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Journal of Magnesium and Alloys 2022年第6期10卷 1672-1679页

作者： Joo-hee Kang Jiwon Park kyung Song Chang-Seok Oh Oleg Shchyglo Ingo Steinbach Korea Institute of Materials Science Changwon 51508Republic of Korea Interdisciplinary Centre for Advanced Materials Simulation Ruhr-University Bochum44801 BochumGermany

In this study the partially divorced eutectic microstructure ofα-Mg andβ-Mg17Al12was investigated by electron backscatter diffraction,transmission electron microscopy,and phase-field modeling in hypoeutectic Mg-Al *** orientation relationships between the individual eutecticαgrains,eutecticβphase,and primaryαgrains were *** the amount of eutectic morphology is primarily determined by the Al content,the in-depth microstructure analyses and the phase-field simulation suggest non-interactive nucleation and growth of eutecticαphase in theβphase grown on the interdendritic primaryα***,phase-field simulations showed a preferred nucleation sequence where theβphase nucleates first and subsequently triggers the nucleation of eutecticαphase at the movingβphase solidification front,which supports the microstructural analysis results.

关键词： Mg-Al alloy Partially divorced eutectic Solidification Electron backscatter diffraction Phase-Field modeling

Comprehensive molecular analysis to predict the efficacy ofchemotherapy containing bevacizumab in patients with metastaticcolorectal cancer

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肿瘤学研究(英文) 2023年第6期31卷 855-866页

作者： SUNG hee lim hee JIN CHO KYOUNG-MEE KIM HO YEONG lim WON KI KANG JEEYUN LEE YOUNG SUK PARK hee CHEOL KIM SEUNG TAE KIM Division of Hematology/Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea Precision Medicine Research Institute Samsung Medical CenterGangnam-guSeoul06351Korea Department of Biomedical Convergence Science and Technology Kyungpook National UniversityDaegu41566Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul06351Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineGangnam-guSeoul06351Korea

Background:Although bevacizumab is an important treatment for metastatic colorectal cancer(CRC),not allpatients with CRC benefit from it;in unselected patient populations,only modest survival benefits have been ***:We evaluated clinical outcomes in 110 patients using comprehensive molecular characterization to identifybiomarkers for a response to bevacizumab-containing *** molecular analysis comprised whole-exomesequencing,ribonucleic acid sequencing,and a methylation array on patient ***:Genomic and molecularcharacterization was successfully conducted in 103 *** of 103 CRC samples were hypermutated,and none ofthe non-hypermutant tumors were microsatellite *** those 103 patients,89 had adenocarcinoma(ADC),15 were diagnosed with mucinous ADC,and six had signet-ring cell carcinoma(SRCC).Consensus molecular subtype(CMS)2 was unique to *** the four SRCCs,two were CMS1,one was CMS4,and the other was *** status was a significantly enriched factor in responders to bevacizumab *** growth factorreceptor(FGFR)1/2 signaling was upregulated in non-responders,whereas cell cycle,transfer ribonucleic acidprocessing,nucleotide excision repair,and oxidative phosphorylation pathways were enriched in ***,IGF1 was differentially expressed in non-responders(log2 fold change=−1.43,p=4.11×10^(−5),falsediscovery rate=0.098),and FLT1 was highly methylated in non-responders(p=7.55×10^(−3)).When the molecularpathways were reanalyzed separately according to the backbone chemotherapy(FOLFOX ***),thesignificance of the molecular pathways varied according to the backbone ***:This studysought a subset of CRC patients with a distinct clinical response to chemotherapy containing *** need to be validated in a large group of homogenous patient cohort and examined according to the differentchemotherapy backbones to create personalized therapeutic oppor

关键词： Bevacizumab Whole-exome sequencing Ribonucleic acid sequencing Methylation array Colorectal cancer

Variational Mode Decomposition for Rotating Machinery Condition Monitoring Using Vibration Signals

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 38-50页

作者： Muhd Firdaus Isham Muhd Salman Leong Meng hee lim Zair Asrar Ahmad Institute Noise and Vibration Universiti Teknologi Malaysia Faculty of Mechanical Engineering Universiti Teknologi Malaysia

The failure of rotating machinery applications has major time and cost effects on the *** monitoring helps to ensure safe operation and also avoids *** signal processing method is essential for ensuring both the efficiency and accuracy of the monitoring *** mode decomposition(VMD)is a signal processing method which decomposes a non-stationary signal into sets of variational mode functions(VMFs)adaptively and *** VMD method offers improved performance for the condition monitoring of rotating machinery ***,determining an accurate number of modes for the VMD method is still considered an open research ***,a selection method for determining the number of modes for VMD is proposed by taking advantage of the similarities in concept between the original signal and *** signal and online gearbox vibration signals have been used to validate the performance of the proposed *** statistical parameters of the signals are extracted from the original signals,VMFs and intrinsic mode functions(IMFs)and have been fed into machine learning algorithms to validate the performance of the VMD *** results show that the features extracted from VMD are both superior and accurate for the monitoring of rotating *** the proposed method offers a new approach for the condition monitoring of rotating machinery applications.

关键词： variational mode decomposition(VMD) monitoring diagnosis vibration signal mode number gear

Rationally designed bioactive milk-derived protein scaffolds enhanced new bone formation

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Bioactive Materials 2023年第2期20卷 368-380页

作者： Min Suk Lee Jin Jeon Sihyeon Park Juhan lim hee Seok Yang Department of Nanobiomedical Science&BK21 FOUR NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Medical Laser Research Center College of MedicineDankook UniversityCheonan31116Republic of Korea Center for Bio-Medical Engineering Core-Facility Dankook UniversityCheonan31116Republic of Korea

Recently,a number of studies reported that casein was composed of various multifunctional bioactive peptides such as casein phosphopeptide andβ-casochemotide-1 that bind calcium ions and induce macrophage chemotaxis,which is crucial for bone homeostasis and bone fracture repair by cytokines secreted in the *** hypothesized that the effects of the multifunctional biopeptides in casein would contribute to improving bone ***,we designed a tissue engineering platform that consisted of casein and polyvinyl alcohol,which was a physical-crosslinked scaffold(milk-derived protein;MDP),via simple freeze-thaw cycles and performed surface modification using 3,4-dihydroxy-L-phenylalanine(DOPA),a mussel adhesive protein,for immobilizing adhesive proteins and cytokines for recruiting cells in vivo(MDP-DOPA).Both the MDP and MDP-DOPA groups proved indirectly contribution of macrophages migration as RAW 264.7 cells were highly migrated toward materials by contained bioactive *** implanted MDP and MDP-DOPA in a mouse calvarial defect orthotopic model and evaluated whether MDP-DOPA showed much faster mineral deposition and higher bone density than that of the no-treatment and MDP *** MDP-DOPA group showed the accumulation of host M2 macrophages and mesenchymal stem cells(MSCs)around the scaffold,whereas MDP presented mostly M1 macrophages in the early stage.

关键词： Casein Bioactive peptides Bone regeneration Protein based scaffold Physical crosslinking

Patient safety culture and handoff evaluation of nurses in small and medium-sized hospitals

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International Journal of Nursing Sciences 2021年第1期8卷 58-64,I0004页

作者： Jung hee Kim Jung lim Lee Eun Man Kim Department of Nursing Science Shinsung UniversityChungnamSouth Korea Department of Nursing Daejeon UniversityDaejeonSouth Korea Department of Nursing Science Sun Moon UniversityChungnamSouth Korea

Objectives:This study was conducted to investigate the current status of handoffs,perception of patient safety culture,and degrees of handoff evaluation in small and medium-sized hospitals and identified factors that make a difference in handoff ***:This is a descriptive study.425 nurses who work at small and medium-sized hospitals in South Korea were included in our *** completed a set of self-reporting questionnaires that evaluated demographic data,handoff-related characteristics,perception of patient safety culture,and handoff ***:Results showed that the overall score of awareness of a patient safety culture was 3.65±0.45,the level was *** score of handoff evaluation was 5.24±*** nurses experienced errors in handoff and most nurses had no guidelines and checklist in the *** evaluation differed significantly according to the level of education,work patterns,duration of hospital employment,handoff method,degree of satisfaction with the current handoff method,errors occurring at the time of handoff,handoff guidelines,and appropriateness of handoff education time(P<0.05).Conclusion:For handoff improvement,guidelines and standards should be *** is necessary to develop a structured handoff education *** formal handoff education should be implemented to spread knowledge uniformly.

关键词： Evaluation studies Handoff Hospital nursing staff Patient safety

Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第20期25卷 2416-2429页

作者： Changhoon Choi Gyu Sang Yoo Won kyung Cho hee Chul Park Department of Radiation Oncology Samsung Medical CenterSeoul 06351South Korea Department of Radiation Oncology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea

Hepatocellular carcinoma (HCC) is the fifth most common cancer, and its incidence is rapidly increasing in North America and Western Europe as well as South-East Asia. Patients with advanced stage HCC have very poor outcomes;therefore, the discovery of new innovative approaches is urgently needed. Cancer immunotherapy has become a game-changer and revolutionized cancer treatment. A comprehensive understanding of tumor-immune interactions led to the development of immune checkpoint inhibitors (ICIs) as new therapeutic tools, which have been used with great success. Targeting immune checkpoint molecules such as programmed cell death-1 (PD-1) and cytotoxic T lymphocyteassociated protein-4 (CTLA-4) reinvigorates anti-tumor immunity by restoring exhausted T cells. Despite their effectiveness in several types of cancer, of the many immune suppressive mechanisms limit the efficacy of ICI monotherapy. Radiation therapy (RT) is an essential local treatment modality for a broad range of malignancies, and it is currently gaining extensive attention as a promising combination partner with ICIs because of its ability to trigger immunogenic cell death. The efficacy of combination approaches using RT and ICIs has been well documented in numerous preclinical and clinical studies on various types of cancers but not HCC. The application of ICIs has now expanded to HCC, and RT is recognized as a promising modality in HCC. This review will highlight the current roles of PD-1 and CTLA-4 therapies and their combination with RT in the treatment of cancers, including HCC. In addition, this review will discuss the future perspectives of the combination of ICIs and RT in HCC treatment.

关键词： Hepatocellular carcinoma Radiation therapy Immune checkpoint inhibitors Abscopal effect

Bilateral snapping triceps syndrome:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8228-8234页

作者： Chul-Hyun Cho kyung-Hwan lim Du-Han Kim Department of Orthopedic Surgery Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea Orthopedic Surgery Allright HospitalDaegu 42038South Korea

BACKGROUND Snapping triceps syndrome(STS)is a rare disease,while occurrence of bilateral STS is extremely *** is usually accompanied by dislocation of the ulnar nerve and double snapping is a clinically important ***,to the best of our knowledge,there has been no report of bilateral STS in young active *** SUMMARY A 23-year-old male presented with a complaint of discomfort and snapping on the medial side of both elbows while performing *** physical examination,two distinct snaps that were both palpable and audible were detected on additional clinical *** ultrasonography showed that the ulnar nerve and the medial head of the triceps were dislocated anteriorly over the medial epicondyle of the elbow during flexion ***,he was diagnosed as dislocation of the ulnar nerve and *** anterior subcutaneous transposition of the ulnar nerve combined with partial resection of the snapping portion of the triceps was *** patient’s pain and snapping symptoms were resolved immediately after *** months later,the patient was completely asymptomatic and returned to normal *** STS should be included in the differential diagnosis for active young patients who present with painful snapping on the medial side of the elbow joint,particularly when dislocation of the ulnar nerve is *** sonography is used to assist in accurate diagnosis and differentiation between isolated dislocation of the ulnar nerve and STS.

关键词： Triceps Triceps snapping syndrome Ulnar nerve Elbow Dynamic sonography Case report

The temporal and spatial variability of the Yellow Sea Cold Water Mass in the southeastern Yellow Sea, 2009–2011

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Acta Oceanologica Sinica 2013年第9期32卷 1-10页

作者： OH kyung-hee LEE Seok SONG Kyu-Min LIE Heung-Jae KIM Young-Taeg Marine Environment and Conservation Research Division Korea Institute of Ocean Science and Technology Ocean Research Division Korea Hydrographic and Oceanographic Administration

The Yellow Sea Cold Water Mass （YSCWM） is one of the important water mass in the Yellow Sea （YS）. It is distributed in the lower layer in the Yellow Sea central trough with the temperature less than 10℃ and the salinity lower than 33.0. To understand the variability of the YSCWM, the hydrographic data obtained in April and August during 2009-2011 are analyzed in the southeastern Yellow Sea. In August 2011, relatively warm and saline water compared with that in 2009 and 2010 was detected in the lower layer in the Yellow Sea central area. Although the typhoon passed before the cruise, the salinity in the Yellow Sea central trough is much higher than the previous season. It means that the saline event cannot be explained by the typhoon but only by the intrusion of saline water during the previous winter. In April 2011, actually, warm and saline water （T 〉 10~C, S 〉34） was observed in the deepest water depth of the southeastern area of the Yellow Sea. The wind data show that the northerly wind in 2011 winter is stronger than in 2009 and 2010 winter season. The strong northerly wind can trigger the intrusion of warm and saline Yellow Sea Warm Current. Therefore, it is proposed that the strong northerly wind in winter season leads to the intrusion of the Yellow Sea Warm Current into the Yellow Sea central trough and influenced a variability of the YSCWM in summer.

关键词： Yellow Sea Cold Water Mass interannual variation saline event atmosphere variability Yellow Sea

Effect of Nucleases on the Cellular Internalization of Fluorescent Labeled DNA-Functionalized Single-Walled Carbon Nanotubes

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Nano Research 2008年第4期1卷 351-360页

作者： Hye kyung Moon Chan Il Chang Dong-Ki Lee hee Cheul Choi Department of Chemistry Pohang University of Science and Technology(POSTECH)San 31Hyoja-DongNam-guPohang 790-784Korea Department of Chemistry Sungkyunkwan UniversityNatural Science CampusSuwon 440-746Korea

Nuclease effects on the cell internalization of single-walled carbon nanotubes(SWNTs)functionalized with fluorescent-labeled DNA in serum containing cell growth media were *** Cy3-labeled DNA-functionalized SWNT conjugates(Cy3DNA-SWNTs)were incubated with HeLa cells in a fatal bovine serum(FBS)medium,a high fl uorescence intensity was obtained from the cells,indicative for the high level inclusion of ***,the fluorescence intensity was remarkably reduced if Cy3DNA-SWNTs were incubated with cells in the FBS-free *** systematic control experiments revealed that Cy3 dye molecules were released from Cy3DNA-SWNT conjugates by nuclease,and the free Cy3 dyes penetrate into HeLa cell with high *** the actual amounts of SWNTs internalized in the cells were almost identical for both cells incubated in the FBS-present and FBS-absent media according to the Raman measurements,one should be cautious to determine the degree of SWNT internalization based on the fl uorescence intensities especially when the coloring dye molecules were linked to oligonucleotides in nuclease containing media.

关键词： Single-walled carbon nanotube oligonucleotide cellular delivery molecular transporter nuclease

Endoscopic cyanoacrylate injection for the treatment of gastric varices in children

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World Journal of Gastroenterology 2015年第9期21卷 2719-2724页

作者： Seak hee Oh Seung Jin Kim Kang Won Rhee kyung Mo Kim Department of Pediatrics Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoul 138-736South Korea

AIM:To evaluate the efficacy and safety of N-butyl-2-cyanoacrylate in treating acute bleeding of gastric varices in ***:The retrospective study included 21 children with 47 episodes of active gastric variceal bleeding who were treated by endoscopic injection of N-butyl-2-cyanoacrylate at Asan Medical Center Children's Hospital between August 2004 and December *** reduce the risk of embolism,each injection consisted of 0.1-0.5 mL of 0.5 mL N-butyl-2-cyanoacrylate diluted with 0.5 or 0.8 mL *** primary outcome was incidence of hemostasis after variceal obliteration and the secondary outcome was complication of the ***:The 21 patients experienced 47 episodes of active gastric variceal bleeding,including rebleeding,for which they received a total of 52 cyanoacrylate *** 42 bleeding episodes,hemostasis was achieved after one injection and following five bleeding episodes it was achieved after two *** mean volume of each single aliquot of cyanoacrylate injected was 0.3 ± 0.1 mL(range:0.1-0.5 m L).Injection achieved hemostasis in 45 of 47(95.7%) episodes of acute gastric variceal *** patients(52.4%) developed rebleeding events,with the mean duration of hemostasis being 11.1 ± 11.6 mo(range:1.0-39.2 mo).No treatment-related complications such as distal embolism were noted with the exception of abdominal pain in one patient(4.8%).Among four mortalities,one patient died of variceal ***:Endoscopic variceal obliteration using a small volume of aliquots with repeated cyanoacrylate injection was an effective and safe option for the treatment of gastric varices in children.

关键词： Cyanoacrylate Gastric varix Children Endoscopic va