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Breast adenoid cystic carcinoma arising in microglandular adenosis:A case report and review of literature

World Journal of Clinical Cases 2021年第25期9卷 7579-7587页

作者： Jin Kyung An jeong Joo Woo Eun Kyung Kim hee Yong Kwak Department of Radiology Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea Department of Pathology Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea Department of Surgery Nowon Eulji Medical CenterEulji University School of MedicineSeoul 01830South Korea

BACKGROUND Breast adenoid cystic carcinoma(AdCC)is a rare invasive carcinoma composed of epithelial and myoepithelial *** adenosis(MGA)is a rare benign proliferative lesion consisting of small,uniform,and round glands formed by a single layer of epithelial cells and basement membrane without a myoepithelial cell *** may progress to atypical MGA and carcinoma arising in *** various invasive carcinomas from MGA,AdCC has been rarely ***,we report a case of AdCC arising in *** SUMMARY A 59-year-old woman was diagnosed with a newly developed density on a routine *** density was similar to or slightly lower than that of the breast *** showed an irregular mass with a slightly higher echo than that of *** resonance imaging showed an irregular mass with a similar T1 signal intensity and a slightly higher T2 signal intensity compared to muscles or the breast *** lesion showed heterogeneous internal enhancement with an initially slow and delayed persistent enhancing ***,the tumor was composed of invasive AdCC,in situ AdCC,and *** is composed of basaloid and ductal epithelial cells forming cribriform or solid sheets,or haphazardly scattered small cribriform or tubular *** showed small glands with a single epithelial lining and retained lumen.S-100 staining was strongly positive in MGA *** patient underwent breast-conserving surgery with sentinel lymph node *** Breast AdCC arising in MGA showed unique imaging findings that was different from usual invasive cancer.

关键词： Breast neoplasms Fibrocystic breast disease Carcinoma Adenoid cystic Case report

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Pulmonary amyloidosis and multiple myeloma mimicking lymphoma in a patient with Sjogren’s syndrome:A case report

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World Journal of Clinical Cases 2022年第3期10卷 1016-1023页

作者： Joa Kim Yun Sung Kim hee jeong Lee Sang Gon Park Department of Internal Medicine RheumatologyChosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Chosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Hemato-OncologyChosun University HospitalGwangju 501-717South Korea

BACKGROUND Sjogren’s syndrome(SS),which affect salivary gland function,is an autoimmune *** may involve extraglandular *** 10 to 20 percent of SS patients have clinically significant lung disease,but presentation of pulmonary amylodosis is extremly *** incidence of benign monoclonal gammopathy in SS patients is high,but multiple myeloma is *** case involving the simultaneous occurrence of two rare diseases,pulmonary amyloidosis and multiple myeloma,in the same patient with SS has been reported so *** SUMMARY A 41-year-old male patient was referred to our hematology department due to incidentally detected gastric *** had been diagnosed with SS four years *** miliary nodules,ground glass opacity in both lung fields,and enlargement of both inguinal lymph nodes was observed on chest and abdomen computer *** on the pathological findings of lung and lymph node biopsied specimens,the patient was diagnosed with pulmonary amyloidosis and multiple *** amyloidosis and multiple myeloma associated with SS has rarely been *** This is an extremely rare case of simultaneous pulmonary amyloidosis and multiple myeloma in the same patient with SS.

关键词： Case report Sjogren’s syndrome Amyloidosis Multiple myeloma Plasmacytoma

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Association between scrub typhus encephalitis and diffusion tensor tractography detection of Papez circuit injury:A case report

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World Journal of Clinical Cases 2021年第13期9卷 3194-3199页

作者： Hyeok Gyu Kwon jeong-hee Yang Jee-Hyun Kwon Dongseok Yang Department of Physical Therapy College of Health ScienceEulji UniversitySanseong-daero 13135Gyeonggi-doSouth Korea Department of Plastic Surgery Biomedical Research InstituteSeoul National University HospitalJongno-gu 03080SeoulSouth Korea Department of Neurology University of Ulsan College of MedicineUlsan University HospitalDong-gu 44033UlsanSouth Korea Department of Physical Medicine and Rehabilitation University of Ulsan College of MedicineUlsan University HospitalDong-gu 44033UlsanSouth Korea

BACKGROUND It is difficult to restore the cognitive functions of patients with impaired cognition caused by brain *** tensor imaging can visualize the integrity of neural tracts in the white matter(WM)*** is unclear whether encephalitis following scrub typhus damages the *** the first time,we aimed to report diffusion tensor tractography(DTT)findings in a chronic patient with cognitive impairment following scrub typhus encephalitis,which revealed injury to the Papez circuit of the *** SUMMARY A 70-year-old male patient was affected by encephalitis caused by scrub typhus that occurred 23 years *** had poor cognition and his clinical examination findings were as follows:Mini-Mental Status Examination score,14;and handgrip strength(right/left,kg),32.3/*** revealed serious injuries of the left thalamocingulate tract and right mammillothalamic tract in the Papez circuit,and a partial injury of the anterior part of the *** Using DTT,we found a relationship between cognitive impairment and the integrity of the Papez circuit following scrub typhus.

关键词： Diffusion tensor imaging Scrub typhus Encephalitis White matter Papez circuit Cognition Case report

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Investigation of prodromal features in metabolic syndrome based on transcriptome analysis

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Genes & Diseases 2023年第3期10卷 708-711页

作者： Sang-Min Park Musun Park Hyo-jeong Ban Su-Jin Baek Soo Yeon Kim Siwoo Lee hee-jeong Jin Korean Medicine(KM)Data Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea

Metabolic syndrome(MetS)is a complex condition that significantly increases the risk of several diseases,including heart disease and *** with MetS show both pro-inflammatory and pro-thrombotic states;however,the state... 详细信息

关键词： diseases Metabolic Patients

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Coexisting cytomegalovirus colitis in an immunocompetent patient with Clostridioides difficile colitis:A case report

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World Journal of Clinical Cases 2023年第10期11卷 2343-2348页

作者： Jun Hyoung Kim hee-Sung Kim Hye Won jeong Department of Internal Medicine Chungbuk National University HospitalCheongju 28644ChungbukSouth Korea Department of Internal Medicine Chungbuk National University College of MedicineCheongju 28644ChungbukSouth Korea

BACKGROUND Clostridioides difficile(***)colitis is one of the most common infections in hospitalized patients,characterized by fever and *** usually improves after appropriate antibiotic treatment;if not,comorbidities should be ***(CMV)colitis is a possible co-existing diagnosis in patients with *** infection with poor treatment ***,compared with immunocompromised patients,CMV colitis in immunocompetent patients is not well *** SUMMARY We present an unusual case of co-existing CMV colitis in an immunocompetent patient with *** *** 80-year-old female patient was referred to the infectious disease department due to diarrhea,abdominal discomfort,and fever for 1 wk during her hospitalization for *** toxin B polymerase chain reaction on stool samples was *** *** infection was diagnosed,oral vancomycin treatment was *** symptoms including diarrhea,fever and abdominal discomfort improved for ten ***,the symptoms worsened again with bloody diarrhea and ***,a sigmoidoscopy was performed for evaluation,showing a longitudinal ulcer on the sigmoid *** biopsy confirmed CMV colitis,and the clinical symptoms improved after using *** Co-existing CMV colitis should be considered in patients with aggravated *** infection on appropriate treatment,even in immunocompetent hosts.

关键词： Cytomegalovirus Clostridioides difficile Coinfection Colitis Immunocompetent Case report

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Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

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Chinese Journal of Integrative Medicine 2022年第9期28卷 802-808页

作者： Bo-Ra Jeon Muhammad Irfan Seung Eun Lee jeong Hoon Lee Man hee Rhee Laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal Science(NIHHS)Eumseong27709Republic of Korea

Objective:To examine the antiplatelet and antithrombotic activity of Rumex acetosella ***:Standard light aggregometry was used for platelet aggregation,intracellular calcium mobilization assessed using Fura-2/AM,granule secretion(ATP release)by luminometer,and fibrinogen binding to integrin α_(Ⅱb)β_(3) detected using flow *** blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase(MAPK)and phosphoinositide 3-kinase(PI3K)/Akt ***:Rumex acetosella displayed the ability to inhibit platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin α_(Ⅱb)β_(3).Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation(all P<0.01).Conclusion:Rumex acetosella extract exhibits antiplatelet activity via modulating GPVI signaling,and it may protect against the development of platelet-related cardiovascular diseases.

关键词： antiplatelet ethnomedicine integrinα_(Ⅱb)β_(3) mitogen-activated protein kinase Rumex acetosella L.

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Bimodal grain structures and tensile properties of a biomedical Co-20Cr-15W-10Ni alloy with different pre-strains

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Rare Metals 2021年第1期40卷 20-30页

作者： Cheng-Lin Li Seong-Woo Choi jeong Mok Oh Jae-Keun Hong Jong-Taek Yeom Joo-hee Kang Qing-Song Mei Chan hee Park Department of Materials Engineering School of Power and Mechanical EngineeringWuhan UniversityWuhan 430072China Advanced Metals Division.Korea Institute of Materials Science Changwon 51508Republic of Korea Materials Testing&Reliability Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

The influence of pre-strain on the formation of bimodal grain structures and tensile properties of a Co-20 Cr-15 W-10 Ni alloy was *** bimodal grain structures consist of fine grains(FGs;2-3μm in diameter)and coarse grains(CGs;8-16μm in diameter),which can be manipulated by changing the pre-strain(ε=0.3-0.7)and annealing temperatures(1000-1100℃).High pre-strain applied in the samples can intensify the plasticity heterogeneity through increasing the total dislocation density and the local volumes of high-density *** can essentially result in finer FGs,a higher FG volume fraction,and overall grain refinement in the samples after ***-temperature essentially increases both the size and volume fraction of CGs,leading to an increase in the average grain *** tensile test suggests that the bimodal grain structured samples exhibited both high strength and ductility,yield strengths of621-877 MPa and ultimate tensile strengths of1187-1367 MPa with uniform elongations of 55.0%-71.4%.The superior strength-ductility combination of the samples arises from the specific deformation mechanisms of the bimodal grain *** tensile properties strongly depend on the size ratio and volume fraction of FGs/CGs in addition to the average grain size in the bimodal grain *** grain structures can be modified via changing the pre-strain and annealing temperature.

关键词： Biomaterials Bimodal grain structure Deformation heterogeneity Pinning High strength/ductility

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Feasibility of full-spectrum endoscopy:Korea's first full-spectrum endoscopy colonoscopic trial

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World Journal of Gastroenterology 2016年第8期22卷 2621-2629页

作者： jeong-Yeop Song Youn hee Cho Mi A Kim jeong-Ae Kim Chun Tek Lee Moon Sung Lee Division of Gastroenterology Department of Internal Medicine LCT Hospital Division of Gastroenterology Department of Internal Medicine Soon Chun Hyang University Bucheon Hospital

AIM: To evaluate the full-spectrum endoscopy(FUSE) colonoscopy system as the first report on the utility thereof in a Korean ***: We explored the efficacy of the FUSE colonoscopy in a retrospective, single-center feasibility study performed between February 1 and July 20, 2015. A total of 262 subjects(age range: 22-80) underwent the FUSE colonoscopy for colorectal cancer screening, polyp surveillance, or diagnostic evaluation. The cecal intubation success rate, the polyp detection rate(PDR), the adenoma detection rate(ADR), and the diverticulum detection rate(DDR), were calculated. Also, the success rates of therapeutic interventions were evaluated with biopsy ***: All patients completed the study and the success rates of cecal and terminal ileal intubation were 100% with the FUSE colonoscope; we found 313 polyps in 142 patients and 173 adenomas in 95. The overall PDR, ADR and DDR were 54.2%, 36.3%, and 25.2%, respectively, and were higher in males, and increased with age. The endoscopists and nurses involved considered that the full-spectrum colonoscope improved navigation and orientation within the *** colonoscopy was aborted because of colonoscope ***: The FUSE colonoscopy yielded a higher PDR, ADR, DDR than did traditional colonoscopy, without therapeutic failure or complications, showing feasible, effective, and safe in this first Korean trial.

关键词： Colonoscopy Colonoscopes Feasibility studies Colonic polyps

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Pediatric appendicitis with appendicolith often presents with prolonged abdominal pain and a high risk of perforation

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World Journal of Pediatrics 2018年第2期14卷 184-190页

作者： hee Mang Yoon Jung Heon Kim Jong Seung Lee jeong-Min Ryu Dae Yeon Kim jeong-Yong Lee Department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Emergency Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pediatric Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pediatrics Asan Medical CenterUniversity of Ulsan College of Medicine88Olympic-ro 43-gilSongpa-guSeoul 05505South Korea

Background Appendicolith can cause appendiceal obstruction and acute *** high prevalence may be related to the high perforation rate in pediatric *** study assessed the characteristics of appendicolith and its clinical significance in pediatric *** A retrospective study was performed among children and adolescents younger than 17 years who were preopera-tively diagnosed with appendicitis in the pediatric emergency department(ED).A total of 269 patients with a mean age of 9.98±3.37 years were *** features and contrast-enhanced computed tomography findings were *** Among the 269 patients,147(54.6%)had appendicoliths,with a mean maximal diameter of 5.21±2.34 ***-pared to the no appendicolith group,the appendicolith group demonstrated more prolonged abdominal pain(≥48 hours)before the ED visit(23.1%vs.11.5%;P=0.013),clinical features of severe appendicitis(presence of fever,vomiting,posi-tive urine ketone,and increased C-reactive protein),and higher rate of perforation(43.5%vs.9.8%;P<0.001).Multivariate risk factor analysis for perforated appendicitis in the appendicolith group revealed that maximal diameter of 5 mm or more in the appendicolith(adjusted odds ratio[aOR]2.919;95%CI 1.325-6.428,P=0.008)and proximal collapse adjacent to the appendicolith(aOR 2.943;95%CI 1.344-6.443,P=0.007)were *** Pediatric appendicitis with appendicolith often presents with prolonged abdominal pain and severe clinical conditions with a high risk of perforation.

关键词： Appendicitis Appendicolith Computed tomography Pediatrics Risk factors

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Bio-inspired untethered fully soft robots in liquid actuated by induced energy gradients

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National Science Review 2019年第5期6卷 970-981页

作者： Liang Xiong Lyu Fen Li Kang Wu Pan Deng Seung hee jeong Zhigang Wu Han Ding State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology

Soft robotics with new designs, fabrication technologies and control strategies inspired by nature have been totally changing our view on *** fully exploit their potential in practical applications, untethered designs are preferred in ***, hindered by the limited thermal/mechanical performance of soft materials, it has been always challenging for researchers to implement untethered solutions, which generally involve rigid forms of high energy-density power sources or high energy-density processes.A number of insects in nature, such as rove beetles, can gain a burst of kinetic energy from the induced surface-energy gradient on water to return to their familiar habitats, which is generally known as Marangoni *** by such a behavior, we report the agile untethered mobility of a fully soft robot in liquid based on induced energy gradients and also develop corresponding fabrication and maneuvering *** robot can reach a speed of 5.5 body lengths per second, which is 7-fold more than the best reported, 0.69(body length per second), in the previous work on untethered soft robots in liquid by *** controlling the robots, we demonstrate a soft-robot swarm that can approach a target simultaneously to assure a hit with high *** employing any high energy-density power sources or processes, our robot exhibits many attractive merits, such as quietness, no mechanical wear, no thermal fatigue, invisibility and ease of robot fabrication, which may potentially impact many fields in the future.

关键词： fully soft robot untethered induced energy gradients Marangoni propulsion robot swarm

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