检索结果-南通市图书馆

Rare Metals 2006年第z2期25卷 184-188页

作者： PARK Sook hee kang Chan Hyoung Department of Advanced Materials Engineering Korea Polytechnic University Shihung Kyonggi-do 429-793 Korea

Employing Li2CO3, NiO, Co3O4, and MnCO3 powders as starting materials, Li[Ni1/3Co1/3Mn1/3]O2 was synthesized by solid-state reaction method. Various grinding aids were applied during milling in order to optimize the synthesis process. After successive heat treatments at 650 and 950 ℃, the prepared powders were characterized by X-ray diffraction (XRD) analysis, scanning electron microscopy, and transmission electron microscopy. The powders prepared by adding salt (NaCl) as grinding aid exhibit a clear R3m layer structure. The powders by other grinding aids like heptane show some impurity peaks in the XRD pattern. The former powders show a uniform particle size distribution of less than 1 μm average size while the latter shows a wide distribution ranging from 1 to 10 μm. Energy dispersive X-ray (EDX) analysiss show that the ratio of Ni, Co, and Mn content in the powder is approximately 1/3, 1/3, and 1/3, respecively. The EDX data indicate no incorporation of sodium or chlorine into the powders. Charge-discharge tests gave an initial discharge capacity of 160 mAh·g-1 for the powders with NaCl addition while 70 mAh·g-1 for the powders with heptane.

关键词： lithium ion battery cathode materials layered structure solid-state method discharge density

电针预防化疗诱导的周围神经病变：随机对照试验

在线全文

学校读者我要写书评

暂无评论

中国针灸 2024年

作者：姚瑶张曦平葛任洁 Im hee Shin 姚昶南京中医药大学附属医院乳腺外科大邱天主教大学医学院医学统计学系

目的：探讨电针预防化疗诱导的周围神经病变（CIPN）的临床疗效。方法：将52例拟行紫杉烷辅助/新辅助化疗的乳腺癌患者随机分为电针组（26例，脱落3例）和常规护理组（26例，脱落1例）。常规护理组在标准化疗方案基础上予以常规护理；... 详细信息

目的：探讨电针预防化疗诱导的周围神经病变（CIPN）的临床疗效。方法：将52例拟行紫杉烷辅助/新辅助化疗的乳腺癌患者随机分为电针组（26例，脱落3例）和常规护理组（26例，脱落1例）。常规护理组在标准化疗方案基础上予以常规护理；电针组在常规护理组基础上加用电针干预，穴取印堂及双侧八邪（第二）、外关、合谷、曲池、足三里、阴陵泉、三阴交、太溪、太冲、悬钟、八风（第四），同侧太冲、三阴交连接电针，疏密波，频率2 Hz/10 Hz，每次30 min，自第1周期化疗前1 d开始，前2周每周2次，后每周1次，共治疗12周。比较两组患者试验第24周CIPN发生率，观察两组患者试验前及试验第12、24周欧洲癌症研究与治疗组织的化疗引起周围神经毒性生活质量问卷20（EORTC QLQ-CIPN20）得分、中医证候量表积分、欧洲癌症研究与治疗组织生命质量量表（EORTC QLQ-C30）得分，检测两组患者试验前及试验第12周感觉神经传导速度、运动神经传导速度。结果：试验第24周时，电针组CIPN总发生率为17.4%（4/23），低于常规护理组的72.0%（18/25，P＜0.001）；电针组高级别CIPN发生率为0%（0/23），低于常规护理组28.0%（7/25，P＜0.05）。试验第12、24周时，常规护理组EORTC QLQ-CIPN20感觉神经症状得分、总分较试验前升高（P＜0.001，P＜0.05，P＜0.01）；试验第24周时，电针组EORTC QLQ-CIPN20感觉神经症状得分低于常规护理组（P＜0.05）。试验第12周时，常规护理组患者感觉神经中右侧腓浅神经传导速度较试验前下降（P＜0.05）；电针组感觉神经中左侧正中神经、右侧腓浅神经传导速度高于常规护理组（P＜0.05，P＜0.01）。试验第12、24周时，电针组中医证候量表次症积分均较试验前下降（P＜0.05），常规护理组中医证候量表主症、次症积分及总积分均较试验前升高（P＜0.01，P＜0.001，P＜0.05）；试验第12周时，电针组主症、次症积分及总积分均低于常规护理组（P＜0.05，P＜0.01），试验第24周时，电针组患者次症、总积分低于常规护理组（P＜0.05）。试验第12周时，常规护理组EORTC QLQ-C30疲倦、疼痛、恶心呕吐得分均较试验前升高（P＜0.05，P＜0.01）；试验第24周时，电针组EORTC QLQ-C30总体健康状况得分较试验前升高（P＜0.001），恶心呕吐、食欲丧失得分较试验前降低（P＜0.01）。试验第12周时，电针组EORTC QLQ-C30总体健康状况得分高于常规护理组（P＜0.01），疼痛、恶心呕吐得分低于常规护理组（P＜0.01，P＜0.05）；试验第24周时，电针组EORTC QLQ-C30总体健康状况得分高于常规护理组（P＜0.001），食欲丧失得分低于常规护理组（P＜0.05）。结论：电针能降低CIPN的发生率及严重程度，改善神经传导速度，提高患者生活质量。

关键词：化疗诱导的周围神经病变乳腺癌电针随机对照试验

Comprehensive molecular analysis to predict the efficacy ofchemotherapy containing bevacizumab in patients with metastaticcolorectal cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

肿瘤学研究(英文) 2023年第6期31卷 855-866页

作者： SUNG hee LIM hee JIN CHO kyoung-MEE KIM HO YEONG LIM WON KI kang JEEYUN LEE YOUNG SUK PARK hee CHEOL KIM SEUNG TAE KIM Division of Hematology/Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea Precision Medicine Research Institute Samsung Medical CenterGangnam-guSeoul06351Korea Department of Biomedical Convergence Science and Technology Kyungpook National UniversityDaegu41566Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul06351Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea

Background:Although bevacizumab is an important treatment for metastatic colorectal cancer(CRC),not allpatients with CRC benefit from it;in unselected patient populations,only modest survival benefits have been ***:We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identifybiomarkers for a response to bevacizumab-containing *** molecular analysis comprised whole-exomesequencing,ribonucleic acid sequencing,and a methylation array on patient ***:Genomic and molecularcharacterization was successfully conducted in 103 *** of 103 CRC samples were hypermutated,and none ofthe non-hypermutant tumors were microsatellite *** those 103 patients,89 had adenocarcinoma(ADC),15 were diagnosed with mucinous ADC,and six had signet-ring cell carcinoma(SRCC).Consensus molecular subtype(CMS)2 was unique to *** the four SRCCs,two were CMS1,one was CMS4,and the other was *** status was a significantly enriched factor in responders to bevacizumab *** growth factorreceptor(FGFR)1/2 signaling was upregulated in non-responders,whereas cell cycle,transfer ribonucleic acidprocessing,nucleotide excision repair,and oxidative phosphorylation pathways were enriched in ***,IGF1 was differentially expressed in non-responders(log2 fold change=−1.43,p=4.11×10^(−5),falsediscovery rate=0.098),and FLT1 was highly methylated in non-responders(p=7.55×10^(−3)).When the molecularpathways were reanalyzed separately according to the backbone chemotherapy(FOLFOX ***),thesignificance of the molecular pathways varied according to the backbone ***:This studysought a subset of CRC patients with a distinct clinical response to chemotherapy containing *** need to be validated in a large group of homogenous patient cohort and examined according to the differentchemotherapy backbones to create personalized therapeutic oppor

关键词： Bevacizumab Whole-exome sequencing Ribonucleic acid sequencing Methylation array Colorectal cancer

A study on the interference effects for tidal current power rotors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2010年第11期53卷 3094-3101页

作者： Chul-hee JO kang-hee LEE Jin-Young YIM Department of Naval Architecture & Ocean Engineering Inha University

Due to global warming, the need to secure an alternative resource has become more important nationally. With the high tidal range of up to 9.7 m on the west coast of Korea, numerous tidal current projects are being planned and constructed. To extract a significant quantity of power, a tidal current farm with a multi-arrangement is necessary in the ocean. The rotor, which initially converts the energy, is a very important component because it affects the efficiency of the entire system, and its performance is determined by various design variables. The power generation is strongly dependent on the size of the rotor and the incoming flow velocity. However, the interactions between devices also contribute significantly to the total power capacity. Therefore, rotor performance considering the interaction problems needs to be investigated for generating maximum power in a specific field. This paper documents a performance study of devices considering the interference between rotating rotors with axial, transverse and diagonal arrangements.

关键词： TCP (tidal current power) renewable energy interference effect rotor CWC (circulation water channel) CFD (computational fluid dynamics)

Micro-accelerometer Based on Vertically Movable Gate Field Effect Transistor

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2015年第3期7卷 282-290页

作者： Heung Seok kang kang-hee Lee Dong-Youk Yang Byoung hee You In-Hyouk Song Korea Atomic Energy Research Institute LOGTECH Co. Ltd 914 Gumgang Hightech Valley 1st Department of Engineering Technology Texas State University601 University Dr. San Marcos TX 78666 USA

A vertically movable gate field effect transistor(VMGFET) is proposed and demonstrated for a microaccelerometer application. The VMGFET using air gap as an insulator layer allows the gate to move on the substrate vertically by external forces. Finite element analysis is used to simulate mechanical behaviors of the designed structure. For the simulation, the ground acceleration spectrum of the 1952 Kern County Earthquake is employed to investigate the structural integrity of the sensor in vibration. Based on the simulation, a prototype VMGFET accelerometer is fabricated from silicon on insulator wafer. According to current–voltage characteristics of the prototype VMGFET, the threshold voltage is measured to be 2.32 V, which determines the effective charge density and the mutual transconductance of1.545910-8C cm-2and 6.59 m A V-1, respectively. The device sensitivity is 9.36–9.42 m V g-1in the low frequency,and the first natural frequency is found to be 1230 Hz. The profile smoothness of the sensed signal is in 3 d B range up to1 k Hz.

关键词： MEMS Micro-accelerometer Suspended gate FET Vertically movable gate FET VMGFET

Spectrum of COVID-19 induced liver injury:A review report

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第4期16卷 517-536页

作者： Lokjan Singh Anil Kumar Maya Rai Bibek Basnet Nishant Rai Pukar Khanal Kok-Song Lai Wan-hee Cheng Ahmed Morad Asaad Shamshul Ansari Department of Microbiology Karnali Academy of Health ScienceTeaching HospitalJumla 21200KarnaliNepal Health Sciences Asian College of Advance StudiesPurbanchal UniversitySatdobato 24122LalitpurNepal Department of Biotechnology Graphic Era(Deemed to be University)Dehradun 248002UttarakhandIndia Department of Pharmacology&Toxicology KLE College of PharmacyBelagaviKLE Academy of Higher Education and ResearchBelagavi 590010KarnatakaIndia Division of Health Sciences Abu Dhabi Women's CollegeHigher Colleges of TechnologyAbu Dhabi 41012United Arab Emirates Health and Life Sciences INTI International UniversityNilai 71800Malaysia Department of Microbiology College of MedicineZagazig UniversityZagazig 44519Egypt

The coronavirus disease 2019(COVID-19)pandemic has caused changes in the global health system,causing significant setbacks in healthcare systems *** pandemic has also shown resilience,flexibility,and creativity in reacting to the *** severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection targets most of the respiratory tract,resulting in a severe sickness called acute respiratory distress syndrome that may be fatal in some *** the lung is the primary organ targeted by COVID-19 viruses,the clinical aspect of the disease is varied and ranges from asymptomatic to respiratory ***,due to an unorganized immune response and several affected mechanisms,the liver may also experience liver cell injury,ischemic liver dysfunction,and drug-induced liver injury,which can result in respiratory failure because of the immune system’s disordered response and other compromised processes that can end in multisystem organ *** with liver cirrhosis or those who have impaired immune systems may be more likely than other groups to experience worse results from the SARS-CoV-2 *** thus intend to examine the pathogenesis,current therapy,and consequences of liver damage concerning COVID-19.

关键词： Autoimmune liver disease COVID-19 Clinical manifestation of liver Drug-induced liver injury SARS-CoV-2

Recent TCP(Tidal Current Power) projects in Korea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2010年第1期53卷 57-61页

作者： Chul hee JO kang hee LEE Yu Ho RHO School of Engineering Inha University253Yonghyun-DongNam-GuIncheon 402-751Republic of Korea Graduate School Department.of Naval Architecture & Ocean EngineeringInha University253Yonghyun-DongNam-GuIncheon 402-751Republic of Korea

Having strong current on the west coast with up to 10 m tidal range in Korea,there are many suitable and applicable locations for TCP(Tidal Current Power) application in *** only the west coast,but also the south west regions having narrow channels between islands creating fast ocean stream are suitable for *** first TCP application in Korea is 1 MW helical VAT(Vertical Axis Turbine) device installed in Wooldolmog area in *** first HAT(Horizontal Axis Turbine) TCP device of 25 KW was developed and installed in cooling water weir of Samchonpo power plant in ***,a 100 kW prototype HAT TCP device is being planned to be installed in Daebang strait in *** big project would be Inchon TCP farm of 200 MW on the west coast in *** consortium of 5 members was formed in April,*** site will be the largest TCP site in the *** paper describes recent TCP projects in Korea with background and environmental conditions of the projects.

关键词： TCP(Tidal Current Power) ocean energy renewable energy clean energy HAT(Horizontal Axis Turbine) VAT(Vertical Axis Turbine)

Aqueous extract of freeze-dried Protaetia brevitarsis larvae promotes osteogenesis by activating β-catenin signaling

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2022年第3期12卷 115-123页

作者： Jayasingha Arachchige Chathuranga Chanaka Jayasingha kyoung Tae Lee Yung Hyun Choi Chang-hee kang Mi-Hwa Lee Gi-Young Kim Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Research Institute for Basic Sciences Jeju National UniversityJeju 63243Republic of Korea Forest Biomaterials Research Center National Institute of Forest ScienceJinju 52817Republic of Korea Department of Biochemistry College of Korean MedicineDong-Eui UniversityBusan 47227Republic of Korea Nakdonggang National Institute of Biological Resources Sangju 37242Republic of Korea

Objective:To investigate the effect of an aqueous extract of Protaetia brevitarsis(AEPB)on osteogenesis using preosteoblast MC3T3-E1 cells and zebrafish ***:Flow cytometric analysis was used to measure the *** phosphatase activity was detetmined using p-nitrophenyl phosphate as a *** deposition was detected using alizarin red staining along with osteogenic marker expression in preosteoblast MC3T3E1 *** addition,vertebral formation in zebrafish larvae was detected using calcein staining and osteogenic gene ***:AEPB highly promoted the expression of osteogenic markers including runt-related transcription factor 2,osterix,and alkaline phosphatase,along with elevated levels of mineralization in MC3T3-E1 ***,AEPB accelerated vertebral formation in zebrafish larvae accompanied by upregulated expression of osteogenic ***535,an inhibitor of Wnt/β-catenin,suppressed AEPB-induced osteogenic gene expression and vertebral formation,indicating that AEPB stimulates osteogenesis by activating the Wnt/β-catenin signaling ***:AEPB stimulates osteoblast differentiation and bone formation by activatingβ-***,AEPB is a promising material that induces osteogenesis,and is useful for the treatment of bone resorption diseases.

关键词： Protaetia brevitarsis Osteoblast differentiation Bone formation β-catenin MC3T3-E1

Development of polyimide films reinforced with boron nitride and boron nitride nanosheets for transparent flexible device applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2018年第5期11卷 2366-2378页

作者： You Jin Min Kyeong-hee kang Dae-Eun Kim Department of Mechanical Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seoul 03722 Republic of Korea

The benefits of reinforcing polyimide （PI） films with boron nitride （BN） particles and boron nitride nanosheets （BNNSs） were assessed with the aim of enhancing their thermal, optical, and mechanical properties for flexible device applications. BNNSs were prepared from BN particles using a liquid-phase exfoliation method assisted by an ultrasonic probe-type sonicator and centrifugator. PI-based composite films blended with BNNSs and BN particles were fabricated at various concentrations via mechanical stirring and spin coating. The transparency of the PI/BNNS composite films remained almost the same as that of pure PI films up to 3 wt.% whereas the transparency of the PI/BN composite films decreased with increasing concentration of the BN fillers at 550 nm. The thermal stability improved significantly with increasing concentrations of both BN and BNNS relative to that of pure PI films. The temperature for 5% weight loss of the PI/BNNS composite film was higher than that of the PI/BN composite film at the same filler concentration. The composite films with 2 wt.% BN or BNNS showed the lowest wear rate, and the PI/BNNS composite films showed more stable frictional behavior compared to the PI/BN composite films. In addition, bending tests showed that the PI/BNNS composite films exhibited excellent flexibility compared to the PI/BN composite films. Overall, the results indicate that the BNNS can be effectively used as a filler that can enhance the thermal and mechanical properties of polymer materials for flexible device applications.

关键词： polyimide (PI) boron nitride (BN) transparency thermal properties flexibility tribology

Trends in colorectal cancer incidence according to an increase in the number of colonoscopy cases in Korea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第1期16卷 51-60页

作者： Ga hee Kim Yeong Chan Lee Tae Jun Kim Sung Noh Hong Dong Kyung Chang Young-Ho Kim Dong-Hoon Yang Chang Mo Moon Kyunga Kim Hyun Gun Kim Eun-Ran Kim Division of Gastroenterology Department of Internal MedicineAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineEwha Womans UniversitySeoul 07985South Korea Biomedical Statistics Center Samsung Medical CenterSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineSeoul 04401South Korea

BACKGROUND The incidence of colorectal cancer(CRC)and preinvasive CRC(e.g.,early colon cancer and advanced adenoma)is gradually increasing in several *** To evaluate the trend in incidence of CRC and preinvasive CRC according to the increase in the number of colonoscopies performed in *** This retrospective cohort study enrolled Korean patients from 2002 to 2020 to evaluate the incidence of CRC and preinvasive CRC,and assess the numbers of diagnostic colonoscopies and colonoscopic ***-related complications by age group were also *** The incidence of CRC showed a rapid increase,then decreased after 2012 in the 50-75 year-age *** the study period,the rate of incidence of preinvasive CRC increased at a similar level in patients under 50 and 50-75 years of *** 2009,the increase has been rapid,showing a pattern similar to the increase in *** rate of colonoscopic polypectomy in patients aged under 50 was similar to the rate in patients over 75 years of age after *** rate of complications after colonoscopy and related deaths within 3 mo was high for those over 75 years of *** The diagnosis of preinvasive CRC increased with the increase in the number of colonoscopies *** the risk of colonoscopy-related hospitalization and death is high in the elderly,if early lesions at risk of developing CRC are diagnosed and treated under or at the age of 75,colonoscopy-related complications can be reduced for those aged 76 years or over.

关键词： Colorectal cancer Preinvasive colorectal cancer Colorectal polypectomy Colonoscopy