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Treatment of pediatric average-risk medulloblastoma using craniospinal irradiation less than 2500 cGy and chemotherapy: single center experience in Korea

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World Journal of Pediatrics 2017年第4期13卷 367-373页

作者： Jong Hyung Yoon Kyung Duk Park Hyoung Jin Kang Hyery Kim Ji Won Lee Seung-Ki Kim Kyu-Chang Wang Sung-Hye Park Il Han Kim hee young shin Department of Pediatrics Cancer Research InstituteSeoul National University College of MedicineSeoul Department of Pediatrics Hallym University College of medicineChuncheon Sacred Heart HospitalChuncheonKorea Departments of Neurosurgery Seoul National University College of MedicineSeoul Pathology Seoul National University College of MedicineSeoul Radiation Oncology Seoul National University College of MedicineSeoul

Background:Although craniospinal irradiation (CSI) of 2340 cGy plus tumor booster with chemotherapy have been established as a standard treatment of childhood average-risk (AvR) medulloblastoma (MBL) in Western counties,there are a few recent reports in outcomes ofAvR MBL using this strategy in Korean and other Asian *** investigated the outcome of the Korean children with AvR MBL who were treated with CSI <2500 cGy and ***:Between January 2001 and December 2010,clinical characteristics and outcomes of 42 patients who were diagnosed with AvR MBL postoperatively and treated with radiation including CSI <2500 cGy and chemotherapy in Seoul National University Children's Hospital were ***:Their median age was 9 years (range:3-18.8),and 29 were *** subtypes were classic type in 28 patients,nodular/desmoplastic in 7,and large cell/anaplastic (LCA) in *** the patients received adjuvant radiotherapy (CSI with median 2340 cGy and booster) and multiagent chemotherapy as the first-fine *** a median follow-up of 54 months,12 patients experienced relapse or progression of the *** 3-and 5-year disease-free survival (DFS) rates were 78.0%±6.5% and 75.0%±6.9%,respectively,and overall survival (OS) rates were 85.3%±5.6% and 76.8%±6.9%,*** LCA subtype was associated with poorer DFS (P=0.023) and OS (P=0.008),compared with non-LCA ***:The outcomes of children and adolescents with AvR MBL treated with radiation including CSI <2500 cGy and chemotherapy,are compatible to those in Western countries;however,the LCA subtype has a poor outcome with this strategy.

关键词： average-risk craniospinal irradiation medulloblastoma

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Higher plasma bilirubin predicts veno-occlusive disease in early childhood undergoing hematopoietic stem cell transplantation with cyclosporine

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World Journal of Transplantation 2016年第2期6卷 403-410页

作者： Kwi Suk Kim Aree Moon Hyoung Jin Kang hee young shin young hee Choi Hyang Sook Kim Sang Geon Kim Department of Pharmacy Seoul National University Hospital College of Pharmacy Duksung Women’s University Department of Pediatrics Cancer Research InstituteSeoul National University College of Medicine College of Pharmacy Dongguk University College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University

AIM: To analyze the association between plasma bilirubin levels and veno-occlusive disease(VOD) in non-adult patients undergoing hematopoietic stem cell transplantation(HSCT) during cyclosporine ***: A total of 123 patients taking cyclosporinewere evaluated using an electronic medical system at the Seoul National University Children's Hospital from the years 2004 through 2011. Patients were grouped by age and analyzed for incidence and type of adverse drug reactions(ADRs) including VOD. RESULTS: The HSCT patients were divided into three age groups: G#1 ≥ 18; 9 ≤ G#2 ≤ 17; and G#3 ≤ 8 years of age). The majority of transplant donor types were cord blood transplantations. Most prevalent ADRs represented acute graft-vs-host disease(a GVHD) and VOD. Although the incidences of a GVHD did not vary among the groups, the higher frequency ratios of VOD in G#3 suggested that an age of 8 or younger is a risk factor for developing VOD in HSCT patients. After cyclosporine therapy, the trough plasma concentrations of cyclosporine were lower in G#3 than in G#1, indicative of its increased clearance. Moreover, in G#3 only, a maximal total bilirubin level(BILmax) of ≥ 1.4 mg/d L correlated with VOD incidence after cyclosporine therapy. CONCLUSION: HSCT patients 8 years of age or younger are more at risk for developing VOD, diagnosed as hyperbilirubinemia, tender hepatomegaly, and ascites/weight gain after cyclosporine therapy, which may be represented by a criterion of plasma BILmax being ≥ 1.4 mg/d L, suggestive of more sensitive VOD indication in this age group.

关键词： Hematopoietic stem cell transplantation Veno-occlusive disease Cyclosporine Adverse drug reaction Total bilirubin

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Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra Jeon Changmin shin Sun-young Kwon Sojin shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

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Properties of multilayer gallium and aluminum doped ZnO(GZO/AZO) transparent thin films deposited by pulsed laser deposition process

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 96-99页

作者： Jin-Hyun shin Dong-Kyun shin hee-young LEE Jai-Yeoul LEE Department of Materials Engineering Yeungnam University

Multilayer gallium and aluminum doped ZnO （GZO/AZO） films were fabricated by alternative deposition of Ga-doped zinc oxide（GZO） and Al-doped zinc oxide（AZO） thin film by using pulsed laser deposition（PLD） process. The electrical and optical properties of these GZO/AZO thin films were investigated and compared with those of GZO and AZO thin films. The GZO/AZO （1：1） thin film deposited at 400 ~C shows the electrical resistivity of 4.18 x 10 4 ~.cm, an electron concentration of 7.5 x 1020/cm3, and carrier mobility of 25.4 cm2/（V.s）. The optical transmittances of GZO/AZO thin films are over 85%. The optical band gap energy of GZO/AZO thin films linearly decreases with increasing the AI ratio.

关键词： multilayer thin films Ga-doped zinc oxide Al-doped zinc oxide pulsed laser deposition

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

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2D material inorganic liquid crystals for tunable deep UV light modulation

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National Science Review 2022年第12期9卷 62-63页

作者： young hee Lee Department of Energy Science and Department of Physics Sungkyunkwan University IBS Center for Integrated Nanostructure Physics Institute for Basic Science Sungkyunkwan University

Modulation of light refers to the modulation of electromagnetic radiation in the optical region including visible light as well as ultraviolet and infrared radiation,in which the amplitude (and therefore the intensity),phase,frequency or polarization of the radiated oscillations can be changed [1].Optical modulator devices are widely used in industry,as represented by liquid crystal optical modulators having an annual global market worth of over US$100 ***,

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Facial Expression Recognition of Various Internal States via Manifold Learning

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Journal of Computer Science & Technology 2009年第4期24卷 745-752页

作者： young-Suk shin IEEE Department of Information and Communication Engineering Chosun University

Emotions are becoming increasingly important in human-centered interaction architectures. Recognition of facial expressions, which are central to human-computer interactions, seems natural and desirable. However, facial expressions include mixed emotions, continuous rather than discrete, which vary from moment to moment. This paper represents a novel method of recognizing facial expressions of various internal states via manifold learning, to achieve the aim of humancentered interaction studies. A critical review of widely used emotion models is described, then, facial expression features of various internal states via the locally linear embedding （LLE） are extracted. The recognition of facial expressions is created with the pleasure-displeasure and arousal-sleep dimensions in a two-dimensional model of emotion. The recognition result of various internal state expressions that mapped to the embedding space via the LLE algorithm can effectively represent the structural nature of the two-dimensional model of emotion. Therefore our research has established that the relationship between facial expressions of various internal states can be elaborated in the two-dimensional model of emotion, via the locally linear embedding algorithm.

关键词： manifold learning locally linear embedding dimension model pleasure-displeasure dimension arousal-sleep dimension

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Reciprocal inhibition of expression between RAV1 and BES1 modulates plant growth and development in Arabidopsis

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Journal of Integrative Plant Biology 2023年第5期65卷 1226-1240页

作者： Dami Yang Hyun-young shin Hyun Kyung Kang Yun Shang So young Park Dong-Hoon Jeong Kyoung hee Nam Department of Biological Sciences Sookmyung Women's UniversitySeoul 04310Republic of Korea Research Institute for Women's HealthSookmyung Women's UniversitySeoul 04310Republic of Korea Department of Life Science and Multidisciplinary Genome Institute Hallym UniversityChuncheon 24252Republic of Korea Present Address:Peking University Institute of Advanced Agricultural ScienceWeifang 261325China

RAV1(Related to ABI3/VP1)is a plant-specific B3 and AP2 domain-containing transcription factor that acts as a negative regulator of growth in many plant *** expression of RAV1 is downregulated by brassinosteroids(BRs);large-scale transcriptome analyses have shown that the expression of RAV1 was previously targeted by BRI1-EMS-SUPPRESOR1(BES1)and BRASSINAZOLE-RESISTANT1(BZR1),which are critical transcription factors for the BR-signaling *** RAV1-overexpressing transgenic plants,we showed that RAV1 overexpression reduced the BR signaling capacity,resulting in the downregulation of BR biosynthetic genes and BES1 ***,we demonstrated that BES1,not BZR1,is directly bound to the RAV1 promoter and repressed RAV1 expression,and vice versa;RAV1 is also bound to the BES1 promoter and repressed BES1 *** mutual inhibition was specific to RAV1 and BES1 because RAV1 exhibited binding activity to the BZR1 promoter but did not repress BZR1 *** observed that constitutively activated BR signaling phenotypes in bes1-D were attenuated by the repression of endogenous BES1 expression in transgenic bes1-D plants overexpressing ***-sequencing analysis of RAV1-overexpressing transgenic plants and bes1-D mutant plants revealed differentially expressed genes by RAV1 and BES1 and genes that were oppositely co-regulated by RAV1 and ***1 and BES1 regulated different transcriptomes but co-regulated a specific set of genes responsible for the balance between growth and *** results suggested that the mutual inhibitory transcriptional activities of RAV1 and BES1 provide fine regulatory mechanisms for plant growth and development.

关键词： BES1 growth modulation RAV1 transcriptional regulation

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Implementation of Turbulent Mixing over a Stratocumulus-Topped Boundary Layer and Its Impact in a GCM

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Advances in Atmospheric Sciences 2009年第5期26卷 995-1004页

作者： Sun-hee shin Kyung-Ja HA Division of Earth Environmental System Pusan National University

The effect of a vertical diffusion scheme over a stratocumulus topped boundary layer （STBL） was investigated using the YONU AGCM （Yonsei University Atmospheric General Circulation Model）. To consider the impact of clouds on the turbulence production, the turbulence mixing term, driven by radiative cooling at the cloud top, is implemented as an extended non-local diffusion scheme. In the model with this new scheme, the STBL parameterization significantly influences the lower atmosphere over the tropical and subtropical regions. Consideration of the turbulent mixing within the cloud layer leads to continuous stratocumulus formation. The cloud-top radiative cooling tends to favor more rapid entrainment and produces top-down turbulent mixing. This cooling develops a mixed layer without initiation of deep convection by surface fluxes. Variations in thermodynamical and dynamical features are produced by planetary boundary layer （PBL） cloud development. The simulated stratocumulus induces more mixing of heat and moisture due to the cloud forcing. Over STBL regions, the lower boundary layer becomes warmer and drier. It also weakens vertical motion and zonal trade winds in the eastern Pacific, which indicates that stratocumulus cloud cover plays a role in weakening the Walker circulation; that is, cloud cover damps the tropical circulation.

关键词： stratocumulus topped boundary layer non-local diffusion scheme tropical circulation general circulation model

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Difficulties, strategies, and recent research and development of layered sodium transition metal oxide cathode materials for high-energy sodium-ion batteries

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Journal of Energy Chemistry 2024年第3期90卷 40-57,I0003页

作者： Kouthaman Mathiyalagan Dongwoo shin young-Chul Lee Department of Nano Science and Technology Convergence Gachon University1342 Seongnam-DaeroSujeong-GuGyeonggi-DoSeongnam-Si 13120Republic of Korea Department of Bio Nano Technology Gachon University1342 Seongnam-DaeroSujeong-GuGyeonggi-DoSeongnam-Si 13120Republic of Korea

Energy-storage systems and their production have attracted significant interest for practical *** are the foundation of sustainable energy sources for electric vehicles(EVs),portable electronic devices(PEDs),*** recent decades,Lithium-ion batteries(LIBs) have been extensively utilized in largescale energy storage devices owing to their long cycle life and high energy ***,the high cost and limited availability of Li are the two main obstacles for *** this regard,sodium-ion batteries(SIBs) are attractive alternatives to LIBs for large-scale energy storage systems because of the abundance and low cost of sodium *** is one of the most important components in the battery,which limits cost and performance of a *** the classified cathode structures,layered structure materials have attracted attention because of their high ionic conductivity,fast diffusion rate,and high specific ***,we present a comprehensive review of the classification of layered structures and the preparation of layered ***,the review article discusses extensively about the issues of the layered materials,namely(1) electrochemical degradation,(2) irreversible structural changes,and(3) structural instability,and also it provides strategies to overcome the issues such as elemental phase composition,a small amount of elemental doping,structural design,and surface alteration for emerging *** addition,the article discusses about the recent research development on layered unary,binary,ternary,quaternary,quinary,and senary-based O3-and P2-type cathode materials for high-energy *** review article provides useful information for the development of high-energy layered sodium transition metal oxide P2 and O3-cathode materials for practical SIBs.

关键词： O3-type P2-type Cathode materials Sodium-ion batteries Layered structure

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