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Modeling of subthreshold characteristics for undoped and doped deep nanoscale short channel double-gate MOSFETs

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Journal of Semiconductors 2012年第12期33卷 27-30页

作者：靳晓诗刘溪吴美乐揣荣岩 jung-hee lee Jong-Ho lee School of Information Science and Engineering Shenyang University of Technology School of EECS Kyungpook National University School of EECS Eng.and ISRC(Inter-University Semiconductor Research Center) Seoul National University

A model of subthreshold characteristics for both undoped and doped double-gate （DG） MOSFETs has been proposed. The models were developed based on solution of 2-D Poisson＇s equation using variable separa- tion technique. Without any fitting parameters, our proposed models can exactly reflect the degraded subthreshold characteristics due to nanoscale channel length. Also, design parameters such as body thickness, gate oxide thick- ness and body doping concentrations can be directly reflected from our models. The models have been verified by comparing with device simulations＇ results and found very good agreement.

关键词： double-gate MOSFETs deep nanoscale modeling

Trap and 1/f-noise effects at the surface and core of GaN nanowire gateall-around FET structure

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Nano Research 2019年第4期12卷 809-814页

作者： Mallem Siva Pratap Reddy Ki-Sik Im jung-hee lee Raphael Caulmione Sorin Cristoloveanu School of Electronics Engineering Kyungpook National University Daegu 41566 Republic of Korea Advanced Material Research Center Kumoh National Institute of Technology Gumi 39177 Republic of Korea SOITEC Bernin 38190 France Institute of Microelectronics Electromagnetism and Photonics Grenoble Polytechnic Institute Minatec Grenoble 38016 France

Using capacitance,conductance and noise measurements,we investigate the trapping behavior at the surface and in the core of triangular-shaped one-dimensional (1 D) array of GaN nanowire gate-all-around field effect transistor (GAA FET),fabricated via a top-down *** surface traps in such a low dimensional device play a crucial role in determining the device *** estimated surface trap density rapidly decreases with increasing frequency,ranging from 6.07 × 1012 cm-2·eV-1 at 1 kHz to 1.90 × 1011 cm-2·eV-1 at 1 MHz,*** noise results reveal that the power spectral density increases with gate voltage and clearly exhibits 1/f-noise signature in the accumulation region (Vgs > Vth =3.4 V) for all *** the surface depletion region (1.5 V < Vgs < Vth),the device is governed by 1/fat lower frequencies and 1/f2 noise at frequencies higher than ~ 5 *** 1/f2 noise characteristics is attributed to additional generation-recombination (G-R),mostly caused by the electron trapping/detrapping process through deep traps located in the surface depletion region of the *** cutoff frequency for the 1/f2 noise characteristics further shifts to lower frequency of 102-103 Hz when the device operates in deep-subthreshold region (Vgs < 1.5 V).In this regime,the electron trapping/detrapping process through deep traps expands into the totally depleted nanowire core and the G-R noise prevails in the entire nanowire channel.

关键词： gate-all-around field effect transistor (FET) nanowire GaN trap 1/f-noise

Generation and measurement of arbitrary four-dimensional spatial entanglement between photons in multicore fibers

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Photonics Research 2019年第1期7卷 19-27页

作者： hee jung lee hee SU PARK Korea Research Institute of Standards and Science(KRISS) Agency for Defense Development

High-dimensional entanglement is a valuable resource for secure and efficient quantum information processing.A major challenge for practical use of multidimensional quantum systems is the establishment of controls over arbitrary superposition states in realistic conditions. This work demonstrates spatially entangled photon pairs propagating through two separate four-core optical fibers with the amplitudes and phases of the superposition being independently controllable. Using quantum state analyzers that can detect arbitrary multicore superposition states, Bell-type CGLMP inequalities in two, three, and four dimensions are directly tested. Enhanced violation of the inequality by slight nonmaximality of entanglement is also demonstrated.

关键词： High-dimensional entanglement efficient quantum demonstrates spatially

Development of a Specific CHIKV-E2 Monoclonal Antibody for Chikungunya Diagnosis

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Virologica Sinica 2019年第5期34卷 563-571页

作者： Jaemoo Kim Jihyun Yang Young Bong Kim hee-jung lee Sehyun Kim Haryoung Poo Infectious Disease Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea Department of Biosystems and Bioengineering University of Science and TechnologyDaejeon 34113Republic of Korea Department of Biomedical Science and Engineering Konkuk UniversitySeoul 05029Republic of Korea Department of Bio-Industrial Technologies Konkuk UniversitySeoul 05029Republic of Korea

Chikungunya fever is a vector-borne viral disease transmitted to humans by chikungunya virus(CHIKV)-infected *** have been many outbreaks of CHIKV infection worldwide,and the virus poses ongoing risks to global *** prevent and control CHIKV infection,it is important to improve the current CHIKV diagnostic approaches to allow for the detection of low CHIKV concentrations and to correctly distinguish CHIKV infections from those due to other mosquito-transmitted viruses,including dengue virus(DENV),Japanese encephalitis virus(JEV),and Zika virus(ZIKV).Here,we produced monoclonal antibodies(mAbs)against the CHIKV envelope 2 protein(CHIKV-E2)and compared their sensitivity and specificity with commercially available mAbs using enzyme-linked immunosorbent assays(ELISA).Two anti-CHIKV-E2 mAbs,19-1 and 21-1,showed higher binding affinities to CHIKV-E2 protein than the commercial mAbs *** particular,the 19-1 mAb had the strongest binding affinity to inactivated ***,the 19-1 mAb had very little cross-reactivity with other mosquito-borne viruses,such as ZIKV,JEV,and *** results suggest that the newly produced anti-CHIKV-E2 mAb,19-1,could he used for CHIKV diagnostic approaches.

关键词： Chikungunya virus(CHIKV) Envelope 2 Monoclonal antibody Diagnosis• Sensitivity Specificity

Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro

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Journal of Traditional Chinese Medicine 2021年第2期41卷 219-226页

作者： FENG Jinghui Set Byeol Kim hee jung lee Su Min Sim Soon Sung Lim Hong Won Suh Department of Pharmacology College of MedicineHallym UniversityChuncheon 200-702South Korea Department of Food Sciences and Nutrition College of NaturalHealthand Life SciencesHallym UniversityChuncheon 200-702Republic of

OBJECTIVE:To investigate the possible antinociceptive effects of Salvia(S.)miltiorrhiza Bunge and its single components in monosodium urate(MSU)-induced pain model in mice and lipopolysaccharide(LPS)-induced inflammation model in RAW264.7 ***:Pretreatment of *** Bunge extract(from 1 to 50μg/mL)concentration-dependently attenuated LPS-induced nitric oxide(NO)*** extract of *** Bunge(50 or 100 mg/kg)also caused reversals of decreased threshold for pain in the MSU-treated group as measured by Von-Frey ***,we assessed the antinociceptive and anti-inflammatory properties of the active single components from *** Bunge such as 15,16-dihydrotanshinoneⅠ,tanshinoneⅠ,cryptotanshinone,miltirone,tanshinoneⅡA,and salvianolic acid *** of them showed an anti-inflammatory effect in LPS-induced NO release model and an antinociceptive effect in MSU-treated pain ***:Our results suggest that *** Bunge extract may exert anti-inflammatory effect by reducing LPS-induced NO release and an antinociceptive property in MSU-treated pain ***,tanshinoneⅡA,miltirone,cryptotanshinone,and 15,16-dihydrotanshinoneⅠ,not only appear to be responsible for LPS-induced NO release induced by *** Bunge,but also in the production of *** Bunge extract-induced antinociception in MSU-treated pain ***:Therefore,the analgesic and anti-inflammatory property of *** Bunge indicate it as a therapeutic potential candidate for the treatment of pain and inflammation.

关键词： Salvia miltiorrhiza lipopolysaccharides nitric oxide inflammation analgesics

High efficiency and stable solid-state fiber dye-sensitized solar cells obtained using TiO_(2) photoanodes enhanced with metal organic frameworks

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Journal of Energy Chemistry 2022年第4期31卷 458-466页

作者： Jae Ho Kim Hyun Woo Park Sung-Jun Koo Daseul lee Eunyeong Cho Yong-Ki Kim Myunghun Shin Jin Woo Choi hee jung lee Myungkwan Song Department of Energy and Electronic Material Korea Institute of Materials Science(KIMS)797 Changwon-daeroSungsan-guChangwonGyeongsangnam-do 51508Republic of Korea Composites Research Division Korea Institute of Materials Science(KIMS)797 Changwon-daeroSungsan-GuChangwonGyeongsangnam-do 51508Republic of Korea School of Electronics and Information Engineering Korea Aerospace UniversityGoyang-cityGyeonggi-do 10540Republic of Korea

Solid-state fiber dye-sensitized solar cells(SS-FDSSCs) have been the subject of intensive attention and development in recent years. Although this field is only in its infancy, metal–organic frameworks(MOFs) are one such material that has been utilized to further improve the power conversion efficiency of solar cells. In this study, MOF-integrated DSSCs were shown to have potential in the development of solar cell devices with efficiency comparable to or better than that of conventional solar cells. The power conversion efficiency(PCE) of SS-FDSSCs was improved by embedding MOF-801 into a mesoporous-TiO_(2)(mp-TiO_(2)) layer, which was used as a photoanode in SS-FDSSCs, which are inherently flexible. The PCE of the MOF-integrated SS-FDSSCs was 6.50%, which is comparable to that of the reference devices(4.19%).The MOF-801 enhanced SS-FDSSCs decreased the series resistance(R_(s)) value, resulting in effective electron extraction with improved short-circuit current density(J_(SC)), while also increasing the shunt resistance(R_(sh)) value to prevent the recombination of photo-induced electrons. The result is an improved fill factor and, consequently, a higher value for the PCE.

关键词： Photoanode Metal organic frameworks Solid-state electrolyte Dye-sensitized solar cells Fiber-shaped solar cells

Research on Cavitation Characteristics and Influencing Factors of Herringbone Gear Pump

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2917-2946页

作者： Jinlong Yang Kwang-hee lee Chul-hee lee Department of Mechanical Engineering of Inha University Incheon22212South Korea

Cavitation is a common issue in pumps,causing a decrease in pump head,a fall in volumetric efficiency,and an intensification of outlet flow *** is one of the main hazards that affect the regular operation of the *** on pump cavitation mainly focuses on mixed flow pumps,jet pumps,external spur gear pumps,***,there are few cavitation studies on external herringbone gear *** addition,pumps with different working principles significantly differ in the flow and complexity of the internal flow ***,it is urgent to study the cavitation characteristics of external herringbone gear *** with experimentalmethods,visual research and cavitation area identification are achieved through computation fluid dynamic(CFD),and changing the boundary conditions and shape of the gear rotor is *** simulation yields a head error of only 0.003%under different grid numbers,and the deviation between experimental and simulation results is less than 5%.The study revealed that cavitation causes flow pulsation at the outlet,and the cavitation serious area is mainly distributed in the meshing gap and meshing *** can be inhibited by reducing the speed,increasing the inlet pressure,and changing the helix angle can be *** example,when the inlet pressure is 5 bar,the maximumgas volume fraction in themeshing area is less than 50%.These results provide a reference for optimizing the design and finding the optimal design parameters to reduce or eliminate cavitation.

关键词： Herringbone gear pump cavitation rotating speed inlet pressure helix angle TwinMesh

Tetramic acid-motif natural products from a marine fungus Tolypocladium cylindrosporum FB06 and their anti-Parkinson activities

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Marine Life Science & Technology 2024年第1期6卷 84-92页

作者： Yuna jung Chaesun Kwon Taeyeon Kim Jin Woo lee Min-Kyoo Shin Sang hee Shim Natural Products Research Institute College of PharmacySeoul National UniversitySeoul 08826Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea College of Pharmacy Duksung Women’s UniversitySeoul 01369Republic of Korea

Tetramic acid-containing natural products are attracting significantly increasing attention from biologists and chemists due to their intriguing structures and biological *** the present study,two new tetramic acid alkaloids tolypyridone I(1)and tolypyridone J(2),together with five known ones(3–7),were isolated from cultures of a marine fungus Tolypocladium cylindrosporum FB06 isolate obtained from a marine sediment in Beaufort sea of North *** structures were elucidated using 1D,2D NMR,and *** configurations were established on the basis of 1H coupling constants,ROESY correlations and DP4 *** 2 was isolated as mixtures of rotational isomers with C-3 to C-7 axis between 4-hydroxy-2-pyridone and 1-ethyl-3,5-dimethylcyclohexane,hindering *** our unbiased screening to discover neuroprotective compounds in an in vitro Parkinson’s disease(PD)model,SH-SY5Y dopaminergic cells were treated with isolated compounds followed by treatment with 1-methyl-4-phenylpyridinium(MPP^(+)),a parkinsonian *** tested compounds,F-14329(7)significantly protected cells from MPP^(+)-induced ***^(+)-mediated cell death is known to be related to the regulation of Bcl-2 family proteins,specifically the down-regulation of anti-apoptotic Bcl-2 and the up-regulation of pro-apoptotic Bax *** with 2 mmol/L of MPP^(+)for 24 h significantly reduced Bcl-2 levels compared to control treated with ***,treatment with F-14329(7)attenuated such *** study demonstrates that tetramic acid-motif compounds could be potential lead compounds for treating PD.

关键词： Tolypocladium cylindrosporum Tetramic acid Tolypyridone Parkinson’s disease

Adverse effects of early-life stress:focus on the rodent neuroendocrine system

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Neural Regeneration Research 2024年第2期19卷 336-341页

作者： Seung Hyun lee Eui-Man jung Department of Molecular Biology College of Natural SciencesPusan National UniversityBusanRepublic of Korea

Early-life stress is associated with a high prevalence of mental illnesses such as post-traumatic stress disorders,attention-deficit/hyperactivity disorder,schizophrenia,and anxiety or depressive behavior,which constitute major public health *** the early stages of brain development after birth,events such as synaptogenesis,neuron maturation,and glial differentiation occur in a highly orchestrated manner,and external stress can cause adverse long-term effects throughout *** body utilizes multifaceted mechanisms,including neuroendocrine and neurotransmitter signaling pathways,to appropriately process external *** individuals first exposed to early-life stress deploy neurogenesis as a stress-defense mechanism;however,in adulthood,early-life stress induces apoptosis of mature neurons,activation of immune responses,and reduction of neurotrophic factors,leading to anxiety,depression,and cognitive and memory *** process involves the hypothalamus-pituitary-adrenal axis and neurotransmitters secreted by the central nervous system,including norepinephrine,dopamine,and *** rodent early-life stress model is generally used to experimentally assess the effects of stress during *** paper reviews the use of the early-life stress model and stress response mechanisms of the body and discusses the experimental results regarding how early-life stress mediates stress-related pathways at a high vulnerability of psychiatric disorder in adulthood.

关键词： early-life stress hypothalamic-pituitary-adrenergic axis maternal separation mental illness neurodevelopmental disorder neuroendocrine system neurotransmitter