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Incidental accumulation of Technetium-99m pertechnetate in subacute cerebral infarction: A case report

World Journal of Clinical Cases 2022年第23期10卷 8400-8405页

作者： Yeon-hee Han Hwan-Jeong Jeong Hyun Goo kang Seok Tae Lim Department of Nuclear Medicine Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJounbuk National University Medical School and HospitalJeonju 54907JeonbukSouth Korea Department of Neurology Jeonbuk National University Medical School and HospitalJeonju 54907JeonbukSouth Korea

BACKGROUND When interpreting nuclear medicine images,unexpected findings are sometimes *** these findings and determining the mechanism of their occurrence could have a significant impact on early diagnosis of critical diseases and the appropriate management of *** SUMMARY A 59-year-old man was admitted to the emergency room due to left hemiparesis,left hemifacial palsy,and mild *** 2 wk of hospitalization,the patient complained of dry eyes and ***,salivary scintigraphy was performed to evaluate the functional status of his salivary *** accumulation in the right frontoparietal area was found on salivary ***-attenuated inversion recovery phase magnetic resonance(FLAIR phase MR)image showed diffuse high signal intensity in the same *** and posterior horns of the right lateral ventricle were obliterated and the midline was slightly shifted to the left side due to right frontoparietal *** salivary scintigraphy,Tc-99m pertechnetate was incidentally accumulated in a subacute cerebral infarction *** years after the diagnosis of acute infarction,the second series of salivary scintigraphy showed no abnormal activity in the *** phase MR image also demonstrated markedly decreased high signal intensity in the previous infarction lesion without evidence of swelling indicating chronic cerebral *** This case highlights that Tc-99m pertechnetate could accumulate in a subacute cerebral infarction *** mechanism of an unexpected uptake of Tc-99m pertechnetate in unusual sites should be evaluated and kept in mind for better interpretation.

关键词： Cerebral infarction Tc-99m pertechnetate Salivary scintigraphy Case report

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Endoscopic cyanoacrylate injection for the treatment of gastric varices in children

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World Journal of Gastroenterology 2015年第9期21卷 2719-2724页

作者： Seak hee Oh Seung Jin Kim kang Won Rhee Kyung Mo Kim Department of Pediatrics Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoul 138-736South Korea

AIM:To evaluate the efficacy and safety of N-butyl-2-cyanoacrylate in treating acute bleeding of gastric varices in ***:The retrospective study included 21 children with 47 episodes of active gastric variceal bleeding who were treated by endoscopic injection of N-butyl-2-cyanoacrylate at Asan Medical Center Children's Hospital between August 2004 and December *** reduce the risk of embolism,each injection consisted of 0.1-0.5 mL of 0.5 mL N-butyl-2-cyanoacrylate diluted with 0.5 or 0.8 mL *** primary outcome was incidence of hemostasis after variceal obliteration and the secondary outcome was complication of the ***:The 21 patients experienced 47 episodes of active gastric variceal bleeding,including rebleeding,for which they received a total of 52 cyanoacrylate *** 42 bleeding episodes,hemostasis was achieved after one injection and following five bleeding episodes it was achieved after two *** mean volume of each single aliquot of cyanoacrylate injected was 0.3 ± 0.1 mL(range:0.1-0.5 m L).Injection achieved hemostasis in 45 of 47(95.7%) episodes of acute gastric variceal *** patients(52.4%) developed rebleeding events,with the mean duration of hemostasis being 11.1 ± 11.6 mo(range:1.0-39.2 mo).No treatment-related complications such as distal embolism were noted with the exception of abdominal pain in one patient(4.8%).Among four mortalities,one patient died of variceal ***:Endoscopic variceal obliteration using a small volume of aliquots with repeated cyanoacrylate injection was an effective and safe option for the treatment of gastric varices in children.

关键词： Cyanoacrylate Gastric varix Children Endoscopic va

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Immunoglobulin G4-related spinal pachymeningitis:A case report

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World Journal of Clinical Cases 2024年第32期12卷 6551-6558页

作者： Tae-Seok Chae Da-Sol Kim Gi-Wook Kim Yu Hui Won Myoung-Hwan Ko Sung-hee Park Jeong-Hwan Seo Department of Physical Medicine&Rehabilitation Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Physical Medicine&Rehabilitation Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a complex immune-mediated condition that causes fibrotic inflammation in several organs.A significant clinical feature of IgG4-RD is hypertrophic pachymeningitis,which manifests as inflammation of the dura mater in intracranial or spinal *** IgG4-RD can affect multiple areas,the spine is a relatively rare site compared to the more frequent involvement of intracranial *** SUMMARY A 70-year-old male presented to our hospital with a two-day history of fever,altered mental status,and generalized *** initial brain magnetic resonance imaging(MRI)revealed multiple small infarcts across various cerebral *** the second day after admission,a physical examination revealed motor weakness in both lower extremities and diminished sensation in the right lower *** evaluation revealed findings consistent with acute motor sensory *** initial management with intravenous immunoglobulin for presumed Guillain-Barrésyndrome,the patient exhibited progressive worsening of motor *** the 45th day of hospitalization,an enhanced MRI of the entire spine,focusing specifically on the thoracic 9 to lumbar 1 vertebral level,raised the suspicion of IgG4-related spinal ***,the patient was administered oral prednisolone and participated in a comprehensive rehabilitation program that included gait training and lower extremity strengthening *** IgG4-related spinal pachymeningitis,diagnosed on MRI,was treated with corticosteroids and a structured rehabilitation regimen,leading to significant improvement.

关键词： Immunoglobulin G4 related disease Immunoglobulin G4 related spinal pachymeningitis Manual motor test Electromyography Magnetic resonance imaging Case report

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High-Throughput Pb Recycling for Perovskite Solar Cells Using Biomimetic Whitlockite

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Energy & Environmental Materials 2023年第3期6卷 170-176页

作者： Jung Sug Hong hee Jung Kim Chang Hwun Sohn Oh Yeong Gong Jin Hyuk Choi kang hee Cho Gill Sang Han Ki Tae Nam Hyun Suk Jung Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Korea

Pb contamination in aquatic environments causes severe pollution;therefore,harmless absorbents are *** this study,we report a novel synthesis of whitlockite(WH,Ca_(18)Mg_(2)(HPO_(4))_(2)(PO_(4))_(12)),which is the second most abundant biomineral in human bone,and its application as a high-performing Pb^(2+)***(HAP)and WH are prepared via a simple precipitation *** Pb2+absorption performance and mechanism of the synthesized biominerals are investigated in aqueous solutions at neutral *** results demonstrate that WH exhibits an excellent Pb2+absorption capacity of 2339 mg g^(−1),which is 1.68 times higher than the recorded value for ***,the absorbed Pb^(2+) ions are recycled into high-purity PbI_(2).This is employed as a precursor for the fabrication of perovskite solar cells(PSCs),resulting in a conversion efficiency of 19.00%comparable to that of commercial PbI2 powder(99.99%purity).Our approach provides an efficient way to remove Pb^(2+)ions from water and reuse them in the recycling of PSCs.

关键词： Pb absorption Pb recycling perovskite solar cells water purification whitlockite

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Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood-brain barrier

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药学学报:英文版 2023年第9期13卷 3834-3848页

作者： Thuy Giang Nguyen Cao Ji hee kang Su Jin kang Quan Truong Hoang Han Chang kang Won Jong Rhee Yu Shrike Zhang Young Tag Ko Min Suk Shim Division of Bioengineering Incheon National UniversityIncheon 22012Republic of Korea College of Pharmacy Gachon UniversityIncheon 21936Republic of Korea Department of Pharmacy Integrated Research Institute of Pharmaceutical Sciencesand BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future PharmacyCollege of Pharmacythe Catholic University of KoreaGyeonggi-do 14662Republic of Korea Research Center for Bio Materials&Process Development Incheon National UniversityIncheon 22012Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA

Glioblastoma(GBM)is the most aggressive malignant brain tumor and has a high mortality *** therapy(PDT)has emerged as a promising approach for the treatment of malignant brain ***,the use of PDT for the treatment of GBM has been limited by its low blood-brain barrier(BBB)permeability and lack of cancer-targeting ***,brain endothelial cell-derived extracellular vesicles(bEVs)were used as a biocompatible nanoplatform to transport photosensitizers into brain tumors across the *** enhance PDT efficacy,the photosensitizer chlorin e6(Ce6)was linked to mitochondria-targeting triphenylphosphonium(TPP)and entrapped into *** Ce6(TPP-Ce6)selectively accumulated in the mitochondria,which rendered brain tumor cells more susceptible to reactive oxygen species-induced apoptosis under light ***,the encapsulation of TPP-Ce6 into b EVs markedly improved the aqueous stability and cellular internalization of TPP-Ce6,leading to significantly enhanced PDT efficacy in U87MG GBM *** in vivo biodistribution study using orthotopic GBM-xenografted mice showed that b EVs containing TPP-Ce6[b EV(TPP-Ce6)]substantially accumulated in brain tumors after BBB penetration via transferrin receptor-mediated *** such,b EV(TPP-Ce6)-mediated PDT considerably inhibited the growth of GBM without causing adverse systemic toxicity,suggesting that mitochondria are an effective target for photodynamic GBM therapy.

关键词： Extracellular vesicle Chlorin e6 Triphenylphosphonium Mitochondria-targeting photosensitizer Photodynamic therapy Blood-brain barrier Glioblastoma Transferrin receptor

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Clinical significance of tumor-infiltrating lymphocytes for gastric cancer in the era of immunology

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World Journal of Gastrointestinal Oncology 2017年第7期9卷 293-299页

作者： Byung Woog kang Jong Gwang Kim In hee Lee Han Ik Bae An Na Seo Department of Hematology/Oncology Kyungpook National University Hospital Kyungpook National University School of Medicine Department of Pathology Kyungpook National University Hospital Kyungpook National University School of Medicine

Immunotherapy has begun to revolutionize cancer treatment, by introducing therapies that target the host immune system instead of the tumor, therapies that possess unique adverse event profiles, and therapies that may cure certain types of cancer. The immune microenvironment of tumors is emerging as the most important means of understanding the relationship between a patient' immune system and their cancer, informing prognosis, and guiding immunotherapy, such as an antibody blockade of immune checkpoints. For some solid tumors, simple quantitation of lymphocyte infiltration would seem to have prognostic significance, suggesting that lymphocyte infiltration is not passive but may actively promote or inhibit tumor growth. For gastric cancers, several studies have provided strong evidence that immune cells contribute to determining prognosis. However, the exact role of immune cells in gastric cancer remains unclear. Therefore, this review focuses on the clinical significance of immune cells, especially tumor-infiltrating lymphocytes, in gastric cancer.

关键词： Gastric cancer Tumor-infiltrating lymphocytes Immunotherapy

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Constructing an Automation Table for an Image-Based Arabidopsis Resistance Assay

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Engineering 2020年第5期6卷 495-499页

作者： Goldi Makhija Dinesh SPujara In-Hyouk Song Byoung hee You Hong-Gu kang Department of Engineering Technology Texas State UniversitySan MarcosTX 78666USA Department of Biology Texas State UniversitySan MarcosTX 78666USA Caresoft Global Inc. Burr RidgeIL 60527USA

*** Crop improvement is becoming critical for food security due to a continuously changing climate and increasing population[1].The management of plant diseases is one of the most important factors in food *** example,wheat,a major crop plant,has been historically subject to periodic total *** a recent instance,when a new strain of wheat stem rust spread from East Africa to the Middle East,the price of wheat spiked significantly,threatening livelihoods in developing countries[2].This example highlights the importance of learning how plants fend off potential pathogens and pests,in order to secure food resources.

关键词： Automation wheat instance

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Effects of electrochemical synthetic conditions on surface property and photocatalytic performance of copper and iron-mixed p-type oxide electrodes

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Journal of Materials Science & Technology 2018年第9期34卷 1503-1510页

作者： Sun hee Yoon Dong Suk Han Unseock kang Seung Yo Choi Wubulikasimu Yiming Ahmed Abdel-Wahab Hyunwoong Park Chemical Engineering Program Texas A&M University at Qatar School of Energy Engineering Kyungpook National University Department of Mechanical Engineering Texas A&M University at Qatar

Earth-abundant copper and iron-mixed oxide（CuO/CuFeO_2; CFO） film electrodes are synthesized using an electrochemical deposition（ED） technique at two different ED potentials（-0.36 and-0.66 V vs saturated calomel electrode（SCE）; denoted as ED-1 and ED-2, respectively）. Then, their surface morphologies are compared, and the photo（electro）catalytic activities for the reduction of Cr（VI） are examined in aqueous solutions at pH 7 under simulated sunlight（AM 1.5 G; 100 mW cm（-2））. The degree of the electrical potential applied to the ED process significantly affects the thickness of the synthesized electrode film and the intensity ratio of the diffraction peaks of CuO（111） and CuFeO_2（012）. A 200 μm thick ED-2 sample with a distinct stacking of CuO on CuFeO_2 exhibits a larger broadband absorption spectrum than the 50-μm thick ED-1 with less separate stacking. Furthermore, the ED-2 sample has a higher intensity ratio of the diffraction peaks of CuO（111） and CuFe02（012） than ED-1. As-synthesized ED-2 samples produce larger photocurrents, leading to faster Cr（VI） reduction on the surface under given potential bias（-0.5 V vs SCE）or bias-free conditions. The energy levels（i.e., flatband potential） for the two samples are almost the same（only 10 mV difference）, presumably supposing that the enhanced photoactivity of the ED-2 sample for Cr（VI） reduction is due to the facilitated charge transfer. The time-resolved photoluminescence emission spectra analysis reveal that the lifetime（r） of the charge carriers in the ED-1 sample is 0.103 ns, which decreases to 0.0876 ns in the ED-2. The ED-2 sample synthesized at a high negative potential is expected to contribute greatly to the application of other solar-to-fuel energy conversion fields as a highly efficient electrode material.

关键词： Artificial photosynthesis Solar fuel Delafossites Morphology Charge transfer

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Strong contact coupling of neuronal growth cones with height-controlled vertical silicon nanocolumns

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Nano Research 2018年第5期11卷 2532-2543页

作者： Seong-Min Kim Seyeong Lee Dongyoon Kim Dong-hee kang Kisuk Yang Seung-Woo Cho Jin Seok Lee Insung S. Choi Kyungtae kang Myung-Han Yoon School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwongju 61005 Republic of Korea Department of Biotechnology Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea Department of Chemistry Sookmyung Women's University Seoul 04310 Republic of Korea Center for Cell-Encapsulation Research Department of Chemistry KAIST Daejeon 34141 Republic of Korea Department of Applied Chemistry Kyung Hee University Yongin Gyeonggi 17104 Republic of Korea

In this study, we report that height-controlled vertically etched silicon nano- column arrays （vSNAs） induce strong growth cone-to-substrate coupling and accelerate in vitro neurite development while preserving the essential features of initial neurite formation. Large-scale preparation of vSNAs with flat head morphology enabled the generation of well-controlled topographical stimulation without cellular impalement. A systematic analysis on topography- induced variations on cellular morphology and cytoskeletal dynamics was conducted. In addition, neurite development on the grid-patterned vSNAs exhibited preferential adhesion to the nanostructured region and outgrowth directionality. The arrangement of cytoskeletal proteins and the expression of a focal adhesion complex indicated that a strong coupling existed between the underlying nanocolumns and growth cones. Furthermore, the height-controlled nanocolumn substrates differentially modulated neurite polarization and elongation. Our findings provide an important insight into neuron-nanotopography interactions and their role in cell adhesion and neurite development.

关键词： vertical silicon nanostructures metal-assisted chemical etching primary hippocampal neurons neurite outgrowth cytoskeletal dynamics

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