemistry Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Integrated Metabolomics Research Group Western Seoul CenterKorea Basic Science InstituteSeoul 03759Korea Biological Resource Center Korea Research Institute of Bioscience and BiotechnologyJeongeup56212Korea Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea College of Pharmacy Chung-Ang UniversitySeoul 06974Korea

Dear Editor,Plant tissue culture involves callus formation and de novo shoot ***,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-inducing medium(CIM),followed by shoot regeneration on cytokinin-rich shoot-inducing medium(SiM).Callus results from division of pericycle-like cells(Atta et al.,2009;Sugimoto et al.,2010);its cellular identity resembles that of lateral root primordia(Atta et al.,2009;Sugimoto et al.,2010).Callus acquires cellular pluripotency by forming root stem cell niches on CIM(Sugimoto et al.,2010)。

关键词： Adenosine callus

Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression

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中医杂志:英文版 2023年第4期43卷 686-694页

作者： Dong-Wook Kang Jae-Gyun Choi hee Ju Song Jaehyuk Kim Miae Lee Taehee Kim Suk-Yun Kang Yeonhee Ryu Hwa Seung Yoo Jin sun Lee Jin Bong par. Sang Do Lee Hyun-Woo Kim Depar.ment of Physiology and Medical Science College of Medicine and Brain Research InstituteChungnam National UniversityDaejeon 35015Republic of Korea KM Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea East-West Cancer Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon 35234Republic of Korea Depar.ment of Surgery Chungnam National University HospitalDaejeon 35015Republic of Korea Laboratory of Veterinary Pharmacology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea

OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable *** study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in ***:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR *** was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind *** blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal ***:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

关键词： analgesia brain-derived neurotrophic factor chemotherapy-induced peripheral neuropathy docetaxel nerve stimulation