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Septic shock due to Granulicatella adiacens after endoscopic ultrasound-guided biopsy of a splenic mass:A case report

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World Journal of Gastroenterology 2021年第8期27卷 751-759页

作者： Seo-Yeon Cho Eunae Cho Chang-Hwan Park hee-joon kim Joo-Yeon Koo Division of Gastroenterology Department of Internal MedicineChonnam National University HospitalGwangju 61469South Korea Department of Surgery Chonnam National University HospitalGwangju 61469South Korea Department of Pathology Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Endoscopic ultrasound-guided fine needle aspiration or biopsy(EUS-FNA or FNB)has become a popular method for diagnosing various lesions of the gastrointestinal tract and surrounding tissue due to the accuracy and *** the best of our knowledge,no case report of severe infection after EUS-FNB of a solid lesion in the spleen has been ***,we report a rare case of septic shock after EUS-FNB of a splenic *** SUMMARY A 45-year-old male patient presented to the outpatient clinic due to an incidentally detected splenic mass.A definitive diagnosis could not be established based on the abdominal magnetic resonance *** of the spleen showed a 6 cm-sized,relatively well-demarcated,heterogeneous mass,and EUS-FNB with a 22G needle was *** days after the procedure patient developed septic shock and a splenic abscess was *** culture revealed growth of Granulicatella *** the treatment with antibiotics the patient underwent surgical resection,and the pathological examination showed diffuse large B-cell *** patient received chemotherapy and he is in complete *** Infection of a splenic mass after EUS-FNB is a rare complication and prophylactic antibiotics might be considered.

关键词： Endoscopic ultrasound Endoscopic ultrasound-guided fine needle biopsy Splenic neoplasms Lymphoma Septic shock Case report

Early extrahepatic recurrence as a pivotal factor for survival after hepatocellular carcinoma resection:A 15-year observational study

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World Journal of Gastroenterology 2022年第36期28卷 5351-5363页

作者： Jae Hyun Yoon Sung Kyu Choi Sung Bum Cho hee joon kim Yang Seok Ko Chung Hwan Jun Department of Gastroenterology and Hepatology Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Gastroenterology and Hepatology Hwasun Chonnam National University Hospital and College of MedicineHwasun 58128South Korea Department of Surgery Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Surgery Hwasun Chonnam National University Hospital and College of MedicineHwasun 58128South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea

BACKGROUND Surgical resection is one of the most widely used modalities for the treatment of hepatocellular carcinoma(HCC).Early extrahepatic recurrence(EHR)of HCC after surgical resection is considered to be closely associated with poor ***,data regarding risk factors and survival outcomes of early EHR after surgical resection remain *** To investigate the clinical features and risk factors of early EHR and elucidate its association with survival *** From January 2004 to December 2019,we enrolled treatment-naïve patients who were≥18 years and underwent surgical resection for HCC in two tertiary academic *** excluding patients with tumor types other than HCC and/or ineligible data,this retrospective study finally included 779 *** resection of HCC was performed according to the physicians’decisions and the EHR was diagnosed based on contrast-enhanced computed tomography or magnetic resonance imaging,and pathologic confirmation was performed in selected *** Cox regression analysis was performed to identify the variables associated with *** Early EHR within 2 years after surgery was diagnosed in 9.5%of patients during a median followup period of 4.4 *** recurrence-free survival period was 5.2 mo,and the median time to EHR was 8.8 mo in patients with early *** 52.7%of patients with early EHR,EHR occurred as the first recurrence of HCC after surgical *** multivariate analysis,serum albumin100 U/L,surgical margin involvement,venous and/or lymphatic involvement,satellite nodules,tumor necrosis detected by pathology,tumor size≥7 cm,and macrovascular invasion were determined as risk factors associated with early *** sub-categorizing the patients according to the number of risk factors,the rates of both EHR and survival showed a significant correlation with the risk of early ***,multivariate analysis revealed that early E

关键词： Early extrahepatic recurrence Hepatocellular carcinoma Prognosis Surgery Survival

Postmortem ^(7)Li NMR analysis for assessing the reversibility of lithium metal electrodes in lithium metal batteries

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Journal of Energy Chemistry 2024年第7期94卷 430-440页

作者： Jaewon Baek Sunha kim hee-Tak kim Oc hee Han Department of Chemical&Biomolecular Engineering KAISTDaejeon 34141Republic of Korea Metropolitan Seoul Center Korea Basic Science InstituteSeoul 03759Republic of Korea Graduate School of Analytical Science&Technology Chungnam National UniversityDaejeon 34134Republic of Korea

Despite the proficiency of lithium(Li)-7 NMR spectroscopy in delineating the physical and chemical states of Li metal electrodes,challenges in specimen preparation and interpretation impede its *** this study,we conducted a comprehensive postmortem analysis utilizing ^(7)Li NMR,employing a stan-dard magic angle spinning probe to examine protective-layer coated Li metal electrodes and LiAg alloy electrodes against bare Li metal electrodes within Li metal batteries(LMBs).Our investigation explores the effects of sample burrs,alignment with the magnetic field,the existence of liquid electrolytes,and precycling on the ^(7)Li NMR *** contrasting NMR spectra before and after cycling,we identi-fied alterations in Li^(0) and Li^(+) signals attributable to the degradation of the Li metal *** NMR analyses decisively demonstrate the efficacy of the protective layer in mitigating dendrite and solid elec-trolyte interphase ***,we noted that Li*ions near the Li metal surface exhibit magnetic susceptibility anisotropy,revealing a novel approach to studying diamagnetic species on Li metal elec-trodes in *** study provides valuable insights and practical guidelines for characterizing distinct lithium states within LMBs.

关键词： NMR spectroscopy Lithium-7 Lithium metal battery Electrolyte Electrode-protective layer Solid electrolyte interface Magnetic susceptibility anisotropy Lithium-metal NMR signal Diamagnetic^(7)Li NMR signal

Body-Shaping Membrane to Regenerate Breast Fat by Elastic Structural Holding

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Research 2024年第1期2023卷 165-180页

作者： Hye-Seon kim Jeongeun Park Hyun-Su Ha Sewoom Baek Chan hee Lee Kyubae Lee Suji Park Jueun kim Se Won Yi Hak-joon Sung Department of Medical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Republic of Korea TMD LAB Co.Ltd. 6th Floor31Gwangnaru-ro 8-gilSeongdong-guSeoul 04799Republic of Korea

Tissue regeneration requires structural holding and movement support using tissue-type-specific aids such as bone casts,skin bandages,and joint ***,an unmet need exists in aiding breast fat regeneration as the breast moves following continuous body motion by exposing the breast fat to dynamic ***,the concept of elastic structural holding is applied to develop a shape-fitting moldable membrane for breast fat regeneration(“adipoconductive”)after surgical defects are *** membrane has the following key characteristics:(a)It contains a panel of honeycomb structures,thereby efficiently handling motion stress through the entire membrane;(b)a strut is added into each honeycomb in a direction perpendicular to gravity,thereby suppressing the deformation and stress concentration upon lying and standing;and(c)thermo-responsive moldable elastomers are used to support structural holding by suppressing large deviations of movement that occur *** elastomer became moldable upon a temperature shift above T_(m).The structure can then be fixed as the temperature *** a result,the membrane promotes adipogenesis by activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous implant placed on the motion-prone back areas of rodents in vivo.

关键词： thereby shaking Elastic

Recovery of Gold from Aqueous Solution Containing Au（Ⅲ） by Silicon Organic Polymer

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Journal of Chemistry and Chemical Engineering 2017年第1期11卷 15-21页

作者： Ganchimeg Yunden Burmaa Gunchin Naoki Kano hee joon kim School of Applied Sciences Mongolian University of Sciences and Technology Ulaanbaatar Mongolia The Institute of Chemistry and Chemical Technology Mongolian Academy of Sciences Enkhtaivan Avenue 54b BayanzurkhDistrict Ulaanbaatar 13330 Mongolia Department of Chemistry and Chemical Engineering Faculty of Engineering Niigata University 8050 Ikarashi 2-Nocho Nishi-kuNiigata-shi Niigata 950-2181 Japan

The silicon organic polymer containing PSOT-3 （dioxothiocarbamide groups） has been synthesized and characterized, and the adsorption of Au（III） on PSOT-3 was investigated. The results showed that PSOT-3 had good adsorption capacity for Au（III）, and the adsorption of Au（III） was found to be the most effective in 0.1-0.3 mol/dm^3 hydrochloric acid solution. The adsorption is physical and the process is endothermic, and Freundlich isotherm fits the data better than the Langmuir isotherm. The adsorption can be generally described by electrostatic interaction （Coulomb＇s force） between the adsorbent and the adsorbate. The high adsorption capacity of this sorbent has significant potential for gold recovery from aqueous solutions.

关键词： Gold adsorption adsorption kinetics silicon organic polymer thermodynamic parameters.

Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

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Signal Transduction and Targeted Therapy 2024年第1期9卷 173-210页

作者： Md Entaz Bahar Hyun joon kim Deok Ryong kim Department of Biochemistry and Convergence Medical Sciences and Institute of Medical Science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea Department of Anatomy and Convergence Medical Sciences and Institute of Medical Science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea

Metastatic dissemination of solid tumors,a leading cause of cancer-related mortality,underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis,chemoresistance,and the mechanistic backgrounds of individuals whose cancers are prone to *** most prevalent signaling cascade governed by multi-kinase inhibitors is the mitogen-activated protein kinase(MAPK)pathway,encompassing the RAS–RAF–MAPK kinase(MEK)–extracellular signal-related kinase(ERK)*** kinase is a primary mediator of the MAPK pathway,responsible for the sequential activation of downstream targets,such as MEK and the transcription factor ERK,which control numerous cellular and physiological processes,including organism development,cell cycle control,cell proliferation and differentiation,cell survival,and *** in this signaling cascade are associated with diseases such as *** inhibitors(RAFi)combined with MEK blockers represent an FDAapproved therapeutic strategy for numerous RAF-mutant cancers,including melanoma,non-small cell lung carcinoma,and thyroid ***,the development of therapy resistance by cancer cells remains an important ***,an intracellular lysosome-dependent catabolic recycling process,plays a critical role in the development of RAFi resistance in ***,targeting RAF and autophagy could be novel treatment strategies for RAF-mutant *** this review,we delve deeper into the mechanistic insights surrounding RAF kinase signaling in tumorigenesis and ***,we explore and discuss the ongoing development of next-generation RAF inhibitors with enhanced therapeutic ***,this review sheds light on the functional interplay between RAF-targeted therapies and autophagy in cancer.

关键词： RAF insight mechanism

Wearable Triboelectric Nanogenerators Based on Printed Polyvinylidene Fluoride Films Incorporated with Cobalt-Based Metal-Organic Framework for Self-Powered Mobile Electronics

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Energy & Environmental Materials 2024年第4期7卷 396-403页

作者： Myeong-Hyeon kim Sang-joon Park Tae-Jun Ha Department of Electronic Materials Engineering Kwangwoon University

In this study,wearable triboelectric nanogenerators comprising bar-printed polyvinylidene fluoride (PVDF) films incorporated with cobalt-based metalorganic framework (Co-MOF) were *** enhanced output performance of the TENCs was attributed to the phase transition of PVDF from α-crystals to β-crystals,as facilitated by the incorporation of the MOF.

关键词： bar printing phase transition polyvinylidene fluoride incorporated with cobalt-based metal–organic framework self-powered mobile electronics wearable triboelectric nanogenerators

Insights into the changes in the surface properties of goethite with Ni in the lattice in the presence of salicylhydroxamic acid:Experimental and density functional theory studies

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 665-677页

作者： Levie Mweene Gilsang Hong hee-Eun Jeong hee-won Kang Hyunjung kim Department of Earth Resources and Environmental Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea

Comparative experiments and theoretical analysis of the surface chemistry changes of goethite(GT)and goethite containing Ni(GTN)in the lattice in the presence of salicylhydroxamic acid(SA)were *** was revealed that in the presence of 100 g·t^(-1)of SA,the flotation recovery of GTN and GT increased with increasing pH,achieving a maximum recovery of 98.9%for both minerals at p H 8.3 and decreasing beyond that pH,with GTN having a slightly higher recovery than GT,except at pH *** was further confirmed by the higher complexation energies of GTN···SA(-883.87 kJ·mol^(-1))compared with GT···SA(-604.23 kJ·mol^(-1))resulting from covalent,closed-shell,and conventional hydrogen *** higher adsorption of SA onto GTN relative to GT was due to the formation of aπ-hole in GTN,thereby promoting a higher interaction of the collector with the ***,the presence of Ni in the GT lattice improves and decreases the adsorption and desorption of SA onto and from the mineral,respectively,compared with those onto and from GT.

关键词： nickel goethite adsorption salicylhydroxamic acid recovery

Emission wavelength selection via anomalous polarized fluorescence in ZnO-C nanowires

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Nano Research 2024年第5期17卷 4489-4497页

作者： joon Kiat Kang kim Yong Lim Chorng Haur Sow Department of Physics National University of SingaporeSingapore 117542Singapore

Defect fluorescence from high aspect ratio semiconductor nanowires typically displays a weak polarization parallel to the nanowire’s long axis due to dielectric mismatch in high aspect ratio ***,anomalous 2.2 eV defect fluorescence distinctly polarized perpendicular to the nanowire is observed and measured from carbon-incorporated zinc oxide *** observations are significant because polarized defect emissions with consistent polarization on a mesoscopic scale are *** a systematic study and comparison of experimental results with density functional theory calculations,an oriented defect complex comprising carbon substituting on an oxygen site and an oxygen vacancy(CO-VO)is deduced to be responsible for the anomalous yellow fluorescence,demonstrating a method for relating atomic-scale defect geometry to mesoscopic *** anomalous emission can appear in both green-and red-fluorescing nanowires grown with different carbon concentrations,verifying the independence and uniqueness of the 2.2 eV *** allows for polarization-dependent emission wavelength selection from a single nanowire.

关键词： anomalous polarization defects fluorescence zinc oxide carbon